Online citations, reference lists, and bibliographies.

Cyclodextrin Complexes: Perspective From Drug Delivery And Formulation.

Shery Jacob, Anroop B Nair
Published 2018 · Biology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Cyclodextrins (CDs) have been widely investigated as a unique pharmaceutical excipient for past few decades and is still explored for new applications. They are highly versatile oligosaccharides which possess multifunctional characteristics, and are mainly used to improve the physicochemical stability, solubility, dissolution rate, and bioavailability of drugs. Stability constant, factors affecting complexation, techniques to enhance complexation efficiency, the preparation methods for molecular inclusion complexes and release of guest molecules are discussed in brief. In addition, different CD derivatives and their pharmacokinetics are elaborated. Further, the significance of CD complex in aqueous solubility, dissolution and bioavailability, stability, and taste masking is explained. The recent advancement of CDs in developing various drug delivery systems is enlightened. Indeed, the potential of CDs by means of inclusion complex formation have widen the applicability of these materials in various drug delivery systems including ocular, osmotic, mucoadhesive, transdermal, nasal, and targeted delivery systems. Feasibility studies have been performed on the benefit of these cyclic oligomers as nanocarriers, a strategy that can modify the drugs with improved physicochemical properties. Studies also demonstrated the feasibility of CDs to self-assemble in the form of stable nanoaggregates, which may extend the scope of CDs in drug delivery to the continually expanding list of new drug entities.
This paper references
10.1211/jpp.61.04.0003
A study on the effect of inorganic salts in transungual drug delivery of terbinafine.
A. Balakrishnan Nair (2009)
10.1016/j.ijpharm.2013.10.005
A novel lactoferrin-modified β-cyclodextrin nanocarrier for brain-targeting drug delivery.
Yajing Ye (2013)
10.1016/j.ijpharm.2011.04.031
Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery.
Azza A. Mahmoud (2011)
10.1016/j.jconrel.2015.05.254
β-cyclodextrin based colon targeted delivery systems of aspirin: Synthesis, and in vitro assessment.
Peipei Ma (2015)
10.1088/0957-4484/19/18/185101
Novel drug nanocarriers combining hydrophilic cyclodextrins and chitosan.
Adriana Trapani (2008)
10.1111/j.1755-3768.2011.02299.x
Topical drug delivery to the eye: dorzolamide.
Thorsteinn Loftsson (2012)
10.1016/j.ijpharm.2014.04.029
β-Cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs.
Massimiliano Pio di Cagno (2014)
10.1016/j.carbpol.2015.04.048
Liposomes incorporating cyclodextrin-drug inclusion complexes: Current state of knowledge.
Riham Gharib (2015)
10.1021/mp3005963
Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability.
Peter W J Morrison (2013)
10.1016/j.jpba.2009.11.013
Preparation and solid-state characterization of bupivacaine hydrochloride cyclodextrin complexes aimed for buccal delivery.
Mario Jug (2010)
10.2147/DDDT.S97982
Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres
Lu Shan (2016)
10.1002/ejoc.200700933
Amphiphilic Cyclodextrins – Advances in Synthesis and Supramolecular Chemistry†
Florence Sallas (2008)
10.1016/j.ijpharm.2015.04.044
Fast releasing oral electrospun PVP/CD nanofiber mats of taste-masked meloxicam.
Wipada Samprasit (2015)
10.1016/j.ijpharm.2017.11.048
Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation.
Priyanka C. Bhatt (2018)
10.4081/ams.2011.e12
Gastro-retentive floating beads of curcumin β-cyclodextrin complex to treat stomach tumors
Shishu Goindi (2011)
10.1023/A:1023098730627
Mucoadhesive Sustained Drug Delivery System Based on Cationic Polymer and Anionic Cyclodextrin/Triclosan Complex
Hakon Hrafn Sigurdsson (2002)
10.1016/j.ijpharm.2004.08.002
Applicability of (SBE)7m-β-CD in controlled-porosity osmotic pump tablets (OPTs)
Kazuto Okimoto (2004)
10.1088/0957-4484/23/9/095101
Solid lipid nanoparticles with and without hydroxypropyl-β-cyclodextrin: a comparative study of nanoparticles designed for colonic drug delivery.
