Online citations, reference lists, and bibliographies.
← Back to Search

Evaluation Of The Antimicrobial Potential Of Two Flavonoids Isolated From Limnophila Plants

G. Brahmachari, N. Mandal, Shyamal K. Jash, Rajiv Roy, Lalan C. Mandal, A. Mukhopadhyay, B. Behera, Sasadhar Majhi, A. Mondal, A. Gangopadhyay
Published 2011 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The antimicrobial potential of two bioflavonoids, i.e., 5,7‐dihydroxy‐4′,6,8‐trimethoxyflavone (1) and 5,6‐dihydroxy‐4′,7,8‐trimethoxyflavone (2), isolated from Limnophila heterophylla Benth. and L. indica (Linn.) Druce (Scrophulariaceae), respectively, were evaluated against the microbial strains Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Alternaria solani, and Candida albicans. Compounds 1 and 2 exhibited moderate but broad antimicrobial activities against both Gram‐positive and Gram‐negative bacteria and also against the fungal pathogens. Moreover, the mechanism of action of 1 and 2 on the cellular functions or structures of some of the microorganisms was studied. Compound 1 showed a bactericidal effect against E. coli and S. aureus (MICs of 200 and 250 μg/ml, resp.), while compound 2 was found to effectively kill B. subtilis by cell lysis. The growth of A. solani and C. albicans was inhibited by compounds 1 and 2, respectively. The effects of the flavonoids on the cellular structures and the carbohydrate metabolic pathways were studied by scanning electron microscopy (SEM) of the treated cells and by assessing the specific activity of key enzymes of the pathways, respectively. At sublethal doses, they enhanced the activity of gluconeogenic fructose bisphosphatase, but decreased the activity of phosphofructokinase and isocitrate dehydrogenase, the key enzymes of the EmbdenMeyerhofParnas pathway and the tricarboxylic acid cycle, respectively.
This paper references
Natural Products Chemistry
W. Ollis (1964)
Constituents of Iva Species. V. Isolation, Structure, and Synthesis of Nevadensin, a New Flavone from Iva Nevadensis M. E. Jones and Iva Acerosa (Nutt.) Jackson1,2
L. Farkas (1966)
Antibiotic susceptibility testing by a standardized single disk method.
A. Bauer (1966)
Tricarboxylic Acid Cycle Enzymes and Morphogenesis in Blastocladiella emersonii
B. T. Khouw (1969)
Relationship between catabolism of glycerol and metabolism of hexosephosphate derivatives by Pseudomonas aeruginosa
H. E. Heath (1978)
The transport and metabolism of glucose in cowpea rhizobia
M. Stowers (1983)
Lei Peng (1984)
Chemical and pharmacological investigations of Limnophila conferta and Limnophila heterophylla
G. S. Reddy (1991)
Mode of action of pediocin AcH from Pediococcus acidilactici H on sensitive bacterial strains
A. Bhunia (1991)
Natural products in drug discovery and development.
G. Cragg (1997)
The influence of natural products upon drug discovery.
D. Newman (2000)
Comparative Evaluation of Disk Diffusion with Microdilution Assay in Susceptibility Testing of Caspofungin against Aspergillus and Fusarium Isolates
S. Arikan (2002)
Natural products as sources of new drugs over the period 1981-2002.
D. Newman (2003)
Antimycobacterial and antioxidant flavones fromLimnophila geoffrayi
A. Suksamrarn (2003)
The role of natural product chemistry in drug discovery.
M. S. Butler (2004)
Increase in activity of essential oil components carvacrol and thymol against Escherichia coli O157:H7 by addition of food stabilizers.
S. Burt (2005)
The killing effect of cryptolepine on Staphylococcus aureus
I. K. Sawer (2005)
Succinate-mediated catabolite repression of enzymes of glucose metabolism in root-nodule bacteria
N. C. Mandal (2005)
Antimicrobial activity of saponins from Acacia auriculiformis.
P. Mandal (2005)
Chemistry of natural products: recent trends and developments.
G. Brahmachari (2006)
Progress in the Research on Naturally Occurring Flavones and Flavonols: An Overview
Goutam Gorai (2006)
in Floriculture
G. Brahmachari (2006)
Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects
G. Brahmachari (2008)
Anti-tuberculosis Compounds from two Bolivian Medicinal Plants, Senecio Mathewsii and Usnea Florida
Q. Hong (2008)
Chemical Constituents of Limnophila indica.
G. Brahmachari (2008)
Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans.
N. Guo (2009)
Antimicrobial natural products: an update on future antibiotic drug candidates.
M. Saleem (2010)
Post-antibacterial effect of thymol
G. Zarrini (2010)
Flavonoids: new roles for old molecules.
C. Buer (2010)
Handbook of Pharmaceutical Natural Products
G. Brahmachari (2010)
Fitoterapia 2005
P. Mandal (2011)
Change of Carbon Metabolic Activity of Rhizobium Under Carbon Starvation
D. Bakshi (2013)

