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Pyrazolo[1,5‐a]Pyrimidine Derivative As Precursor For Some Novel Pyrazolo[1,5‐a]Pyrimidines And Tetraheterocyclic Compounds

Nadia H. Metwally, Magda Ahmed Abdallah, Selima Ali Almabrook
Published 2017 · Chemistry

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The 2-(cyanomethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile reacted with phenyl isothiocyanate to afford the respective thioanilide derivative that is a novel compound that has been unreported hitherto. The latter was used as a precursor to synthesize several novel polyheterocyclic compounds , , , and . Treatment of the enamine derivative of compound with each of hydrazine hydrate and hydroxylamine hydrochloride yielded the tetraheterocyclic compounds and , respectively. The structures of all the newly synthesized compounds were confirmed on basis of their elemental, spectral data, and plausible mechanism has been postulated to account for their formation. X-ray crystallography was carried out as a further evidence for the structure of the isolated product .
This paper references
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.
C. Almansa (2001)
sp2‐Hybridized silicon: Parameters for molecular modeling
Adrian G. Brook (1990)
A Facile One-Pot Synthesis of Some New Spiro-thiazolidin-4-ones and Benzimidazoles of Biological Interest
Nadia H. Metwally (2007)
Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.
Z. Wu (2004)
Some reactions with omega-bromoacetophenone: A novel synthesis of some polysubstituted pyridine, pyrimidine, pyrazolo[1,5-a]pyrimidine and benzimidazolo[1,2-a]pyrimidine derivatives
F. Abdelrazek (2003)
Heterocyclic Synthesis with Nitriles: Synthesis of some novel pyrrolo [2,1‐b]thiadiazoline, pyrrolo[2,1‐b]thiadiazolo[3,2‐a]pyrimidine and pyridine derivatives
Nadia H. Metwally (1998)
Role of Tyrosine Kinase Inhibitors in Cancer Therapy
A. Arora (2005)
Synthesis of Enaminones and Their Reaction with Dimethyl Acetylene Dicarboxylate
M. Shahram (2008)
Enaminones as Building Blocks in Heterocyclic Syntheses: Reinvestigating the Product Structures of Enaminones with Malononitrile. A Novel Route to 6-Substituted-3-Oxo-2,3-Dihydropyridazine-4-Carboxylic Acids
A. Al-Najjar (2008)
Synthesis and Antimicrobial Activity of Some Novel Substituted Bis-Pyridone, Pyrazole, and Thiazole Derivatives
Nadia H. Metwally (2015)
Heterocyclic Enamines: The Versatile Intermediates in the Synthesis of Heterocyclic Compounds and Natural Products
Y. Cheng (2004)
New Thiazoles Containing Pyrazolopyrimidine Moiety as Possible Analgesic Agents
K. K. V. Raj (2006)
Synthesis, Reactions and Antitumour Screening of new Enaminones
Ahmad S. Shawali (2010)
Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABAA Receptors
R. E. Petroski (2006)
The Reaction of Malononitrile with Hydrazine1,2
E. Taylor (1959)
Studies on the Reaction of Cycloalkanones with Malonodinitrile
Fathy Mohamed Abdelrazek (2014)
Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials.
L. Meijer (2003)
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.
Y. Xu (2015)

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