← Back to Search
Clinical Problems Of Patients With Cachexia Due To Chronic Illness: A Congress Report
S. Hadzibegovic, Philipp Sikorski, Sophia K Potthoff, J. Springer, A. Lena, M. Anker
Published 2020 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Cachexia is a complex and multifactorial comorbidity characterized by a metabolic imbalance. It is defined as a body weight loss ≥5% in the last 12 months in patients with a chronic illness who also suffer from at least three of the following five symptoms: fatigue, decreased muscle strength, low fat‐free mass index, anorexia, and/or altered biochemistry (haemoglobin < 12 g/dL, serum albumin < 3.2 g/dL, increased interleukin 6, or C‐reactive protein). It is influenced by immunological, neurohormonal, and mucointestinal impairments and aggravated by factors such as malabsorption and dietary deficiencies. Cachexia is frequently seen in different chronic diseases: in 50–80% of advanced cancer patients, 30–50% of dialysis patients, 20–30% of chronic obstructive pulmonary disease patients, 20–30% of rheumatoid arthritis patients, 10% of patients after neurologic stroke, and 10–20% of chronic heart failure (CHF) patients. As an example, CHF patients share many risk factors with cachexia that also contribute to its development: high prevalence of comorbidities, immunoflammatory alterations, worsening nutritional status, and a sedentary lifestyle with a high risk for frailty due to a decrease of daily life activities or frequent rehospitalizations. Hence, wasting disorders are associated with poorer quality of life, longer hospitalization rates, and increased mortality. Therefore, there is a need for annually meetings, in person or digital, where clinicians and basic researches can share their knowledge on the topic. Over 400 participants from more than 35 countries attended the ‘12 International Conference on Cachexia, Sarcopenia and Muscle Wasting’, which was held in Berlin, Germany, from 6 to 8 December 2019. It provided a great platform for new updates about cachexia and muscle wasting disorders. Among a variety of lectures and poster presentations, one special clinical session was dedicated to the most frequent symptoms in patients with cachexia and their treatments: swallowing problems, pain, depression, muscle weakness, fatigue, and shortness of breath.
This paper references
Differences in Symptom Burden Among Cancer Patients With Different Stages of Cachexia.
T. Zhou (2017)
Classification of neuropathic pain in cancer patients: A Delphi expert survey report and EAPC/IASP proposal of an algorithm for diagnostic criteria
C. Brunelli (2014)
Comportamento do ergorreflexo na insuficiência cardíaca
J. Belli (2011)
Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival.
A. Ryan (2019)
Establishing a clinical phenotype for cachexia in end stage kidney disease – study protocol
J. Reid (2018)
Cachexia in chronic heart failure: Prognostic implications and novel therapeutic approaches
Y. Akashi (2005)
Skeletal muscle wasting in chronic heart failure
Tsuyoshi Suzuki (2018)
The Edmonton Classification System for Cancer Pain: comparison of pain classification features and pain intensity across diverse palliative care settings in eight countries.
C. Nekolaichuk (2013)
The prevalence of patient-reported dysphagia and oral complications in cancer patients
J. Frowen (2019)
Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure.
J. Floras (1993)
Progressive resistance training in cachectic head and neck cancer patients undergoing radiotherapy: a randomized controlled pilot feasibility trial
Manuel Grote (2018)
Role of Inflammation Gene Polymorphisms on Pain Severity in Lung Cancer Patients
C. Reyes-Gibby (2009)
Do patients with chronic heart failure have chest pain?
A. Clark (2013)
Anti-cytokines in the treatment of cancer cachexia.
B. Prado (2019)
Heart Failure Association of the European Society of Cardiology position paper on frailty in patients with heart failure
C. Vitale (2019)
Kidney cachexia or protein‐energy wasting in chronic kidney disease: facts and numbers
L. Koppe (2019)
Presbyphagia and Sarcopenic Dysphagia: Association between Aging, Sarcopenia, and Deglutition Disorders.
H. Wakabayashi (2014)
Transition from acute to chronic pain after surgery.
P. Lavandʼhomme (2017)
Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer
T. Naito (2019)
Depression in heart failure a meta-analytic review of prevalence, intervention effects, and 3418 Editorial ESC
T Rutledge (2020)
associations with clinical outcomes
Ergoreflex activity in heart failure.
