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Emerging Implications Of Nanotechnology On Cancer Diagnostics And Therapeutics

A. Cuenca, H. Jiang, S. Hochwald, M. Delano, W. Cance, S. Grobmyer
Published 2006 · Medicine

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Nanotechnology is multidisciplinary field that involves the design and engineering of objects <500 nanometers (nm) in size. The National Cancer Institute has recognized that nanotechnology offers an extraordinary, paradigm‐changing opportunity to make significant advances in cancer diagnosis and treatment. In the last several decades, nanotechnology has been studied and developed primarily for use in novel drug‐delivery systems (e.g. liposomes, gelatin nanoparticles, micelles). A recent explosion in engineering and technology has led to 1) the development of many new nanoscale platforms, including quantum dots, nanoshells, gold nanoparticles, paramagnetic nanoparticles, and carbon nanotubes, and 2) improvements in traditional, lipid‐based nanoscale platforms. The emerging implications of these platforms for advances in cancer diagnostics and therapeutics form the basis of this review. A widespread understanding of these new technologies is important, because they currently are being integrated into the clinical practice of oncology. Cancer 2006. © 2006 American Cancer Society.
This paper references
10.1007/S00216-005-0247-7
Nano-oncology: drug delivery, imaging, and sensing
N. G. Portney (2006)
10.1016/J.JCONREL.2005.06.013
Novel biomimetic polymersomes as polymer therapeutics for drug delivery.
J. Xu (2005)
10.1021/JA017002J
Control of photoluminescence properties of CdSe nanocrystals in growth.
L. Qu (2002)
10.1245/ASO.2004.03.054
In Vivo Optical Imaging of Pleural Space Drainage to Lymph Nodes of Prognostic Significance
C. Parungo (2004)
10.1038/NCHEMBIO0605-5
Ribonucleic general acid
S. Strobel (2005)
10.1021/nl0347334
Probing the Cytotoxicity Of Semiconductor Quantum Dots.
Austin M. Derfus (2004)
10.1088/0031-9155/49/18/N03
The use of gold nanoparticles to enhance radiotherapy in mice.
J. Hainfeld (2004)
10.1016/S1076-6332(96)80551-4
Characterization of normal and cancerous lymph nodes on indirect computed tomography lymphographic studies after interstitial injection of iodinated nanoparticles.
E. Wisner (1996)
10.1073/PNAS.0502680102
Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction.
N. W. Kam (2005)
10.1177/153303460400300104
Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer
C. Loo (2004)
10.1021/JA050062V
Carbon nanotubes as intracellular protein transporters: generality and biological functionality.
N. W. Kam (2005)
10.1016/S1076-6332(96)80331-X
Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model.
E. Wisner (1996)
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
K. Sokolov (2003)
10.1038/nrd1632
Recent advances with liposomes as pharmaceutical carriers
V. Torchilin (2005)
10.1007/s003300000712
A new liposomal liver-specific contrast agent for CT: first human phase-I clinical trial assessing efficacy and safety
P. Leander (2001)
10.1021/NL049126A
Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain
Y. Wang (2004)
10.1093/JNCI/DJH124
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
Hisataka Kobayashi (2004)
Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
A. Lübbe (1996)
10.1038/nm1096
Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
E. B. Voura (2004)
10.1016/S1359-6446(03)02903-9
Nanotech approaches to drug delivery and imaging.
S. Sahoo (2003)
10.1117/12.529235
Nanoshells as an optical coherence tomography contrast agent
J. Barton (2004)
Immunotar - geted nanoshells for integrated cancer imaging and ther
C Loo (2005)
10.1080/10717540490433895
Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery
G. Paciotti (2004)
10.1126/SCIENCE.281.5385.2013
Semiconductor nanocrystals as fluorescent biological labels.
M. Bruchez (1998)
The use of ligand conjugated supraparamagnetic iron oxide nanoparticles for early detection of metastasis NSTI Nanotechnol
C Leuschner (2005)
Sentinel lymph node mapping of the pleural space. Chest
CP Parungo (2005)
10.1016/j.addr.2012.09.022
PEGylated nanoparticles for biological and pharmaceutical applications.
H. Otsuka (2003)
10.1016/J.CANLET.2004.02.004
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.
D. O'Neal (2004)
10.1016/J.YGYNO.2005.07.050
Fluorescent nanocrystals for use in early cervical cancer detection.
Dawn L Nida (2005)
10.1378/CHEST.127.5.1799
Sentinel lymph node mapping of the pleural space.
C. Parungo (2005)
10.1038/nbt994
In vivo cancer targeting and imaging with semiconductor quantum dots
X. Gao (2004)
Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.
P. Winter (2003)
10.1039/B410943K
Biomedical applications of functionalised carbon nanotubes.
A. Bianco (2005)
10.1021/NL047950T
Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents.
J. Chen (2005)
10.1016/S0169-409X(02)00044-3
Nanoparticles in cancer therapy and diagnosis.