This paper is referenced by
The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota
M. Makarewicz (2021)
Nuclear Magnetic Resonance Spectroscopic Behaviour of Some Selective Natural Flavonoids: A Look Through
Shyamal K. Jash (2020)
Antibacterial Flavonoids and Other Compounds from the Aerial Parts of Vernonia guineensis Benth. (Asteraceae)
Steven Collins Njonte Wouamba (2020)
Effects of Nevadensin from Rice Paddy Herb (Limnophila aromatica) on Growth and Physiological Parameters of Hybrid Catfish (Clarias macrocephalus × C. gariepinus)
Aroon Jankhama (2020)
FT-IR, UV–visible, and NMR Spectral Analyses, Molecular Structure, and Properties of Nevadensin Revealed by Density Functional Theory and Molecular Docking
A. Kumar (2020)
Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone “6,7,4′-Trimethyl Flavone” Isolated from Wulfenia amherstiana
M. Kakar (2020)
Antibacterial activity of flavonoids and their structure–activity relationship: An update review
F. Farhadi (2019)
Sopherone A and B: Two new biologically relevant dibenzo-α-pyrones from Cassia sophera.
G. Brahmachari (2019)
Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis
Anahí C. Sánchez-Chávez (2019)
1 LC-MS / MS Tandem Mass Spectrometry for Analysis of 2 Phenolic Compounds and Pentacyclic Triterpenes in 3 Antifungal Extracts of Terminalia brownii ( Fresen ) 4
E. Salih (2017)
Experimental and quantum chemical studies on poriferasterol – A natural phytosterol isolated from Cassia sophera Linn. (Caesalpiniaceae)
G. Brahmachari (2017)
Evaluation of Biochemical Toxicity and Antioxidant Propertiesof Pioglitazone on Albino Wistar Rats
O. O. Ogunlana (2017)
Structural confirmation, single X-ray crystallographic behavior, molecular docking and other physico-chemical properties of gerberinol, a natural dimethyl dicoumarol from Gerbera lanuginosa Benth. (Compositae)
G. Brahmachari (2017)
3,5,7-Trimethoxyphenanthrene-1,4-dione: a new biologically relevant natural phenanthrenequinone derivative from Dioscorea prazeri and studies on its single X-ray crystallographic behavior, molecular docking and other physico-chemical properties
G. Brahmachari (2016)
Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects - An Update
G. Brahmachari (2015)
Antibacterial evaluation of flavonoid compounds against E. coli by microcalorimetry and chemometrics
Weijun Kong (2015)
Natural Products as Antimicrobial Agents – an Update
M. Saleem (2014)
Chemical and Pharmacological Aspects of Limnophila aromatica (Scrophulariaceae): An Overview
D. Gorai (2014)
A new pentacyclic triterpene with potent antibacterial activity from Limnophila indica Linn. (Druce).
G. Brahmachari (2013)
A structure-activity relationship study of flavonoids as inhibitors of E. coli by membrane interaction effect.
T. Wu (2013)
Nevadensin: Isolation, chemistry and bioactivity
G. Brahmachari (2010)
Semantic Scholar Logo Some data provided by SemanticScholar