← Back to Search
Emerging Implications Of Nanotechnology On Cancer Diagnostics And Therapeutics
A. Cuenca, H. Jiang, S. Hochwald, M. Delano, W. Cance, S. Grobmyer
Published 2006 · Medicine
Download PDFAnalyze on Scholarcy
Nanotechnology is multidisciplinary field that involves the design and engineering of objects <500 nanometers (nm) in size. The National Cancer Institute has recognized that nanotechnology offers an extraordinary, paradigm‐changing opportunity to make significant advances in cancer diagnosis and treatment. In the last several decades, nanotechnology has been studied and developed primarily for use in novel drug‐delivery systems (e.g. liposomes, gelatin nanoparticles, micelles). A recent explosion in engineering and technology has led to 1) the development of many new nanoscale platforms, including quantum dots, nanoshells, gold nanoparticles, paramagnetic nanoparticles, and carbon nanotubes, and 2) improvements in traditional, lipid‐based nanoscale platforms. The emerging implications of these platforms for advances in cancer diagnostics and therapeutics form the basis of this review. A widespread understanding of these new technologies is important, because they currently are being integrated into the clinical practice of oncology. Cancer 2006. © 2006 American Cancer Society.
This paper references
Nano-oncology: drug delivery, imaging, and sensing
N. G. Portney (2006)
Novel biomimetic polymersomes as polymer therapeutics for drug delivery.
J. Xu (2005)
Control of photoluminescence properties of CdSe nanocrystals in growth.
L. Qu (2002)
In Vivo Optical Imaging of Pleural Space Drainage to Lymph Nodes of Prognostic Significance
C. Parungo (2004)
Ribonucleic general acid
S. Strobel (2005)
Probing the Cytotoxicity Of Semiconductor Quantum Dots.
Austin M. Derfus (2004)
The use of gold nanoparticles to enhance radiotherapy in mice.
J. Hainfeld (2004)
Characterization of normal and cancerous lymph nodes on indirect computed tomography lymphographic studies after interstitial injection of iodinated nanoparticles.
E. Wisner (1996)
Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction.
N. W. Kam (2005)
Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer
C. Loo (2004)
Carbon nanotubes as intracellular protein transporters: generality and biological functionality.
N. W. Kam (2005)
Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model.
E. Wisner (1996)
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
K. Sokolov (2003)
Recent advances with liposomes as pharmaceutical carriers
V. Torchilin (2005)
A new liposomal liver-specific contrast agent for CT: first human phase-I clinical trial assessing efficacy and safety
P. Leander (2001)
Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain
Y. Wang (2004)
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
Hisataka Kobayashi (2004)
Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
A. Lübbe (1996)
Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
E. B. Voura (2004)
Nanotech approaches to drug delivery and imaging.
S. Sahoo (2003)
Nanoshells as an optical coherence tomography contrast agent
J. Barton (2004)
Immunotar - geted nanoshells for integrated cancer imaging and ther
C Loo (2005)
Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery
G. Paciotti (2004)
Semiconductor nanocrystals as fluorescent biological labels.
M. Bruchez (1998)
The use of ligand conjugated supraparamagnetic iron oxide nanoparticles for early detection of metastasis NSTI Nanotechnol
C Leuschner (2005)
Sentinel lymph node mapping of the pleural space. Chest
CP Parungo (2005)
PEGylated nanoparticles for biological and pharmaceutical applications.
H. Otsuka (2003)
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.
D. O'Neal (2004)
Fluorescent nanocrystals for use in early cervical cancer detection.
Dawn L Nida (2005)
Sentinel lymph node mapping of the pleural space.
C. Parungo (2005)
In vivo cancer targeting and imaging with semiconductor quantum dots
X. Gao (2004)
Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.
P. Winter (2003)
Biomedical applications of functionalised carbon nanotubes.
A. Bianco (2005)
Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents.
J. Chen (2005)
Nanoparticles in cancer therapy and diagnosis.
I. Brigger (2002)
Nanocrystal targeting in vivo
M. Akerman (2002)
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
W. Gradishar (2005)
Molecular Imaging of Angiogenesis in Nascent Vx-2 Rabbit Tumors Using a Novel ανβ3-targeted Nanoparticle and 1.5 Tesla Magnetic Resonance Imaging
P. Winter (2003)
Past, present and future drug treatment for rheumatoid arthritis and systemic lupus erythematosus
P. Mottram (2003)
Nanotechnology-based Drug Delivery for Cancer
K. Jain (2005)
Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications.
H. Maeda (2003)
Targeted polymeric micelles for delivery of poorly soluble drugs
V. Torchilin (2004)
Iodinated nanoparticles for indirect computed tomography lymphography of the craniocervical and thoracic lymph nodes in normal dogs.
E. Wisner (1994)
Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots1
N. Morgan (2005)
Liposomes for the sustained drug release in vivo.
G. Blume (1990)
Acoustically active liposomes for drug encapsulation and ultrasound-triggered release.
S. Huang (2004)
Self-Assembled Carbohydrate-Stabilized Ceramic Nanoparticles for the Parenteral Delivery of Insulin
A. K. Cherian (2000)
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
David D. Stark (1988)
Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies
Goldie Kaul (2005)
Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies.
D. Nyman (2005)
Photothermal tumor ablation in mice using near infraredabsorbing nanoparticles
DP O’Neal (2004)
Nanoshell-enabled photonicsbased imaging and therapy of cancer
C Loo (2004)
Superparamagnetic gadonanotubes are high-performance MRI contrast agents.
B. Sitharaman (2005)
Targeted Drug Delivery in Cancer Therapy
Jaspreet K. Vasir (2005)
Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice.
M. Oyewumi (2004)
Immunotargeted nanoshells for integrated cancer imaging and therapy.
C. Loo (2005)
Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging.
C. Parungo (2005)
Biodistribution and Targeting Potential of Poly(ethylene glycol)-modified Gelatin Nanoparticles in Subcutaneous Murine Tumor Model
Goldie Kaul (2004)
Shining a light on cancer research. NCI Alliance for Nanotechnology in Cancer USA
J Alper (2005)
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Eyk A Schellenberger (2002)
Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy.
H. Dvorak (1990)
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
M. Harisinghani (2003)
Locoregional cancer treatment with magnetic drug targeting.
C. Alexiou (2000)
In vivo molecular and cellular imaging with quantum dots.
X. Gao (2005)
Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer.
A. Rockall (2005)
Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
M. Zhao (2001)
Novel Nanosensors for Rapid Analysis of Telomerase Activity
J. Grimm (2004)
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
B. Dubertret (2002)
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta (2005)
Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement.
S. C. Michel (2002)
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
R. Weissleder (1990)
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
M. Stroh (2005)
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
X. Wu (2003)
Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI‐007)
B. Damascelli (2001)
Metal nanoshells as a contrast agent in near-infrared diffuse optical tomography
C. Wu (2005)
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs
V. Torchilin (2003)
Detection of tumor marker CA125 in ovarian carcinoma using quantum dots.
Hui-zhi Wang (2004)
Quantum Dots Get Wet
C. Seydel (2003)
Human pharmacokinetics and modeling of the concentration-attenuation relationship of a new liposomal liver-specific contrast agent for CT.
P. Höglund (1998)
In vivo near-infrared fluorescence imaging.
J. V. Frangioni (2003)
Shining a light on cancer research
J. Alper (2005)
Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography.
J. Copland (2004)
The use of ligand conjugated supraparamagnetic iron oxide nanoparticles for early detection of metastasis
C Leuschner (2005)
Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer.
N. Ibrahim (2005)
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed (2004)
Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots.
N. Morgan (2005)
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
L. R. Hirsch (2003)
Multicenter clinical trial of ultrasmall superparamagnetic iron oxide in the evaluation of mediastinal lymph nodes in patients with primary lung carcinoma
B. Nguyen (1999)
MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
D. Artemov (2003)
This paper is referenced by
Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis.
J. Wang (2007)
Research and Reviews: Journal of Pharmaceutics and Nanotechnology Targeted Nanoparticles for Anti-Cancer Drug Delivery: A Review
Kadambini Tripathy (2016)
Nanoparticles: Cancer Management Applications
Shyamasree Ghosh (2017)
Development and characterization of plasmonic materials for chemical sensing: an investigation Into novel SPR architectures
Devon A. Boyne (2015)
Gold Nanorods Targeted to Delta Opioid Receptor: Plasmon-Resonant Contrast and Photothermal Agents
Kvar C. L. Black (2008)
Hybrid gadolinium oxide nanoparticles combining imaging and therapy
Jean-Luc Bridot (2009)
Studies on the interaction of CdTe QDs with bovine serum albumin
Peng Liu (2012)
Optical Methods for Caries Detection, Diagnosis, and Therapeutic Intervention
Daniel Fried (2014)
Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release
C. Cuscó (2016)
Pharmacological Applications of Biocompatible Carbon Nanotubes and Their Emerging Toxicology Issues
Taejoon Park (2008)
Sculpted amphiphilic liposomal particles for modifiable medicinal applications.
Dipak K. Sarker (2009)
Optimized Synthesis of Water-Soluble and Small-Size CdSe Quantum Dots
Jiao Yun Xia (2011)
Evaluation of selected metal nanoparticles on hatching and survival of larvae and fry of Indian major carp, rohu (Labeo rohita)
Padmini Swain (2016)
Chitosan–Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
H. Hosseinzadeh (2012)
Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells
Ping-Hsiu Wu (2017)
Functionalized gold nanorods for molecular optoacoustic imaging
Mohammad Eghtedari (2007)
Targeted nanomaterials for radiotherapy.
F. Escorcia (2007)
Cell delivery of therapeutic nanoparticles.
J. McMillan (2011)
Gold clusters and nanoparticles in reverse micelles formed by tritons X-100, X-114, and X-45
M. G. Spirin (2011)
Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery
Yu Nie (2012)
Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment
S. Gao (2018)
[The future of new therapies in clinical medicine].
Patricia Gálvez (2011)
Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform
N. Fischer (2014)
Nanomedicines: a theranostic approach for hepatocellular carcinoma
Afreen Usmani (2018)
Emerging trends of nanomedicine – an overview
S. Sandhiya (2009)
Carbon Nanotubes: Potential Benefits and Risks of Nanotechnology in Nuclear Medicine
R. Reilly (2007)
In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics
B. Saha (2007)
Aggregation of antitumoral drug emodin on Ag nanoparticles: SEF, SERS and fluorescence lifetime experiments.
P. Sevilla (2009)
A novel mycotoxin purification system using magnetic nanoparticles for the recovery of aflatoxin B1 and zearalenone from feed
H. Kim (2012)
Polymeric nanoparticles for gene delivery
Surendra Nimesh (2013)
Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells
Bo Tao (2020)
Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine
T. Liu (2017)See more