Online citations, reference lists, and bibliographies.

Risk Of Fractures In Patients With Pernicious Anemia.

J B Goerss, Chang Hwi Kim, Elizabeth J. Atkinson, Richard Eastell, W Michael O'fallon, L. Joseph Iii Melton
Published 1992 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
In a series of postmenopausal women previously studied by our group, pernicious anemia was associated with reduced bone mineral density of the spine and with vertebral fractures. To determine whether osteoporotic fractures represent an important clinical problem for such patients, we conducted a population-based retrospective cohort study of all Rochester, Minnesota residents newly diagnosed with pernicious anemia from 1950 through 1979. These 131 individuals were followed through the inpatient and outpatient records of all medical care providers in the community for 1550 person-years. In comparison with fracture rates from the general community, patients with pernicious anemia had a 1.9-fold increase in proximal femur fractures, a 1.8-fold increase in vertebral fractures, and a 2.9-fold increase in distal forearm fractures (all p less than 0.05). Increases in the risk of proximal humerus and pelvis fractures were not statistically significant. Clinicians should be aware that pernicious anemia is associated with an increased risk of osteoporotic fractures, but the mechanism is unknown.
This paper references
10.1093/oxfordjournals.aje.a114383
Osteoporosis and the risk of hip fracture.
L. Joseph Iii Melton (1986)
10.1080/00401706.1982.10487769
The Statistical Analysis of Failure Time Data
J. Klein (1982)
10.1016/0002-9343(87)90219-1
Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine.
Douglas S. Ross (1987)
10.1093/oxfordjournals.aje.a115204
Epidemiology of vertebral fractures in women.
L. Joseph Iii Melton (1989)
10.1056/NEJM198507113130202
Calcium absorption and achlorhydria.
R. Recker (1985)
10.1073/pnas.86.8.2834
Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach.
P. Persson (1989)
10.1038/scientificamerican1081-54
The patient record in epidemiology.
L. Kurland (1981)
10.1136/bmj.294.6575.798
Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.
J. P. Devogelaer (1987)
10.1001/archinte.1983.00350030052010
Exogenous hyperthyroidism with osteoporosis.
M. Fallon (1983)
10.1111/j.1365-2265.1983.tb02873.x
Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormone(s) and antithyroid treatment.
B. Krølner (1983)
10.1007/BF01880413
The contribution of bone loss to postmenopausal osteoporosis
S. Hui (1990)
10.1042/cs0820681
Pernicious anaemia as a risk factor for osteoporosis.
R. Eastell (1992)
10.1016/S0025-6196(12)60867-2
Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota.
Larry W. Schafer (1985)
10.1210/jcem-60-1-74
A prospective study of bone mass in patients with type I diabetes.
S. Hui (1985)
10.1056/NEJM198807143190202
Cobalamin and osteoblast-specific proteins.
R. Carmel (1988)
10.1007/BF02555245
Secular trends in the incidence of hip fractures
J. I. Joseph Melton (1987)
10.1093/biomet/40.3-4.354
SOME SIMPLE APPROXIMATE TESTS FOR POISSON VARIATES
D. R. Cox (1953)
10.7326/0003-4819-111-9-738
Risk for colorectal adenocarcinoma in pernicious anemia. A population-based cohort study.
N. Talley (1989)
10.1001/archinte.1986.00360130058007
Bone loss in hypothyroidism with hormone replacement. A histomorphometric study.
J. M. Coindre (1986)
10.1172/JCI111254
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
10.1210/endo-96-5-1217
The importance of the stomach in gastrin-induced hypocalcemia in the rat.
James A. Schulak (1975)
The relationship between pernicious anemia and cancer of the stomach.
Hoffman Nr (1970)
10.1111/J.0954-6820.1979.TB13517.X
Pernicious anaemia as a risk factor in gastric cancer.
L. Elsborg (1979)
10.1097/00003086-198103000-00008
Epidemiologic features of pelvic fractures.
L. J. Melton (1981)
10.1001/jama.1988.03720210027023
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women.
T L Paul (1988)
10.3109/00365528109181996
Serum group I pepsinogens.
Helge Lyder Waldum (1981)
Regression models and life tables (with discussion
D. Cox (1972)
10.1002/hep.1840140215
Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis.
R. Eastell (1991)
10.1097/00003086-198208000-00003
Epidemiologic features of humeral fractures.
S. Rose (1982)
10.1002/ijc.2910030120
Possible association between pernicious anaemia and leukaemia: a prospective study of 1,625 patients with a note on the very high incidence of stomach cancer.
E. Blackburn (1968)
10.1210/jcem-69-4-837
Reduced bone mass in reproductive-aged women with endometriosis.
Florence Comite (1989)
10.1097/00003086-198211000-00005
Colles' fracture and subsequent hip fracture risk.
Roger C. Owen (1982)
10.1002/JBMR.5650070214
Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989.
C. Cooper (1992)



This paper is referenced by
10.2217/1745509X.4.6.651
Vitamin B 12 and health in old age
T. Kwok (2008)
10.1093/ajcn/85.2.460
Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial.
Timothy J Green (2007)
10.3109/00365521.2016.1141317
Impaired skeletal health in patients with chronic atrophic gastritis
K. Aasarød (2016)
10.1038/nrgastro.2011.272
The risks of PPI therapy
P. Moayyedi (2012)
10.5772/29936
Morbidity and Mortality in Anemia
Fawzia Ahmed Habib (2012)
10.1016/j.coph.2016.09.002
Potential clinical indications for a CCK2 receptor antagonist.
Malcolm Boyce (2016)
10.3390/nu7053322
B-Vitamins and Bone Health–A Review of the Current Evidence
Zhaoli Dai (2015)
10.1517/14740338.2013.797961
Indications and safety of proton pump inhibitor drug use in patients with cancer
George Triadafilopoulos (2013)
10.1007/s00394-004-0531-x
Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents
Rosalie A. M. Dhonukshe-Rutten (2005)
EVIEWS IN BASIC AND CLINICAL ASTROENTEROLOGY AND HEPATOLOGY
J. Lynch ()
10.3949/CCJM.75.5.333
Perioperative management of bariatric surgery patients: focus on metabolic bone disease.
Susan E.I. Williams (2008)
Vitamin B 12 , bone mineral density and fracture risk in adults : A systematic review
Luciana Leal Gomes de Macêdo (2017)
10.3949/ccjm.70.3.247
Osteoporosis in men: suspect secondary disease first.
Angelo A. Licata (2003)
10.1042/cs0950735
Gastrectomy osteopenia in the rat: the role of vitamin B12 deficiency and the type of reconstruction of the digestive tract.
A Wojtyczka (1998)
Morbidity and Mortality in Anemia 3 2 . 3 Folic acid deficiency anemia
Fawzia Ahmed Habib (2012)
10.1007/s001980170031
Identifying Bone-Mass-Related Risk Factors for Fracture to Guide Bone Densitometry Measurements: A Systematic Review of the Literature
M. Espallargues (2001)
10.1590/S0482-50042012000600005
Níveis séricos de vitamina B12 não se relacionam com baixa densidade mineral óssea em mulheres brasileiras na pós-menopausa
Adriana Maria Kakehasi (2012)
10.1111/cen.12730
What is the optimal bone-preserving strategy for patients with Addison's disease?
P. Lee (2015)
10.1016/j.gastrohep.2011.01.002
[Chronic use of proton pump inhibitors: is the risk of osteoporosis and fractures real?].
Miguel Martí-Cabrera (2011)
Vitamin B12: a novel indicator of bone health in vulnerable groups
R.A.M. Dhonukshe-Rutten (1999)
10.1016/j.biochi.2016.04.009
One carbon metabolism and bone homeostasis and remodeling: A review of experimental research and population studies.
Eva Feigerlová (2016)
Vitamin B12 Level Have Prognostic Significance in Multiple Myeloma Patients?
Aysun Şenturk Yikilmaz (2018)
10.1001/jama.296.24.2947
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
10.1016/j.rcreu.2019.12.004
Rol de la homocisteína y vitamina B en el metabolismo óseo
Jemina Narváez (2020)
10.1007/s00404-009-0936-0
The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women
N. Bozkurt (2009)
10.1016/B978-0-12-415853-5.00034-0
Nonskeletal Risk Factors for Osteoporosis and Fractures
Jeri W. Nieves (2013)
10.1016/B978-0-12-809762-5.00032-2
Influence of Goat Milk on Bone and Mineral Metabolism During Iron Deficiency Recovery
Javier Díaz-Castro (2017)
10.1016/0026-0495(94)90078-7
Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia.
Mary Elkins Melton (1994)
10.2165/11536780-000000000-00000
Proton Pump Inhibitors and Fracture Risk
Michael Bodmer (2010)
10.1007/s11938-014-0030-y
Proton Pump Inhibitors and Risk of Bone Fractures
G. Leontiadis (2014)
10.1186/s12876-018-0901-0
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study
Sara Massironi (2018)
10.1515/cclm-2012-0599
One year B and D vitamins supplementation improves metabolic bone markers
Wolfgang Herrmann (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar