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Aquaporin 1 Is An Independent Prognostic Factor In Pleural Malignant Mesothelioma
S. Kao, N. Armstrong, B. Condon, K. Griggs, B. McCaughan, S. Maltby, A. Wilson, D. Henderson, S. Klebe
Published 2012 · Medicine
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Malignant mesothelioma (MM) is an aggressive cancer of serosal membranes, mostly pleura. It is related to asbestos exposure and its incidence in most industrialized countries is projected to remain stable or to increase until 2020. Prognosis remains poor. Clinical prognostic scoring systems lack precision. No prognostic tissue markers are available. Aquaporin 1 (AQP1) is a cell membrane channel involved in water transport, cell motility, and proliferation. A blocker and an agonist are available.
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