Familial Carcinoid Tumors And Subsequent Cancers: A Nation‐wide Epidemiologic Study From Sweden
K. Hemminki, X. Li
Published 2001 · Medicine
Download PDFAnalyze on Scholarcy
Carcinoids are rare neuroendocrine tumors, mainly located in the bowel, stomach and lung. Familial risks in carcinoid tumours are not well known apart from multiple endocrine neoplasia 1 (MEN1). We used the nation‐wide Swedish Family‐Cancer Database on 10.1 million individuals for assessment. Carcinoid tumors were retrieved from the Cancer Registry covering the years 1958–1998. The offspring generation, aged 0–66 years, accumulated 190 million person‐years at risk. The age‐adjusted incidence rates were 0.76 for men and 1.29/100,000 for women. Standardized incidence ratios (SIRs) were calculated for offspring when their parents had a carcinoid or any other cancer. When parents presented with carcinoids, SIRs for offspring were 4.35 (n = 8, 95% CI 1.86–7.89) for small intestinal and 4.65 (n = 4, 95% CI 1.21–10.32) for colon carcinoids. If both offspring and parents presented with small intestinal carcinoids, the SIR was 12.31 (n = 4, 95% CI 3.20–27.34). Offspring carcinoids were also increased if parents presented with bladder and endocrine gland tumors, the latter association probably partially due to MEN1. Risks for second cancers were increased, particularly at sites where familial risks were found, including carcinoids in the small intestine. © 2001 Wiley‐Liss, Inc.
This paper references
Basic pathology. Philadelphia: WBSaunders
V Kumar (1997)
Second primary neoplasms in 633,964 cancer patients in Sweden, 1958–1996
C. Dong (2001)
Increased risk of second primary malignancies in patients with gynecological cancer. A Swedish record-linkage study.
K. Bergfeldt (1995)
An analysis of 8305 cases of carcinoid tumors
I. Modlin (1997)
Carcinoid tumors in Denmark 1978–1989 and the risk of subsequent cancers. A population‐based study
T. Westergaard (1995)
Multiple primary cancers of the colon, breast and skin (melanoma) as models for polygenic cancers
C. Dong (2001)
Carcinoid tumours. Frequency in a defined population during a 12-year period.
T. Berge (1976)
Sibling risks in cancer: clues to recessive or X-linked genes?
K. Hemminki (2001)
Statistical methods in cancer research
P. Simpson (2001)
The epidemiology of carcinoid tumours in England and Scotland.
J. Newton (1994)
Epidemiology of carcinoid neoplasms in Vaud, Switzerland, 1974–97
F. Levi (2000)
Endometrial cancer in the family-cancer database.
K. Hemminki (1999)
A. Bornstein (1957)
Medical progress : Carcinoid tumors
M. Kulke (1999)
Endometrial cancer in the FamilyCancer Database
K Hemminki (1999)
Tumours of the digestive system
S Hamilton (2000)
Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence.
C. Metayer (2000)
The Concise Handbook of Family Cancer Syndromes
N. Lindor (1998)
The epidemiology of endocrine tumours.
J. Monson (2000)
Familial occurrence of carcinoid tumors and association with other malignant neoplasms.
D. Babovic‐Vuksanovic (1999)
Age‐specific familial risks in common cancers of the offspring
K. Hemminki (1998)
Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment.
A. Swerdlow (2000)
Familial cancers in a nationwide family cancer database: age distribution and prevalence.
K. Hemminki (1999)
This paper is referenced by
Peptide receptor radionuclide therapy of neuroendocrine tumors with (90)Y-DOTATOC: is treatment response predictable by pre-therapeutic uptake of (68)Ga-DOTATOC?
M. Öksüz (2014)
The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors
S. Schimmack (2011)
Carcinoid Tumours in the Gastrointestinal Tract — A Population-Based Study from Western Norway
S. Helland (2006)
A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors
J. Dumanski (2017)
Gut of UKNETwork for neuroendocrine tumours
A. Corrie (2005)
Signs and genetics of rare cancer syndromes with gastroenterological features.
William F. Bruno (2015)
Socioeconomic factors in cancer in Sweden
K. Hemminki (2003)
Introduction: Definition, historical aspects, classification, staging, prognosis and therapeutic options
R. Arnold (2005)
First Report on Metastasizing Small Bowel Carcinoids in First-Degree Relatives in Three Generations
J. Järhult (2010)
Epithelial Tumours of the Small Intestine
Kieran Sheahan (2012)
Hereditary hormone excess: genes, molecular pathways, and syndromes.
S. Marx (2005)
TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
G. Rindi (2006)
Endocrine tumors of the gastrointestinal tract and pancreas:grading, tumor size and proliferation index do not predict malignant behavior
B. Alexiev (2007)
The MEN1 Gene and Pituitary Tumours
S. Agarwal (2009)
Bronchial Carcinoid and Type 1 Multiple Endocrine Neoplasia Syndrome. A Case Report
Carmen de Francisco Montero (2010)
Metachronous and Synchronous Cancers in Patients with Neuroendocrine Tumors
M. Verrico (2019)
Incidence trends and risk factors of carcinoid tumors
K. Hemminki (2001)
Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
H. Li (2012)
Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.
T. Rafnar (2011)
Evidence for a heritable contribution to neuroendocrine tumors of the small intestine.
Deborah W. Neklason (2016)
Excess risk of subsequent primary cancers among colorectal carcinoma survivors, 1975–2001
F. Ahmed (2006)
Decoding the Molecular and Mutational Ambiguities of Gastroenteropancreatic Neuroendocrine Neoplasm Pathobiology
M. Kidd (2015)
Epigenetics: The Science of Change
Bob Weinhold (2006)
Radiothérapie interne vectorisée des tumeurs neuro-endocrines avec 90Y-DOTATOC : la fixation préthérapeutique du 68Ga-DOTATOC est-elle prédictive de la réponse au traitement ?
M. Oeksuez (2014)
Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?
K. Hemminki (2002)
Advances in the detection and management of neuroendocrine (carcinoid and pancreatic islet cell) tumours
D. Papadogias (2006)
Clinical and immunohistochemical studies of small bowel carcinoid tumours
Kalle Landerholm (2011)
Other cancers in lung cancer families are overwhelmingly smoking-related cancers
Hongyao Yu (2017)
Second Cancers in Patients with Neuroendocrine Tumors
H. Tsai (2013)
The diagnosis and medical management of advanced neuroendocrine tumors.
G. Kaltsas (2004)
Metastatic carcinoid tumors: a clinical review.
J. M. Zuetenhorst (2005)
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries
A. Agasarova (2018)See more