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Monoamine Oxidase Inhibiting Activity Of A Series Of (+/-)-4-methoxy-beta-hydroxyphenethylamines.

Gary G. Ferguson, William J. Keller
Published 1975 · Chemistry, Medicine
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The synthesis and selected pharmacological testing of (+/-)-4-methoxy-beta-hydroxyphenethylamine [1-(4-methoxyphenyl)-2-aminoethanol] and its N-methylated derivatives are presented. Members of this series were found to exert partial prevention of reserpine-induced hypothermia in mice and to inhibit monoamine oxidase in Warburg studies. Activity was essentially dose dependent. The secondary amine was the most active member of the series. The tertiary amine was least active, and the primary amine exhibited intermediate activity.



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