Online citations, reference lists, and bibliographies.
← Back to Search

Advances In Mucoadhesion And Mucoadhesive Polymers.

V. Khutoryanskiy
Published 2011 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives.
This paper references
10.1016/j.jconrel.2008.11.012
Are in vivo gastric bioadhesive forces accurately reflected by in vitro experiments?
B. Laulicht (2009)
10.1007/BFB0115603
Sedimentation analysis of potential interactions between mucins and a putative bioadhesive polymer
I. Fiebrig (1994)
10.1016/j.biomaterials.2009.08.030
The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin.
M. Chen (2009)
10.1016/S0939-6411(97)00101-X
Preparation and in vitro characterisation of mucoadhesive polymeric microspheres as intra-nasal delivery systems
M. A. El-Hameed (1997)
10.1016/J.ADDR.2005.07.006
Comparison of the mucoadhesive properties of various polymers.
V. Grabovac (2005)
10.1016/S0928-0987(00)00194-9
Characterization of chitosan hydrochloride--mucin rheological interaction: influence of polymer concentration and polymer:mucin weight ratio.
S. Rossi (2001)
10.1016/J.EJPS.2003.10.028
Assessment of chitosan derivatives as buccal and vaginal penetration enhancers.
G. Sandri (2004)
10.1248/CPB.37.1366
Factors affecting the bioadhesive property of tablets consisting of hydroxypropyl cellulose and carboxyvinyl polymer.
K. Satoh (1989)
10.1016/J.CARBPOL.2009.07.020
Mucoadhesive property and biocompatibility of methylated N-aryl chitosan derivatives
Warayuth Sajomsang (2009)
10.1016/S0168-3659(97)00138-7
A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration.
F. Madsen (1998)
10.1016/j.biomaterials.2009.07.060
In situ gelling properties of chitosan-thioglycolic acid conjugate in the presence of oxidizing agents.
D. Sakloetsakun (2009)
10.1211/0022357055227
Pharmaceutical applications of mucoadhesion for the non‐oral routes
K. Edsman (2005)
10.1021/LA050988G
Hydroxypropyl guar-borate interactions with tear film mucin and lysozyme.
C. Lu (2005)
10.1016/J.IJPHARM.2007.01.037
Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications.
V. Khutoryanskiy (2007)
10.1016/j.addr.2009.11.026
Chitosan-based nanostructures: a delivery platform for ocular therapeutics.
M. de la Fuente (2010)
10.1016/S0928-0987(00)00065-8
Characterization of chitosan hydrochloride-mucin interaction by means of viscosimetric and turbidimetric measurements.
S. Rossi (2000)
10.1016/0169-409X(95)00015-Y
Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels
M. Zignani (1995)
10.1016/j.jconrel.2009.01.011
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption.
M. Rekha (2009)
10.1016/J.IJPHARM.2007.02.019
Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride.
N. A. Fefelova (2007)
10.1016/S0168-3659(01)00288-7
Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres.
J. Wang (2001)
10.1016/J.JCONREL.2004.09.015
Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide.
Th F Vandamme (2005)
10.1016/S0168-3659(00)00216-9
Evaluation of poly(acrylic acid-co-ethylhexyl acrylate) films for mucoadhesive transbuccal drug delivery: factors affecting the force of mucoadhesion.
A. H. Shojaei (2000)
10.1021/BM034028P
Mucin/poly(acrylic acid) interactions: a spectroscopic investigation of mucoadhesion.
Minesh M Patel (2003)
10.1007/s11095-004-9007-1
In Vitro and ex Vivo Intestinal Tissue Models to Measure Mucoadhesion of Poly (Methacrylate) and N-Trimethylated Chitosan Polymers
S. Keely (2004)
10.1366/000370209788964449
Spectroscopic Ellipsometry of Mucin Layers on an Amphiphilic Diblock Copolymer Surface
N. A. Nikonenko (2009)
10.1016/J.ADDR.2005.07.002
Thiomers: a new generation of mucoadhesive polymers.
