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Cytogenetic Analysis Of Tissues From Patients With Familial Paragangliomas Of The Head And Neck

A. Zaslav, D. Myssiorek, C. Mucia, J. Fox
Published 1995 · Medicine

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Background. Paragangliomas of the head and neck are slow‐growing tumors that originate from neural crest cells. Between 7% and 9% of these tumors have a familial occurrence. The suspected gene for familial paragangliomas (FP) is transmitted with an autosomal dominant mode of inheritance with incomplete penetrance, and appears to exhibit genomic imprinting. It has been demonstrated by family studies that individuals who inherit the gene(s) from their father will develop the disease. Through linkage analysis, the gene(s) for FP has been postulated to be located on the long arm of chromosome 11. The discovery of many different genes has been elucidated through the cytogenetic analysis of affected individuals who carry specific chromosome aberrations. This project was designed to look for chromosome abnormalities in several second‐generation family members to further assist in the localization of the gene(s) for FP.



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