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Accounting For Patient Variability In Finite Element Analysis Of The Intact And Implanted Hip And Knee: A Review.

M. Taylor, R. Bryan, F. Galloway
Published 2013 · Medicine, Engineering

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It is becoming increasingly difficult to differentiate the performance of new joint replacement designs using available preclinical test methods. Finite element analysis is commonly used and the majority of published studies are performed on representative anatomy, assuming optimal implant placement, subjected to idealised loading conditions. There are significant differences between patients and accounting for this variability will lead to better assessment of the risk of failure. This review paper provides a comprehensive overview of the techniques available to account for patient variability. There is a brief overview of patient-specific model generation techniques, followed by a review of multisubject patient-specific studies performed on the intact and implanted femur and tibia. In particular, the challenges and limitations of manually generating models for such studies are discussed. To efficiently account for patient variability, the application of statistical shape and intensity models (SSIM) are being developed. Such models have the potential to synthetically generate thousands of representative models generated from a much smaller training set. Combined with the automation of the prosthesis implantation process, SSIM provides a potentially powerful tool for assessing the next generation of implant designs. The potential application of SSIM are discussed along with their limitations.
This paper references
10.1016/J.MEDENGPHY.2003.11.008
Specialised CT scan protocols for 3-D pre-operative planning of total hip replacement.
R. Lattanzi (2004)
10.1097/BLO.0b013e31802ba491
Finite Element-based Preclinical Testing of Cemented Total Hip Implants
J. Stolk (2007)
10.1016/j.bone.2009.04.241
Prediction of proximal femur strength using a CT-based nonlinear finite element method: differences in predicted fracture load and site with changing load and boundary conditions.
M. Bessho (2009)
10.1016/J.JBIOMECH.2005.07.029
Probabilistic finite element prediction of knee wear simulator mechanics.
P. Laz (2006)
10.1016/J.MEDENGPHY.2007.05.006
A modified method for assigning material properties to FE models of bones.
B. Helgason (2008)
A Large Scale Finite Element Study of an Osseointegrated Cementless Tibial Tray
Francis Galloway (2012)
10.1002/jor.22056
Influence of loading and activity on the primary stability of cementless tibial trays
M. Taylor (2012)
10.1243/09544119JEIM332
Size and shape of the resection surface geometry of the osteoarthritic knee in relation to total knee replacement design
C. Fitzpatrick (2008)
10.1016/S0169-2607(98)00011-X
TRI2SOLID: an application of reverse engineering methods to the creation of CAD models of bone segments.
M. Viceconti (1998)
10.1016/S0021-9290(00)00055-5
The mesh-matching algorithm: an automatic 3D mesh generator for finite element structures.
B. Couteau (2000)
10.1016/S0021-9290(97)00038-9
The effects of cement-stem debonding in THA on the long-term failure probability of cement.
N. Verdonschot (1997)
10.1002/JOR.1100140424
Adaptiive finite element modeling of long‐term polyethylene wear in total hip arthroplasty
T. Maxian (1996)
10.1016/S0021-9290(01)00040-9
Hip contact forces and gait patterns from routine activities.
G. Bergmann (2001)
10.1016/S0021-9290(98)00022-0
Finite element analysis of the implanted proximal tibia: a relationship between the initial cancellous bone stresses and implant migration.
M. Taylor (1998)
10.1016/J.JBIOMECH.2004.05.022
Determination of muscle loading at the hip joint for use in pre-clinical testing.
M. Heller (2005)
10.1016/j.medengphy.2010.09.014
Evaluation of the generality and accuracy of a new mesh morphing procedure for the human femur.
L. Grassi (2011)
10.1016/J.JBIOMECH.2005.03.024
Primary stability of an anatomical cementless hip stem: a statistical analysis.
M. Viceconti (2006)
10.1016/J.JBIOMECH.2004.05.044
Bone ingrowth simulation for a concept glenoid component design.
A. Andreykiv (2005)
10.1097/00003086-199802000-00032
Cementless Implant Composition and Femoral Stress: A Finite Element Analysis
R. Namba (1998)
10.1016/S1350-4533(98)00054-X
Comparison of geometry-based and CT voxel-based finite element modelling and experimental validation.
M. Lengsfeld (1998)
10.1007/s11999-008-0424-z
Stemmed Implants Improve Stability in Augmented Constrained Condylar Knees
J. Rawlinson (2008)
10.1016/j.gaitpost.2010.11.018
Predicted knee kinematics and kinetics during functional activities using motion capture and musculoskeletal modelling in healthy older people.