A. Bernkop-Schnürch (2005)
10.1016/0168-3659(95)00094-1
Design and evaluation of sustained-release and buccal adhesive propranolol hydrochloride tablets
B. Taylan (1996)
10.1016/j.ijpharm.2008.02.017
Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly(vinyl alcohol) gel.
A. E. Ivanov (2008)
10.1002/MARC.200700197
Natural and Synthetic Polyampholytes, 2
S. Kudaibergenov (2007)
10.1007/BFB0118476
Characterization of a PEO-PPO-PEO block copolymer system
K. Schillén (1993)
10.1007/s10856-010-4069-6
Novel mucoadhesive system based on sulfhydryl-acrylate interactions
M. Davidovich-Pinhas (2010)
10.1016/J.ADDR.2005.09.017
Dendrimers in gene delivery.
C. Dufès (2005)
10.1016/S0168-3659(00)00329-1
Carbopol/pluronic phase change solutions for ophthalmic drug delivery.
H. Lin (2000)
10.1016/0021-9797(77)90162-X
On the relationship between the electrostatic and the molecular component of the adhesion of elastic particles to a solid surface
B. Derjaguin (1977)
10.1016/J.EURPOLYMJ.2003.10.019
Synthetic glycopolymers: an overview
V. Ladmiral (2004)
10.1016/0378-5173(94)00299-K
An investigation of some factors influencing the in vitro assessment of mucoadhesion
S. A. Mortazavi (1995)
10.1016/S0040-6031(98)00275-5
Water–mucin phases: conditions for mucus liquid crystallinity
J. Davies (1998)
10.1016/J.BIOMATERIALS.2005.05.075
Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate.
K. Kafedjiiski (2006)
10.1016/S0168-3659(01)00227-9
Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine.
A. Bernkop-Schnürch (2001)
10.1016/S0169-409X(01)00115-6
Drug transfer through mucus.
K. Khanvilkar (2001)
10.1016/J.CARBPOL.2007.05.026
Viscometric study of pectin–mucin interaction and its mucoadhesive bond strength
Nartaya Thirawong (2008)
10.1021/BM050802S
Dendrimers: novel polymeric nanoarchitectures for solubility enhancement.
U. Gupta (2006)
10.1248/CPB.31.4561
Highly viscous gel ointment containing carbopol for application to the oral mucosa.
M. Ishida (1983)
10.1021/BM0609691
Rheology of gastric mucin exhibits a pH-dependent sol-gel transition.
J. Celli (2007)
10.1002/1521-3935(20010401)202:7<1089::AID-MACP1089>3.0.CO;2-S
Radiation synthesis of linear and crosslinked poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride and complex formation with potassium hexacyanoferrates (II, III) in aqueous solutions
V. Khutoryanskiy (2001)
10.1002/1520-6017(200101)90:1<38::AID-JPS5>3.0.CO;2-3
Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo.
M. Thanou (2001)
10.1016/S0144-8617(98)00097-6
Are chitosan-mucin interactions specific to different regions of the stomach? Velocity ultracentrifugation offers a clue
M.P. Deacon (1999)
10.1016/J.COCIS.2005.11.001
Mucin structure, aggregation, physiological functions and biomedical applications
R. Bansil (2006)
10.1080/08927011003646809
Adhesion of microorganisms to bovine submaxillary mucin coatings: effect of coating deposition conditions
Ibraheem A. Bushnak (2010)
10.1016/j.jconrel.2009.01.029
Evaluating the mucoadhesive properties of drug delivery systems based on hydrated thiolated alginate.
M. Davidovich-Pinhas (2009)
10.1021/BM0604000
Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude.
Xioazhong Qu (2006)
10.1016/j.ejpb.2008.09.028
Mucoadhesive polymeric platforms for controlled drug delivery.
G. Andrews (2009)
10.1016/S0014-827X(03)00044-2
An in vitro investigation for vaginal bioadhesive formulations: bioadhesive properties and swelling states of polymer mixtures.
