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Intrinsic Laryngeal Muscles Are Spared From Degeneration In The Dy3k/dy3k Mouse Model Of Congenital Muscular Dystrophy Type 1A

M. Häger, M. Durbeej
Published 2009 · Medicine

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Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (MDC1A). Here, we analyzed whether the intrinsic laryngeal muscles (ILM) are spared in the dy3K/dy3K mouse model of complete laminin α2 chain absence. No muscle degeneration was evident; expression of various laminin chains was similar to that of limb muscles, and sustained integrin α7B expression was noted in laminin α2 chain‐deficient ILM. We conclude that ILM are spared in MDC1A. Muscle Nerve 39: 91–94, 2009
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