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Electro‐Oxidation Of The Pharmaceutical Furosemide: Kinetics, Mechanism, And By‐Products

H. Olvera-Vargas, N. Oturan, D. Buisson, E. Hullebusch, M. Oturan
Published 2015 · Chemistry

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Furosemide is a widely prescribed diuretic whose unambiguous presence in water appointed it as an emerging pollutant. This work focuses on the electrochemical degradation of this drug in aqueous solutions by electrochemical advanced oxidation processes, electro-Fenton and anodic oxidation, using Pt/carbon-felt and boron doped diamond (BDD)/carbon-felt cells with H2O2 electrogeneration. The higher oxidation power of the electro-Fenton process using a BDD anode was demonstrated. The oxidative degradation of furosemide by electrochemically generated •OH radicals follows a pseudo-first order kinetics. The absolute rate constant of the oxidation reaction of furosemide by •OH was determined using a competition kinetics method and found to be 3.4 × 109 M−1 s−1. The evolution of the total organic carbon removal during the treatment as a mineralization efficiency parameter was investigated. It was found that the electrochemical degradation of furosemide yields formation of aromatic by-products which are oxidized afterwards to aliphatic carboxylic acids before their conversion to CO2 and inorganic ions (NH4+, NO3–, Cl–, and SO42–). The toxicity assessment by the Microtox® method revealed formation of oxidation reaction intermediates more toxic than the parent molecule. Nevertheless, the overall results confirm the high effectiveness of anodic oxidation and electro-Fenton processes for the removal of furosemide and its by-products from aqueous media.
This paper references
Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans.
M. Hezari (1992)
Reaction of inflammation inhibitors with chemically and electrochemically generated hydroxyl radicals
M. Oturan (1992)
Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid.
V. Pichette (1996)
An ecologically effective water treatment technique using electrochemically generated hydroxyl radicals for in situ destruction of organic pollutants: Application to herbicide 2,4-D
M. Oturan (2000)
Boron doped diamond electrodes for nitrate elimination in concentrated wastewater
C. Lévy-Clément (2003)
Electrochemical oxidation of hydroquinone, resorcinol, and catechol on boron-doped diamond anodes.
B. Nasr (2005)
Pharmaceuticals: a threat to drinking water?
O. Jones (2005)
Application of diamond electrodes to electrochemical processes
M. Panizza (2005)
Electrochemical oxidation of phenolic wastes with boron-doped diamond anodes.
P. Cañizares (2005)
A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters.
S. Castiglioni (2005)
Heterogeneous photocatalytic degradation of pharmaceuticals in water by using polycrystalline TiO2 and a nanofiltration membrane reactor
R. Molinari (2006)
Advanced Oxidation Processes for Organic Contaminant Destruction Based on the Fenton Reaction and Related Chemistry
J. Pignatello (2006)
Catalytic behavior of the Fe3+/Fe2+ system in the electro-Fenton degradation of the antimicrobial chlorophene
I. Sirés (2007)
Mineralization of clofibric acid by electrochemical advanced oxidation processes using a boron-doped diamond anode and Fe2+ and UVA light as catalysts
I. Sirés (2007)
Removal of textile dyes from water by the electro-Fenton process
A. Lahkimi (2007)
Formation of cytotoxic protein reactive metabolites from furosemide: Biological consequences of drug metabolism
D. Antoine (2007)
Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents.
S. Esplugás (2007)
Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.
Ling-Jen Chen (2007)
Study of the toxicity of diuron and its metabolites formed in aqueous medium during application of the electrochemical advanced oxidation process "electro-Fenton".
N. Oturan (2008)
Electrochemical alternatives for drinking water disinfection.
C. A. Martínez-Huitle (2008)
Oxidation pathways of malachite green by Fe3+-catalyzed electro-Fenton process
M. Oturan (2008)
Human pharmaceuticals in surface waters. Implementation of a prioritization methodology and application to the French situation.
J. Besse (2008)
Sulfamethoxazole abatement by means of ozonation.
R. Dantas (2008)
Degradation of picloram by the electro-Fenton process.
A. Ozcan (2008)
Reaction sequence for the mineralization of the short-chain carboxylic acids usually formed upon cleavage of aromatics during electrochemical Fenton treatment
M. Oturan (2008)
The presence of pharmaceuticals in the environment due to human use--present knowledge and future challenges.
K. Kümmerer (2009)
Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes.
Maria Klavarioti (2009)
Mechanism and kinetics of sulfamethoxazole photocatalytic ozonation in water.
F. Beltrán (2009)
Electro-Fenton process and related electrochemical technologies based on Fenton's reaction chemistry.
E. Brillas (2009)
A comparative study on the efficiency of electro-Fenton process in the removal of propham from water
A. Özcan (2009)
Direct and mediated anodic oxidation of organic pollutants.
M. Panizza (2009)
Electro-oxidation of reverse osmosis concentrates generated in tertiary water treatment.
G. Pérez (2010)
Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation.
R. Rosal (2010)
Use of conductive-diamond electrochemical oxidation for wastewater treatment
M. Rodrigo (2010)
Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment
A. Dirany (2011)
Degradation of Alizarin Red by electro-Fenton process using a graphite-felt cathode
M. Panizza (2011)
Preparative access to transformation products (TPs) of furosemide: a versatile application of anodic oxidation
Céline Laurencé (2011)
Comparative decolorization of monoazo, diazo and triazo dyes by electro-Fenton process
Sergi Garcia-Segura (2011)
Unprecedented total mineralization of atrazine and cyanuric acid by anodic oxidation and electro-Fenton with a boron-doped diamond anode
N. Oturan (2011)
Removal of total ammonia nitrogen (TAN), nitrate and total organic carbon (TOC) from aquaculture wastewater using electrochemical technology: A review
W. T. Mook (2012)
Remediation of water pollution caused by pharmaceutical residues based on electrochemical separation and degradation technologies: a review.
I. Sirés (2012)
Electrochemical treatment of the antibiotic sulfachloropyridazine: kinetics, reaction pathways, and toxicity evolution.
A. Dirany (2012)
Mineralization of flumequine in acidic medium by electro-Fenton and photoelectro-Fenton processes.
Sergi Garcia-Segura (2012)
Removal of pharmaceuticals from a WWTP secondary effluent by ultrafiltration/reverse osmosis followed by electrochemical oxidation of the RO concentrate
A. Urtiaga (2013)
Mineralization of sulfanilamide by electro-Fenton and solar photoelectro-Fenton in a pre-pilot plant with a Pt/air-diffusion cell.
Abdellatif El-Ghenymy (2013)
Removal of residual anti-inflammatory and analgesic pharmaceuticals from aqueous systems by electrochemical advanced oxidation processes. A review
Ling Feng (2013)
Electrochemistry: as cause and cure in water pollution—an overview
S. Vasudevan (2013)
Reactive metabolites in the biotransformation of molecules containing a furan ring.
L. Peterson (2013)
Degradation of 40 selected pharmaceuticals by UV/H2O2.
B. Wols (2013)
Mineralization of the antibiotic chloramphenicol by solar photoelectro-Fenton: From stirred tank reactor to solar pre-pilot plant
Sergi Garcia-Segura (2014)
Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide.
Céline Laurencé (2014)
Electrochemical advanced oxidation processes: today and tomorrow. A review
I. Sirés (2014)
Advanced Oxidation Processes in Water/Wastewater Treatment: Principles and Applications. A Review
M. Oturan (2014)

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