P. Worsley (2011)
10.1016/j.medengphy.2011.07.006
Biomechanical robustness of a new proximal epiphyseal hip replacement to patient variability and surgical uncertainties: a FE study.
Saulo Martelli (2012)
10.1002/jor.21221
Predicting the effect of tray malalignment on risk for bone damage and implant subsidence after total knee arthroplasty
Jowene Wong (2011)
10.1016/j.medengphy.2009.01.002
Probabilistic analysis of an uncemented total hip replacement.
Carolina Dopico-González (2009)
10.1016/j.bone.2012.01.012
Ct-based finite element models can be used to estimate experimentally measured failure loads in the proximal femur.
Janne E. M. Koivumäki (2012)
10.1016/j.jbiomech.2009.05.038
Use of a statistical model of the whole femur in a large scale, multi-model study of femoral neck fracture risk.
R. Bryan (2009)
10.1243/09544119JEIM739
A review of probabilistic analysis in orthopaedic biomechanics
P. Laz (2010)
10.1016/j.cmpb.2009.07.005
Development of subject-specific and statistical shape models of the knee using an efficient segmentation and mesh-morphing approach
M. A. Baldwin (2010)
10.1097/00003086-199703000-00038
Cement Debonding Process of Total Hip Arthroplasty Stems
N. Verdonschot (1997)
10.1016/1350-4533(95)00031-3
Stress and strain distribution within the intact femur: compression or bending?
M. Taylor (1996)
10.1109/TBME.2006.879473
Finite-Element Modeling of Bones From CT Data: Sensitivity to Geometry and Material Uncertainties
F. Taddei (2006)
10.1016/J.ENGFRACMECH.2004.09.002
Analysis of the debonding of the stem–cement interface in intramedullary fixation using a non-linear fracture mechanics approach
M. A. Pérez (2005)
10.1016/J.CLINBIOMECH.2004.04.014
Initial stability of ankle arthrodesis with three-screw fixation. A finite element analysis.
A. Alonso-Vázquez (2004)
10.1016/J.JBIOMECH.2006.07.029
Cement mantle fatigue failure in total hip replacement: experimental and computational testing.
J. Jeffers (2007)
10.1016/j.jbiomech.2011.06.025
Development of a statistical shape model of the patellofemoral joint for investigating relationships between shape and function.
Clare K Fitzpatrick (2011)
10.1080/10255842.2010.515984
Development of a parametric finite element model of the proximal femur using statistical shape and density modelling
D. Nicolella (2012)
10.1006/cviu.1995.1004
Active Shape Models-Their Training and Application
T. Cootes (1995)
10.1007/s10439-010-9996-3
Comparative Finite Element Analysis of the Debonding Process in Different Concepts of Cemented Hip Implants
M. A. Pérez (2010)
10.1016/S0021-9290(97)00123-1
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1998)
10.1243/095441105X93631
Finite element analysis of the resurfaced femoral head.
M. Taylor (2006)
10.1109/42.730410
Optimal CT scanning plan for long-bone 3-D reconstruction
C. Zannoni (1998)
10.1016/J.MEDENGPHY.2004.12.016
Femoral strain changes after total hip arthroplasty--patient-specific finite element analyses 12 years after operation.
M. Lengsfeld (2005)
10.1115/1.2401177
Effect of varus/valgus malalignment on bone strains in the proximal tibia after TKR: an explicit finite element study.
A. Perillo-Marcone (2007)
10.1002/jor.21040
Computational assessment of the effect of polyethylene wear rate, mantle thickness, and porosity on the mechanical failure of the acetabular cement mantle
Oliver J. Coultrup (2010)
10.1080/17453670610046424
Prediction of torsional failure in 22 cadaver femora with and without simulated subtrochanteric metastatic defects: A CT scan-based finite element analysis
S. Spruijt (2006)
10.1016/j.clinbiomech.2009.03.009
Subject specific finite element analysis of implant stability for a cementless femoral stem.
Sune H. Pettersen (2009)
10.1016/J.JBIOMECH.2007.03.013
Incorporating uncertainty in mechanical properties for finite element-based evaluation of bone mechanics.
P. Laz (2007)
10.1016/j.bone.2011.03.682
Male-female differences in the association between incident hip fracture and proximal femoral strength: a finite element analysis study.
J. Keyak (2011)
10.1080/10255840701535965
An anatomical subject-specific FE-model for hip fracture load prediction
L. Duchemin (2008)
10.1097/00003086-199510000-00007
Preclinical testing of total hip stems. The effects of coating placement.
