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Familial Colorectal Adenocarcinoma From The Swedish Family‐cancer Database

K. Hemminki, X. Li
Published 2001 · Medicine

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Familial risks for colorectal (CRC) adenocarcinoma were characterized from the Swedish Family‐Cancer Database covering 9.6 million individuals, whose family relationships and cancers were obtained from registered sources, not sensitive to reporting or ascertainment bias. Cancer cases were retrieved from the Swedish Cancer Registry from years 1958–96. Standardized incidence ratios (SIRs) were calculated based on gender‐, age‐, period‐ and tumor type specific rates. A total of 4,794 and 67,925 CRCs were recorded in offspring and parents, respectively. For colon and rectal adenocarcinoma, the SIRs in offspring were 2.28 and 1.68 by parental CRC adenocarcinoma, giving attributable proportions of 6.45 and 3.31%, respectively. The SIR of CRC was over 10 when both offspring and parents were diagnosed at a young age. The risk for parental CRC adenocarcinoma was over 100 when 2 or more children were affected. The risk in siblings was also very high when a parent was affected. The familial cancer sites that associated with CRC were those typical of hereditary nonpolyposis colorectal cancer (HNPCC). This is the largest study published on familial CRC and the only one reporting specifically on adenocarcinoma. The data suggest that HNPCC is the largest single disease entity among CRCs, probably accounting for less than 50% of familial CRC. Other familial components appear heterogeneous, characterized by incomplete penetrance, recessive mode of inheritance and few associated tumor sites. © 2001 Wiley‐Liss, Inc.
This paper references
10.1002/1097-0142(20010301)91:5<1061::AID-CNCR1098>3.0.CO;2-9
Increased cancer risk in the offspring of women with colorectal carcinoma
K. Hemminki (2001)
10.1093/JNCI/86.21.1600
Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands.
D. Goldgar (1994)
10.1002/(SICI)1097-0215(19981005)78:2<172::AID-IJC9>3.0.CO;2-W
Age‐specific familial risks in common cancers of the offspring
K. Hemminki (1998)
10.1002/(SICI)1097-0142(19960915)78:6<1149::AID-CNCR1>3.0.CO;2-5
Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review
H. Lynch (1996)
risk in the offspring of women with colorectal cancer
K Hemminki (2001)
10.1093/JNCI/92.19.1592
Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women.
R. Kaaks (2000)
10.1093/JNCI/89.23.1758
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines.
M. Rodriguez-Bigas (1997)
10.1002/(SICI)1097-0215(20000115)85:2<201::AID-IJC9>3.0.CO;2-L
Familial relationships in thyroid cancer by histo‐pathological type
K. Hemminki (2000)
10.1136/jmg.36.11.801
Genetic susceptibility to non-polyposis colorectal cancer
H. Lynch (1999)
10.1093/JNCI/89.4.287
Cancer in twins: genetic and nongenetic familial risk factors.
A. Ahlbom (1997)
10.1097/00001648-199911000-00010
Two centuries of mortality in ten large families with Huntington disease: a rising impact of gene carriership.
K. Innes (1999)
[Modern epidemiology].
M. Graffar (1971)
10.1136/jmg.35.12.978
Genetic implications of double primary cancers of the colorectum and endometrium.
T. Pal (1998)
10.1007/springerreference_33707
[Hereditary nonpolyposis colorectal cancer].
Y. Yuasa (2000)
10.1080/02841860152619214
The nation-wide Swedish family-cancer database--updated structure and familial rates.
K. Hemminki (2001)
10.1136/GUT.47.1.148
DNA mismatch repair genes and colorectal cancer.
J. Wheeler (2000)
10.1016/S0165-4608(96)00290-7
An update of HNPCC (Lynch syndrome).
H. Lynch (1997)
10.2307/2670139
Statistical methods in cancer research. Volume IV. Descriptive epidemiology.
J. Estève (1994)
10.1002/1097-0215(200102)9999:9999<::AID-IJC1147>3.0.CO;2-C
Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families
C. Dong (2001)
causes, occurrence and control
IARC. Cancer (1990)
10.1002/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L
Cancer risk in mutation carriers of DNA‐mismatch‐repair genes
M. Aarnio (1999)
10.1002/JSO.1035
Statistical methods in cancer research
P. Simpson (2001)
10.7326/0003-4819-118-10-199305150-00005
Cancer Risk in Relatives of Patients with Common Colorectal Cancer
D. St. John (1993)
10.1016/S0092-8674(00)81333-1
Lessons from Hereditary Colorectal Cancer
K. Kinzler (1996)
10.1002/(SICI)1098-2272(1998)15:3<225::AID-GEPI2>3.0.CO;2-3
National database of familial cancer in Sweden
K. Hemminki (1998)
10.1016/S0959-8049(99)00066-0
Familial cancers in a nationwide family cancer database: age distribution and prevalence.
K. Hemminki (1999)
10.1054/bjoc.2000.1585
Sibling risks in cancer: clues to recessive or X-linked genes?
K. Hemminki (2001)
Hereditary nonpolyposis colorectal
HT Lynch (1999)
10.1056/NEJM199412223312501
A prospective study of family history and the risk of colorectal cancer.
C. Fuchs (1994)
10.1097/00001648-199911000-00016
Parental age and risk of sporadic and familial cancer in offspring: implications for germ cell mutagenesis.
K. Hemminki (1999)
Stockholm: The National Board of Health and Welfare
(1997)
10.1056/NEJM199805213382101
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.
L. Aaltonen (1998)
10.1002/1097-0142(19850815)56:4<934::AID-CNCR2820560439>3.0.CO;2-I
Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource
Henry T. Lynch (1985)
10.1002/1097-0142(20000815)89:4<741::AID-CNCR4>3.0.CO;2-W
Increased cancer risk in offspring of women with colorectal carcinoma
M. Planck (2000)
10.1056/NEJM200007133430201
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
P. Lichtenstein (2000)
10.1200/JCO.2000.18.11.2193
Population-based molecular detection of hereditary nonpolyposis colorectal cancer.
R. Salovaara (2000)
Increased cancer risk in the offspring of women with colorectal cancer
K Hemminki (2001)
10.1054/bjoc.2000.1718
Familial colorectal adenocarcinoma and hereditary nonpolyposis colorectal cancer: a nationwide epidemiological study from Sweden
K. Hemminki (2001)
10.1093/JNCI/86.21.1618
Family history of cancer and colon cancer risk: the Utah Population Database.
M. Slattery (1994)
10.1038/bjc.1991.446
Cancer: Causes, Occurrence and Control
L. Kinlen (1991)
10.1093/JNCI/91.11.916
Colorectal cancer: molecules and populations.
J. Potter (1999)
risk in offspring of women with colorectal carcinoma : a Swedish register - based cohort study
J Esteve (2000)
10.1002/(SICI)1097-0215(19961115)68:4<428::AID-IJC5>3.0.CO;2-2
Familial aggregation of colorectal cancer in the general population
B. Carstensen (1996)



This paper is referenced by
10.1016/j.patbio.2012.01.003
Colorectal cancer: comparison of clinicopathologic features between Moroccans patients less than 50 years old and older.
A. Benmoussa (2013)
10.1097/GIM.0b013e3182064384
How well does family history predict who will get colorectal cancer? Implications for cancer screening and counseling
D. Taylor (2011)
10.1016/J.SONCN.2005.06.008
Modifying cancer risk factors: the gene-environment interaction.
E. Giarelli (2005)
10.1080/15592294.2015.1068490
MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles
M. Yu (2015)
10.1016/J.GCB.2009.07.008
Cancer colorectal : du diagnostic au dépistage
J. Faivre (2009)
Family history and environmental risk factors for colon cancer.
E. Fernández (2004)
10.1186/1897-4287-8-8
Population screening for hereditary and familial cancer syndromes in Valka district of Latvia
A. Vanags (2010)
10.1053/j.gastro.2014.07.006
Increased risk of colorectal neoplasia among family members of patients with colorectal cancer: a population-based study in Utah.
N. Samadder (2014)
10.1007/1-84628-058-3_3
Familial Colorectal Cancer
S. Dolwani (2005)
10.1016/J.GIE.2006.12.065
Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey.
Jeong-Sik Byeon (2007)
10.21037/jgo.2016.12.13
Family history of colorectal cancer and its impact on survival in patients with resected stage III colon cancer: results from NCCTG Trial N0147 (Alliance).
Claire L. Jansson‐Knodell (2017)
Cancer in first-degree relatives and risk of glioma in adults.
D. Hill (2003)
10.1097/CEJ.0b013e32833b4886
Individual cancer risk as a function of current age and risk profile
M. Goossens (2010)
10.1002/ijc.20938
Familial risks for colorectal cancer show evidence on recessive inheritance
K. Hemminki (2005)
10.1002/ijc.11478
Familial risk of cancer: Data for clinical counseling and cancer genetics
K. Hemminki (2004)
10.1002/ijc.20341
Familial risk for colon and rectal cancers
K. Hemminki (2004)
10.1016/j.cgh.2017.04.022
The Impact of Family History on the Risk of Colorectal Neoplasia and Screening Practices.
N. Samadder (2017)
10.1186/1897-4287-3-1-7
The Swedish Family-Cancer Database: Update, Application to Colorectal Cancer and Clinical Relevance
K. Hemminki (2005)
Cancer colorectal : du diagnostic au dépistage Colorectal cancer: From diagnosis to screening
J. Faivrea (2009)
10.1016/j.cgh.2018.09.038
Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases.
N. Samadder (2018)
10.1016/J.EJCA.2004.07.016
Familial association of colorectal adenocarcinoma with cancers at other sites.
K. Hemminki (2004)
10.1053/j.gastro.2015.07.055
Incidence and mortality of colorectal cancer in individuals with a family history of colorectal cancer.
R. Schoen (2015)
10.1038/sj.bjc.6604276
Association of colorectal adenoma with other malignancies in Swedish families
E. Hiripi (2008)
10.1053/j.gastro.2009.11.044
Population-based family history-specific risks for colorectal cancer: a constellation approach.
D. P. Taylor (2010)
10.1007/s10620-014-3465-z
Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening
N. Samadder (2014)
10.1007/978-3-540-26577-1_5
Use of disease registers
M. Rosén (2005)
10.1007/978-0-387-09834-0_5
Use of Health Registers
R. Sund (2014)
10.1093/annonc/mdn527
Age of onset in familial cancer.
A. Brandt (2008)
10.1016/j.cgh.2015.06.040
Increased Risk of Colorectal Cancer Among Family Members of All Ages, Regardless of Age of Index Case at Diagnosis.
N. Samadder (2015)
10.1016/J.IJROBP.2004.12.063
Radiation exposure and familial aggregation of cancers as risk factors for colorectal cancer after radioiodine treatment for thyroid carcinoma.
C. Rubino (2005)
10.1016/J.EJCA.2005.09.023
Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis.
A. Butterworth (2006)
10.1055/a-1016-4977
Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
M. van Leerdam (2019)
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