Depth Of Invasion, Tumor Budding, And Worst Pattern Of Invasion: Prognostic Indicators In Early-stage Oral Tongue Cancer
A. Almangush, I. Bello, H. Keski-Säntti, L. Mäkinen, J. Kauppila, M. Pukkila, J. Hagström, J. Laranne, S. Tommola, Outi Nieminen, Y. Soini, Veli-Matti Kosma, P. Koivunen, R. Grénman, I. Leivo, Tuula Salo
Published 2014 · Medicine, Biology
Download PDFAnalyze on Scholarcy
Oral (mobile) tongue squamous cell carcinoma (SCC) is characterized by a highly variable prognosis in early‐stage disease (T1/T2 N0M0). The ability to classify early oral tongue SCCs into low‐risk and high‐risk categories would represent a major advancement in their management.
This paper references
The prognostic value of individual histologic grading parameters in small lingual squamous cell carcinomas. The importance of the pattern of invasion
E. Odell (1994)
Nerve growth factor receptor (p75NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma
T. M. Søland (2008)
Stromal features are predictive of disease mortality in oral cancer patients.
D. Marsh (2011)
Malignancy grading is no better than conventional histopathological grading in small squamous cell carcinoma of tongue and floor of mouth: retrospective study in 128 patients.
M. Weijers (2009)
Predictive value of histopathologic parameters in early squamous cell carcinoma of oral tongue.
H. Keski-Säntti (2007)
Elective versus therapeutic neck dissection in early carcinoma of the oral tongue.
A. Fakih (1989)
Tumor‐host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer
M. Vered (2010)
Oral squamous cell carcinoma grading systems--analysis of the best survival predictor.
Rhayany de Castro Lindenblatt (2012)
Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis
M G Kellermann (2007)
Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients
W. Jerjes (2010)
Early stage squamous cell cancer of the oral tongue—clinicopathologic features affecting outcome
I. Ganly (2012)
Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas.
G. Anneroth (1987)
Correlation of clinical, histological, and cytokeratin profiles of squamous cell carcinoma of the oral tongue with prognosis.
E. J. D. Silveira (2007)
The importance of stromal inflammation in squamous cell carcinoma of the tongue.
L. Lundqvist (2012)
Clinical and histopathologic parameters in survival of oral squamous cell carcinoma.
Waruna Lakmal Dissanayaka (2012)
Occult lymph node metastasis in small oral tongue cancers
C. M. Ho (1992)
Nerve growth factor receptor (p75 NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma
Tm Sïland (2008)
Validation of the Histologic Risk Model in a New Cohort of Patients With Head and Neck Squamous Cell Carcinoma
M. Brandwein-Gensler (2010)
Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding Is a Significant Independent Prognostic Factor
M. Koike (2008)
Significant invasion depth of early oral tongue cancer originated from the lateral border to predict regional metastases and prognosis.
J. Jung (2009)
Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer.
I. Bello (2011)
Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma
Y. Chang (2010)
Advances and applications of oral cancer basic research.
S. D. da Silva (2011)
Predictive value of tumor thickness for cervical lymph‐node involvement in squamous cell carcinoma of the oral cavity
S. H. Huang (2009)
Oral Squamous Cell Carcinoma: Histologic Risk Assessment, but Not Margin Status, Is Strongly Predictive of Local Disease-free and Overall Survival
M. Brandwein-Gensler (2005)
Tumor budding correlates with poor prognosis and epithelial-mesenchymal transition in tongue squamous cell carcinoma.
Cheng Wang (2011)
Tangled fibroblasts in tumor‐stroma interactions
M. Liu (2011)
Tumor thickness in early tongue cancer.
R. Morton (1994)
Prognostic factors of clinically stage I and II oral tongue carcinoma—A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, martinez‐gimeno score, and pathologic features
Anthony Po Wing Yuen (2002)
Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I).
I. Bello (2010)
Significance of myofibroblasts in oral squamous cell carcinoma.
C. Thode (2011)
A New Prognostic Staging System for Rectal Cancer
H. Ueno (2004)
Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II).
I. Bello (2010)
Prognostic factors in tongue cancer – relative importance of demographic, clinical and histopathological factors
S. Kantola (2000)
Clinical and histopathologic parameters in survival of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol
W L Dissanayaka (2012)
Histologic classification and grading of malignancy in carcinoma of the larynx.
P. Jakobsson (1973)
New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas.
M. Bryne (1989)
De-escalation of surgery for early oral cancer--is it oncologically safe?
C. Barry (2013)
Tumor budding and E-Cadherin expression in endometrial carcinoma: are they prognostic factors in endometrial cancer?
