Electro‐Oxidation Of The Pharmaceutical Furosemide: Kinetics, Mechanism, And By‐Products
Hugo Olvera-Vargas, Nihal Oturan, Didier Buisson, Eric D. van Hullebusch, Mehmet A Oturan
Published 2015 · Chemistry
Download PDFAnalyze on Scholarcy
Furosemide is a widely prescribed diuretic whose unambiguous presence in water appointed it as an emerging pollutant. This work focuses on the electrochemical degradation of this drug in aqueous solutions by electrochemical advanced oxidation processes, electro-Fenton and anodic oxidation, using Pt/carbon-felt and boron doped diamond (BDD)/carbon-felt cells with H2O2 electrogeneration. The higher oxidation power of the electro-Fenton process using a BDD anode was demonstrated. The oxidative degradation of furosemide by electrochemically generated •OH radicals follows a pseudo-first order kinetics. The absolute rate constant of the oxidation reaction of furosemide by •OH was determined using a competition kinetics method and found to be 3.4 × 109 M−1 s−1. The evolution of the total organic carbon removal during the treatment as a mineralization efficiency parameter was investigated. It was found that the electrochemical degradation of furosemide yields formation of aromatic by-products which are oxidized afterwards to aliphatic carboxylic acids before their conversion to CO2 and inorganic ions (NH4+, NO3–, Cl–, and SO42–). The toxicity assessment by the Microtox® method revealed formation of oxidation reaction intermediates more toxic than the parent molecule. Nevertheless, the overall results confirm the high effectiveness of anodic oxidation and electro-Fenton processes for the removal of furosemide and its by-products from aqueous media.
This paper references
Electrochemistry: as cause and cure in water pollution—an overview
Subramanyan Vasudevan (2013)
Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans.
Mehri Hezari (1992)
Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide.
Céline Laurencé (2014)
Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes.
Maria Klavarioti (2009)
Catalytic behavior of the Fe3+/Fe2+ system in the electro-Fenton degradation of the antimicrobial chlorophene
Ignasi Sirés (2007)
Advanced Oxidation Processes for Organic Contaminant Destruction Based on the Fenton Reaction and Related Chemistry
Joseph J. Pignatello (2006)
Preparative access to transformation products (TPs) of furosemide: a versatile application of anodic oxidation
Céline Laurencé (2011)
Boron doped diamond electrodes for nitrate elimination in concentrated wastewater
Claude Lévy-Clément (2003)
Degradation of 40 selected pharmaceuticals by UV/H2O2.
B. A. Wols (2013)
Formation of cytotoxic protein reactive metabolites from furosemide: Biological consequences of drug metabolism
D. Antoine (2007)
An ecologically effective water treatment technique using electrochemically generated hydroxyl radicals for in situ destruction of organic pollutants: Application to herbicide 2,4-D
Mehmet A Oturan (2000)
Removal of total ammonia nitrogen (TAN), nitrate and total organic carbon (TOC) from aquaculture wastewater using electrochemical technology: A review
Wei Tze Mook (2012)
Electrochemical oxidation of hydroquinone, resorcinol, and catechol on boron-doped diamond anodes.
Bensalah Nasr (2005)
A comparative study on the efficiency of electro-Fenton process in the removal of propham from water
Ali Özcan (2009)
Unprecedented total mineralization of atrazine and cyanuric acid by anodic oxidation and electro-Fenton with a boron-doped diamond anode
Nihal Oturan (2011)
Mineralization of the antibiotic chloramphenicol by solar photoelectro-Fenton: From stirred tank reactor to solar pre-pilot plant
Sergi Garcia-Segura (2014)
Remediation of water pollution caused by pharmaceutical residues based on electrochemical separation and degradation technologies: a review.
Ignasi Sirés (2012)
Removal of pharmaceuticals from a WWTP secondary effluent by ultrafiltration/reverse osmosis followed by electrochemical oxidation of the RO concentrate
Ana María Urtiaga (2013)
Advanced Oxidation Processes in Water/Wastewater Treatment: Principles and Applications. A Review
Mehmet A Oturan (2014)
Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents.
Santiago Esplugás (2007)
Sulfamethoxazole abatement by means of ozonation.
Renato Falcão Dantas (2008)
Pharmaceuticals: a threat to drinking water?
Oliver A. H. Jones (2005)
Mechanism and kinetics of sulfamethoxazole photocatalytic ozonation in water.
F. Beltrán (2009)
The presence of pharmaceuticals in the environment due to human use--present knowledge and future challenges.
Klaus Kuemmerer (2009)
Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment
Ahmad Dirany (2011)
Electrochemical treatment of the antibiotic sulfachloropyridazine: kinetics, reaction pathways, and toxicity evolution.
