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High-pressure Liquid Chromatographic Assay For Chloramphenicol, Chloramphenicol-3-monosuccinate, And Chloramphenicol-1-monosuccinate.

J. T. Burke, W. Wargin, M. R. Blum
Published 1980 · Chemistry, Medicine

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A high-pressure liquid chromatographic method for the sensitive and rapid determination of chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate is presented. The procedure utilizes a reversed-phase chromatographic column with UV absorption detection. The assay is useful for monitoring patients receiving chloramphenicol, determining the pharmacokinetics of parenteral chloramphenicol sodium succinate, and certifying sterile chloramphenicol sodium succinate.
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