Copper(I) Bromide Promoted Reaction Of Grignard Compounds With Propiolaldehyde Diethyl Acetal. An Efficient Synthesis Of Allenic Ethers And α,β-ethylenic Aldehydes
Published 2010 · Chemistry
Interaction between ethereal solutions of Grignard compounds RMgBr and propiolaldehyde diethyl acetal I in the presence of copper(I) bromide gives allenic ethers, III. Acid hydrolysis affords trans-α,β-ethylenic aldehydes, IV, in good to excellent yields.