E. Baloğlu (2003)
10.14219/JADA.ARCHIVE.1947.0306
Penicillin; new methods for its use in dentistry.
C. A. Scrivener (1947)
10.1016/0168-3659(85)90038-0
Adhesive topical drug delivery system
T. Nagai (1985)
10.1016/j.ijpharm.2008.12.001
In vitro and ex vivo bioadhesivity analysis of polymeric intravaginal caplets using physicomechanics and computational structural modeling.
Valence M. K. Ndesendo (2009)
10.1016/J.ADDR.2005.07.001
The basics and underlying mechanisms of mucoadhesion.
J. Smart (2005)
10.1016/S0014-827X(02)00004-6
Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization.
C. Hascicek (2003)
10.1021/bm800276d
Why is chitosan mucoadhesive?
Ioannis A Sogias (2008)
10.1016/J.TIFS.2005.12.007
Trends in muco-adhesive analysis
S. Harding (2006)
10.1002/MARC.200700162
Natural and Synthetic Polyampholytes, 1
A. Ciferri (2007)
10.1016/0378-5173(89)90229-9
A novel in situ method to test polymers and coated microparticles for bioadhesion
K. Rao (1989)
10.1023/A:1015812615635
A Simple Rheological Method for the in Vitro Assessment of Mucin-Polymer Bioadhesive Bond Strength
E. E. Hassan (2004)
10.1039/B918007A
Multilayered hydrogel coatings covalently-linked to glass surfaces showing a potential to mimic mucosal tissues
Olga V. Khutoryanskaya (2010)
10.1002/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G
Bioadhesive-based dosage forms: the next generation.
J. W. Lee (2000)
10.1016/j.ijpharm.2007.12.001
Evaluation of mucoadhesiveness of polymers by BIACORE method and mucin-particle method.
J. Thongborisute (2008)
10.1002/(SICI)1521-4095(200006)12:11<843::AID-ADMA843>3.0.CO;2-T
Recent Advances in Antimicrobial Dendrimers
C. Chen (2000)
10.1016/J.ADDR.2004.03.001
Nanoscale technology of mucoadhesive interactions.
N. Peppas (2004)
10.1016/J.IJPHARM.2003.12.018
Effect of chitosan and of N-carboxymethylchitosan on intraocular penetration of topically applied ofloxacin.
G. Di Colo (2004)
10.1016/0378-5173(96)04542-5
Tanned leather : a good model for determining hydrogels bioadhesion
H. Blanco-Fuente (1996)
10.1016/j.addr.2008.09.008
Barrier properties of mucus.
Richard A. Cone (2009)
10.1016/0142-9612(95)00307-X
Hydrogels as mucoadhesive and bioadhesive materials: a review.
N. Peppas (1996)
10.1002/POLA.1991.080291308
N‐(2‐hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties
R. Rathi (1991)
10.1016/J.IJPHARM.2003.06.001
Matrix tablets based on thiolated poly(acrylic acid): pH-dependent variation in disintegration and mucoadhesion.
D. Guggi (2004)
10.1016/S0168-3659(02)00363-2
Nasal drug delivery--possibilities, problems and solutions.
L. Illum (2003)
10.1016/S0928-0987(97)10004-5
Bioadhesive drug delivery systems. I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate.
L. S. Nielsen (1998)
10.1016/0168-3659(85)90050-1
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
N. Peppas (1985)
10.1016/j.addr.2008.11.002
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
S. Lai (2009)
10.1016/J.IJPHARM.2007.06.040
Synthesis and characterization of a chitosan-N-acetyl cysteine conjugate.
T. Schmitz (2008)
10.1021/bc800342d
Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels.
Raghavendra S. Navath (2008)
10.1016/S0378-5173(98)00215-4
An investigation of the interfacial interaction between poly(acrylic acid) and glycoprotein
Z. Değim (1998)
10.1002/MABI.200400200
pH effects on the complexation, miscibility and radiation-induced crosslinking in poly(acrylic acid)-poly(vinyl alcohol) blends.
Z. S. Nurkeeva (2005)
10.1016/J.POLYMER.2005.01.026
Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends
D. Ameye (2005)
10.1016/S0168-3659(00)00365-5
Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion.
M. Repka (2001)
10.1016/S0144-8617(98)00109-X
Synthesis of a fluorescent chitosan derivative and its application for the study of chitosan-mucin interactions
R. Qaqish (1999)
10.1002/MABI.200700185
Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose.
K. Luo (2008)
10.1002/(SICI)1097-4628(19990923)73:13<2749::AID-APP23>3.0.CO;2-9
A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly (ethylene glycol)
H. Choi (1999)
10.1016/S0939-6411(96)00009-4
Factors affecting in vitro gastric mucoadhesion IV. Influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers
M. Tobyn (1997)
10.1016/0168-3659(87)90004-6
BIOADHESIVE ANALYSIS OF CONTROLLED-RELEASE SYSTEMS. I. FRACTURE AND INTERPENETRATION ANALYSIS IN POLY(ACRYLIC ACID)-CONTAINING SYSTEMS
G. Ponchel (1987)
10.1016/J.ADDR.2005.07.005
The use of mucoadhesive polymers in ocular drug delivery.
A. Ludwig (2005)
10.1021/BM0493990
Viscoelastic properties and dynamics of porcine gastric mucin.
J. Celli (2005)
10.1016/J.ADDR.2005.07.008
Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems.
H. Takeuchi (2005)
10.1016/J.CARBPOL.2008.12.016
Chitosan: an option for development of essential oil delivery systems for oral cavity care?
A. Pedro (2009)
10.1021/BM060090L
Design of mucoadhesive polymeric films based on blends of poly(acrylic acid) and (hydroxypropyl)cellulose.
A. V. Dubolazov (2006)
10.1021/bm9009667
PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin.
P. Griffiths (2010)
10.1021/LA0511844
Mucin-chitosan complexes at the solid-liquid interface: multilayer formation and stability in surfactant solutions.
A. Dėdinaitė (2005)
10.1007/bf00552302
The science of adhesion
A. J. Kinloch (1980)
10.1016/J.COCIS.2010.05.015
Mucin layers and multilayers — Physicochemical properties and applications
O. Svensson (2010)
10.1016/0079-6816(94)90042-6
On the role of electrostatic forces in the adhesion of polymer particles to solid surfaces
B. Derjaguin (1994)
10.1038/360458A0
Viscous fingering of HCI through gastric mucin
K. Ramakrishnan Bhaskar (1992)
10.1023/A:1016467219657
Mechanisms of Mucoadhesion of Poly(acrylic Acid) Hydrogels
H. Park (2004)
10.1021/bm8006242
Designing temperature-responsive biocompatible copolymers and hydrogels based on 2-hydroxyethyl(meth)acrylates.
Olga V. Khutoryanskaya (2008)
10.1016/j.biotechadv.2009.06.007
Application of chitosan microspheres for nasal delivery of vaccines.
M. L. Kang (2009)



This paper is referenced by
10.1007/s12668-020-00754-w
Comparison Between the Pharmacokinetics Data of Ketorolac Tromethamine Wafer a Novel Drug Delivery System and Conventional Ketorolac Tromethamine Tablets to Enhance Patient Compliance Using a New LC-MS/MS Method
D. A. Mostafa (2020)
10.1016/j.elecom.2020.106737
Electrochemically prepared poly(L-lysine) and 3-hydroxyphenylboronic acid composite as a conventional adhesion material for rice suspension cells
Mei Zeng (2020)
10.1016/j.actbio.2019.02.027
A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization.
C. González-Obeso (2019)
10.2147/IJN.S92638
Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei
Matheus Aparecido Dos Santos Ramos (2015)
10.1016/j.jconrel.2017.11.048
Microneedles as the technique of drug delivery enhancement in diverse organs and tissues.