J. Belli (2011)
Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta‐analysis
R. Santo (2018)
Editorial 3419 ESC Heart Failure 2020
T Naito (2019)
Sarcopenia and dysphagia: Position paper by four professional organizations
I. Fujishima (2019)
Improved strength prediction combining clinically available measures of skeletal muscle mass and quality
B. Bourgeois (2019)
The prognostic significance of weight loss in chronic obstructive pulmonary disease‐related cachexia: a prospective cohort study
H. Kwan (2019)
Comparison of sarcopenia and cachexia in men with chronic heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF)
Amir Emami (2018)
Eating‐related distress and need for nutritional support of families of advanced cancer patients: a nationwide survey of bereaved family members
K. Amano (2016)
What low back pain is and why we need to pay attention
J. Hartvigsen (2018)
Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction.
Koen W. Streng (2018)
Pain during exacerbation of chronic obstructive pulmonary disease: A prospective cohort study
M. Maignan (2019)
Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non‐small cell lung cancer: results of a prospective cardiovascular long‐term study
M. Anker (2016)
Standards for the management of cancer‐related pain across Europe—A position paper from the EFIC Task Force on Cancer Pain
M. Bennett (2019)
Abdominal skeletal muscle mass as a predictor of mortality in Japanese patients undergoing left ventricular assist device implantation
M. Tsuji (2019)
Skeletal muscle mass is associated with severe dysphagia in cancer patients
H. Wakabayashi (2015)
Prevalence and prognostic impact of non‐cardiac co‐morbidities in heart failure outpatients with preserved and reduced ejection fraction: a community‐based study
A. Iorio (2018)
The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members.
J. Reid (2009)
Sarcopenia: a time for action
J Bauer (2019)
Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure.
C. Demers (2001)
Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
J. Brown (2018)
Cachexia: a new definition.
W. Evans (2008)
RESOLVD Pilot Study Investigators. Reliability, validity, and responsiveness of the six‐minute walk test in patients with heart failure
C Demers (2001)
A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
T. Solheim (2017)
Efficacy of modified chin tuck against resistance exercise using hand-free device for dysphagia in stroke survivors: A randomized controlled trial.
Hwan-hee Kim (2019)
Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?
M. Chabowski (2018)
Trajectory of performance status and symptom scores for patients with cancer during the last six months of life.
H. Seow (2011)
ESPEN guidelines on nutrition in cancer patients.
J. Arends (2017)
Prevalence of behavioral health disorders and associated chronic disease burden in a commercially insured health system: findings of a case-control study.
J. Q. Young (2015)
Protein imbalance in the development of skeletal muscle 3416 Editorial ESC Heart Failure 2020; 7: 3414–3420 DOI: 10.1002/ehf2.13052 wasting in tumour‐bearing mice
JL Brown (2018)
Opti - mizing cancer pain management in resource ‐ limited settings
SH Ahmedzai (2019)
Vul - nerabilities of patients recovering from an exacerbation of chronic heart fail
DK Moser (2005)
Consensus definition of sarcopenia, cachexia and precachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and
The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention
Calvin Cole (2018)
The Prevalence and Prognosis of Sarcopenic Dysphagia in Patients Who Require Dysphagia Rehabilitation
H. Wakabayashi (2018)
Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk
Jiao Wu (2019)
Progressive Resistance Training to Impact Physical Fitness and Body Weight in Pancreatic Cancer Patients: A Randomized Controlled Trial
J. Wiskemann (2019)
Phase II Trial of Mirtazapine for Cancer-Related Cachexia and Anorexia
R. Riechelmann (2010)
Sarcopenia: revised European consensus on definition and diagnosis
A. Cruz-Jentoft (2019)
Physiological changes and clinical correlations of dyspnea in cancer outpatients.
D. Dudgeon (2001)
Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer.
J. Gewandter (2015)
chexia in chronic heart failure : prognostic implications and novel therapeutic approaches
J Wu (2005)
Olanzapine for cachexia in patients with advanced cancer: an exploratory study of effects on weight and metabolic cytokines
A. Naing (2015)
Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa
R. G. Costa (2019)
Sarcopenia: revised European consensus on definition and diagnosis
A. Cruz-Jentoft (2019)
Fibroblast growth factor 21 in patients with cardiac cachexia: a possible role of chronic inflammation
Maria Refsgaard Holm (2019)
The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study
George Markousis-Mavrogenis (2019)
Randomized Trial of Low-Dose Morphine Versus Weak Opioids in Moderate Cancer Pain.
E. Bandieri (2016)
Optimizing cancer pain management in resource-limited settings
S. Ahmedzai (2018)
von Haehling S. Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer
L Cramer (2014)
The relationship between the BMI‐adjusted weight loss grading system and quality of life in patients with incurable cancer
L. Daly (2019)
Lean Mass Abnormalities in Heart Failure: The Role of Sarcopenia, Sarcopenic Obesity, and Cachexia.
