Online citations, reference lists, and bibliographies.
← Back to Search

The C‐Myc Protein Induces Cell Cycle Progression And Apoptosis Through Dimerization With Max.

B. Amati, T. Littlewood, G. Evan, H. Land
Published 1993 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The c‐Myc protein (Myc) is involved in cellular transformation and mitogenesis, but is also a potent inducer of programmed cell death, or apoptosis. Whether these apparently opposite functions are mediated through common or distinct molecular mechanisms remains unclear. Myc and its partner protein, Max, dimerize and bind DNA in vitro and in vivo through basic/helix‐loop‐helix/leucine zipper motifs (bHLH‐LZ). By using complementary leucine zipper mutants (termed MycEG and MaxEG), which dimerize efficiently with each other but not with their wild‐type partners, we demonstrate that both cell cycle progression and apoptosis in nontransformed rodent fibroblasts are induced by Myc‐Max dimers. MycEG or MaxEG alone are inactive, but co‐expression restores ability to prevent withdrawal from the cell cycle and to induce cell death upon removal of growth factors. Thus, Myc can control two alternative cell fates through dimerization with a single partner, Max.
This paper references



This paper is referenced by
10.1158/0008-5472.CAN-07-2462
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.
Valerie B. Sampson (2007)
10.1038/ncb1601
The ubiquitin-specific protease USP28 is required for MYC stability
N. Popov (2007)
10.1023/A:1009702513648
Cardiomyocyte Apoptosis in Experimental Health Failure
H. Sabbah (2004)
10.1016/J.BMC.2005.11.052
A credit-card library approach for disrupting protein-protein interactions.
Yang Xu (2006)
10.1182/BLOOD-2004-03-0802
Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines.
P. Wermuth (2005)
10.1016/0304-3835(95)03835-K
Oncogene regulation of endonuclease activation in apoptosis.
D. McConkey (1995)
10.1111/j.1365-2362.1994.tb01067.x
Apoptosis in disease
J. Savill (1994)
10.1096/fasebj.12.9.633
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
L. M. Facchini (1998)
10.1128/MCB.14.6.4032
Repression of cyclin D1: a novel function of MYC.
A. Philipp (1994)
10.1016/S0145-2126(99)00157-5
Overexpression of Ras, Raf and L-myc but not Bcl-2 family proteins is linked with resistance to TCR-mediated apoptosis and tumorigenesis in thymic lymphomas from TCR transgenic mice.
M. Kobzdej (2000)
10.1007/978-1-4757-9217-1_5
C-MYC: Oncogene and Tumour Suppressor Gene
G. Evan (1994)
10.6092/UNIBO/AMSDOTTORATO/417
TRANSCRIPTION REGULATION OF ABC DRUG TRANSPORTERS BY MYC ONCOPROTEINS
G. Dellavalle (2007)
10.1158/0008-5472.CAN-05-0500
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
A. Huang (2005)
Mediated Apoptosis is Caspase-Dependent and can be Suppressed by Coexpression of HoxA 9 in Murine and Human Cell Lines Running Title : Meis 1-mediated apoptosis
Peter J Wermuth (2004)
Signalling pathways in renal cell carcinoma with a focus on telomerase regulation
Raviprakash T. Sitaram (2010)
Disruption of the Cyclin D / Cyclin-dependent Kinasc / 1 NK 4 / Ketinoblastoina Protein Regulatory Pathway in Human Neuroblastoma 1
John Easton (2006)
cdc 25 A Is Necessary but Not Sufficient for Optimal c-myc – Induced Apoptosis and Cell Proliferation of Vascular Smooth Muscle Cells
K. Macdonald (1999)
10.1016/S0733-8651(05)70196-X
Apoptotic proteins. p53 and c-myc related pathways.
N. McCarthy (2001)
10.1038/sj.onc.1208779
Nfkb1 is dispensable for Myc-induced lymphomagenesis
U. Keller (2005)
10.1128/MCB.15.7.3470
The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max.
R. Hopewell (1995)
Myc-Funktion im Zellwachstum und Identifikation von neuen Myc-regulierten Genen in B-Zellen
M. Schuhmacher (2001)
proliferationin stimulation of normal intestinal epithelial cell plays a critical myc Polyamine-modulated expression of c-
M S Bernard (2016)
10.1038/sj.cdd.4400417
TNFα-mediated cell death is independent of Cdc25A
G. Krupitza (1998)
10.1002/(SICI)1097-4652(200006)183:3<399::AID-JCP13>3.0.CO;2-7
Analysis of Myc/Max/Mad network members in adipogenesis: Inhibition of the proliferative burst and differentiation by ectopically expressed Mad1
B. Pulverer (2000)
10.1128/MCB.20.4.1162-1169.2000
c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis
M. Stoneley (2000)
10.1016/0092-8674(95)90355-0
Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
D. Ayer (1995)
10.1186/s12859-017-1652-6
MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells
Debangana Chakravorty (2017)
10.1016/S0006-2952(01)00625-6
A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.
Y. Ye (2001)
10.1007/978-1-4615-5895-8_1
THE INTEGRATED CONTROL OF CELL PROLIFERATION AND CELL VIABILITY
G. Evan (1996)
10.1089/107999099312902
Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain.
N. Lee (1999)
10.1038/srep01953
Partition of Myc into Immobile vs. Mobile Complexes within Nuclei
Tilman Rosales (2013)
10.1007/978-3-642-79562-6_1
Immediate-early genes — how immediate and why early?
G. Evan (1995)
See more
Semantic Scholar Logo Some data provided by SemanticScholar