← Back to Search
MnO2-modified Persistent Luminescence Nanoparticles For Detection And Imaging Of Glutathione In Living Cells And In Vivo.
N. Li, W. Diao, Y. Han, W. Pan, T. Zhang, B. Tang
Published 2014 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Persistent luminescence nanoparticles (PLNPs) hold great promise for the detection and imaging of biomolecules. Herein, we have demonstrated a novel nanoprobe, based on the manganese dioxide (MnO2 )-modified PLNPs, that can detect and image glutathione in living cells and in vivo. The persistent luminescence of the PLNPs can be efficiently quenched by the MnO2 nanosheets. In the presence of glutathione (GSH), MnO2 was reduced to Mn(2+) and the luminescence of PLNPs can be restored. The persistent luminescence property can allow detection and imaging without external excitation and avoid the background noise originating from the in situ excitation. This strategy can offer a promising platform for detection and imaging of reactive species in living cells or in vivo.
This paper references
Intracellular glutathione detection using MnO(2)-nanosheet-modified upconversion nanoparticles.
Renren Deng (2011)
Fluorescence resonance energy transfer inhibition assay for α-fetoprotein excreted during cancer cell growth using functionalized persistent luminescence nanoparticles.
Bo-Yue Wu (2011)
Glutathione in Cancer Biology and Therapy
J. Estrela (2006)
A multicolor nanoprobe for detection and imaging of tumor-related mRNAs in living cells.
N. Li (2012)
The importance of glutathione in human disease.
D. Townsend (2003)
A highly selective and instantaneous nanoprobe for detection and imaging of ascorbic acid in living cells and in vivo.
N. Li (2014)
A near-infrared colorimetric fluorescent chemodosimeter for the detection of glutathione in living cells.
M. Li (2014)
Multiplexed detection and imaging of intracellular mRNAs using a four-color nanoprobe.
W. Pan (2013)
Glutathione deficiency is associated with impaired survival in HIV disease.
L. Herzenberg (1997)
Reactivity of some sulphur- and non-sulphur-containing amino acids towards water soluble colloidal MnO2. A kinetic study
S. M. Z. Andrabi (2006)
Sunlight-activated long-persistent luminescence in the near-infrared from Cr(3+)-doped zinc gallogermanates.
Zhengwei Pan (2011)
The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells.
T. Maldiney (2014)
Sensitive and selective sensor for biothiols in the cell based on the recovered fluorescence of the CdTe quantum dots-Hg(II) system.
Bingyan Han (2009)
A tumour mRNA-triggered nanocarrier for multimodal cancer cell imaging and therapy.
N. Li (2014)
Determination of glutathione and glutathione disulfide in biological samples: an in-depth review.
P. Monostori (2009)
Functional near infrared-emitting Cr3+/Pr3+ co-doped zinc gallogermanate persistent luminescent nanoparticles with superlong afterglow for in vivo targeted bioimaging.
Abdukader Abdukayum (2013)
A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cells.
B. Tang (2007)
Regulation of gene expression by reactive oxygen.
T. Dalton (1999)
Oxidation of cysteine and glutathione by soluble polymeric MnO2.
Julián Herszage (2003)
Nanoprobes with near-infrared persistent luminescence for in vivo imaging
Quentin le Masne de Chermont (2007)
Photoactivated CdTe/CdSe quantum dots as a near infrared fluorescent probe for detecting biothiols in biological fluids.
Y. Zhang (2009)
Effect of core diameter, surface coating, and PEG chain length on the biodistribution of persistent luminescence nanoparticles in mice.
T. Maldiney (2011)
Selective detection of cysteine and glutathione using gold nanorods.
P. K. Sudeep (2005)
Oxidized redox state of glutathione in the endoplasmic reticulum.
C. Hwang (1992)
Design of bis-spiropyran ligands as dipolar molecule receptors and application to in vivo glutathione fluorescent probes.
N. Shao (2010)
BODIPY-based ratiometric fluorescent sensor for highly selective detection of glutathione over cysteine and homocysteine.
Li-Ya Niu (2012)
Cyanine-based fluorescent probe for highly selective detection of glutathione in cell cultures and live mouse tissues.
J. Yin (2014)
Fluorescent and colorimetric probes for detection of thiols.
Xiaoqiang Chen (2010)
Potent method for the simultaneous determination of glutathione and hydrogen peroxide in mitochondrial compartments of apoptotic cells with microchip electrophoresis-laser induced fluorescence.