S. Carbone (2019)
Hospital dental hygienist intervention improves activities of daily living, home discharge and mortality in post‐acute rehabilitation
Ai Shiraishi (2019)
Rehabilitation Nutrition for Iatrogenic Sarcopenia and Sarcopenic Dysphagia
A. Nagano (2018)
Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer.
L. Cramer (2014)
Definition and classification of cancer cachexia: an international consensus.
K. Fearon (2011)
How successful are we in relieving terminal dyspnea in cancer patients? A real-world multicenter prospective observational study
M. Mori (2019)
Cachexia as a common characteristic in multiple chronic disease
N. Scherbakov (2018)
Depression and chronic heart failure in the elderly: an intriguing relationship
I. Liguori (2018)
Sarcopenia: A Time for Action. An SCWD Position Paper
J. Bauer (2019)
wasting in tumour-bearing mice
J L Brown (2018)
Development, reliability, and validity of a diagnostic algorithm for sarcopenic dysphagia
T. Mori (2017)
Chemotherapy‐induced peripheral neurotoxicity: A critical analysis
S. Park (2013)
The Characteristics of Pain in Patients Diagnosed with Depression and Heart Failure
Christine Haedtke (2017)
Relationship of depression, anxiety, and social isolation to chronic heart failure outpatient mortality.
E. Friedmann (2006)
Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review
M. Anker (2019)
Palliative care in heart failure: facts and numbers
J. Riley (2017)
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics".
M. Muscaritoli (2010)
Psychological and behavioral approaches to cancer pain management.
K. Syrjala (2014)
Chest pain, depression and anxiety in coronary heart disease: Consequence or cause? A prospective clinical study in primary care.
Eric W. de Heer (2019)
Symptoms and quality of life in heart failure: the muscle hypothesis.
A. J. Coats (1994)
AWARENESS, UNDERSTANDING AND TREATMENT PRACTICES WHEN MANAGING CACHEXIA IN END-STAGE KIDNEY DISEASE.
C. Mckeaveney (2019)
What are the criteria for response to cachexia treatment?
J. Crawford (2019)
Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure.
S. von Haehling (2007)
Body weight changes and incidence of cachexia after stroke
N. Scherbakov (2019)
Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle
J. Hulmi (2018)
Pain and difficulties performing valued life activities in women and men with rheumatoid arthritis
I. Ahlstrand (2015)
Pitfalls in the measurement of muscle mass: a need for a reference standard
F. Buckinx (2018)
Relationship of depression, chronic disease, self-rated health, and gender with health care utilization among community-living elderly.
Kyu-Man Han (2018)
Identification of risk groups for oropharyngeal dysphagia in hospitalized patients in a university hospital.
D. Bassi (2014)
Possible mechanisms underlying the development of cachexia in COPD
P. Wagner (2008)
Systematic assessment and characterization of chronic pain in multiple sclerosis patients
D. Ferraro (2017)
Principles of cancer pain management: An overview and focus on pharmacological and interventional strategies
J. Yoong (2018)
Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes.
T. Rutledge (2006)
Effects of nutrition and physical exercise intervention in palliative cancer patients: A randomized controlled trial.
A. Uster (2018)
The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients
D. Walsh (2000)
Principles of opioid use in cancer pain.
R. Portenoy (2014)
Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism
F. Pin (2019)
Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitalizations and mortality
E. Platz (2018)
Differences in nutritional status and activities of daily living and mobility in elderly hospitalized patients with heart failure
Masahiro Kitamura (2019)
A comparative study of the palliative care needs of heart failure and cancer patients
N. O’Leary (2009)
chexia : a new de fi nition
One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA
S. Arthur (2014)
Highlights in heart failure
D. Tomasoni (2019)
Chemotherapy‐induced peripheral neuropathy: A current review
Nathan P. Staff (2017)
Weight loss in heart failure is associated with increased mortality only in non‐obese patients without diabetes
J. Niedziela (2019)
Vulnerabilities of patients recovering from an exacerbation of chronic heart failure.
D. Moser (2005)
Breathlessness in cancer patients.
E. Cachia (2008)
CAncer Pain management in Resource‐limited settings (CAPER) Working Group. Optimizing cancer pain management in resource‐limited settings
SH Ahmedzai (2019)
Association between vitamin D deficiency and heart failure risk in the elderly
Catarina Magalhães Porto (2018)
Factors associated with health-related quality of life in stable ambulatory congestive heart failure patients: Systematic review
A. Baert (2018)
Dyspnea review for the palliative care professional: treatment goals and therapeutic options.
Miguel Ángel Cuervo Pinna (2012)