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Valproic Acid Protection Against The Brachial Plexus Root Avulsion‐induced Death Of Motoneurons In Rats

Dianxiu Wu, Q. Li, X. Zhu, Guangzhi Wu, Shusen Cui
Published 2013 · Medicine

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In this study, the role of valproic acid (VPA) in protecting motoneuron after brachial plexus root avulsion was investigated in adult rats. Sixty rats were used in this study, and underwent the brachial plexus root avulsion injury, which was created by using a micro‐hemostat forceps to pull out brachial plexus root from the intervertebral foramen. The animals were divided into two groups, VPA group administered with VPA dissolved in drinking water (300 mg/kg) daily, and control group had drinking water every day. The spinal cords (C5‐T1) were harvested at day 1, 2, 3, 7, 14, and 28 for immunohistochemistry analysis, TUNEL staining, Nissl staining, and electron microscopy, respectively. The results showed that with VPA administration, the survival of motoneurons was promoted and the cell apoptosis was inhibited. The number of c‐Jun and Bcl‐2 positive motoneurons was increased immediately after avulsion both in control and VPA group, however, the percent of c‐Jun positive motoneurons was decreased and the percent of Bcl‐2 positive motoneurons was increased by VPA treatment significantly. Our results indicated that motoneurons were protected by VPA against cell death induced by brachial plexus root avulsion through c‐Jun inhibition and Bcl‐2 induction. © 2013 Wiley Periodicals, Inc. Microsurgery 33:551–559, 2013.
This paper references
The mood stabilizer valproic acid induces proliferation and myelination of rat Schwann cells
Wu Fei (2011)
Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat
L. Zhou (2006)
Contralateral C7 nerve root transfer to neurotize the upper trunk via a modified prespinal route in repair of brachial plexus avulsion injury
S. Wang (2012)
Differential Schwann cell migration in adult and old mice: an in vitro study
A. Santos (2000)
The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum.
Katrina Boeckeler (2006)
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
S. Estus (1994)
Spinal cord implantation of avulsed ventral roots in primates; correlation between restored motor function and morphology
R. Hallin (1999)
Ventral root avulsion: An experimental model of death of adult motor neurons
V. Koliatsos (1994)
Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin.
J. Yamauchi (2008)
Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury
A. Bergerot (2004)
Valproic acid induces caspase 3-mediated apoptosis in microglial cells
M. Dragunow (2006)
Trophic Factor Modulation of c-Jun Expression in Supraspinal Neurons after Chronic Spinal Cord Injury
J. Houlé (1998)
Valproate may improve strength and function in patients with type III/IV spinal muscle atrophy
C. Weihl (2006)
A dose‐effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model
Haodong Lin (2007)
The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets.
Z. Szupera (2000)
Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function
Y. Liu (1999)
Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neuritis after adult spinal cord injury
MH Tuszynski (1996)
Apoptosis and Expression of BCL-2 in Facial Motoneurons after Facial Nerve Injury
Zheng-Min Wang (2002)
Nerve Growth Factor Delivery by Gene Transfer Induces Differential Outgrowth of Sensory, Motor, and Noradrenergic Neurites after Adult Spinal Cord Injury
M. Tuszynski (1996)
Neurotrophin‐4 delivered by fibrin glue promotes peripheral nerve regeneration
Q. Yin (2001)
Herpes Simplex Virus Vector-Mediated Expression of Bcl-2 Protects Spinal Motor Neurons from Degeneration Following Root Avulsion
M. Yamada (2001)
Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion
W. Wu (1993)
Axonal regeneration and motor neuron survival after microsurgical nerve reconstruction
M. Choi (2013)
Expression of Nitric-Oxide Synthase (NOS) in Injured CNS Neurons as Shown by NADPH Diaphorase Histochemistry
W. Wu (1993)
Reinnervation of thenar muscle after repair of total brachial plexus avulsion injury with contralateral C7 root transfer: Report of five cases
L. Wang (2011)
Axillary nerve neurotization with the anterior deltopectoral approach in brachial plexus injuries
J. J. Jerome (2012)
Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor
A. L. Oliveira (2002)
Survival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion.
L. Zhou (2006)
Mechanisms of action of valproate: a commentatory
C. U. Johannessen (2000)
Neurotrophin4 delivered by fibrin glue promotes peripheral nerve regeneration
Q Yin (2001)
Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits.
J. L. Scism (1997)
R. Leffert (1965)
Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats
S. Cui (2003)
EGb761 protects motoneurons against avulsion-induced oxidative stress in rats
X. Cheng (2010)
Valproic acid improves outcome after rodent spinal cord injury: Potential roles of histone deacetylase inhibition
L. Lv (2011)
BDNF Prevents and Reverses Adult Rat Motor Neuron Degeneration and Induces Axonal Outgrowth
A. Kishino (1997)
The proto-oncogene Bcl-2 and its role in regulating apoptosis
G. Kroemer (1997)
Glial cell line-derived neurotrophic factor enhances axonal regeneration following sciatic nerve transection in adult rats
Zhe-yu Chen (2001)
Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction
Yan Leng (2010)
Valproic acid enhances microglial phagocytosis of amyloid-β1–42
A. M. Smith (2010)
Bcl-2 promotes regeneration of severed axons in mammalian CNS
D. Chen (1997)
Repair of avulsed ventral nerve roots by direct ventral intraspinal implantation after brachial plexus injury.
H. Fournier (2005)
Potential Roles of Gene Expression Change in Adult Rat Spinal Motoneurons Following Axonal Injury: A Comparison among c-jun, Low-Affinity Nerve Growth Factor Receptor (LNGFR), and Nitric Oxide Synthase (NOS)
W. Wu (1996)
Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.
L. Li (1995)
Properties of motoneurons underlying their regenerative capacity after axon lesions in the ventral funiculus or at the surface of the spinal cord
S. Cullheim (2002)
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
M. Lam (1994)
Nerve root grafting and distal nerve transfers for C5-C6 brachial plexus injuries.
J. Bertelli (2010)
A double‐blind placebo‐controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth*
P. Yuan (2001)
c-JUN-like immunoreactivity in the CNS of the adult rat: Basal and transynaptically induced expression of an immediate-early gene
T. Herdegen (1991)
Repair of brachial plexus lesions by end‐to‐side side‐to‐side grafting neurorrhaphy: Experience based on 11 cases
S. Amr (2005)
The anatomy, investigations and management of adult brachial plexus injuries
J. Gregory (2009)
Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse.
L. Li (1994)
Apoptosis-Suppressor Gene bcl-2 Expression after Traumatic Brain Injury in Rats
R. Clark (1997)
Repair of ruptured spinal nerve roots in a brachial plexus lesion. Case report.
T. Carlstedt (1995)
Sensory disturbances and pain complaints after brachial plexus root injury: A prospective study involving 150 adult patients
J. Bertelli (2011)
CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport
W. Pardridge (1998)
A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
J. Ham (1995)
Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro
L. Lv (2012)
against programmed cell death
Y Tsujimoto (1995)
The effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult rat.
Y. Gu (1997)
Combined Use of Carboxyl-Directed Protein Pegylation and Vector-Mediated Blood-Brain Barrier Drug Delivery System Optimizes Brain Uptake of Brain-Derived Neurotrophic Factor Following Intravenous Administration
W. Pardridge (2004)
Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo
L. Novikov (1997)
The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS
G. Chen (1999)
Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures
H. Gibbons (2011)
Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat
A. McKay Hart (2001)
Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells
T. Pan (2005)
The cellular and molecular basis of peripheral nerve regeneration
S. Y. Fu (2007)
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
Y. Tsujimoto (1986)
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?
M. Dragunow (1993)
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
G. Raivich (2004)
Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat
Huaiyu Gu (2005)
Axonal regeneration and motor neuron survival after microsurgical nerve reconstruction
Ida K. Fox (2012)

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