R. Huiskes (1995)
10.1007/BF00134322
Finite element modelling—predictor of implant survival?
M. Taylor (1995)
10.1359/jbmr.081201
Finite Element Analysis of the Proximal Femur and Hip Fracture Risk in Older Men
E. Orwoll (2009)
10.1115/1.2165701
Acetabular cup geometry and bone-implant interference have more influence on initial periprosthetic joint space than joint loading and surgical cup insertion.
K. Ong (2006)
10.1118/1.3425791
Assessment of the individual fracture risk of the proximal femur by using statistical appearance models.
B. Schuler (2010)
10.1016/J.CLINBIOMECH.2006.12.003
Influence of changes in stem positioning on femoral loading after THR using a short-stemmed hip implant.
A. Speirs (2007)
10.1097/00004728-199001000-00020
Mechanical properties of trabecular bone from the proximal femur: a quantitative CT study.
J. C. Lotz (1990)
10.1016/J.CLINBIOMECH.2006.01.010
Bone remodelling inside a cemented resurfaced femoral head.
S. Gupta (2006)
10.1016/J.JBIOMECH.2003.12.004
A combined RSA and FE study of the implanted proximal tibia: correlation of the post-operative mechanical environment with implant migration.
A. Perillo-Marcone (2004)
10.1016/J.MEDENGPHY.2006.11.007
Determination of suitable sample sizes for multi-patient based finite element studies.
I. A. J. Radcliffe (2007)
10.1016/S0268-0033(01)00053-5
Influence of femoral anteversion on proximal femoral loading: measurement and simulation in four patients.
M. Heller (2001)
10.1016/j.jbiomech.2008.05.017
An accurate estimation of bone density improves the accuracy of subject-specific finite element models.
E. Schileo (2008)
10.1016/S0021-9290(03)00011-3
The primary stability of a cementless stem varies between subjects as much as between activities.
A. Pancanti (2003)
10.1016/J.JBIOMECH.2006.08.003
Prediction of strength and strain of the proximal femur by a CT-based finite element method.
M. Bessho (2007)
10.1243/095441105X34293
Effect of Bone Material Properties on the Initial Stability of a Cementless Hip Stem: A Finite Element Study
A. S. Wong (2005)
10.1016/J.CLINBIOMECH.2006.12.001
Investigation into the affect of cementing techniques on load transfer in the resurfaced femoral head: a multi-femur finite element analysis.
I. A. J. Radcliffe (2007)
10.1016/1350-4533(95)00033-X
Sensitivity of femoral strain pattern analyses to resultant and muscle forces at the hip joint.
M. Lengsfeld (1996)
10.1109/83.277895
Three-dimensional elastic matching of volumes
M. Moshfeghi (1994)
10.1016/j.jbiomech.2012.05.015
Influence of femur size and morphology on load transfer in the resurfaced femoral head: A large scale, multi-subject finite element study.
R. Bryan (2012)
10.1016/S0021-9290(00)00225-6
Hip-joint and abductor-muscle forces adequately represent in vivo loading of a cemented total hip reconstruction.
J. Stolk (2001)
10.1016/j.jbiomech.2010.12.027
Efficient computational method for assessing the effects of implant positioning in cementless total hip replacements.
M. T. Bah (2011)
10.1016/j.clinbiomech.2008.11.003
Subject specific finite element analysis of stress shielding around a cementless femoral stem.
Sune H. Pettersen (2009)
10.1016/J.CLINBIOMECH.2007.08.024
Mathematical relationships between bone density and mechanical properties: a literature review.
B. Helgason (2008)
10.1016/j.medengphy.2011.05.010
A new hip epiphyseal prosthesis: design revision driven by a validated numerical procedure.
Saulo Martelli (2011)
10.1016/J.CLINBIOMECH.2007.03.011
Investigation into the effect of varus-valgus orientation on load transfer in the resurfaced femoral head: a multi-femur finite element analysis.
I. A. J. Radcliffe (2007)
10.1016/0141-5425(93)90066-8
Validation of an automated method of three-dimensional finite element modelling of bone.
J. Keyak (1993)
10.1002/(SICI)1096-8644(199606)100:2<207::AID-AJPA4>3.0.CO;2-U
"Race" specificity and the femur/stature ratio.
M. Feldesman (1996)
10.1016/j.medengphy.2009.10.008
Statistical modelling of the whole human femur incorporating geometric and material properties.
R. Bryan (2010)
10.1016/S0276-1092(09)79646-4
18 years of results with cemented primary hip prostheses in the Norwegian Arthroplasty Register: Concerns about some newer implants
B. Morrey (2010)
10.1016/J.JBIOMECH.2007.02.010
Subject-specific finite element models can accurately predict strain levels in long bones.
E. Schileo (2007)
10.1016/J.CLINBIOMECH.2006.05.007
Low-dose computed tomography: a solution for in vivo medical imaging and accurate patient-specific 3D bone modeling?
S. Van Sint Jan (2006)
10.1302/0301-620X.76B3.8175848
Early migration and late aseptic failure of proximal femoral prostheses.
M. Freeman (1994)
10.2106/00004623-198567080-00010
Prediction of vertebral body compressive fracture using quantitative computed tomography.
R. Mcbroom (1985)
10.1016/0141-5425(82)90009-7
Finite-element-analysis and experimental investigation of stresses in a femur.
A. Rohlmann (1982)
10.1016/j.jbiomech.2009.04.022
In-silico wear prediction for knee replacements--methodology and corroboration.
M. Strickland (2009)
10.1109/TMI.2011.2163074
Reconstructing the 3D Shape and Bone Mineral Density Distribution of the Proximal Femur From Dual-Energy X-Ray Absorptiometry
Tristan Whitmarsh (2011)
10.1097/00003086-200212000-00037
Stair Climbing is More Detrimental to the Cement in Hip Replacement than Walking
J. Stolk (2002)
10.2106/00004623-197759070-00021
The compressive behavior of bone as a two-phase porous structure.
D. Carter (1977)
10.1016/j.jmbbm.2011.06.005
Computer simulating a clinical trial of a load-bearing implant: an example of an intramedullary prosthesis.
P. Prendergast (2011)
10.1243/09544119JEIM728
Extensive Risk Analysis of Mechanical Failure for an Epiphyseal Hip Prothesis: A Combined Numerical—Experimental Approach
S. Martelli (2011)
Stress shielding and bone resorption in THA: clinical versus computer-simulation studies.
R. Huiskes (1993)
10.2106/JBJS.F.00222
Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030.
S. Kurtz (2007)
10.1098/rsta.2008.0090
An efficient approach to converting three-dimensional image data into highly accurate computational models
P. Young (2008)
10.1016/j.jbiomech.2011.09.009
Development of a statistical model of knee kinetics for applications in pre-clinical testing.
F. Galloway (2012)
10.1016/S0021-9290(99)00099-8
Femoral strength is better predicted by finite element models than QCT and DXA.
D. Cody (1999)
10.1109/ICCV.1999.791209
Advances in active appearance models
G. Edwards (1999)
10.1016/S1350-4533(98)00081-2
Material properties assignment to finite element models of bone structures: a new method.
C. Zannoni (1998)
10.1002/JOR.20346
Predicting revision risk for aseptic loosening of femoral components in total hip arthroplasty in individual patients—A finite element study
A. B. Lennon (2007)
10.1007/s10439-010-0196-y
Robust QCT/FEA Models of Proximal Femur Stiffness and Fracture Load During a Sideways Fall on the Hip
D. Dragomir-Daescu (2010)
10.1016/J.JBIOMECH.2006.07.027
Comparison of long-term numerical and experimental total knee replacement wear during simulated gait loading.
L. A. Knight (2007)
10.1007/11866565_50
Statistical Finite Element Model for Bone Shape and Biomechanical Properties
Laura Belenguer Querol (2006)
10.1243/PIME_PROC_1993_207_304_02
Finite Element Analysis of Poor Distal Contact of the Femoral Component of a Cementless Hip Endoprosthesis
M. Taylor (1993)



This paper is referenced by
10.1016/j.clinbiomech.2018.09.002
Evaluating the primary stability of standard vs lateralised cementless femoral stems – A finite element study using a diverse patient cohort☆
R. M. Al-Dirini (2018)
10.1155/2015/945379
A Hertzian Integrated Contact Model of the Total Knee Replacement Implant for the Estimation of Joint Contact Forces
Tien Tuan Dao (2015)
10.1053/J.SART.2017.05.003
DOES A SHORT STEMMED HUMERAL IMPLANT REALLY MAKE A DIFFERENCE
Reuben Gobezie (2017)
10.1007/s10237-020-01295-7
Computational framework for population-based evaluation of TKR-implanted patellofemoral joint mechanics
Azhar A. Ali (2020)
Femoral fracture risk prediction in metastatic bone disease
L.C.E.M. Derikx (2015)
10.1016/j.jbiomech.2014.12.017
Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease.
L. Derikx (2015)
10.1002/jor.23744
Influence of collars on the primary stability of cementless femoral stems: A finite element study using a diverse patient cohort
R. M. Al-Dirini (2018)
10.1016/j.bone.2015.06.025
Comparison of proximal femur and vertebral body strength improvements in the FREEDOM trial using an alternative finite element methodology.
P. Zysset (2015)
10.1002/cnm.3168
Sampling strategies for approximating patient variability in population-based finite element studies of total hip replacement.
D. O'Rourke (2019)
Computational Biomechanical Modeling of the Human Knee During Kneeling
T. R. Abo-Alhol (2013)
10.1016/j.jbiomech.2016.09.039
Analysis of an early intervention distal femoral resurfacing implant for medial osteoarthritis.
Miriam Chaudhary (2016)
10.1016/j.medengphy.2018.04.016
How can a short stem hip implant preserve the natural, pre-surgery force flow? A finite element analysis on a collar cortex compression concept (CO4).
Bernhard Eidel (2018)
10.1002/cnm.2634
Development of mapped stress-field boundary conditions based on a Hill-type muscle model.
P. Cardiff (2014)
10.1002/cnm.2618
A physically motivated constitutive model for 3D numerical simulation of skeletal muscles.
J. Weickenmeier (2014)
10.1115/1.4039824
Biomechanical Robustness of a Contemporary Cementless Stem to Surgical Variation in Stem Size and Position.
R. M. Al-Dirini (2018)
10.1016/J.TRIBOINT.2018.08.009
Computational modeling of polyethylene wear in total hip arthroplasty using patient-specific kinematics-coupled finite element analysis
Yun Peng (2019)
10.3929/ethz-a-010394755
Investigation of the Mechanical Behavior of Facial Soft Tissues
J. Weickenmeier (2015)
10.1016/B978-0-12-810493-4.00018-3
Statistical Shape and Appearance Models for Bone Quality Assessment
Patrik Raudaschl (2017)
10.1016/j.jbiomech.2018.11.013
Virtual trial to evaluate the robustness of cementless femoral stems to patient and surgical variation.
R. M. Al-Dirini (2019)
10.1007/978-3-319-12289-2_5
Bone Reposition Planning for Corrective Surgery Using Statistical Shape Model: Assessment of Differential Geometrical Features
N. Sepasian (2014)
10.1007/978-3-030-38171-4_13
Testing and Tribology: How Were Designs Tested for Wear, Strength, and Kinematics?
P. Walker (2020)
10.1016/j.medengphy.2016.11.013
Multiobjective optimization of cartilage stress for non-invasive, patient-specific recommendations of high tibial osteotomy correction angle - a novel method to investigate alignment correction.
Keke Zheng (2017)
10.1299/mer.19-00338
Computational biomechanics of knee joint arthroplasty : a review
Kyoung-Tak Kang (2020)
10.1007/s40032-020-00611-5
The Relevance of Biomechanical Analysis in Joint Replacements: A Review
Bidyut Pal (2020)
10.1002/jor.24636
Patient and surgical variability in the primary stability of cementless acetabular cups: A finite element study
Dermot O' Rourke (2020)
10.1016/J.COMPSTRUC.2017.05.003
The mechanical behavior of skin: Structures and models for the finite element analysis
J. M. Benítez (2017)
10.1007/s10237-019-01235-0
Computational efficient method for assessing the influence of surgical variability on primary stability of a contemporary femoral stem in a cohort of subjects.
R. M. Al-Dirini (2019)
10.1002/CNM.2541
Special issue on patient specific modelling (PSM)
Perumal Nithiarasu (2013)
10.1002/cnm.2583
Finite element analysis on longitudinal and radial functionally graded femoral prosthesis.
Azim Ataollahi Oshkour (2013)
10.1002/jemt.22899
Assessment of fracture risk in proximal tibia with tumorous bone defects by a finite element method
Yulin Lin (2017)
10.1016/j.jbiomech.2014.12.019
Four decades of finite element analysis of orthopaedic devices: where are we now and what are the opportunities?
M. Taylor (2015)
10.1016/j.jse.2015.11.011
Comparison of proximal humeral bone stresses between stemless, short stem, and standard stem length: a finite element analysis.
Najmeh Razfar (2016)
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