I. Brigger (2002)
10.1073/pnas.152463399
Nanocrystal targeting in vivo
M. Akerman (2002)
10.1200/JCO.2005.04.937
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
W. Gradishar (2005)
Molecular Imaging of Angiogenesis in Nascent Vx-2 Rabbit Tumors Using a Novel ανβ3-targeted Nanoparticle and 1.5 Tesla Magnetic Resonance Imaging
P. Winter (2003)
10.1046/j.1440-1711.2003.01184.x
Past, present and future drug treatment for rheumatoid arthritis and systemic lupus erythematosus
P. Mottram (2003)
10.1177/153303460500400408
Nanotechnology-based Drug Delivery for Cancer
K. Jain (2005)
10.1016/S1567-5769(02)00271-0
Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications.
H. Maeda (2003)
10.1007/s00018-004-4153-5
Targeted polymeric micelles for delivery of poorly soluble drugs
V. Torchilin (2004)
10.1016/S1076-6332(12)80012-2
Iodinated nanoparticles for indirect computed tomography lymphography of the craniocervical and thoracic lymph nodes in normal dogs.
E. Wisner (1994)
10.1016/J.ACRA.2004.04.023
Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots1
N. Morgan (2005)
10.1016/0005-2736(90)90440-Y
Liposomes for the sustained drug release in vivo.
G. Blume (1990)
10.1016/J.BBAMEM.2004.07.003
Acoustically active liposomes for drug encapsulation and ultrasound-triggered release.
S. Huang (2004)
10.1081/DDC-100101255
Self-Assembled Carbohydrate-Stabilized Ceramic Nanoparticles for the Parenteral Delivery of Insulin
A. K. Cherian (2000)
10.1148/RADIOLOGY.168.2.3393649
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
David D. Stark (1988)
10.1007/s11095-005-4590-3
Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies
Goldie Kaul (2005)
10.1200/JCO.2004.00.6148
Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies.
D. Nyman (2005)
Photothermal tumor ablation in mice using near infraredabsorbing nanoparticles
DP O’Neal (2004)
Nanoshell-enabled photonicsbased imaging and therapy of cancer
C Loo (2004)
10.1039/B504435A
Superparamagnetic gadonanotubes are high-performance MRI contrast agents.
B. Sitharaman (2005)
10.1177/153303460500400405
Targeted Drug Delivery in Cancer Therapy
Jaspreet K. Vasir (2005)
10.1016/J.JCONREL.2004.01.002
Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice.
M. Oyewumi (2004)
10.1021/NL050127S
Immunotargeted nanoshells for integrated cancer imaging and therapy.
C. Loo (2005)
10.1016/J.JTCVS.2004.08.001
Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging.
C. Parungo (2005)
10.1080/10611860400013451
Biodistribution and Targeting Potential of Poly(ethylene glycol)-modified Gelatin Nanoparticles in Subcutaneous Murine Tumor Model
Goldie Kaul (2004)
Shining a light on cancer research. NCI Alliance for Nanotechnology in Cancer USA
J Alper (2005)
10.1016/S1076-6332(03)80212-X
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Eyk A Schellenberger (2002)
Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy.
H. Dvorak (1990)
10.1056/NEJMOA022749
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
M. Harisinghani (2003)
Locoregional cancer treatment with magnetic drug targeting.
C. Alexiou (2000)
10.1016/J.COPBIO.2004.11.003
In vivo molecular and cellular imaging with quantum dots.
X. Gao (2005)
10.1200/JCO.2005.07.166
Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer.
A. Rockall (2005)
10.1038/nm1101-1241
Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
M. Zhao (2001)
10.1158/0008-5472.CAN-03-2798
Novel Nanosensors for Rapid Analysis of Telomerase Activity
J. Grimm (2004)
10.1126/SCIENCE.1077194
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
B. Dubertret (2002)
10.1038/nature03794
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta (2005)
10.1148/RADIOL.2252011605
Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement.
S. C. Michel (2002)
10.1148/RADIOLOGY.175.2.2326474
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
R. Weissleder (1990)
10.1038/nm1247
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
M. Stroh (2005)
10.1038/nbt764
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
X. Wu (2003)
10.1002/1097-0142(20011115)92:10<2592::AID-CNCR1612>3.0.CO;2-4
Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI‐007)
B. Damascelli (2001)
10.1016/J.OPTCOM.2005.04.057
Metal nanoshells as a contrast agent in near-infrared diffuse optical tomography
C. Wu (2005)
10.1073/PNAS.95.8.4607
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
10.1073/pnas.0931428100
Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs
V. Torchilin (2003)
10.1093/ABBS/36.10.681
Detection of tumor marker CA125 in ovarian carcinoma using quantum dots.
Hui-zhi Wang (2004)
10.1126/SCIENCE.300.5616.80
Quantum Dots Get Wet
C. Seydel (2003)
10.1016/S1076-6332(98)80056-1
Human pharmacokinetics and modeling of the concentration-attenuation relationship of a new liposomal liver-specific contrast agent for CT.
P. Höglund (1998)
10.1016/J.CBPA.2003.08.007
In vivo near-infrared fluorescence imaging.
J. V. Frangioni (2003)
Shining a light on cancer research
J. Alper (2005)
10.1016/J.MIBIO.2004.06.002
Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography.
J. Copland (2004)
The use of ligand conjugated supraparamagnetic iron oxide nanoparticles for early detection of metastasis
C Leuschner (2005)
10.1200/JCO.2005.11.013
Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer.
N. Ibrahim (2005)
10.1038/nrc1566
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
10.1016/J.JCONREL.2003.12.021
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed (2004)
Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots.
N. Morgan (2005)
10.1073/pnas.2232479100
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
L. R. Hirsch (2003)
10.1002/(SICI)1522-2586(199909)10:3<468::AID-JMRI31>3.0.CO;2-I
Multicenter clinical trial of ultrasmall superparamagnetic iron oxide in the evaluation of mediastinal lymph nodes in patients with primary lung carcinoma
B. Nguyen (1999)
10.1002/mrm.10406
MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
D. Artemov (2003)



This paper is referenced by
10.1117/1.2764463
Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis.
J. Wang (2007)
Research and Reviews: Journal of Pharmaceutics and Nanotechnology Targeted Nanoparticles for Anti-Cancer Drug Delivery: A Review
Kadambini Tripathy (2016)
10.1081/E-EBPPC-120050073
Nanoparticles: Cancer Management Applications
Shyamasree Ghosh (2017)
Development and characterization of plasmonic materials for chemical sensing: an investigation Into novel SPR architectures
Devon A. Boyne (2015)
10.2310/7290.2008.0007
Gold Nanorods Targeted to Delta Opioid Receptor: Plasmon-Resonant Contrast and Photothermal Agents
Kvar C. L. Black (2008)
10.1039/B815836C
Hybrid gadolinium oxide nanoparticles combining imaging and therapy
Jean-Luc Bridot (2009)
10.1002/JCTB.3815
Studies on the interaction of CdTe QDs with bovine serum albumin
Peng Liu (2012)
10.1201/B17288-16
Optical Methods for Caries Detection, Diagnosis, and Therapeutic Intervention
Daniel Fried (2014)
10.1039/C6PY01275B
Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release
C. Cuscó (2016)
10.1007/978-1-4020-6845-4_12
Pharmacological Applications of Biocompatible Carbon Nanotubes and Their Emerging Toxicology Issues
Taejoon Park (2008)
10.2174/157016309787581039
Sculpted amphiphilic liposomal particles for modifiable medicinal applications.
Dipak K. Sarker (2009)
10.4028/www.scientific.net/AMR.266.46
Optimized Synthesis of Water-Soluble and Small-Size CdSe Quantum Dots
Jiao Yun Xia (2011)
10.1111/ARE.12510
Evaluation of selected metal nanoparticles on hatching and survival of larvae and fry of Indian major carp, rohu (Labeo rohita)
Padmini Swain (2016)
10.2147/IJN.S26365
Chitosan–Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
H. Hosseinzadeh (2012)
10.2147/IJN.S137833
Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells
Ping-Hsiu Wu (2017)
10.1117/12.716380
Functionalized gold nanorods for molecular optoacoustic imaging
Mohammad Eghtedari (2007)
10.2217/17435889.2.6.805
Targeted nanomaterials for radiotherapy.
F. Escorcia (2007)
10.1016/B978-0-12-416020-0.00014-0
Cell delivery of therapeutic nanoparticles.
J. McMillan (2011)
10.1134/S1061933X1102013X
Gold clusters and nanoparticles in reverse micelles formed by tritons X-100, X-114, and X-45
M. G. Spirin (2011)
10.1177/0885328210384889
Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery
Yu Nie (2012)
10.1002/9781119275602.CH3.4
Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment
S. Gao (2018)
10.1016/j.medcli.2010.12.005
[The future of new therapies in clinical medicine].
Patricia Gálvez (2011)
10.1371/journal.pone.0093342
Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform
N. Fischer (2014)
10.1080/21691401.2017.1374282
Nanomedicines: a theranostic approach for hepatocellular carcinoma
Afreen Usmani (2018)
10.1111/j.1472-8206.2009.00692.x
Emerging trends of nanomedicine – an overview
S. Sandhiya (2009)
10.2967/jnumed.107.041723
Carbon Nanotubes: Potential Benefits and Risks of Nanotechnology in Nuclear Medicine
R. Reilly (2007)
10.1007/s11671-007-9104-2
In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics
B. Saha (2007)
10.1039/b903935j
Aggregation of antitumoral drug emodin on Ag nanoparticles: SEF, SERS and fluorescence lifetime experiments.
P. Sevilla (2009)
10.4142/jvs.2012.13.4.363
A novel mycotoxin purification system using magnetic nanoparticles for the recovery of aflatoxin B1 and zearalenone from feed
H. Kim (2012)
10.1533/9781908818645.137
Polymeric nanoparticles for gene delivery
Surendra Nimesh (2013)
10.1177/1934578X20932761
Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells
Bo Tao (2020)
10.1016/J.PMATSCI.2017.03.004
Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine
T. Liu (2017)
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