Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Comparing Brain Activation Associated With Isolated Upper And Lower Limb Movement Across Corresponding Joints

A. Luft, G. Smith, L. Forrester, J. Whitall, R. Macko, T. Hauser, A. Goldberg, D. Hanley
Published 2002 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
It was shown recently that functional activation across brain motor areas during locomotion and foot movements are similar but differ substantially from activation related to upper extremity movement (Miyai [ 2001 ]: Neuroimage 14:1186–1192). The activation pattern may be a function of the behavioral context of the movement rather than of its mechanical properties. We compare motor system activation patterns associated with isolated single‐joint movement of corresponding joints in arm and leg carried out in equal frequency and range. Eleven healthy volunteers underwent BOLD‐weighted fMRI while performing repetitive elbow or knee extension/flexion. To relate elbow and knee activation to the well‐described patterns of finger movement, serial finger‐to‐thumb opposition was assessed in addition. After identifying task‐related voxels using statistical parametric mapping, activation was measured in five regions of interest (ROI; primary motor [M1] and somatosensory cortex [S1], premotor cortex, supplementary motor area [SMA] divided into preSMA and SMA‐proper, and cerebellum). Differences in the degree of activation across ROIs were found between elbow and knee movement. SMA‐proper activation was prominent for knee, but almost absent for elbow movement (P < 0.05); finger movement produced small but constant SMA‐proper activation. Ipsilateral M1 activation was detected during knee and finger movement, but was absent for the elbow task (P < 0.05). Knee movement showed less lateralization in M1 and S1 than other tasks (P < 0.05). The data demonstrate that central motor structures contribute differently to isolated elbow and knee movement. Activation during knee movement shows similarities to gait‐related activation patterns. Hum. Brain Mapping 17:131–140, 2002. © 2002 Wiley‐Liss, Inc.
This paper references
10.1016/S0009-9260(05)80985-7
Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268
M. J. Torrens (1990)
10.1002/(SICI)1097-0193(1998)6:2<105::AID-HBM3>3.0.CO;2-7
Comparing motion‐ and imagery‐related activation in the human cerebellum: A functional MRI study
A. Luft (1998)
10.1523/JNEUROSCI.17-14-05528.1997
Distributed Neural Systems Underlying the Timing of Movements
S. Rao (1997)
10.1006/nimg.2001.0816
Attention versus Intention in the Primate Premotor Cortex
D. Boussaoud (2001)
10.1016/0926-6410(95)00033-X
Do imagined and executed actions share the same neural substrate?
J. Decety (1996)
10.1007/BF00231461
Cortical areas and the selection of movement: a study with positron emission tomography
M. Deiber (2004)
10.1097/00001756-199412000-00035
Corticospinal projections from mesial frontal and cingulate areas in the monkey.
G. Luppino (1994)
10.1002/NBM.1940070110
Spatial patterns of functional activation of the cerebellum investigated using high field (4 T) MRI
J. M. Ellerman (1994)
10.1002/HBM.460010207
Analysis of functional MRI time‐series
Karl J. Friston (1994)
10.1016/S1388-2457(99)00243-6
Changes in motor cortex excitability during ipsilateral hand muscle activation in humans
W. Muellbacher (2000)
10.1097/00001756-200109170-00012
Cerebral activation during a simple force production task: changes in the time course of the haemodynamic response
K. Peck (2001)
Functional magnetic resonance imaging of complex human movements. Neurology 43:2311–2318
SM Rao (1993)
10.1006/nimg.2001.0905
Cortical Mapping of Gait in Humans: A Near-Infrared Spectroscopic Topography Study
I. Miyai (2001)
10.1006/nimg.1995.1023
Analysis of fMRI Time-Series Revisited—Again
K. Worsley (1995)
10.1002/CPHY.CP010226
Control of Locomotion in Bipeds, Tetrapods, and Fish
S. Grillner (1981)
Functional specialization of the supplementary motor area in monkeys and humans.
R. Passingham (1996)
10.1016/S0006-8993(98)00198-X
Corticostriatal input zones from the supplementary motor area overlap those from the contra- rather than ipsilateral primary motor cortex
M. Takada (1998)
10.1002/ANA.410350617
Parceling of mesial frontal motor areas during ideation and movement using functional magnetic resonance imaging at 1.5 tesla
J. M. Tyszka (1994)
10.1097/00001756-199501000-00003
Activity in the human primary motor cortex related to arm and finger movements.
R. Kawashima (1995)
10.1097/00001756-199911260-00035
Multiple somatotopic representations in the human cerebellum.
M. Rijntjes (1999)
10.1097/00001756-199309150-00002
Activation of precentral and mesial motor areas during the execution of elementary proximal and distal arm movements: a PET study.
M. Matelli (1993)
10.1016/0301-0082(92)90034-C
Movement, posture and equilibrium: Interaction and coordination
J. Massion (1992)
Somato - topic motor representation in the human anterior cerebellum . A high - resolution functional MRI study
RC Oldfield (1996)
10.1002/1531-8249(200005)47:5<606::AID-ANA8>3.0.CO;2-L
The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis
M. Lee (2000)
10.1017/S0317167100032947
Role of the ipsilateral motor cortex in voluntary movement.
