Risk Of Fractures In Patients With Pernicious Anemia.
J B Goerss, Chang Hwi Kim, Elizabeth J. Atkinson, Richard Eastell, W Michael O'fallon, L. Joseph Iii Melton
Published 1992 · Medicine
Download PDFAnalyze on Scholarcy
In a series of postmenopausal women previously studied by our group, pernicious anemia was associated with reduced bone mineral density of the spine and with vertebral fractures. To determine whether osteoporotic fractures represent an important clinical problem for such patients, we conducted a population-based retrospective cohort study of all Rochester, Minnesota residents newly diagnosed with pernicious anemia from 1950 through 1979. These 131 individuals were followed through the inpatient and outpatient records of all medical care providers in the community for 1550 person-years. In comparison with fracture rates from the general community, patients with pernicious anemia had a 1.9-fold increase in proximal femur fractures, a 1.8-fold increase in vertebral fractures, and a 2.9-fold increase in distal forearm fractures (all p less than 0.05). Increases in the risk of proximal humerus and pelvis fractures were not statistically significant. Clinicians should be aware that pernicious anemia is associated with an increased risk of osteoporotic fractures, but the mechanism is unknown.
This paper references
Osteoporosis and the risk of hip fracture.
L. Joseph Iii Melton (1986)
The Statistical Analysis of Failure Time Data
J. Klein (1982)
Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine.
Douglas S. Ross (1987)
Epidemiology of vertebral fractures in women.
L. Joseph Iii Melton (1989)
Calcium absorption and achlorhydria.
R. Recker (1985)
Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach.
P. Persson (1989)
The patient record in epidemiology.
L. Kurland (1981)
Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.
J. P. Devogelaer (1987)
Exogenous hyperthyroidism with osteoporosis.
M. Fallon (1983)
Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormone(s) and antithyroid treatment.
B. Krølner (1983)
The contribution of bone loss to postmenopausal osteoporosis
S. Hui (1990)
Pernicious anaemia as a risk factor for osteoporosis.
R. Eastell (1992)
Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota.
Larry W. Schafer (1985)
A prospective study of bone mass in patients with type I diabetes.
S. Hui (1985)
Cobalamin and osteoblast-specific proteins.
R. Carmel (1988)
Secular trends in the incidence of hip fractures
J. I. Joseph Melton (1987)
SOME SIMPLE APPROXIMATE TESTS FOR POISSON VARIATES
D. R. Cox (1953)
Risk for colorectal adenocarcinoma in pernicious anemia. A population-based cohort study.
N. Talley (1989)
Bone loss in hypothyroidism with hormone replacement. A histomorphometric study.
J. M. Coindre (1986)
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
The importance of the stomach in gastrin-induced hypocalcemia in the rat.
James A. Schulak (1975)
The relationship between pernicious anemia and cancer of the stomach.
Hoffman Nr (1970)
Pernicious anaemia as a risk factor in gastric cancer.
L. Elsborg (1979)
Epidemiologic features of pelvic fractures.
L. J. Melton (1981)
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women.
T L Paul (1988)
Serum group I pepsinogens.
Helge Lyder Waldum (1981)
Regression models and life tables (with discussion
D. Cox (1972)
Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis.
R. Eastell (1991)
Epidemiologic features of humeral fractures.
S. Rose (1982)
Possible association between pernicious anaemia and leukaemia: a prospective study of 1,625 patients with a note on the very high incidence of stomach cancer.
E. Blackburn (1968)
Reduced bone mass in reproductive-aged women with endometriosis.
Florence Comite (1989)
Colles' fracture and subsequent hip fracture risk.
Roger C. Owen (1982)
Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989.
C. Cooper (1992)
This paper is referenced by
Vitamin B 12 and health in old age
T. Kwok (2008)
Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial.
Timothy J Green (2007)
Impaired skeletal health in patients with chronic atrophic gastritis
K. Aasarød (2016)
The risks of PPI therapy
P. Moayyedi (2012)
Morbidity and Mortality in Anemia
Fawzia Ahmed Habib (2012)
Potential clinical indications for a CCK2 receptor antagonist.
Malcolm Boyce (2016)
B-Vitamins and Bone Health–A Review of the Current Evidence
Zhaoli Dai (2015)
Indications and safety of proton pump inhibitor drug use in patients with cancer
George Triadafilopoulos (2013)
Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents
Rosalie A. M. Dhonukshe-Rutten (2005)
EVIEWS IN BASIC AND CLINICAL ASTROENTEROLOGY AND HEPATOLOGY
J. Lynch ()
Perioperative management of bariatric surgery patients: focus on metabolic bone disease.
Susan E.I. Williams (2008)
Vitamin B 12 , bone mineral density and fracture risk in adults : A systematic review
Luciana Leal Gomes de Macêdo (2017)
Osteoporosis in men: suspect secondary disease first.
Angelo A. Licata (2003)
Gastrectomy osteopenia in the rat: the role of vitamin B12 deficiency and the type of reconstruction of the digestive tract.
A Wojtyczka (1998)
Morbidity and Mortality in Anemia 3 2 . 3 Folic acid deficiency anemia
Fawzia Ahmed Habib (2012)
Identifying Bone-Mass-Related Risk Factors for Fracture to Guide Bone Densitometry Measurements: A Systematic Review of the Literature
M. Espallargues (2001)
Níveis séricos de vitamina B12 não se relacionam com baixa densidade mineral óssea em mulheres brasileiras na pós-menopausa
Adriana Maria Kakehasi (2012)
What is the optimal bone-preserving strategy for patients with Addison's disease?
P. Lee (2015)
[Chronic use of proton pump inhibitors: is the risk of osteoporosis and fractures real?].
Miguel Martí-Cabrera (2011)
Vitamin B12: a novel indicator of bone health in vulnerable groups
R.A.M. Dhonukshe-Rutten (1999)
One carbon metabolism and bone homeostasis and remodeling: A review of experimental research and population studies.
Eva Feigerlová (2016)
Vitamin B12 Level Have Prognostic Significance in Multiple Myeloma Patients?
Aysun Şenturk Yikilmaz (2018)
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
Rol de la homocisteína y vitamina B en el metabolismo óseo
Jemina Narváez (2020)
The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women
N. Bozkurt (2009)
Nonskeletal Risk Factors for Osteoporosis and Fractures
Jeri W. Nieves (2013)
Influence of Goat Milk on Bone and Mineral Metabolism During Iron Deficiency Recovery
Javier Díaz-Castro (2017)
Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia.
Mary Elkins Melton (1994)
Proton Pump Inhibitors and Fracture Risk
Michael Bodmer (2010)
Proton Pump Inhibitors and Risk of Bone Fractures
G. Leontiadis (2014)
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study
Sara Massironi (2018)
One year B and D vitamins supplementation improves metabolic bone markers
Wolfgang Herrmann (2013)See more