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CYP1A1, SULT1A1, And SULT1E1 Polymorphisms Are Risk Factors For Endometrial Cancer Susceptibility

H. Hirata, Y. Hinoda, N. Okayama, Y. Suehiro, K. Kawamoto, N. Kikuno, J. Rabban, Lee May Chen, R. Dahiya
Published 2008 · Biology, Medicine

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In estrogen biosynthetic pathways, many enzymes are important for metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect on the enzymes' function. For example, higher expression and activation of biosynthetic enzymes and lower expression and activation of conjugation enzymes may lead to high toxicity or carcinogenesis. The authors hypothesized that single nucleotide polymorphisms (single nucleotide polymorphisms) of CYP1A1, CYP1A2, CYP1B1, CYP17, SULT1A1, SULT1E1, and SHBG genes may be risk factors for endometrial cancer.
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