Online citations, reference lists, and bibliographies.

Aquasomes: A Novel Nanocarrier For Drug Delivery

S. U. Wani, A. Yerawar
Published 2011 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. Aquasomes are the nanobiopharmaceutical carrier system contains the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film. Aquasomes are spherical 60–300 nm particles used for drug and antigen delivery. Properties like protection and preservation of fragile biological molecules, conformational integrity, and surface exposure made it as a successful carrier system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. It has been reported haemoglobin loaded aquasomes using hydroxyapatite core as potential artificial oxygen carrying system. Conformational integrity of aquasomes exploited as a red blood cell substitutes, vaccines for delivery of viral antigen (Epstein-Barr and Immune deficiency virus) to evoke correct antibody and as targeted system for intracellular gene therapy. Enzyme activity and sensitivity towards molecular conformation made aquasome as a novel carrier for enzymes like DNAses and pigment/ dyes.This article reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition.
This paper references
Self assembled carbohydr ate stabilized ceramic nanoparticles for the parent ral drug delivery of insulin
A. Cherian (2000)
Long–Term Stabilization of Biologicals
F. Franks (1994)
Nano - crystalline EpsteinBar Vims decoys . ” 1
N. Kossovsky (1991)
Proteinoligosacchrideinteractions:lysozymephosphor ylase amylase.”curr
L. N Johnson (1985)
proteins at interface ; current issues and future prospects
T. A. Horbett
Macro molecules academ ic press
Bovey (1998)
Proteinoligosacchrideinteractions : lysozymephosphorylase amylase
L. N Johnson (1985)
Phase relations and vi trification in sacchride Solutions and trehalose anomaly.”J
J. L. Green (1989)
Preservation of structural and functional activity in lyophilized sarcoplasmic reticulum.
J. Crowe (1983)
“ Advances in controlled drug delivery system
K. Jain.N.
S.A.”Preservation of structural and functional activity in lyophiliz ed sarcoplasmic reticulum
Crowe (1983)
The acute phase response.
H. Baumann (1994)
Stabilization of protein structure by sugars.
T. Arakawa (1982)
j., Nanoparticles. A new colloidal drug delivery system
S. Bhave (1994)
Cross linking encapsulated hemoglobin with solid phase supports: lipid enveloped hemoglobin adsorbed to surface modified ceramic particles exhibit physiological oxygen lability.
N. Kossovsky (1994)
A new colloidal drug delivery system ” the Eastern pharmacist
S. Bhave (1994)
J.”The acute phase response
H. Bauman (1994)
A non-denaturing solid p hase pharmaceutical carrier comprised of surfacemodified nanocrystalline materials.
N. Kossovsky (1990)
Proteins at Interfaces: Current Issues and Future Prospects
T. Horbett (1987)
The entropic cost of bound water in crystals and biomolecules.
J. Dunitz (1994)
Targeted & controlled
P VaysS (2004)
A nondenaturing solid phase pharmaceutical carrier comprised of surface-modified nanocrystalline materials.
N. Kossovsky (1990)
Interaction of sugars with the membrane protein component of the lactose transport system of Escherichia coli.
J. Carter (1968)
Photoinduced destabilization of bilayer vesicles
David A. Frankel (1989)
Nano-crystalline Epstein-Bar Vims decoys.
N. Kossovsky (1991)
Phase relations and vitrification in saccharide-water solutions and the trehalose anomaly
J. Green (1989)
Materials Biotechnology and Blood Substitutes
N. Kossovsky (1991)
Proteins at interfaces : physicochemical and biochemical studies
J. Brash (1987)
Pharmacolog icallyactive polymers”
H. G. Batz (1974)
Malondiaalde hyde de modification of lipoprotein produces avid uptake by human monocytes macrophages
M. E Haberland (1992)
Elaboration and structural analysis of aquasomes loaded with indomethacin.
I. Rojas-Oviedo (2007)
Surface m odified nanocrystalline ceranlic for drug delivery applications.
N. Kossovsky (1994)
Perfecting delivery ”
N. ” Kossovsky (1996)
Intermolecular and Surface Forces.Jacob N. Israelachvili
S. Mclaughlin (1993)
Self-Assembled Carbohydrate-Stabilized Ceramic Nanoparticles for the Parenteral Delivery of Insulin
A. K. Cherian (2000)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar