Online citations, reference lists, and bibliographies.

Colorectal Cancer—global Burden, Trends, And Geographical Variations

Jeffrey Douaiher, Advaitaa Ravipati, Benjamin Grams, S. Chowdhury, O. Alatise, C. Are
Published 2017 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND The aim of this study is to describe the trends and variations in the global burden of colorectal cancer (CRC). METHODS Data (2012-2030) relating to CRC was extracted from GLOBOCAN 2012 database and analyzed. RESULTS The results of our study demonstrate a rising global burden of colorectal cancer which persists until the year 2035 and likely beyond. The rise in the global burden is not uniform with significant variations influenced by geographic location, socio-economic status, age, and gender. Although the EURO region has the highest burden, Asia as a continent continues to bear the heaviest brunt of the disease. Although the burden of disease is higher in more developed regions, mortality is considerably higher in less developed regions and this gap widens over the next two decades. The disease predominantly affects the male gender across all regions of the world. Age has a complex relation with the burden of CRC and is affected by the cross-influences relating to socio-economic status. CONCLUSIONS The results of our study demonstrate a rising global burden of CRC with some unique variations. Knowledge of this data can increase awareness and help strategic targeting of efforts and resources.
This paper references
10.4103/1119-3077.91750
Morphology of colorectal carcinoma among Nigerians: a 30-year review.
K. Ibrahim (2011)
10.1200/JCO.2011.36.4414
Mortality by stage for right- versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results--Medicare data.
J. Weiss (2011)
10.1111/j.1463-1318.2010.02223.x
Colorectal carcinoma in young adults: a retrospective study on Indian patients: 2000–2008
S. Gupta (2010)
10.1001/jamasurg.2013.8
Impact of screening colonoscopy on outcomes in colon cancer surgery.
R. Amri (2013)
10.3748/wjg.v20.i35.12445
Improving the outcomes in oncological colorectal surgery.
J. L. V. van Vugt (2014)
Predictors of proximal versus distal colorectal cancers
EC Gonzalez (2001)
10.4314/EAMJ.V85I6.9622
Correlation of clinical data, anatomical site and disease stage in colorectal cancer.
H. Saidi (2008)
: an analysis of more than a half million adults in the national institutes of health - AARP diet and health study
A Steinbrecher (2012)
[Colonoscopic polypectomy and long-term prevention of colorectal cancer deaths].
J. García-Sánchez (2012)
10.1016/S1470-2045(01)00486-7
Global cancer statistics in the year 2000.
D. Parkin (2001)
SEER STAT fact sheet for colon and rectum cancer
SE Fischer (2016)
10.1002/cncr.29936
Annual Report to the Nation on the Status of Cancer, 1975‐2012, featuring the increasing incidence of liver cancer
A. B. Ryerson (2016)
10.3322/caac.20038
Worldwide Variations in Colorectal Cancer
Melissa M. Center (2009)
10.1002/jso.24410
Predictive global trends in the incidence and mortality of pancreatic cancer based on geographic location, socio-economic status, and demographic shift.
C. Are (2016)
10.7326/0003-4819-113-5-373
Screening for colorectal cancer.
D. Eddy (1990)
10.1016/0959-8049(95)00299-X
Diverging trends in colorectal cancer morbidity and mortality. Earlier diagnosis comes at a price.
L. Bonneux (1995)
Campbell R Predictors of proximal versus distal colorectal cancers
A Miller (2001)
10.1016/S0140-6736(08)60878-8
An estimation of the global volume of surgery: a modelling strategy based on available data
T. Weiser (2008)
Fifty-three years of reporting colorectal cancer in Nigerians--a systematic review of the published literature.
O. Rotimi (2014)
10.1001/jamaoncol.2016.4227
Prognostic Survival Associated With Left-Sided vs Right-Sided Colon Cancer: A Systematic Review and Meta-analysis
F. Petrelli (2017)
10.4149/BLL_2016_013
Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe.
Vlado Simko (2016)
Subsite-specific colorectal cancer incidence rates and stage distributions among Asians and Pacific Islanders in the United States, 1995 to 1999.
X. Wu (2004)
Spectrum of colonoscopy findings in Ile-Ife Nigeria.
O. Alatise (2012)
The increasing incidence of colorectal cancer and the preventive strategy in Japan.
K. Kuriki (2006)
10.1007/s11605-015-3026-6
The Worse Prognosis of Right-Sided Compared with Left-Sided Colon Cancers: a Systematic Review and Meta-analysis
M. Yahagi (2015)
10.1016/j.mayocp.2013.09.006
The increasing incidence of young-onset colorectal cancer: a call to action.
D. Ahnen (2014)
10.1016/S2214-109X(15)70115-4
Global access to surgical care: a modelling study.
B. Alkire (2015)
10.1245/s10434-016-5624-2
Establishing a Cancer Research Consortium in Low- and Middle-Income Countries: Challenges Faced and Lessons Learned
S. E. Fischer (2016)
10.1089/JAYAO.2014.0006
Colorectal Cancer Incidence Among Young Adults in California.
K. Singh (2014)
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN
J Ferlay (2012)
10.1111/j.1440-1746.2011.06944.x
Adherence to follow-up after a positive fecal occult blood test in an organized colorectal cancer screening program in Korea, 2004-2008.
K. S. Choi (2012)
10.3322/caac.21262
Global cancer statistics, 2012
L. Torre (2015)
10.1038/bjc.1995.170
Socioeconomic status and colon cancer incidence: a prospective cohort study.
A. J. V. van Loon (1995)
10.1093/JNCI/94.12.916
Changing area socioeconomic patterns in U.S. cancer mortality, 1950-1998: Part II--Lung and colorectal cancers.
G. Singh (2002)
10.1200/EdBook_AM.2013.33.169
Achieving health equity in colorectal cancer: a call to action.
Toni Marie Cipriano (2013)
10.1002/cncr.31551
Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics
K. Cronin (2018)
10.1111/j.1365-2354.2008.00982.x
Colorectal cancer in Nigeria: 40 years on. A review.
David Omoareghan Irabor (2009)
Golbohm RA: socioeconomic status and colon cancer incidence: a prospective cohort study
AJ vanLoon (1995)
10.1002/ijc.29210
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
J. Ferlay (2015)
10.1158/1055-9965.EPI-12-0659
Examining the Association Between Socioeconomic Status and Invasive Colorectal Cancer Incidence and Mortality in California
A. Steinbrecher (2012)
10.1097/00008469-200404000-00006
Secular trend of colon cancer incidence and mortality in relation to fat and meat intake in Japan
S. Kono (2004)
10.1158/1055-9965.EPI-09-0104
Socioeconomic and Racial Patterns of Colorectal Cancer Screening among Medicare Enrollees in 2000 to 2005
C. Doubeni (2009)
10.3322/caac.21332
Cancer statistics, 2016
Rebecca L. Siegel Mph (2016)
10.1016/S0140-6736(10)60392-3
Global operating theatre distribution and pulse oximetry supply: an estimation from reported data
L. M. Funk (2010)
10.1158/1055-9965.EPI-11-0220
Trends in Colorectal Cancer Test Use among Vulnerable Populations in the United States
C. Klabunde (2011)
10.1002/cncr.26677
Socioeconomic status and the risk of colorectal cancer
C. Doubeni (2012)
10.1136/gutjnl-2014-309086
Colorectal cancer screening: a global overview of existing programmes
E. Schreuders (2015)
10.1111/J.1445-5994.2000.TB00811.X
Proximal shift of colorectal cancer in the Australian Capital Territory over 20 years.
A. Miller (2000)
10.1023/A:1008826109697
Trends in colorectal cancer incidence in Sweden 1959-93 by gender, localization, time period, and birth cohort
M. Thörn (2004)
10.1097/DCR.0000000000000318
Adenocarcinoma of the Rectum in Patients Under Age 40 Is Increasing: Impact of Signet-Ring Cell Histology
P. Tawadros (2015)
Lifetime risk of developing or dying from cancer
AC Society (2016)
10.3322/caac.21332
Cancer statistics, 2016
R. Siegel (2016)
10.1007/BF02564165
The changing distribution of large intestinal cancer
J. Mamazza (1982)
10.1002/(SICI)1097-0142(19990415)85:8<1670::AID-CNCR5>3.0.CO;2-M
Incidence of colorectal carcinoma in the U.S.
R. Troisi (1999)
10.1007/BF02234301
Predictors of proximalvs. distal colorectal cancers
Eduardo C. Gonzalez (2001)
10.1001/JAMA.289.10.1288
Colorectal cancer screening: scientific review.
J. Walsh (2003)
10.1002/ijc.10635
Are there two sides to colorectal cancer?