Ahmad Dirany (2012)
Mineralization of sulfanilamide by electro-Fenton and solar photoelectro-Fenton in a pre-pilot plant with a Pt/air-diffusion cell.
Abdellatif El-Ghenymy (2013)
Mineralization of clofibric acid by electrochemical advanced oxidation processes using a boron-doped diamond anode and Fe2+ and UVA light as catalysts
Ignasi Sirés (2007)
A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters.
Sara Castiglioni (2005)
Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation.
Roberto Rosal (2010)
Removal of textile dyes from water by the electro-Fenton process
Amal Lahkimi (2007)
Electrochemical advanced oxidation processes: today and tomorrow. A review
Ignasi Sirés (2014)
Use of conductive-diamond electrochemical oxidation for wastewater treatment
Manuel Andrés Rodrigo (2010)
Degradation of picloram by the electro-Fenton process.
Ali Ugur Ozcan (2008)
Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.
Ling-Jen Chen (2007)
Electrochemical alternatives for drinking water disinfection.
Carlos A. Martínez-Huitle (2008)
Application of diamond electrodes to electrochemical processes
Marco Panizza (2005)
Oxidation pathways of malachite green by Fe3+-catalyzed electro-Fenton process
Mehmet A Oturan (2008)
Human pharmaceuticals in surface waters. Implementation of a prioritization methodology and application to the French situation.
Jean-Philippe Besse (2008)
Reactive metabolites in the biotransformation of molecules containing a furan ring.
Lisa A. Peterson (2013)
Electrochemical oxidation of phenolic wastes with boron-doped diamond anodes.
Pablo Cañizares (2005)
Degradation of Alizarin Red by electro-Fenton process using a graphite-felt cathode
Marco Panizza (2011)
Heterogeneous photocatalytic degradation of pharmaceuticals in water by using polycrystalline TiO2 and a nanofiltration membrane reactor
Raffaele Molinari (2006)
Study of the toxicity of diuron and its metabolites formed in aqueous medium during application of the electrochemical advanced oxidation process "electro-Fenton".
Nihal Oturan (2008)
Mineralization of flumequine in acidic medium by electro-Fenton and photoelectro-Fenton processes.
Sergi Garcia-Segura (2012)
Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid.
Vincent Pichette (1996)
Comparative decolorization of monoazo, diazo and triazo dyes by electro-Fenton process
Sergi Garcia-Segura (2011)
Removal of residual anti-inflammatory and analgesic pharmaceuticals from aqueous systems by electrochemical advanced oxidation processes. A review
Ling Feng (2013)
Direct and mediated anodic oxidation of organic pollutants.
Marco Panizza (2009)
Electro-oxidation of reverse osmosis concentrates generated in tertiary water treatment.
G. Pérez (2010)
Electro-Fenton process and related electrochemical technologies based on Fenton's reaction chemistry.
Enric Brillas (2009)
Reaction of inflammation inhibitors with chemically and electrochemically generated hydroxyl radicals
Mehmet A Oturan (1992)
Reaction sequence for the mineralization of the short-chain carboxylic acids usually formed upon cleavage of aromatics during electrochemical Fenton treatment
Mehmet A Oturan (2008)
This paper is referenced by
A coupled Bio-EF process for mineralization of the pharmaceuticals furosemide and ranitidine: Feasibility assessment.
Hugo Olvera-Vargas (2016)
A review on efficiency and cost effectiveness of electro- and bio-electro-Fenton processes: Application to the treatment of pharmaceutical pollutants in water
Hélène Monteil (2019)
Microbial biotransformation of furosemide for environmental risk assessment: identification of metabolites and toxicological evaluation
Hugo Olvera-Vargas (2016)
Mechanistic Study and Multi‐Response Optimization of the Electrochemical Treatment of Petroleum Refinery Wastewater
Chandrakant Thakur (2018)
Study on the fate of pharmaceuticals in aqueous media : synthesis, characterization and detection of biotic and abiotic transformation products using electrochemical advanced oxidation processes and bioconversions
Hugo Olvera Vargas (2014)
Effect of electrogenerated hydroxyl radicals, active chlorine and organic matter on the electrochemical inactivation of Pseudomonas aeruginosa using BDD and dimensionally stable anodes
Carmina Bruguera-Casamada (2017)
Kinetics of oxidative degradation/mineralization pathways of the antibiotic tetracycline by the novel heterogeneous electro-Fenton process with solid catalyst chalcopyrite
Natija Barhoumi (2017)
Intensification of UV-C treatment to remove emerging contaminants by UV-C/H2O2 and UV-C/S2O82−: Susceptibility to photolysis and investigation of acute toxicity
Maria Clara V. M. Starling (2019)