Online citations, reference lists, and bibliographies.

Design, Docking, And Synthesis Of Some New Pyrazoline And Pyranopyrazole Derivatives As Anti-inflammatory Agents

Magda Ismail, Nagy M. Khalifa, Hoda H. Fahmy, Eman S Nossier, Mohamed M. Abdulla
Published 2014 · Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Share
Design and synthesis of some novel pyrazoline and pyranopyrazole derivatives as potential anti-inflammatory agents are described. Most of the compounds were tested for their anti-inflammatory (in vitro and in vivo) and ulcerogenic activities. In all tested compounds, it was found that pyrazolines, 2a, and pyrazolopyrano[2,3-d]pyrimidine 9 are the potent anti-inflammatory and selective cyclooxygenase-2 (COX-2) inhibitor. All compounds are mainly in the safe level. Docking study of 2a and 9 revealed higher affinity for binding with the active site of COX-2 enzyme like SC-558, a selective COX-2 inhibitor.



This paper is referenced by
10.1134/S1070363217070283
Synthesis and some reactions of novel (4Z)-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-hydrazinyl-1-phenyl-1H-imidazol-5(4H)-ones
Nagy M. Khalifa (2017)
10.4314/bcse.v33i3.11
Novel synthesis of pyrazole-containing thiophene, 2-alkyloxy-pyridine and thieno[2,3-d]pyrimidine scaffolds as analgesic agents
Nagy M. Khalifa (2019)
10.1134/S1070363217110275
Synthesis and characterization of novel chalcones linked 3-[1-(3-chlorophenyl)-3-(pyren-1-yl)]-1H-pyrazole moiety
Nagy M. Khalifa (2017)
10.3390/molecules22040512
Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents
Eman S Nossier (2017)
SYNTHESIS, IN-SILICO STUDIES, OF NEW SUBSTITUTED PYRAZOLONE BASED HYDRAZONE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES
Mohammed Abrar Alam (2015)
10.3390/molecules21070929
Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents
Abdou Osman Abdelhamid (2016)
10.1134/S1070363217120349
Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-6-(substituted phenyl)-1,2-dihydro-2-oxo(imino)pyridine-3-carbonitriles
Nagy M. Khalifa (2017)
10.1134/S1070363218060300
Efficient Synthesis and Reactions of New Functionally Substituted Pyrido[2,3-d]pyrimidine Candidates
Nagy M. Khalifa (2018)
10.1134/S107036321803026X
Synthesis and Reactions of Novel Fused 1-(8-Hydroxy-7-iodoquinoline-5-sulfonyl)-1H-pyrazolo-[3,4-d]pyrimidine-3-carbonitrile Derivatives
Nagy M. Khalifa (2018)
10.1134/S1070363217100309
Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives
Mohamed A. Al-Omar (2017)
10.1134/S1070363217120398
Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-2-alkyloxy-6-substituted pyridine-3-carbonitriles
Nagy M. Khalifa (2017)
Semantic Scholar Logo Some data provided by SemanticScholar