Online citations, reference lists, and bibliographies.

Liquid Chromatography Tandem Mass Spectrometry Method For Determination Of Bisoprolol In Human Plasma Using D5-bisoprolol As The Internal Standard.

Gang-yi Liu, Wei Wang, Jing-ying Jia, Chuan Wei Lu, Yan-mei Liu, Meng-qi Zhang, Yun Han Liu, Shui-jun Li, Chen Yu
Published 2010 · Chemistry, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope-labeled d5-bisoprolol was used as internal standard. The chromatographic separation was performed on a Capcell Pak C(18) MG III column (100 mm x 2.0 mm, 5 microm). The protonated ion of the analyte was detected in positive ionization by multiple reaction monitoring mode. The mass transition pairs of m/z 326.3 --> 116.3 and m/z 331.3 --> 121.3 were used to detect bisoprolol and the internal standard, respectively. Linearity, accuracy, precision, recovery, matrix effect, dilution test and stability were evaluated during method validation over the range of 0.5-100 ng/mL. The validated method was successfully applied to analyze human plasma samples in a bisoprolol bioavailability study.
This paper references
Method development and robustness testing by experimental design
S Li (2007)
10.1016/j.jchromb.2006.10.013
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Shuijun Li (2007)
Bisoprolol in the treatment of chronic heart failure: from pathophysiology to clinical pharmacology and trial results
Marco Metra (2007)
10.1016/j.jchromb.2006.11.030
Simultaneous determination of 6 beta-blockers, 3 calcium-channel antagonists, 4 angiotensin-II antagonists and 1 antiarrhythmic drug in post-mortem whole blood by automated solid phase extraction and liquid chromatography mass spectrometry. Method development and robustness testing by experimental d
Lena Kristoffersen (2007)
10.1016/j.jchromb.2007.01.043
A high throughput and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the estimation of bisoprolol in human plasma using multiplexing technique.
Jignesh Bhatt (2007)
10.1016/j.chroma.2004.07.102
Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization.
Hans H Maurer (2004)
10.1002/bmc.195
Development, validation and analytical error function of two chromatographic methods with fluorimetric detection for the determination of bisoprolol and metoprolol in human plasma.
A J Braza (2002)
10.1536/IHJ.49.281
Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation.
Haruhisa Ishiguro (2008)
rmation of -blockers in urine using gas chromatography-mass spectrometry
M Taguchi (2008)
10.1177/0091270006291626
A pharmacokinetic comparison of generic tablets containing bisoprolol with the innovator formulation in healthy volunteers.
Dušan Jovanović (2006)
10.1002/bmc.785
Liquid chromatographic-electrospray tandem mass spectrometric determination of bisoprolol in human plasma.
Mingyuan Liu (2007)
10.1002/bmc.1130040415
High performance liquid chromatographic measurement of bisoprolol in plasma.
R J Eastwood (1990)
Bisoprolol in the treatment of chronic heart failure
Pascal de Groote (2007)
10.1016/j.jpba.2007.03.001
LC-ESI-MS method for the determination of bisoprolol in human plasma.
Li Ding (2007)
10.1016/j.aca.2007.11.050
Paradigms in isotope dilution mass spectrometry for elemental speciation analysis.
Juris Meija (2008)
[Screening, quantification and confirmation of beta-blockers in urine using gas chromatography-mass spectrometry].
Liangmin Shangguan (2008)
10.1016/j.jchromb.2003.11.009
Simultaneous determination of the acid/base antihypertensive drugs celiprolol, bisoprolol and irbesartan in human plasma by liquid chromatography.
Eric Caudron (2004)
10.1021/js970316d
Pharmacokinetics and metabolism of bisoprolol enantiomers in humans.
Yuji Horikiri (1998)
10.1248/bpb.28.876
Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients.
Masato Taguchi (2005)



This paper is referenced by
10.1016/j.clinthera.2010.11.001
Relative bioavailability of generic and branded acetylcysteine effervescent tablets: A single-dose, open-label, randomized-sequence, two-period crossover study in fasting healthy Chinese male volunteers.
Yan-mei Liu (2010)
10.1007/s11090-019-10043-4
Construction of Plasma Ion Sources to be Applied in Analysis of Small Organic Compounds Using Mass Spectrometry
Maria Guć (2019)
10.11603/mcch.2410-681x.2019.v.i3.10566
ANALYSIS OF APPROACHES TO THE DEVELOPMENT AND VALIDATION OF THE METHODS OF ANALYSIS OF BISOPROLOL IN DRUGS AND BIOLOGICAL LIQUIDS
L. S. Logoyda (2019)
10.22159/IJAP.2018V10I2.23195
A HPLC-MS/MS METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF BISOPROLOL AND ENALAPRIL IN THE PRESENT OF ENALAPRILAT IN HUMAN PLASMA
Liliya Logoyda (2018)
10.1093/chromsci/bmz064
Cloud Point Extraction in the Determination of Drugs in Biological Matrices.
Grzegorz Kojro (2019)
10.1515/amma-2015-0071
Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis
Mahu Ştefania Corina (2015)
10.1016/j.chroma.2015.10.076
Cloud-point extraction is compatible with liquid chromatography coupled to electrospray ionization mass spectrometry for the determination of bisoprolol in human plasma.
Joanna Giebułtowicz (2015)
SENSITIVE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF BISOPROLOL AND TRIAMTERENE IN HUMAN PLASMA
G. N. Hemavathi (2017)
Semantic Scholar Logo Some data provided by SemanticScholar