B. Iacopetta (2002)



This paper is referenced by
Estudio proteómico en pacientes con metástasis hepáticas de cáncer colo-rectal. Identificación de diferentes perfiles proteómicos en relación a los criterios clínico patológicos convencionales de gravedad
Adalgiza Reyes Romero (2017)
10.12816/EJHM.2018.10582
Enhanced Recovery Program (ERP) versus Traditional care after Elective Left Side Colorectal Cancer Surgery
Ahmad Aboelkassem Ibrahim (2018)
10.1053/j.gastro.2018.08.056
Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer.
C. Hurtado (2018)
10.1371/journal.pone.0200720
Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review
Chantal M den Bakker (2018)
10.1155/2018/8782328
BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report
Yaşar Subutay Peker (2018)
10.1016/j.puhe.2020.01.003
All-cancer incidence in Tehranian adults: more than a decade of follow-up-results from the Tehran Lipid and Glucose Study.
Farzad Hadaegh (2020)
10.9734/JAMMR/2019/V30I130163
Cancer in Cross River State
Godwin Ebughe (2019)
10.1007/s10147-020-01619-8
Magnitude of advantage in tumor response contributes to a better correlation between treatment effects on overall survival and progression-free survival: a literature-based meta-analysis of clinical trials in patients with metastatic colorectal cancer
Yosuke Yoshida (2020)
β ‐ arrestin 2 promotes 5 ‐ FU ‐ induced apoptosis via the NF ‐ κ B pathway in colorectal cancer
Weixia Ren (2018)
10.1002/bjs.11313
Predicting return to work among patients with colorectal cancer
C. D. den Bakker (2019)
10.1016/j.cbi.2019.108725
Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells.
C. Kishore (2019)
10.3390/cancers12020319
Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges
E. Koncina (2020)
10.1016/j.lfs.2018.02.025
A viral map of gastrointestinal cancers.
N. Costa (2018)
10.1038/s41385-018-0085-5
Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A
J. Chan (2018)
10.5937/zz1903033s
Trends in mortality rates of colorectal cancer in central Serbia during the period 1999-2014: A joinpoint regression analysis
Sandra Šipetić-Grujičić (2019)
10.1016/j.biochi.2017.10.002
LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α.
W. Zhang (2018)
10.1186/s12885-018-4786-7
A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK
A. White (2018)
10.13181/MJI.V28I2.2679
Recent evidence on modifiable and non-modifiable risk factors for colorectal cancer (CRC): a systematic synopsis of meta-analyses from 2015 to 2017
Teguh Kristian Perdamaian (2019)
10.1007/s11655-020-3420-0
Effectiveness and Safety Evaluation of Chinese Medicine in Treatment of Metastatic Colorectal Cancer after Chemotherapy Failure: Protocol of a Prospective Multicenter Cohort Study
T. Hao (2020)
10.1109/elticom47379.2019.8943895
Search for Colon Cancer in Higher Plants Based-NCBI Online
Mohammad Basyuni (2019)
10.22037/GHFBB.V13I2.1807
Estimating the cure proportion of colorectal cancer and related factors after surgery in patients using parametric cure models
Neda Izadi (2020)
10.3389/fonc.2017.00183
Cancers Attributable to Alcohol Consumption in Nigeria: 2012–2014
Michael K Odutola (2017)
CMAR_A_233215 451..459
N. Azzam (2020)
10.1158/1055-9965.EPI-19-1148
Serum PIWI-Interacting RNAs piR-020619 and piR-020450 Are Promising Novel Biomarkers for Early Detection of Colorectal Cancer
Zhen-Fei Wang (2020)
10.1016/S2468-1253(19)30076-7
How best to treat older patients with metastatic colorectal cancer?
Julien Taieb (2019)
10.3892/ol.2017.7525
Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.
W. Li (2018)
10.1186/s12885-018-4985-2
Spatially varying effects of predictors for the survival prediction of nonmetastatic colorectal Cancer
Y. Tian (2018)
10.1007/s10147-019-01405-1
Early tumor shrinkage after first-line medical treatment of metastatic colorectal cancer: a meta-analysis
Giuseppe Antonio Colloca (2019)
10.1016/j.critrevonc.2019.102834
Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective.
L. Conti (2019)
10.1016/s2468-1253(19)30345-0
The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
S. Safiri (2019)
10.3389/fonc.2019.00098
Trends in and Predictions of Colorectal Cancer Incidence and Mortality in China From 1990 to 2025
L. Zhang (2019)
IN MORTALITY RATES OF COLORECTAL CANCER IN CENTRAL SERBIA DURING THE PERIOD 1999 – 2014 : A JOINPOINT
S. Grujičić (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar