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The Control Of Chondrogenesis.

Mary B Goldring, Kaneyuki Tsuchimochi, Kosei Ijiri
Published 2006 · Medicine, Biology
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Chondrogenesis is the earliest phase of skeletal development, involving mesenchymal cell recruitment and migration, condensation of progenitors, and chondrocyte differentiation, and maturation and resulting in the formation of cartilage and bone during endochondral ossification. This process is controlled exquisitely by cellular interactions with the surrounding matrix, growth and differentiation factors, and other environmental factors that initiate or suppress cellular signaling pathways and transcription of specific genes in a temporal-spatial manner. Vertebrate limb development is controlled by interacting patterning systems involving prominently the fibroblast growth factor (FGF), bone morphogenetic protein (BMP), and hedgehog pathways. Both positive and negative signaling kinases and transcription factors, such as Sox9 and Runx2, and interactions among them determine whether the differentiated chondrocytes remain within cartilage elements in articular joints or undergo hypertrophic maturation prior to ossification. The latter process requires extracellular matrix remodeling and vascularization controlled by mechanisms that are not understood completely. Recent work has revealed novel roles for mediators such as GADD45beta, transcription factors of the Dlx, bHLH, leucine zipper, and AP-1 families, and the Wnt/beta-catenin pathway that interact at different stages during chondrogenesis.

This paper is referenced by
Expression of miR-1455 p During Chondrogenesis of Mesenchymal Stem Cells
Emily A. Verbus (2018)
Pendant small functional groups on poly(ϵ-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells.
Min Chen (2015)
Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source.
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Comparison of Cardiovascular Parameters Between Patients With Ossification of Posterior Longitudinal Ligament and Patients With Cervical Spondylotic Myelopathy
Masaki Kishiya (2009)
Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib).
Jad El-Hoss (2014)
microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9.
Seul-gi Lee (2014)
Search for Conditions to Detect Epigenetic Marks and Nuclear Proteins in Immunostaining of the Testis and Cartilage
Hisashi Ideno (2014)
Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
Limin Liu (2016)
Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta.
Bénédicte Rabier (2006)
Development of a scaffold incorporating zinc-oxide nano-particles for cartilage tissue engineering under physiological conditions / Eraj Humayun Mirza
Mirza Eraj Humayun (2016)
Injectable cell-laden hydrogel composites for osteochondral tissue engineering
Xuan Guo (2010)
Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Stephanie Morscheid (2019)
miR-204-5p decreases chondrocyte proliferation and amelio- rates the OA-like phenotype in rats with surgically induced OA by targeting Runx2
Jia-qing Cao (2018)
Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner
Christelle Darrieutort-Laffite (2019)
Prevention of methotrexate chemotherapy-induced bone growth arrest and osteoporosis with folinic acid.
Chiaming Fan (2011)
Nanomaterials/Nanocomposites for Osteochondral Tissue.
Ohan S. Manoukian (2018)
Fibrodysplasia (Myositis) Ossificans Progressiva
Michael R. Convente (2018)
In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration.
Kunxi Zhang (2015)
Cell viability and chondrogenic differentiation capability of human mesenchymal stem cells after iron labeling with iron sucrose.
Nikolaos Papadimitriou (2014)
Regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in PEG-ECM hydrogels
Nathaniel S Hwang (2011)
Arterial injury promotes medial chondrogenesis in Sm22 knockout mice.
Jianbin Shen (2011)
Chitosan scaffolds containing hyaluronic acid for cartilage tissue engineering.
Clara R Correia (2011)
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
Takako Hattori (2010)
Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length.
Emily K. Mis (2014)
The cleavage of N-cadherin is essential for chondrocyte differentiation.
Shigeto Nakazora (2010)
A model to study articular cartilage mechanical and biological responses to sliding and rolling loads
Oliver Robert Schätti (2016)
Dynamic formation of cellular aggregates of chondrocytes and mesenchymal stem cells in spinner flask
Huimin He (2019)
Sequence of chondrocranial development in the oriental fire bellied toad Bombina orientalis.
Paul Lukas (2020)
Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role
Stefania D’Adamo (2020)
Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.
Matthew P Leighton (2007)
Development of an osteoblast cell culture system for functional characterization and comparative analyses of mouse models with bone phenotypes and systemic investigation of an Osteogenesis imperfecta disease model
Frank Thiele (2009)
The role of TGFβs and Sox9 during limb chondrogenesis
Yasuhiko Kawakami (2006)
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