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Tumor Volume As A Predictor Of Survival In Human Papillomavirus-positive Oropharyngeal Cancer.

Kara S. Davis, Chwee Ming Lim, D A Clump, Dwight E Heron, James P Ohr, Seungwon W Kim, Umamaheswar Duvvuri, Jonas T Johnson, Robert L Ferris
Published 2016 · Medicine
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BACKGROUND Increasing evidence exists that tumor volume may be a superior prognostic model than traditional TNM staging. It has been observed that oropharyngeal squamous cell carcinoma (oropharyngeal SCC) in the setting of human papillomavirus (HPV) positivity have a greater propensity for cystic nodal metastases, and, thus, presumably larger volume with relatively smaller primary tumors. The influence of HPV status on the predictive value of tumor volume is unknown. METHODS Fifty-three patients with HPV-positive oropharyngeal SCC were treated with definitive chemotherapy and intensity-modulated radiotherapy (IMRT). RESULTS The estimated 2-year overall survival (OS) and disease-free survival (DFS) was 92.2% and 83.6%, respectively. Nodal classification did not predict OS (p = .096) or DFS (p = .170). Similarly, T classification did not predict OS (p = .057) or DFS (p = .309). Lower nodal volume was associated with greater DFS (p = .001). CONCLUSION Nodal tumor volume was found to be predictive of DFS. DFS was best predicted by nodal gross tumor volume (GTV) at 24 months. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1613-E1617, 2016.
This paper references
Human Papillomavirus in Head and Neck Cancer: Its Role in Pathogenesis and Clinical Implications
Christine H. Chung (2009)
Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT
Gabriela Studer (2007)
Human papillomavirus and rising oropharyngeal cancer incidence in the United States.
Anil K Chaturvedi (2011)
Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen.
Jean-François Daisne (2004)
The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral Cancer
William H Westra (2009)
Cystic lymph node metastases of squamous cell carcinoma of Waldeyer's ring origin
Sigrid Regauer (1999)
Intensity-modulated radiation therapy in oropharyngeal carcinoma: effect of tumor volume on clinical outcomes.
Benjamin H Lok (2012)
Pathologically determined tumor volume vs pathologic T stage in the prediction of outcome after surgical treatment of oropharyngeal squamous cell carcinoma.
Iain J Nixon (2013)
Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx.
Rohan R. Walvekar (2008)
Human papillomavirus, smoking, and head and neck cancer.
Parul Khare Sinha (2012)
Human papillomavirus and survival of patients with oropharyngeal cancer.
K Kian Ang (2010)
Primary tumor volume is an important predictor of clinical outcomes among patients with locally advanced squamous cell cancer of the head and neck treated with definitive chemoradiotherapy.
Anna Strongin (2012)
Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer.
Joost L Knegjens (2011)
Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status.
Jessica H. Maxwell (2013)
Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer
Gabriela Studer (2011)
Quality of life in head and neck cancer patients: impact of HPV and primary treatment modality.
Jessica H. Maxwell (2014)
Cystic metastasis from head and neck squamous cell cancer: a distinct disease variant?
David Goldenberg (2006)
Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography: still a Pandora's box?
Slobodan Devic (2010)
Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review
Aimée R Kreimer (2005)
Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography: still a Pandora's box?: in regard to Devic et al. (Int J Radiat Oncol Biol Phys 2010).
Mathieu Hatt (2010)
Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis.
B O'Sullivan (2013)

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The Prognostic Values of Preoperative Tumor Volume and Tumor Diameter in T1N0 Papillary Thyroid Cancer
Seung Taek Lim (2017)
AHNS series: Do you know your guidelines? Management of head and neck cancer in the era of human papillomavirus Educating our patients on human papillomavirus
Theresa Guo (2017)
Uporabnost slikovno preiskovalnih metod pri določanju HPV statusa karcinomov glave in vratu
Cene Jerele (2018)
Tumor volume as a prognostic marker in p16-positive and p16-negative oropharyngeal cancer patients treated with definitive intensity-modulated radiotherapy
Timo Carpén (2018)
Prognostic influence of 3-dimensional tumor volume on breast cancer compared to conventional 1-dimensional tumor size
Ki-Tae Hwang (2018)
Oral and Oropharyngeal squamous cell carcinoma: prognostic and predictive parameters in the etiopathogenetic route
Iacopo Panarese (2019)
Specific growth rates calculated from CTs in patients with head and neck squamous cell carcinoma: a retrospective study performed in Austria
Daniel Dejaco (2019)
Use of radiomic data to improve imputation of HPV (p16) status in oropharyngeal cancer
Aleix Lascorz Guiu (2019)
Human Papillomavirus-Related Head and Neck Cancer
Julie A. Theurer (2019)
Solid Lymph Nodes as an Imaging Biomarker for Risk Stratification in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma
Tanya J Rath (2017)
Prognostic value of tumor volume in patients with head and neck squamous cell carcinoma treated with primary surgery
Daniel Dejaco (2018)
Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging
John M Floberg (2018)
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