A. Rzhevskiy (2018)
10.1016/J.EURPOLYMJ.2015.10.023
Synthesis and in vitro characterisation of preactivated thiolated gelatin
J. Rohrer (2015)
10.1016/j.xphs.2019.05.006
Synthesis and Evaluation of Boronated Chitosan as a Mucoadhesive Polymer for Intravesical Drug Delivery.
Oluwadamilola M. Kolawole (2019)
10.1016/j.ejps.2017.01.008
Thiolated polymers as mucoadhesive drug delivery systems
Sarah Duggan (2017)
10.1002/PI.5411
The effect of thiol content on the gelation and mucoadhesion of thiolated poly(aspartic acid)
B. Szilágyi (2017)
10.1021/ACSBIOMATERIALS.7B00397
Injectable and Degradable Poly(Oligoethylene glycol methacrylate) Hydrogels with Tunable Charge Densities as Adhesive Peptide-Free Cell Scaffolds
Emilia Bakaic (2017)
Formulation et caractérisation d'une forme buccale mucoadhésive thermogélifiante pour administration de sulfate de salbutamol
Ni Zeng (2015)
Development of microencapsulation systems for both oral and topical drug deliveries
P. L. Lam (2013)
10.1016/B978-0-12-804305-9.00009-9
Encapsulation of nutraceuticals in novel delivery systems
J. Fangueiro (2016)
10.1016/j.apsb.2017.03.002
Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system
Liqian Ci (2017)
10.1007/s40259-013-0046-1
Emerging Targets and Novel Approaches to Ebola Virus Prophylaxis and Treatment
J. H. Choi (2013)
10.1016/j.jconrel.2012.06.003
Microencapsulation of probiotics for gastrointestinal delivery.
M. Cook (2012)
10.1097/ACI.0b013e3283645899
The ocular surface epithelial barrier and other mechanisms of mucosal protection: from allergy to infectious diseases
F. Mantelli (2013)
10.1016/j.ijpharm.2017.02.045
Preparation and characterization of gastrointestinal wafer formulations.
Kirsten Kirsch (2017)
10.5530/SRP.2017.1.7
Buccal Mucoadhesive Films: A Review
Dipak Malpure Rajaram (2016)
10.1016/J.FOODHYD.2017.05.043
Mucoadhesion: a food perspective
S. Cook (2017)
1 Advances in Ophthalmic Drug Delivery 1
P. J. Morrison (2015)
10.1016/j.ijpharm.2019.118860
Mucoadhesive Thin Films For The Simultaneous Delivery Of Microbicide And Anti-Inflammatory Drugs In The Treatment Of Periodontal Diseases.
Sim Yee Lim (2019)
10.1002/9781119640240.ch1
Introduction, Theories and Mechanisms of Bioadhesion
K. Pathak (2020)
10.1080/03602559.2017.1324575
Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design
M. Zaman (2018)
10.1007/978-1-4614-9524-6_2
Mucoadhesion and Characterization of Mucoadhesive Properties
T. Yu (2014)
Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine Journal Item
S. Lungare (2019)
10.3390/POLYM7111510
The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application
E. Szymańska (2015)
Prasanna Sakha Development of Microfluidic Applications to Study the Role of Kainate Receptors in Synaptogenesis
Neha Shrestha (2016)
10.1021/acs.molpharmaceut.6b00445
Prolonged Ocular Retention of Mucoadhesive Nanoparticle Eye Drop Formulation Enables Treatment of Eye Diseases Using Significantly Reduced Dosage.
Shengyan Liu (2016)
10.1016/j.xphs.2016.05.005
The Monoglyceride Content Affects the Self-Assembly Behavior, Rheological Properties, Syringeability, and Mucoadhesion of In Situ-Gelling Liquid Crystalline Phase.
K. M. Nunes (2016)
10.1016/j.biomaterials.2011.08.087
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.
M. Chen (2011)
10.3390/polym10030254
Assessing Mucoadhesion in Polymer Gels: The Effect of Method Type and Instrument Variables
Jéssica Bassi da Silva (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar