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Design, Docking, And Synthesis Of Some New Pyrazoline And Pyranopyrazole Derivatives As Anti-inflammatory Agents

Magda Ismail, Nagy M. Khalifa, Hoda H. Fahmy, Eman S Nossier, Mohamed M. Abdulla
Published 2014 · Chemistry

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Design and synthesis of some novel pyrazoline and pyranopyrazole derivatives as potential anti-inflammatory agents are described. Most of the compounds were tested for their anti-inflammatory (in vitro and in vivo) and ulcerogenic activities. In all tested compounds, it was found that pyrazolines, 2a, and pyrazolopyrano[2,3-d]pyrimidine 9 are the potent anti-inflammatory and selective cyclooxygenase-2 (COX-2) inhibitor. All compounds are mainly in the safe level. Docking study of 2a and 9 revealed higher affinity for binding with the active site of COX-2 enzyme like SC-558, a selective COX-2 inhibitor.
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