Gianpiera Spada (2012)
10.1081/PDT-100100548
Development and Testing of an Improved Parenteral Formulation of Phenytoin Using 2-Hydroxypropyl-β-cyclodextrin
James Blanchard (2000)
10.1080/13543776.2017.1384816
Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: a patent review
Tâmara Coimbra Diniz (2018)
10.1038/sj.gt.3301527
Development of formulations that enhance physical stability of viral vectors for gene therapy
MA Croyle (2001)
10.1016/j.ejpb.2015.05.019
Intranasal delivery of dopamine to the striatum using glycol chitosan/sulfobutylether-β-cyclodextrin based nanoparticles.
Sante Di Gioia (2015)
Cyclodextrins: application in different routes of drug administration.
Shyam Shimpi (2005)
10.3109/08982104.2013.788026
Novel tretinoin formulations: a drug-in-cyclodextrin-in-liposome approach
Andreia Ascenso (2013)
10.1002/jps.21567
Release mechanisms of a sparingly water-soluble drug from controlled porosity-osmotic pump pellets using sulfobutylether-beta-cyclodextrin as both a solubilizing and osmotic agent.
Sutthilug Sotthivirat (2009)
10.1016/j.carbpol.2007.11.005
Novel thiolated carboxymethyl chitosan-g-β-cyclodextrin as mucoadhesive hydrophobic drug delivery carriers
Mani Prabaharan (2008)
10.7150/ijms.7.232
Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats
Ibrahim Abdullah Alsarra (2010)
10.1007/s13346-012-0114-y
Transdermal delivery of cyclodextrin-solubilized curcumin
Raksha Ghanghoria (2012)
10.1016/j.jfluchem.2008.09.005
Sustained release applications of a fluoroalkyl ester-functionalized amphiphilic cyclodextrin by inclusion complex formation with water-soluble drugs in supercritical carbon dioxide
Hullathy Subban Ganapathy (2008)
10.1155/2014/950358
Hydroxypropyl-β-cyclodextrin: A Novel Transungual Permeation Enhancer for Development of Topical Drug Delivery System for Onychomycosis
Pradeep Chouhan (2014)
10.1016/S0032-9592(03)00258-9
Cyclodextrins and their uses: a review
E.M.M. Del Valle (2004)
10.1080/08982104.2016.1224897
Preparation and evaluation of niosome gel containing acyclovir for enhanced dermal deposition
Shery Jacob (2017)
10.3109/02713683.2010.536294
Formulation of Indomethacin Eye Drops via Complexation with Cyclodextrins
Maaly A Halim Mohamed (2011)
10.1007/s13346-013-0140-4
Cyclodextrin-based targeting strategies for tumor treatment
Juan-juan Yin (2013)
10.1166/jnn.2013.8091
Carboxymethyl dextran-cyclodextrin conjugate as the carrier of doxorubicin.
Maharajan Sivasubramanian (2013)
10.1016/j.carbpol.2018.01.011
Taste masking and rheology improvement of drug complexed with beta-cyclodextrin and hydroxypropyl-β-cyclodextrin by hot-melt extrusion.
Lorena F.B. Malaquias (2018)
Preparation of solid drug/cyclodextrin complexes of acidic and basic drugs.
Thorsteinn Loftsson (2004)
10.3109/03639045.2016.1141932
Cyclodextrin–poloxamer aggregates as nanocarriers in eye drop formulations: dexamethasone and amphotericin B
Phatsawee Jansook (2016)
10.1080/03639045.2018.1425426
Preparation and evaluation of carfentanil nasal spray employing cyclodextrin inclusion technology
Peng Yang (2018)
10.1002/jps.10517
Inhibitory effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced cellular damage: In vitro and in vivo studies.
Yukihiko Nagase (2003)
10.1016/j.ejps.2008.11.006
The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder.
