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“Chronic Myelogenous Leukemia In Primary Blast Crisis” Rather Than “de Novo BCR‐ABL1‐positive Acute Myeloid Leukemia”

Cédric Pastoret, Roch Houot
Published 2017 · Medicine
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Key Clinical Message Differentiating chronic myelogenous leukemia in primary blast crisis (CML‐BC) from de novo BCR‐ABL1‐positive acute myeloid leukemia (AML) is a diagnostic challenge with therapeutic consequences. In our case, a basophilia, the presence of the Philadelphia chromosome in all metaphases and the strict exclusion of molecular hallmarks of AML lead us to retain the diagnosis of CML‐BC rather than BCR‐ABL1+ AML.
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