Z. Chen (2010)
Turn-on fluorescence sensor for intracellular imaging of glutathione using g-C₃N₄ nanosheet-MnO₂ sandwich nanocomposite.
X. Zhang (2014)
This paper is referenced by
Turning solid into gel for high-efficient persistent luminescence-sensitized photodynamic therapy.
Shao-Kai Sun (2019)
Recent Progress in Time-Resolved Biosensing and Bioimaging Based on Lanthanide-Doped Nanoparticles.
Q. Ma (2019)
Direct low-temperature synthesis of ultralong persistent luminescence nanobelts based on a biphasic solution-chemical reaction
Haoyang Liu (2018)
Black phosphorus quantum dots nanocomposites based activatable bimodal imaging and determination of intracellular glutathione
H. Li (2020)
Dual ligand co-functionalized fluorescent gold nanoclusters for the "turn on" sensing of glutathione in tumor cells.
Shenghao Xu (2016)
A magnetic/fluorometric bimodal sensor based on a carbon dots-MnO2 platform for glutathione detection.
Y. Xu (2016)
Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics
Fei Gong (2020)
Detection of glutathione based on MnO2 nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter
Qingqing Tan (2017)
Platelets redox balance assessment: Current evidence and methodological considerations.
A. Komosa (2017)
Tumor Microenvironment‐Responsive Mesoporous MnO2‐Coated Upconversion Nanoplatform for Self‐Enhanced Tumor Theranostics
J. Xu (2018)
Persistent Luminescence Nanophosphor Involved Near-Infrared Optical Bioimaging for Investigation of Foodborne Probiotics Biodistribution in Vivo: A Proof-of-Concept Study.
Y. Liu (2017)
Two dimensional and layered transition metal oxides
K. Kalantar-zadeh (2016)
Time-Gated Imaging of Latent Fingerprints and Specific Visualization of Protein Secretions via Molecular Recognition.
J. Wang (2017)
Near infrared fluorescent dual ligand functionalized Au NCs based multidimensional sensor array for pattern recognition of multiple proteins and serum discrimination.
Shenghao Xu (2017)
Artificially controlled degradable inorganic nanomaterial for cancer theranostics.
Y. Liu (2017)
Visible-light photoelectrochemical sensor for glutathione based on CoFe2O4-nanosphere-sensitized copper tetraaminophthalocyanine–graphene oxide
Wenfeng Zhuge (2020)
Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides.
Xiao-Peng He (2016)
Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes
Songyi Lee (2018)
A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging
Yuyan Jiang (2019)
Synthesis and characterization of hyaluronic acid coated manganese dioxide microparticles that act as ROS scavengers.
J. Bizeau (2017)
Hydrogels for Medical and Environmental Applications
A. Jayakumar (2020)
A FRET-based carbon dot-MnO2 nanosheet architecture for glutathione sensing in human whole blood samples.
Y. Wang (2015)
Solution growth of 3D MnO2 mesh comprising 1D nanofibres as a novel sensor for selective and sensitive detection of biomolecules.
Bushra Tehseen (2018)
Chemically engineered persistent luminescence nanoprobes for bioimaging
T. L'ecuyer (2016)
Turn-on fluorescent glutathione detection based on lucigenin and MnO2 nanosheets.
M. Halawa (2019)
Persistent luminescence nanoprobe for biosensing and lifetime imaging of cell apoptosis via time-resolved fluorescence resonance energy transfer.
L. Zhang (2015)
A MnO2 nanosheet-assisted GSH detection platform using an iridium(iii) complex as a switch-on luminescent probe.
Zhenzhen Dong (2017)
Radiopaque tantalum oxide coated persistent luminescent nanoparticles as multimodal probes for in vivo near-infrared luminescence and computed tomography bioimaging.
Yu-Chen Lu (2015)
Multiple functional nanoprobe for contrast-enhanced bimodal cellular imaging and targeted therapy.
Hong-Min Meng (2015)
Recent advances in functionalized MnO2 nanosheets for biosensing and biomedicine applications.
J. Chen (2019)
A dual-modal nanoprobe based on Eu(iii) complex-MnO2 nanosheet nanocomposites for time-gated luminescence-magnetic resonance imaging of glutathione in vitro and in vivo.
B. Song (2019)
SrAl12O19: Fe3+ @3‐aminopropyl triethoxysilane: Ambient aqueous stable near‐infrared persistent luminescent nanocomposites
Kang Ru (2020)See more