M. Koyuncuoğlu (2012)
Squamous cell carcinoma of the oral cavity: a clinicopathologic scoring system for evaluating risk of cervical lymph node metastasis.
C. Martínez-Gimeno (1995)
Is preoperative ultrasonography accurate in measuring tumor thickness and predicting the incidence of cervical metastasis in oral cancer?
S. Mark Taylor (2010)
Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness
Yoko Yamaguchi (2010)
The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma.
H. Kurokawa (2005)
This paper is referenced by
What is the consistency between clinical and pathological staging in tongue cancer
Bilge Aydın Türk (2019)
Predictors of locoregional control in stage I/II oral squamous cell carcinoma classified by AJCC 8th edition.
Narayana Subramaniam (2019)
MIGRATION AND INVASION PATTERN ANALYSIS OF ORAL CANCER CELLS IN VITRO
Santeri Palviainen (2018)
Construction of a pathological risk model of occult lymph node metastases for prognostication by semi-automated image analysis of tumor budding in early-stage oral squamous cell carcinoma
Nicklas Juel Pedersen (2017)
Parameters of Stromal Activation and Epithelial to Mesenchymal Transition as Predictive Biomarkers for Induction Chemotherapy in Patients With Locally Advanced Oral Cavity and Oropharyngeal Squamous Cell Cancer
Jana Geweiler (2016)
Elective Neck Dissection, but Not Adjuvant Radiation Therapy, Improves Survival in Stage I and II Oral Tongue Cancer with Depth of Invasion >4 mm
J. Mann (2019)
Histopathological changes in tumor budding between biopsy and resected specimens from patients treated with preoperative S-1 chemotherapy for oral cancer.
Mai Seki-Soda (2019)
Factors Affecting Recurrence of T1 and T2 Tongue Cancer Undergoing Intraoral Resection
Takeshi Mohri (2016)
The relationship between tumor budding and survival in colorectal carcinomas.
Gulali Aktas (2020)
Clinico-pathological prognosticators in oral squamous cell carcinoma
Barnali Majumdar (2017)
Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion
S. Shimizu (2018)
Will the mininvasive approach challenge the old paradigms in oral cancer surgery?
G. Tirelli (2016)
Tumor Budding and Worse Pattern of Invasion Can Predict Nodal Metastasis in Oral Cancers and Associated With Poor Survival in Early-Stage Tumors
Debajyoti Chatterjee (2019)
Practical Challenges in Measurement of Depth of Invasion in Oral Squamous Cell Carcinoma: Pictographical Documentation to Improve Consistency of Reporting per the AJCC 8th Edition Recommendations
Prachi Kukreja (2019)
Tumor budding in laryngeal carcinoma
S. Ekmekci (2019)
Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early‐stage tongue squamous cell carcinoma
N. Yamakawa (2019)
Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer: Systematic review and meta‐analysis
A. Almangush (2020)
Perineural spreading along the trigeminal nerve in a squamous cell carcinoma of the tongue
Adriana Octaviana Dulamea (2015)
Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
S. Liu (2017)
Pathology of Oral and Oropharyngeal Cancers
Saman Warnakulasuriya (2020)
Reproducibility and prognostic value of pattern of invasion scoring in low‐stage oral squamous cell carcinoma
Marjolein G J Heerema (2016)
Histopathological predictors of early stage oral tongue cancer
A. Almangush (2015)
Invasive tumor front in oral squamous cell carcinoma: an independent prognostic factor
Tazeen Jeelani (2019)
Tumor histologic grade as a risk factor for neck recurrence in patients with T1-2N0 early tongue cancer.
Shu-Ting Chuang (2020)
Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review
A. Almangush (2019)
Prognostic significance of tumor budding, tumor‐stroma ratio, cell nests size, and stroma type in laryngeal and pharyngeal squamous cell carcinomas
G. Karpathiou (2019)
The role of tumor microenvironment on oral tongue cancer invasion and prognosis
Elias Sundquist (2018)
Tumor-infiltrating lymphocytes-derived MLL2 independently predicts disease-free survival for patients with early-stage oral squamous cell carcinoma.
Nisha Zhu (2019)
Tumor deposits in head and neck carcinomas
S. Sarioglu (2016)
Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer
Ilkka Heikkinen (2019)
Radiological tumor thickness as a risk factor for local recurrence in early glottic cancer treated with laser cordectomy
Ho-Jin Son (2017)
Association between pathological invasion patterns and late lymph node metastases in patients with surgically treated clinical No early oral tongue carcinoma
Yukiko Hori (2019)See more