Online citations, reference lists, and bibliographies.

A Retrospective Chart Review Of The Effects Of Modafinil On Depression As Monotherapy And As Adjunctive Therapy.

Charles S. Price, Fletcher B. Taylor
Published 2005 · Psychology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Major depression is often refractory to antidepressants, and it is important to explore alternative medication treatments. Among the symptoms common with depression are energy loss/fatigue and anxiety. Modafinil has a novel mechanism of action and may have antidepressant properties. In a single outpatient clinic, data were systematically collected on all patients including those who began modafinil treatment for major depression. This clinician (C.P.) had used modafinil to treat major depression in patients who failed one or more adequate antidepressant treatments. To monitor changes during treatment, charting had included four rating scales: the Beck Depression Inventory, the Zung Self-Rating Depression Scale, and the Hamilton Depression and Hamilton Anxiety Rating Scales. A follow-up chart review identified 45 patients whose major depression was treated with modafinil over a 9-month period. The mean dose of modafinil was 184.3+/-100.0 mg/day (range=50-450 mg/day). For these 45 patients, all four rating scales showed significant improvement following 2 weeks and following 3 months of modafinil treatment. Fifteen of these patients were on modafinil monotherapy, and the remaining 30 on modafinil as an augmenting agent. For both subgroups, all three depression rating scales showed a significant improvement following 2 weeks and 3 months of modafinil treatment. This chart review provides preliminary evidence that modafinil treatment may be beneficial to those with major depression, even when unresponsive to other treatments.
This paper references
A novel augmentation strategy for treating resistant major depression.
Richard Charles Shelton (2001)
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Richard M. Chemelli (1999)
Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults.
Fletcher B. Taylor (2000)
Marietta Hamilton (1960)
Modafinil improves ADHD symptoms: A randomized, double-blind, placebo-controlled study
JM Swanson (2002)
Modafinil monotherapy in depression.
Kenneth R Kaufman (2002)
Reliability and validity of the Hamilton Anxiety Rating Scale in an adolescent sample.
Duncan B. Clark (1994)
Randomized trial of modafinil in the treatment pathological somnolence in narcolepsy
U. S. Modafinil in Narcolepsy Study Group. (1998)
Depression research in European society II: A patient survey of the symptoms, disability and current management of depression in the community
A Tylee (1999)
The use of modafinil for augmentation of antidepressant therapy: A case-series evaluation
Menza (2000)
Depression: Its causes and treatment
Beck AT. (1970)
Modafinil activates arousal and autonomic regions
I Eastbrooke (1999)
Reliability, Discriminant and Predictive Validity of the Zung Self-Rating Depression Scale
Janusz Gabrys (1985)

This paper is referenced by
The off-prescription use of modafinil: An online survey of perceived risks and benefits
Rachel D Teodorini (2020)
Uso de modafinilo en astenia por cáncer avanzado
María Angustias Portela (2011)
Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain
Linda Scoriels (2013)
The Role of Supplements in Treatment of Depression
Seyed Mostafa Mansouripour (2020)
Broadening prescription of modafinil : is the risk of addiction increased ?
Hélène Eysseric (2006)
Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro
Bertha K Madras (2006)
A systematic review of modafinil: Potential clinical uses and mechanisms of action.
Jacob Ballon (2006)
The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial.
Florien W. Boele (2013)
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Meetu Wadhwa (2018)
Using human experience to identify drug repurposing opportunities: theory and practice
D Cavalla (2019)
Modafinil: is it ready for prime time?
Eric E. Prommer (2006)
Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment.
Sandeep Vaishnavi (2006)
Psychostimulants in moderate to severe affective disorder: A systematic review of randomized controlled trials
Leda Abbasowa (2013)
Psychostimulants in the Treatment of Depressive Disorders
Okan Ekinci (2014)
Modafinil Augmentation for Residual Symptoms of Fatigue in Patients with a Partial Response to Antidepressants
J. M. Y. Lam (2007)
Semantic Scholar Logo Some data provided by SemanticScholar