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CYP1A1, SULT1A1, And SULT1E1 Polymorphisms Are Risk Factors For Endometrial Cancer Susceptibility
H. Hirata, Y. Hinoda, N. Okayama, Y. Suehiro, K. Kawamoto, N. Kikuno, J. Rabban, Lee May Chen, R. Dahiya
Published 2008 · Biology, Medicine
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In estrogen biosynthetic pathways, many enzymes are important for metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect on the enzymes' function. For example, higher expression and activation of biosynthetic enzymes and lower expression and activation of conjugation enzymes may lead to high toxicity or carcinogenesis. The authors hypothesized that single nucleotide polymorphisms (single nucleotide polymorphisms) of CYP1A1, CYP1A2, CYP1B1, CYP17, SULT1A1, SULT1E1, and SHBG genes may be risk factors for endometrial cancer.
This paper references
Carcinogenicity of catechol estrogens in Syrian hamsters.
J. Liehr (1986)
Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.
J. Li (1987)
Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.
Li Jj (1987)
Sex Hormone Binding Globulin: Origin, Function and Clinical Significance
C. Selby (1990)
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
D. D. Petersen (1991)
PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene.
S. Hayashi (1991)
A novel CYP1A1 gene polymorphism in African-Americans.
F. Crofts (1993)
Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene.
G. Cosma (1993)
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
L. Bertilsson (1994)
Sequence and functional characterization of the terminal exon of the human insulin receptor gene.
J. Levy (1995)
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.
D. Nebert (1996)
Translational efficiency is regulated by the length of the 3' untranslated region.
Robert L. Tanguay (1996)
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
H. Lachman (1996)
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
I. Cascorbi (1996)
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
E. Cavalieri (1997)
Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.
R. Raftogianis (1997)
Functional role of estrogen metabolism in target cells: review and perspectives.
B. Zhu (1998)
Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit.
P. Cousin (1998)
Identification and characterization of cytosolic sulfotransferases in normal human endometrium.
J. Falany (1998)
Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines.
S. Ozawa (1998)
Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.
C. Sachse (1999)
Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2).
R. Lunn (1999)
Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.
M. Nakajima (1999)
Detection of Three Genetic Polymorphisms in the 5′‐Flanking Region and Intron 1 of Human CYP1A2 in the Japanese Population
M. Chida (1999)
Relationship of phenol sulfotransferase activity (SULT1A1) genotype to sulfotransferase phenotype in platelet cytosol.
S. Nowell (2000)
CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor.
S. Anttila (2001)
Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
D. Schwarz (2001)
Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk.
W. Zheng (2001)
Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.
S. Dawling (2001)
Differential metabolism of benzo
D Schwarz (2001)
Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.
Y. Wang (2002)
: a case - control analysis
A Seremak-Mrozikiewicz (2002)
CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions.
M. Sasaki (2003)
Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics
A. Adjei (2003)
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
G. Liang (2004)
Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
Y. Li (2004)
Genetic Polymorphisms of SULT1A1 and SULT1E1 and the Risk and Survival of Breast Cancer
Ji-Yeob Choi (2005)
CYP1A1 alleles in female genital cancers in the Polish population.
A. Seremak-Mrozikiewicz (2005)
CYP17 gene polymorphism in relation to breast cancer risk: a case-control study
K. Einarsdóttir (2005)
Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study.
S. Boccia (2005)
Genetic Factors in Catechol Estrogen Metabolism in Relation to the Risk of Endometrial Cancer
J. Doherty (2005)
Cytochrome P450-mediated metabolism of estrogens and its regulation in human.
Yuki Tsuchiya (2005)
Cytochrome P450mediated metabolism of estrogens and its regulation in humans
Y Tsuchiya (2005)
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
D. Nebert (2006)
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk
O. N. Mikhailova (2006)
Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Endometrial Cancer Risk in Chinese Women
M. H. Tao (2006)
Impact of polymorphism in sulfotransferase gene on the risk of lung cancer.
Suparna S Pachouri (2006)
A case–control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer
S. Boccia (2006)
Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.
T. Rebbeck (2006)
Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females.
Y. Guo (2006)
Cancer Screening in the United States, 2007: A Review of Current Guidelines, Practices, and Prospects
R. Smith (2007)
SULT1A1 genotype and susceptibility to colorectal cancer
C. Lilla (2007)
Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review.
S. Olson (2007)
Human catechol - O - methyltransferase
fotransferase ( SULT ) 1 A 1 polymorphism as a predisposition factor for
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Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives
MyeongJin Yi (2021)
SULT genetic polymorphisms: physiological, pharmacological and clinical implications
Katsuhisa Kurogi (2021)
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Amal A El Daibani (2020)
Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer
Ying Luo (2020)
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Mayuree Wongpratate (2020)
Mechanistic considerations for reduced endometrial cancer risk by smoking
M. Berg (2019)
SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
Yali Xu (2018)
Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival
S. Li (2018)
The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.
Chunrong Qin (2017)
Sulfonation Disposition of Acacetin: In Vitro and in Vivo.
Q. Zhang (2017)
Detecting, Modelling, and Interpreting Gene-by-Environment Interactions
E. Nelson (2017)
Cytochrome and sulfotransferase gene variation in north African populations.
A. Fernández-Santander (2016)
Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses
V. Vukovic (2016)
Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer
Ada W. Y. Leung (2016)
Improving platinum-based treatments for advanced non-small cell lung cancer
Ada W. Y. Leung (2016)
A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework.
D. Wikoff (2016)
The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases
T. Rizner (2016)
Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy
X. Ren (2015)
CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study
S. Akhtar (2015)
CYP2E1 gene rs6413420 polymorphism was first found in the Bouyei ethnic group of China.
W. Liu (2014)
Regulation of Human Cytosolic Sulfotransferases 1C2 and 1C3 by Nuclear Signaling Pathways in LS180 Colorectal Adenocarcinoma Cells
E. A. Rondini (2014)
Elizabeth A. Rondini (2014)
Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis
Wen-xia Sun (2014)
Sulfotransferase SULT1A1 Arg213His Polymorphism with Cancer Risk: A Meta-Analysis of 53 Case-Control Studies
J. Xiao (2014)
DIESEL AND GASOLINE ENGINE EXHAUSTS AND SOME NITROARENES. IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS.
humAn cArcinogens (2014)
Genomic polymorphisms of SLC29A3 associated with overall survival in advanced non-small-cell lung cancer treated with gemcitabine
X. Chen (2014)
Bioactivation of the human carcinogen aristolochic acid.
V. Sidorenko (2014)
Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis
Jie-ying Liu (2014)
CYP17A1 T-34C polymorphism is not associated with endometrial cancer risk
X. Yang (2013)
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
X. He (2013)See more