R. Chen (1997)
10.1093/CERCOR/11.4.312
Somatotopy in human primary motor and somatosensory hand representations revisited.
P. Hlustík (2001)
10.1007/s002210050437
Isometric force-related activity in sensorimotor cortex measured with functional MRI
G. Thickbroom (1998)
Co-planar stereotactic atlas of the human brain
J Talairach (1988)
Handbook of physiology: motor control
S Grillner (1981)
10.1016/0166-4328(85)90073-7
Premotor cortex: Sensory cues and movement
R. Passingham (1985)
10.1002/hbm.1025
Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization
W. Grodd (2001)
10.1093/BRAIN/116.6.1387
Both primary motor cortex and supplementary motor area play an important role in complex finger movement.
H. Shibasaki (1993)
Mapping of human and macaque sensorimotor areas by integrating architectonic, transmitter receptor, MRI and PET data.
K. Zilles (1995)
10.1093/brain/119.3.1045
Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects.
K. Boetzel (1996)
10.1016/0028-3932(71)90067-4
The assessment and analysis of handedness: the Edinburgh inventory.
R. Oldfield (1971)
10.1523/JNEUROSCI.16-23-07688.1996
Primary Motor and Sensory Cortex Activation during Motor Performance and Motor Imagery: A Functional Magnetic Resonance Imaging Study
C. Porro (1996)
10.1162/089892999563553
Activation of Cortical and Cerebellar Motor Areas during Executed and Imagined Hand Movements: An fMRI Study
M. Lotze (1999)
10.1002/HBM.460030205
A functional magnetic resonance imaging study of cortical regions associated with motor task execution and motor ideation in humans
M. Leonardo (1995)
10.1093/BRAIN/119.3.1023
Somatotopic motor representation in the human anterior cerebellum. A high-resolution functional MRI study.
M. Nitschke (1996)
10.1126/SCIENCE.8342027
Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness.
S. G. Kim (1993)
10.1006/nimg.2000.0733
Orderly Somatotopy in Primary Motor Cortex: Does It Exist?
J. Sanes (2001)
10.1016/S0006-8993(99)01360-8
Bilateral neuromagnetic activation of human primary sensorimotor cortex in preparation and execution of unilateral voluntary finger movements
C. Babiloni (1999)
10.1016/S0006-8993(99)02416-6
Functional brain areas used for the lifting of objects using a precision grip: a PET study
H. Kinoshita (2000)
10.1152/JN.1995.73.1.373
Functional anatomy of the mental representation of upper extremity movements in healthy subjects.
K. Stephan (1995)
10.1006/nimg.2000.0556
fMRI Evaluation of Somatotopic Representation in Human Primary Motor Cortex
M. Lotze (2000)
10.1093/BRAIN/118.4.913
Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects.
M. Jahanshahi (1995)
10.1016/S0166-4328(96)00145-3
Force and the motor cortex
J. Ashe (1997)
10.1097/00001756-200108080-00039
Multiple tactile maps in the human cerebellum
K. Bushara (2001)
10.1006/nimg.2001.0858
Human Somatosensory Area 2: Observer-Independent Cytoarchitectonic Mapping, Interindividual Variability, and Population Map
C. Grefkes (2001)
10.1002/HBM.460020402
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston (1994)
10.1097/00001756-199601310-00021
Cortical representation of self‐paced finger movement
J. Larsson (1996)
10.1002/MRM.1910350312
Movement‐Related effects in fMRI time‐series
Karl J. Friston (1996)
10.1093/CERCOR/5.2.111
Functional anatomy of reaching and visuomotor learning: a positron emission tomography study.
R. Kawashima (1995)
10.1016/S0304-3940(99)00930-1
Cortical activation patterns during complex motor tasks in piano players and control subjects. A functional magnetic resonance imaging study
T. Krings (2000)
10.1152/JN.1997.77.4.2164
Multiple nonprimary motor areas in the human cortex.
G. Fink (1997)
10.1016/S0013-4694(98)00022-4
The organization of the cortical motor system: new concepts.
G. Rizzolatti (1998)
10.1006/nimg.2000.0737
Finger Somatotopy in Human Motor Cortex
R. Beisteiner (2001)
10.1523/JNEUROSCI.14-06-03462.1994
Fields in human motor areas involved in preparation for reaching, actual reaching, and visuomotor learning: a positron emission tomography study
R. Kawashima (1994)
10.1212/WNL.43.11.2311
Functional magnetic resonance imaging of complex human movements
S. Rao (1993)
10.1006/nimg.2001.0776
On Somatotopic Representation Centers for Finger Movements in Human Primary Motor Cortex and Supplementary Motor Area
I. Indovina (2001)
10.1016/S0168-0102(98)00064-9
Effects of movement predictability on cortical motor activation
P. Dassonville (1998)
10.1006/nimg.2000.0626
The Effect of Switching between Sequential and Repetitive Movements on Cortical Activation
L. Jäncke (2000)
10.1016/S0959-4388(96)80027-4
Functions and structures of the motor cortices in humans
P. Roland (1996)



This paper is referenced by
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL ESCOLA DE EDUCAÇÃO FÍSICA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DO MOVIMENTO HUMANO
F. Carpes (2009)
10.1038/srep44780
Altered microstructure rather than morphology in the corpus callosum after lower limb amputation
Z. Li (2017)
10.1016/j.brainres.2013.07.050
Functional somatotopy revealed across multiple cortical regions using a model of complex motor task
D. Cunningham (2013)
10.1016/j.neuroimage.2004.03.035
Optimizing the experimental design for ankle dorsiflexion fMRI
B. MacIntosh (2004)
10.1255/jnirs.1240
Differences of Cortical Activation Pattern during the Use of Fork, Wooden Chopsticks and Metallic Chopsticks: A Functional near Infrared Spectroscopy Study
S. Jang (2016)
Noninvasive Electrical Neuroimaging of the Human Brain during Mobile Tasks including Walking and Running
Joseph T. Gwin (2012)
10.1007/s00221-007-0858-7
How does the brain respond to unimodal and bimodal sensory demand in movement of the lower extremity?
Lewis A. Wheaton (2007)
10.1111/ejn.12597
Ipsilateral corticomotor excitability is associated with increased gait variability in unilateral transtibial amputees
Brenton Hordacre (2014)
10.3389/fnins.2018.00554
Editorial: Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases: New Therapeutic Perspectives Through Non-invasive Neuromodulation and Cutting-Edge Technologies
G. Zito (2018)
10.1016/j.neuroimage.2006.05.043
Lateralization of brain activity during lower limb joints movement. An fMRI study
E. Kapreli (2006)
10.1111/j.1600-0722.2010.00784.x
Comparison of cerebral activity during teeth clenching and fist clenching: a functional magnetic resonance imaging study.
T. Iida (2010)
10.3109/09638288.2015.1103790
The potential for non-invasive brain stimulation to improve function after amputation
Brenton G Hordacre (2016)
10.1007/978-3-030-23580-2_10
A Neuroscience of Dance: Potential for Therapeusis in Neurology
Gerry Leisman (2020)
10.1016/j.neuroimage.2010.08.066
Electrocortical activity is coupled to gait cycle phase during treadmill walking
Joseph T. Gwin (2011)
10.1007/s11682-012-9158-3
Pilot fMRI investigation of representational plasticity associated with motor skill learning and its functional consequences
E. Plow (2012)
10.1515/RNS.2011.047
Cognition in action: imaging brain/body dynamics in mobile humans
K. Gramann (2011)
10.1177/0269215514542356
The effects of mirror therapy on the gait of subacute stroke patients: a randomized controlled trial
Sang Gu Ji (2015)
10.1111/ane.12085
High‐frequency rTMS using a double cone coil for gait disturbance
W. Kakuda (2013)
10.1152/JAPPLPHYSIOL.00450.2004
Cerebral metabolism during upper and lower body exercise.
M. Dalsgaard (2004)
10.1007/s10548-016-0500-8
Developmental Trajectory of Beta Cortical Oscillatory Activity During a Knee Motor Task
M. Kurz (2016)
10.1201/B15552-28
Functional Near-Infrared Spectroscopy for Autorehabilitation Cyber-Physical Systems: Toward Intelligent Signal Processing for Rehab Progress Indication
Fei Hu (2013)
10.1002/hbm.25275
Cortical reorganization after motor stroke: A pilot study on differences between the upper and lower limbs.
E. Binder (2020)
10.1016/j.neulet.2012.11.041
Differences of the frontal activation patterns by finger and toe movements: A functional MRI study
Mi Young Lee (2013)
10.1016/j.neurobiolaging.2010.06.005
White matter hyperintensities alter functional organization of the motor system
P. Linortner (2012)
10.1097/PHM.0000000000000850
Priming With 1-Hz Repetitive Transcranial Magnetic Stimulation Over Contralesional Leg Motor Cortex Does Not Increase the Rate of Regaining Ambulation Within 3 Months of Stroke: A Randomized Controlled Trial
Y. Huang (2018)
10.1111/ner.13228
Repetitive Transcranial Magnetic Stimulation With H-Coil Coupled With Cycling for Improving Lower Limb Motor Function After Stroke: An Exploratory Study.
R. Chieffo (2020)
10.3389/fnhum.2020.00260
Cortical Activation During Shoulder and Finger Movements in Healthy Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Chieh-Ling Yang (2020)
10.5535/arm.2017.41.6.905
Neural Correlates of Motor Recovery Measured by SPECT at Six Months After Basal Ganglia Stroke
J. W. Choi (2017)
10.1016/S0010-9452(08)70477-5
Lower Limb Sensorimotor Network: Issues of Somatotopy and Overlap
E. Kapreli (2007)
Development of a unique whole-brain model for upper extremity neuroprosthetic control
Dominic E. Nathan (2010)
Identification and Intervention for Action Planning Deficits in Children With Hemiplegic Cerebral Palsy
Swati M. Surkar (2016)
10.1002/bimj.201100041
Joint generalized models for multidimensional outcomes: a case study of neuroscience data from multimodalities.
X. Wang (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar