Online citations, reference lists, and bibliographies.

Safety And Efficacy Of Shilajit (mumie, Moomiyo).

S. Stohs
Published 2014 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Shilajit (mumie; moomiyo, mummiyo) has been used for a wide variety of illnesses and conditions for many years. However, relatively few well-controlled human studies have been conducted on the effects of shiliajit, although a growing number of studies have been published in recent years involving animal and in vitro systems. The safety of shilajit is well documented based on animal and human studies. Various research studies indicate that shilajit exhibits antioxidant, anti-inflammatory, adaptogenic, immunomodulatory, and anti-dyslipidemic properties. Animal and human studies indicate that shilajit enhances spermatogenesis. Furthermore, animal and human data support its use as a 'revitalizer', enhancing physical performance and relieving fatigue with enhanced production of ATP. Key constituents in shilajit responsible for these effects appear to be dibenzo-α-pyrones and fulvic acid and their derivatives. Various mechanistic studies provide support for the above observed effects. Additional well-controlled human and animal studies involving the use of standardized products are needed.
This paper references
10.1002/ptr.2650050505
The need for formulation of Shilajit by its isolated active constituents
Shibnath Ghosal (1991)
Pharmacology of shilajit
SB Acharya (1988)
Shilajit dibenzo-apyrones: mitochondria targeted antioxidants
S Bhattacharayya (2009)
10.4196/kjpp.2011.15.5.285
Glycine- and GABA-mimetic Actions of Shilajit on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice.
H. Yin (2011)
10.1002/ptr.2650090703
Shilajit-induced potentiation of the hypoglycaemic action of insulin and inhibition of streptozotocin induced diabetes in rat†
Narayanasamy Kanikkannan (1995)
Treatment of long tubular bone fractures with mumie and preparation and experimental and clinical conditions
NS Kelginbaev (1973)
BENEFICIAL EFFECT OF PROCESSED SHILAJIT ON SWIMMING EXERCISE INDUCED IMPAIRED ENERGY STATUS OF MICE
S. Bhattacharyya (2009)
SHILAJIT: EVALUTION OF ITS EFFECTS ON BLOOD CHEMISTRY OF NORMAL HUMAN SUBJECTS
P. Sharma (2003)
10.1016/0048-9697(87)90521-3
Effect of humic substances on mitochondrial respiration and oxidative phosphorylation.
Simon A. Visser (1987)
10.1007/s10616-010-9333-6
Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid
Hideko Motojima (2010)
Treatment of long tubular bone fractures with Mumie Assil preparations in experiments and clinical conditions
Kel'ginbaev Ns (1973)
Safe use of shilajit during pregnancy in female mice
A Al-Hamaidi (2003)
10.1155/2012/674142
Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
Carlos Carrasco-Gallardo (2012)
10.1002/ptr.2465
Shilajit in Perspective
Elizabeth Williamson (2009)
Safe use of shilajit during pregnancy in female mice.Online
A Al-Hamaidi (2003)
Effect of humic acid substances on mitochondrial respiration and oxidative phosphorylation
Visser SA. (1987)
Glycine- and GABAminetic actions of shilajit on the substantia gelatinosa neurons of the trigeminal subnucleus caudatis in mice
EJ Yin H. Yang (2011)
10.1002/PTR.857
Effects of Shilajit on the development of tolerance to morphine in mice.
P. Tiwari (2001)
Shilajit: Evaluation of its effects on blood chemistry of normal human subjects
P Sharma (2003)
10.1093/ajcn/72.2.624S
Selected herbals and human exercise performance.
Luke R. Bucci (2000)
10.1002/ptr.2650090110
Shilajit attenuates streptozotocin induced diabetes mellitus and decrease in pancreatic islet superoxide dismutase activity in rats
S. Bhattacharya (1995)
10.4103/0971-6580.72668
Oxidative Stress Induced by Lead and Antioxidant Potential of Certain Adaptogens in Poultry
M. Kumar (2010)
10.1016/0378-8741(90)90102-Y
Antiulcerogenic and antiinflammatory studies with shilajit.
R. Goel (1990)
Application of mumie in therapeutic practice (in Russian)
VE Anisimov (1982)
10.1177/1557988312462738
Parasympathomimetic Effect of Shilajit Accounts for Relaxation of Rat Corpus Cavernosum
S. Kaur (2013)
10.1111/j.1439-0272.2009.00956.x
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia
T. K. Biswas (2010)
10.1016/S0197-0186(96)00025-3
Systemic administration of defined extracts from Withania somnifera (Indian ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain
R. Schliebs (1997)
Antiulcerogenic and antiinflammatory studieswith shilajit.J Ethnopharmacol29: 95–103
RK Goel (1990)
10.1002/ptr.2650070608
Effect of Shilajit on mouse peritoneal macrophages
S. Bhaumik (1993)
10.1016/j.jep.2012.06.002
Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats.
Dinesh Kumar Surapaneni (2012)
PrimaVie
S. Raju (2012)
Antiulcerogenic and anti - inflammatory studieswith shilajit
RK Goel (1990)
10.1002/PTR.2100
Shilajit: a review.
S. Agarwal (2007)
10.1007/BF02334644
Chemical composition of mumijo and methods for determining its authenticity and quality (a review)
L. Frolova (2006)
10.1016/j.jep.2011.04.033
Review on shilajit used in traditional Indian medicine.
E. Wilson (2011)
10.1016/J.JEP.2006.03.039
The spermatogenic and ovogenic effects of chronically administered Shilajit to rats.
Jeong-Sook Park (2006)
Shilajit-induced potentiation of the hypoglycemic action of insulin and inhibition of streptozotocin induceddiabetes in rats.Phytother
N Kanikkannan (1994)
10.1007/BF00760687
Industrial synthesis of isovaleric acid
A. V. Luk'yanov (2004)
10.1002/ptr.2650090308
Shilajit induced morphometric and functional changes in mouse peritoneal macrophages
Shibnath Ghosal (1995)
10.1021/JF021101E
Characterization and biological activities of humic substances from mumie.
I. Schepetkin (2003)
10.1002/DDR.10058
Medical drugs from humus matter: Focus on mumie
I. Schepetkin (2002)



This paper is referenced by
10.1016/j.cimid.2020.101505
Immunostimulant effect of a mixed herbal extract on infectious bursal disease virus (IBDV) vaccinated chickens in the context of a co-infection model of avian influenza virus H9N2 and IBDV.
Abdelfattah H. Eladl (2020)
10.1515/hmbci-2019-0040
Hepatoprotective effects of Shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats
Baran Ghezelbash (2020)
10.12991/JRP.2019.178
Optimization of the conditions of the extraction and purification stages of the Shilajit substance
Fedor Bugaev (2019)
10.1201/B19308-47
Sexual Dysfunctions and Nutraceutical Therapy: An Examination of Human Research
G. Bruno (2015)
Effects of asphaltum (shilajit) combined with vitamin E and selenium on the reproductive parameters of female rabbits.
Muhammad Idrees (2016)
Effect of Shilajit on the Levels of Pro-inflammatory and Anti-inflammation Cytokines in Hepatic Injury in Male Rats
Farhood Ghaaazi Firozsalari (2018)
10.1089/jmf.2016.0010
The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation.
Amitava Das (2016)
10.1016/B978-0-12-802147-7.00013-9
Nutraceuticals in Arthritis
Ramesh C. Gupta (2016)
10.2174/1573401313666170823160217
Shilajit (Mumie): Current Status of Biochemical, Therapeutic and Clinical Advances
Tanuja Mishra (2019)
10.4236/OJVM.2016.67016
Comparative Evaluation of Different Treatment for Purulent Wounds in Dogs
Ahmad Massoud Niazi (2016)
10.31661/gmj.v9i0.1743
Health Beneficial Effects of Moomiaii in Traditional Medicine
Solmaz Rahmani Barouji (2020)
10.1016/B978-0-12-802147-7.00051-6
Chapter 51 – Shilajit
Shailesh K. Bhavsar (2016)
10.1002/ptr.5591
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.
A. Izzo (2016)
10.1080/07315724.2018.1564088
Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms
Amitava Das (2019)
DOES SHILAJIT HAVE AN EFFECT ON NEW BONE REMODELLING IN THE RAPID MAXILLARY EXPANSION TREATMENT ? A BIOCHEMICAL , HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
Mine Geçgelen Cesur (2019)
Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains.
M. Jafari (2019)
10.1111/and.13064
Profertility effects of Shilajit on cadmium‐induced infertility in male mice
R. Mishra (2018)
10.1186/s12970-019-0270-2
The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels
Joshua L Keller (2019)
10.1007/s00404-015-3924-6
Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries
M. Keçeci (2015)
10.4172/2155-9600.1000547
Protection against Gluten-mediated Tight Junction Injury with a NovelLignite Extract Supplement
J. Gildea (2016)
10.1016/B978-0-12-805413-0.00012-0
Energy and Health Benefits of Shilajit
S. Stohs (2017)
Semantic Scholar Logo Some data provided by SemanticScholar