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Determination Of L‐hyoscyamine In Atropine And D‐hyoscyamine In L‐hyoscyamine By Chiral Capillary Electrophoresis As An Alternative To Polarimetry

S. Heine, K. Ebert, G. Blaschke
Published 2003 · Chemistry, Medicine

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A method for the separation of atropine enantiomers, D‐ and L‐hyoscyamine by capillary electrophoresis (CE) has been developed and validated. The advantages of the CE method compared with polarimetry include smaller amounts of analytes and a lower limit of detection of the unwanted enantiomer. Moreover, the present method enables a baseline separation of the analytes and tropic acid, one of the typical impurities of atropine. The developed enantioseparation of atropine was performed using a commercially available sulfated β‐cyclodextrin and was validated for the determination of L‐hyoscyamine in atropine as well as for the enantiomeric purity of L‐hyoscyamine.

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