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Pharmaceutical Aspects Of Intranasal Delivery Of Vaccines Using Particulate Systems.
S. Sharma, T. Mukkur, H. Benson, Y. Chen
Published 2009 · Medicine
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The nasal route offers a promising opportunity for the delivery of vaccines. This review analyses the opportunities and novel delivery strategies based on particulate systems for the nasal delivery of vaccines, including liposomes, proteosomes, virosomes, nano- and microparticulate systems, with and without adjuvants. The influence of pharmaceutical aspects of the particulate formulations on nasal delivery is analysed. Recently developed delivery devices for nasal vaccination are also described. Potential barriers to clinical and commercial success of some novel intranasal vaccines are critically evaluated. Although particulate systems may offer potential in the nasal delivery of vaccines by enhancing uptake by antigen-presenting cells, the real success in enhancement of vaccine delivery can only be achieved by careful design and manipulation of physicochemical properties of particulate vaccine delivery systems.
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Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model
I. Alhashmi (2012)
Delivery of antigens used for vaccination: recent advances and challenges.
R. Scherließ (2011)
Intranasal immunisation of mice against Streptococcus equi using positively charged nanoparticulate carrier systems.
L. Figueiredo (2012)
Synthetic nanoparticle-based vaccines against respiratory pathogens
Kathleen A. Ross (2013)
Vaccine Delivery: Current Routes of Administration and Novel Approaches
N. Sahni (2016)
In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations.
R. Scherließ (2013)
Intranasal drug delivery: how, why and what for?
A. Pires (2009)
Section II: Topical Treatment of Impaired Mucosal Membranes
Christoph Bittera (2011)
The mucosal immune system for vaccine development.
Aayam Lamichhane (2014)
The emergence of peptides in the pharmaceutical business: From exploration to exploitation
T. Uhlig (2014)
Mucosal vaccination by the intranasal route. Nose-associated lymphoid tissue (NALT)-Structure, function and species differences.
R. Pabst (2015)
Design of lipid microparticle dispersions based on the physicochemical properties of the lipid and aqueous phase.
A. Lauterbach (2015)
Biomineralized vaccine nanohybrid for needle-free intranasal immunization.
X. Wang (2016)
Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals
L. D. Plessis (2014)
DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
V. Erdmann (2013)
Nanomedicine: Emerging Field of Nanotechnology to Human Health
Chandana Mohanty (2012)
Present and future medical applications of microbial exopolysaccharides
M. Moscovici (2015)See more