Laura E. Matilainen (2009)
10.4155/tde-2017-0087
Cross-linked hyaluronan films loaded with acetazolamide-cyclodextrin-triethanolamine complexes for glaucoma treatment.
Javier Adrián Calles (2018)
Influence of β - cyclodextrin complexation on lovastatin release from osmotic pump tablets (OPT)
Ali Mehramizi (2007)
10.1080/10837450701563277
In Vitro Controlled Release of Alfuzosin Hydrochloride Using HPMC-Based Matrix Tablets and Its Comparison with Marketed Product
Anroop B Nair (2007)
10.2174/1568026616666161222101104
Amphiphilic Cyclodextrin Derivatives for Targeted Drug Delivery to Tumors.
Nazlı Erdoğar (2017)
10.1016/j.drudis.2015.11.017
Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex.
Sunil S. Jambhekar (2016)
10.1016/j.jconrel.2010.03.012
Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles.
Maite Agüeros (2010)
10.1016/j.exer.2015.01.022
A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure.
Noriaki Nagai (2015)
10.1007/s10637-017-0461-0
New doxorubicin nanocarriers based on cyclodextrins
Maurizio Viale (2017)
10.1016/j.drudis.2015.11.016
Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency.
Sunil S. Jambhekar (2016)
10.1208/s12249-010-9411-2
Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent
Navjot Kaur (2010)
10.1016/j.reactfunctpolym.2016.08.008
Poly(lactide-co-glycolide)/cyclodextrin (polyethyleneimine) microspheres for controlled delivery of dexamethasone
Sanda Bucătariu (2016)
10.1016/j.eurpolymj.2009.01.031
Preparation and characteristics of hydroxypropyl-β-cyclodextrin polymeric nanocapsules loading nimodipine
Yong-Zhong Du (2009)
10.1016/j.colsurfb.2014.05.030
Itraconazole-hydroxypropyl-β-cyclodextrin loaded deformable liposomes: in vitro skin penetration studies and antifungal efficacy using Candida albicans as model.
Abdullah H. Alomrani (2014)
10.1208/s12249-010-9541-6
Response Surface Methodology to Optimize Novel Fast Disintegrating Tablets Using β Cyclodextrin as Diluent
Sameer G Late (2010)
10.1080/03639045.2016.1236808
Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability
Juilee A. Kulkarni (2017)
10.1016/j.fjps.2016.08.001
Formulation of risperidone in floating microparticles to alleviate its extrapyramidal side effects
Hussein Osman Ammar (2016)
10.1016/S0378-5173(00)00365-3
Influence of cyclodextrin complexation on the in vitro permeation and skin metabolism of dexamethasone.
Ruben Fernandez Lopez (2000)
10.1208/pt070238
Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex
Erem Bilensoy (2008)
10.1371/journal.pone.0109090
Thermosensitive and Mucoadhesive Sol-Gel Composites of Paclitaxel/Dimethyl-β-Cyclodextrin for Buccal Delivery
Soon Gil Choi (2014)
10.1016/j.jconrel.2007.07.018
The utility of cyclodextrins for enhancing oral bioavailability.
Rebecca L Carrier (2007)
10.1080/10611860600834433
Drug delivery strategies for common orofacial diseases
Xin-ming Liu (2006)
10.1208/s12249-012-9877-1
Molecular Modeling-Based Inclusion Mechanism and Stability Studies of Doxycycline and Hydroxypropyl-β-Cyclodextrin Complex for Ophthalmic Delivery
Haohao Zhang (2012)
10.1016/j.ijpharm.2017.06.029
Poly(ethylene oxide)/hydroxypropyl-β-cyclodextrin films for oromucosal delivery of hydrophilic drugs.
Ivana d'Angelo (2017)
10.1248/cpb.57.545
Preparation and evaluation of gastroretentive floating tablets of Silymarin.
Rajeev Garg (2009)
10.3389/fphar.2018.00091
Nanoliposome-Encapsulated Brinzolamide-hydropropyl-β-cyclodextrin Inclusion Complex: A Potential Therapeutic Ocular Drug-Delivery System
Fazhan Wang (2018)
10.1016/j.ijpharm.2007.02.034
alpha-Cyclodextrin/oil beads: an innovative self-assembling system.
Amélie Bochot (2007)
10.1080/03639040802337021
Preparation and Evaluation of Fast-Disintegrating Effervescent Tablets of Glibenclamide
Shery Jacob (2009)
10.1016/j.ijpharm.2017.07.044
Formulations and toxicologic in vivo studies of aqueous cyclosporin A eye drops with cyclodextrin nanoparticles.
Sunna Jóhannsdóttir (2017)
10.1208/s12249-016-0589-9
Potential Use of Cyclodextrin Complexes for Enhanced Stability, Anti-inflammatory Efficacy, and Ocular Bioavailability of Loteprednol Etabonate
Osama Abd El-Aazeem Soliman (2016)
10.1016/j.ijpharm.2009.12.039
5-Fluorouracil acetic acid/beta-cyclodextrin conjugates: drug release behavior in enzymatic and rat cecal media.
Koichi Udo (2010)
10.1007/s10847-004-8841-9
Co-grinding with Cyclodextrin as a Nanoparticle Preparation Method of a Poorly Water Soluble Drug
Yuichi Tozuka (2004)
10.1016/j.ejps.2009.02.010
Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.
Maite Agüeros (2009)
10.1080/17425247.2017.1248398
Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease
Francesco Trotta (2016)
10.1016/j.ejps.2011.10.002
Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine.
Barbara Luppi (2011)
10.1021/ma020664o
New Supramolecular Assemblies of a Cyclodextrin-Grafted Chitosan through Specific Complexation
Rachel Auzély-Velty and (2002)
10.1016/S0928-0987(03)00025-3
Multimodal molecular encapsulation of nicardipine hydrochloride by β-cyclodextrin, hydroxypropyl-β-cyclodextrin and triacetyl-β-cyclodextrin in solution. Structural studies by 1H NMR and ROESY experiments
Catarina Marques Fernandes (2003)
10.1016/j.ejps.2007.09.010
Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex.
Daniele Ribeiro de Araújo (2008)
10.1016/j.ijpharm.2016.01.024
Diclofenac-β-cyclodextrin for colonic drug targeting: In vivo performance in rats.
Amélia C F Vieira (2016)
10.3762/bjnano.8.145
Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
Gamze Varan (2017)
10.1016/j.ejpb.2017.04.028
Cyclodextrin‐based nanosponges for the targeted delivery of the anti‐restenotic agent DB103: A novel opportunity for the local therapy of vessels wall subjected to percutaneous intervention
Vito Coviello (2017)
10.3762/bjoc.11.22
Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin
Hale Ergün Ünal (2015)
10.1155/2014/487563
Connecting Soil Organic Carbon and Root Biomass with Land-Use and Vegetation in Temperate Grassland
Devan Allen McGranahan (2014)
10.1016/j.ejps.2017.05.047
Enhanced dissolution and skin permeation profiles of epalrestat with &bgr;‐cyclodextrin derivatives using a cogrinding method
Takayuki Furuishi (2017)
10.1155/2014/127495
Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer
Saleh A Al-suwayeh (2014)
10.1080/03639045.2017.1414232
A novel ion-activated in situ gelling ophthalmic delivery system based on κ-carrageenan for acyclovir
Pingfei Li (2018)
10.1016/j.ejpb.2007.06.004
Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-cyclodextrin.
Giovanna Corti (2008)
10.1016/j.ijpharm.2006.02.006
Influence of modified cyclodextrins on solubility and percutaneous absorption of celecoxib through human skin.
Cinzia A Ventura (2006)
Effect of hydroxypropyl-beta-cyclodextrin on the solubility, stability and in-vitro release of ciprofloxacin for ocular drug delivery.
Asuman Bozkır (2012)
10.1023/A:1011033121528
Colonic Drug Delivery: Prodrug Approach
V R Sinha (2001)
10.1080/03639045.2018.1442844
In vitro and in vivo evaluation of cyclodextrin-based nanosponges for enhancing oral bioavailability of atorvastatin calcium
Mohamed F Zidan (2018)
10.1002/jps.23373
Transdermal iontophoretic delivery of propofol: a general anaesthetic in the form of its phosphate salt.
Abhishek Juluri (2013)
10.2174/1567201814666170419113933
Development of a Chitosan-based Nanoparticle Formulation for Ophthalmic Delivery of Honokiol.
Feng Deng (2018)
10.1016/j.ijpharm.2014.08.021
Hydroxypropyl-β-cyclodextrin grafted polyethyleneimine used as transdermal penetration enhancer of diclofenac sodium.
Yan Yan (2014)
10.1016/j.ejpb.2008.12.006
Modulation of release rate and barrier transport of Diclofenac incorporated in hydrophilic matrices: role of cyclodextrins and implications in oral drug delivery.
Agnese Miro (2009)
10.1208/s12249-016-0609-9
Improvement of the Ocular Bioavailability of Econazole Nitrate upon Complexation with Cyclodextrins
Abd El-Gawad H Abd El-Gawad (2016)
10.1016/j.carbpol.2012.12.033
β-Cyclodextrin hydrogels for the ocular release of antibacterial thiosemicarbazones.
Romina J. Glisoni (2013)
10.1016/j.carbpol.2017.02.071
Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone.
Calogero Fiorica (2017)
10.1208/s12249-010-9482-0
Parenteral Delivery of HPβCD: Effects on Drug-HSA Binding
Sergey V. Kurkov (2010)
10.1080/10837450.2016.1245319
Enhancement of levodopa stability when complexed with β-cyclodextrin in transdermal patches
Rana M. Obaidat (2018)
10.1007/s10847-006-9259-y
Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer
Erem Bilensoy (2007)
10.1016/j.apsb.2012.05.004
Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release
Sharad Darandale (2012)
10.1021/mp300188f
Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier.
Hidetoshi Arima (2012)
10.1002/jps.22068
Development of mucoadhesive films for buccal administration of flufenamic acid: Effect of cyclodextrin complexation.
Paola Angela Mura (2010)
10.1111/jphp.12549
Development of cyclodextrin hydrogels for vaginal delivery of dehydroepiandrosterone.
Natascia Mennini (2016)
10.1016/j.yrtph.2004.05.008
Safety assessment of ?-cyclodextrin
Ian C. Munro (2004)
10.1111/j.2042-7158.2011.01279.x
Pharmaceutical applications of cyclodextrins: effects on drug permeation through biological membranes.
Thorsteinn Loftsson (2011)
10.1021/mp3003946
Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease.
Bruno M.D.C. Godinho (2013)
10.1016/j.ijpharm.2017.04.050
Cyclodextrin nanosystems in oral drug delivery: A mini review.
Oluwatomide Adeoye (2017)
10.3109/10717544.2013.853213
Enhanced oral bioavailability of acyclovir by inclusion complex using hydroxypropyl-β-cyclodextrin
Anroop B Nair (2014)
10.1016/j.ijpharm.2017.07.016
Intracorneal melatonin delivery using 2-hydroxypropyl-β-cyclodextrin ophthalmic solution for granular corneal dystrophy type 2.
Jun-Hyun Ahn (2017)
10.3390/molecules21121748
Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases
Caroline Coisne (2016)
10.1016/j.xphs.2016.04.007
Brain-Targeting Chemical Delivery Systems and Their Cyclodextrin-Based Formulations in Light of the Contributions of Marcus E. Brewster.
Peter Buchwald (2016)
10.1080/03639045.2017.1371732
Enhancement of oral bioavailability of anti-HIV drug rilpivirine HCl through nanosponge formulation*
Rana Zainuddin (2017)
10.1016/j.ijpharm.2014.08.066
Development of liposomal and microemulsion formulations for transdermal delivery of clonazepam: effect of randomly methylated β-cyclodextrin.
Paola Angela Mura (2014)
10.1016/j.ijbiomac.2014.05.033
Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis.
Erdal Cevher (2014)
10.1016/j.carbpol.2016.04.115
Preparation and evaluation of naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for ocular drug delivery.
Ping Zhang (2016)
10.1080/10611860802556842
Mucoadhesive microspheres for nasal administration of cyclodextrins
Elisabetta Gavini (2009)
10.1016/S0166-3542(01)00218-2
In vitro antiviral efficacy of the ganciclovir complexed with beta-cyclodextrin on human cytomegalovirus clinical strains.
Céline Nicolazzi (2002)
10.1023/A:1023082226992
Effect of 2-Hydroxypropyl-β-cyclodextrin on Release Rate of Metoprolol from Ternary Metoprolol/2-hydroxypropyl-β-cyclodextrin/Ethylcellulose Tablets
Yoichi Ikeda (2002)
10.1371/journal.pone.0150877
β-Cyclodextrin-Based Inclusion Complexation Bridged Biodegradable Self-Assembly Macromolecular Micelle for the Delivery of Paclitaxel
Yanzuo Chen (2016)
10.1039/c0cs00019a
Cyclodextrin-based gene delivery systems.
Carmen Ortiz Mellet (2011)
10.1016/j.ijpharm.2016.04.071
Cyclodextrin-based telmisartan ophthalmic suspension: Formulation development for water-insoluble drugs.
Chutimon Muankaew (2016)
10.1016/j.jconrel.2003.10.002
Modulating drug release with cyclodextrins in hydroxypropyl methylcellulose gels and tablets.
Beatriz Pose-Vilarnovo (2003)
10.1016/j.ijpharm.2005.12.046
Acrylic/cyclodextrin hydrogels with enhanced drug loading and sustained release capability.
Ulf Siemoneit (2006)
10.1023/B:PHAM.0000032998.84488.7a
Cyclodextrins in Nasal Delivery of Low-Molecular-Weight Heparins: In Vivo and in Vitro Studies
Tianzhi Yang (2004)
10.1089/jop.2013.0164
Dorzolamide cyclodextrin nanoparticle suspension eye drops and Trusopt in rabbit.
Gauti Jóhannesson (2014)
10.1016/j.colsurfb.2014.07.005
Folate-conjugated beta-cyclodextrin-based polymeric micelles with enhanced doxorubicin antitumor efficacy.
Lu Zhang (2014)
10.1080/09205063.2014.958016
In vitro drug release of natamycin from β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin-functionalized contact lens materials
Chau-Minh Phan (2014)
10.1016/j.ijpharm.2005.05.042
Evaluation of cyclodextrin solubilization of drugs.
Thorsteinn Loftsson (2005)
10.1016/j.ijpharm.2014.11.052
Gemcitabine and γ-cyclodextrin/docetaxel inclusion complex-loaded liposome for highly effective combinational therapy of osteosarcoma.
Liang Sun (2015)
10.1002/jps.23077
Cyclodextrins as functional excipients: methods to enhance complexation efficiency.
Thorsteinn Loftsson (2012)
10.1016/j.drudis.2015.05.008
Cyclodextrin nanoassemblies: a promising tool for drug delivery.
Véronique Bonnet (2015)
10.1208/s12249-017-0844-8
Development and Evaluation of pH-Responsive Cyclodextrin-Based in situ Gel of Paliperidone for Intranasal Delivery
Atul P Sherje (2017)
10.1016/j.colsurfb.2013.04.045
Flurbiprofen PLGA-PEG nanospheres: role of hydroxy-β-cyclodextrin on ex vivo human skin permeation and in vivo topical anti-inflammatory efficacy.
Estefanía Suárez-Suárez de la Vega (2013)
10.1016/j.ejps.2003.10.029
Influence of hydroxypropyl-beta-cyclodextrin complexation on piroxicam release from buccoadhesive tablets.
Mario Jug (2004)
Investigation of interaction of promethazine with cyclodextrins.
Anna Lutka (2002)
10.1039/B614899A
Per(6-guanidino-6-deoxy)cyclodextrins: synthesis, characterisation and binding behaviour toward selected small molecules and DNA.
Nikolaos Mourtzis (2007)
10.1016/j.xphs.2016.03.009
Thiolated Cyclodextrin: Development of a Mucoadhesive Vaginal Delivery System for Acyclovir.
Muhammad Ijaz (2016)
10.1016/S0928-0987(03)00202-1
The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-β-cyclodextrin
Granero Gladys (2003)
10.1016/j.ijpharm.2010.04.006
Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles.
Nan Zhang (2010)
10.1002/jps.20831
Practical considerations in development of solid dosage forms that contain cyclodextrin.
Lee A Miller (2007)
10.1016/j.jpba.2017.03.042
Host‐guest kinetic interactions between HP‐&bgr;‐cyclodextrin and drugs for prediction of bitter taste masking
Zhen Guo (2017)
10.1016/j.xphs.2016.05.017
Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)-Induced Toxicity.
A. Süha Yalçin (2016)
10.1016/j.colsurfb.2015.10.045
Formulation and evaluation of nano based drug delivery system for the buccal delivery of acyclovir.
Bandar E Aldhubiab (2015)



This paper is referenced by
10.1016/J.MOLLIQ.2019.03.092
Thermodynamic parameters for the complexation of water-soluble betulin derivatives with (2-hydroxypropyl)-β-cyclodextrin determined by affinity capillary electrophoresis
Viktoria V Sursyakova (2019)
10.1016/j.jddst.2020.101643
Engineered nanosponges as versatile biodegradable carriers: An insight
Ankit Jain (2020)
10.1016/J.MOLLIQ.2019.111513
Physicochemical properties and fungicidal activity of inclusion complexes of fungicide chlorothalonil with β-cyclodextrin and hydroxypropyl-β-cyclodextrin
Shuang Gao (2019)
10.1208/s12249-019-1579-5
Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients
J. L. A. Conceição (2020)
10.1016/j.ijpharm.2020.119149
Crystallization tendency of APIs possessing different thermal and glass related properties in amorphous solid dispersions.
Afroditi Kapourani (2020)
10.1016/j.carbpol.2020.116401
Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems.
Bingren Tian (2020)
10.1080/17425247.2020.1730808
Nanocarriers: more than tour de force for thymoquinone.
Charul Rathore (2020)
10.3390/pharmaceutics12010055
Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review
Anna Lechanteur (2020)
10.2174/1389201020666190621104624
Encapsulation of venom-derived peptides and toxins for pharmaceutical application.
Ana Paula dos Santos (2019)
10.1007/s13346-020-00734-3
Improvement of oral bioavailability of carvedilol by liquisolid compact: optimization and pharmacokinetic study
Mimansa Jhaveri (2020)
10.3390/SCIPHARM87030015
Current approaches to use cyclodextrins and mucoadhesive polymers in ocular drug delivery-a mini-review
Tivadar Bíró (2019)
10.1002/AOC.4861
Ultrasound‐assisted green synthesis of Cu‐based complexes of β‐cyclodextrin and their SOD‐like activity
Behnaz Nikzad-kojanag (2019)
10.1186/s40824-020-0184-8
Emerging role of nanosuspensions in drug delivery systems
Shery Jacob (2020)
10.1016/j.biomaterials.2019.119619
Metal-organic frameworks for stimuli-responsive drug delivery.
Ying Wang (2019)
10.3390/molecules25040998
Inclusion of the Phytoalexin trans-Resveratrol in Native Cyclodextrins: A Thermal, Spectroscopic, and X-Ray Structural Study
Laura Catenacci (2020)
10.1039/c9nj03293b
Fluorescence solvatochromism and modulated anticholinergic activity of novel coumarin compounds sequestered in human serum albumin nanocavities
Mostofa Ataur Rohman (2019)
10.1007/s13346-020-00778-5
Cyclodextrin-based delivery systems for in vivo-tested anticancer therapies
Ana Cláudia Santos (2020)
10.1016/j.carbpol.2020.116448
Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model.
Luana Heimfarth (2020)
Semantic Scholar Logo Some data provided by SemanticScholar