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Determination Of Nonsteroidal Anti-inflammatory Drugs In Human Specimens By Capillary Zone Electrophoresis And Micellar Electrokinetic Chromatography.

K. Makino, Y. Itoh, D. Teshima, R. Oishi
Published 2004 · Chemistry, Medicine
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Therapeutic drug monitoring of anti-inflammatory drugs is necessary for the identification of the agents that cause toxic events and for the decision on the treatment for intoxication. Recently, capillary electrophoresis (CE) has been developed for the simple and rapid analyses of a variety of chemical agents. Micellar electrokinetic chromatography (MEKC) can separate acidic, neutral and basic anti-inflammatory drugs in serum. Furthermore, serum samples are directly applied to the CE system without any pretreatments, and some anti-inflammatory drugs can be separated from serum albumin in the MEKC analysis. On the other hand, capillary zone electrophoresis (CZE) enables us to determine a few microg/mL levels of acidic anti-inflammatory drugs with simple running buffer and stacking technique. A rapid and simultaneous determination of several analgesic anti-inflammatory agents, including ibuprofen, acetaminophen, indomethacin, and salicylic acid in human serum has been developed by using CZE. Therefore, the CZE and MEKC analysis may become a potentially useful alternative to high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA) for therapeutic drug monitoring, particularly in serum of patients suffering from intoxication by overdosage of nonsteroidal anti-inflammatory agents.

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Spectrophotometric and spectrofluorometric methods for the determination of non-steroidal anti-inflammatory drugs: A review
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Analytical Methods for Therapeutic Drug Monitoring and Toxicology: Xu/Therapeutic Drug Monitoring
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A novel, environmentally friendly sodium lauryl ether sulfate-, cocamidopropyl betaine-, cocamide monoethanolamine-containing buffer for MEKC on microfluidic devices.
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Monolithic Spin Column Extraction and GC-MS for Simultaneously Detecting Nine Cold Medication Compounds and the Drug Bromoisovaleryl Urea in Human Serum
Takeshi Saito (2009)
Infrared microspectroscopy analysis of ibuprofen release from drug eluting beads in uterine tissue.
Julien Namur (2009)
Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column
Xiao-Pen Lee (2010)
Monitoring of the non-steroid anti-inflammatory drug indomethacin: development of immunochemical methods for its purification and detection
Nir Skalka (2011)
Development of micellar electrokinetic chromatography method for the determination of three defined impurities in indomethacin.
Petra Riasová (2018)
A fast ultra high pressure liquid chromatographic method for qualification and quantification of pharmaceutical combination preparations containing paracetamol, acetyl salicylic acid and/or antihistaminics.
Erick Deconinck (2011)
Estimation of ibuprofen in urine and tablet formulations by transmission Fourier Transform Infrared spectroscopy by partial least square.
Abdul Rauf Khaskheli (2013)
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