Online citations, reference lists, and bibliographies.

Cytohormonal And Morphological Alterations In Cervicovaginal Smears Of Postmenopausal Women On Hormone Replacement Therapy.

Sanjay Gupta, Neeta Kumar, Niti Singhal, Usha Manektala, Shyama Jain, Pushpa Sodhani
Published 2006 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
The objective of the study was to study the cytohormonal and morphological alterations in cervicovaginal smears associated with the use of hormone replacement therapy (HRT) and to assess the utility of vaginal cytology in determining the response to HRT. Ninety postmenopausal women (30 on estrogen-progesterone combination (HRT) for 1 to 24 mo (user 1), 30 on estrogen therapy (ERT) for 1 to 44 mo (user 2), and 30 not on any hormones (nonusers)) were included in the cross-sectional study. Their lateral vaginal wall smears and cervical smears were examined for hormonal and morphological assessments, respectively. The smear pattern showed predominance of parabasal cells in 46.6% of nonusers, while none of the users had >70% parabasal cells. A high percentage (>70%) of intermediate cells was found in 46.6% of users and only in 16.6% of nonusers. A high maturation value (MV) was found in more than 75% of users but in only 16.6% of nonusers. The women with high MV (>50) were significantly less symptomatic than did nonusers. Atrophic changes were present in cervical smears of 14/20 (46.6%) nonusers when compared with 1/60 (1.66%) users. Atypical squamous cells of undetermined significance (ASC-US) were diagnosed in seven users and three nonusers. It persisted on follow-up in four users and one nonuser. Histology revealed one mild dysplasia among users. Lactobacilli were more frequently observed in users. The cytohormonal pattern on vaginal smears correlates well with the response to hormonal therapy and clinical symptoms. Awareness of the morphological alterations associated with the use of replacement hormones would enable the cytologists to reduce the false-positive diagnoses while evaluating postmenopausal smears.



This paper is referenced by
10.1097/GRF.0b013e3180d0a3f0
Common gynecologic problems in geriatric-aged women.
John W. Moroney (2007)
10.5897/AJPP12.433
Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial
Sara Ziagham (2012)
10.1517/13543770802564464
Compounds for the treatment of atropic vaginitis
Camil Castelo-Branco (2008)
10.1007/s00404-015-3616-2
Vaginal epithelium and microflora characteristics in women with premature ovarian failure under hormone therapy compared to healthy women
Cristina Laguna Benetti-Pinto (2015)
Vaginal atrophy and sexual dysfunction in current users of systemic postmenopausal hormone therapy.
Suchada Indhavivadhana (2010)
10.1089/vim.2013.0120
17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha.
Carley Tasker (2014)
10.2478/tjpath.2013.01212
Comparison of Cervical Cytological Screening Results Between Postmenopausal and Elderly Women/ Geriatrik ve Postmenopozal Kadınların Servikal Sitoloji Sonuçlarının Karşılaştırılması
Bülent Çakmak (2014)
Evaluation of nonneoplastic findings on vaginal smears with comparison of intrauterine devices and oral contraceptive pill effects
Rahime Bedir Fındık (2013)
10.1089/AID.2016.0320
Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women.
Andrea Ries Thurman (2017)
10.1210/er.2009-0018
Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection.
Zdeněk Hel (2010)
10.1097/gme.0b013e318193e7cd
An open-label randomized trial to determine the most effective regimen of vaginal estrogen to reduce the prevalence of atrophic changes reported in postmenopausal cervical smears
Deborah J Bateson (2009)
10.1111/IGC.0b013e31819d8b5b
Current Hormone Therapy Associated With Atypical Squamous Cells of Undetermined Significance in Postmenopausal Women
Ki Hoon Ahn (2009)
10.3109/13697137.2015.1005592
Age-related changes in the diagnostic assessment of women with severe cervical lesions
Luca Giannella (2015)
10.1159/000353769
Cytohistologic Correlation in Premenopausal and Postmenopausal Women
Syed M Gilani (2013)
10.1007/s00404-010-1545-7
The effect of vaginally administered genistein in comparison with hyaluronic acid on atrophic epithelium in postmenopause
Maria Le Donne (2010)
10.5935/1676-2444.20190016
Cytomorphological analysis of cervical cytological smears of women aged over 60 years
Luana Taís Hartmann Backes (2019)
10.3109/13697137.2013.860116
Dyspareunia and lubrication in premature ovarian failure using hormonal therapy and vaginal health
Poliana Cordeiro César Pacello (2014)
Semantic Scholar Logo Some data provided by SemanticScholar