Online citations, reference lists, and bibliographies.
← Back to Search

Co-delivery Of Doxorubicin And Bcl-2 SiRNA By Mesoporous Silica Nanoparticles Enhances The Efficacy Of Chemotherapy In Multidrug-resistant Cancer Cells.

A. M. Chen, Min Zhang, Dongguang Wei, Dirk Stueber, O. Taratula, T. Minko, H. He
Published 2009 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Development of multidrug resistance in cancer cells and adverse side effects are the major obstacles for effective cancer chemotherapy.[1-3] Therapeutic strategies to overcome drug resistance and specific tumor targeting with minimal premature drug release should have a great impact on the treatment of cancer. The term multidrug resistance (MDR) is used to define a resistance phenotype where cancer cells become resistant simultaneously to multiple drugs with no obvious structural resemblance and with different molecular targets.[4, 5] The multidrug resistance can be divided into two distinct classes, pump and nonpump resistance.[3] The pump resistance is caused by certain proteins that form membrane-bound ATP-dependent active drug efflux pumps, which significantly decrease the intracellular concentration of the drug and thereby the efficacy of the treatment. Membrane proteins, P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) have been shown to be the main players for pump resistance to a broad range of structurally and functionally distinct cytotoxic agents.[6] The main mechanism of nonpump resistance is an activation of cellular antiapoptotic defense, mainly by Bcl-2 protein. Most of the anticancer drugs trigger apoptosis and simultaneously activate both pump and nonpump cellular defense of multidrug resistance, which prevents cell death. Therefore, to effectively suppress the overall resistance to chemotherapy, it is essential to simultaneously inhibit both pump and nonpump mechanisms of cellular resistance by targeting all the intracellular molecular targets.[3, 7-9]
This paper references
10.1038/nature02870
Unlocking the potential of the human genome with RNA interference
G. Hannon (2004)
10.1093/nar/gkn342
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
R. Juliano (2008)
10.1038/nrd2742
Knocking down barriers: advances in siRNA delivery
K. Whitehead (2009)
10.1023/A:1022687617318
Simultaneous Modulation of Multidrug Resistance and Antiapoptotic Cellular Defense by MDR1 and BCL-2 Targeted Antisense Oligonucleotides Enhances the Anticancer Efficacy of Doxorubicin
R. I. Pakunlu (2004)
10.1007/BF02905214
Diagnostics of multidrug resistance in cancer.
G. Szakács (1998)
Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases.
W. Peters (1992)
10.1038/78523
Enhancement of transfection by physical concentration of DNA at the cell surface
D. Luo (2000)
10.1016/J.BIOMATERIALS.2007.10.018
Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch.
I. Park (2008)
10.1089/DNA.2005.24.805
Enhanced sensitivity of human hepatoma cells to 5-fluorouracil by small interfering RNA targeting Bcl-2.
T. Kanda (2005)
10.1021/ja800086u
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging.
M. Yezhelyev (2008)
10.1038/nm1486
In vivo imaging of siRNA delivery and silencing in tumors
Z. Medarova (2007)
10.1021/JA046275M
A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent.
D. R. Radu (2004)
10.1073/pnas.1233634100
Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
Mini P. Thomas (2003)
10.1089/154545703322460586
Water-soluble polycationic dendrimers with a phosphoramidothioate backbone: preliminary studies of cytotoxicity and oligonucleotide/plasmid delivery in human cell culture.
M. Maszewska (2003)
10.1023/A:1018959029186
Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells
T. Minko (2004)
10.1016/J.CHEMBIOL.2004.06.006
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells.
Ya-Lin Chiu (2004)
10.1074/JBC.M200378200
Differential Regulation of Doxorubicin-induced Mitochondrial Dysfunction and Apoptosis by Bcl-2 in Mammary Adenocarcinoma (MTLn3) Cells*
M. Huigsloot (2002)
10.1158/0008-5472.CAN-04-0001
Enhancement of the Efficacy of Chemotherapy for Lung Cancer by Simultaneous Suppression of Multidrug Resistance and Antiapoptotic Cellular Defense
R. I. Pakunlu (2004)
10.1038/nrc706
Multidrug resistance in cancer: role of ATP–dependent transporters
M. Gottesman (2002)
10.1002/(SICI)1097-0215(20000401)86:1<108::AID-IJC17>3.0.CO;2-8
Efficacy of the chemotherapeutic action of HPMA copolymer‐bound doxorubicin in a solid tumor model of ovarian carcinoma
T. Minko (2000)
10.1002/ijc.20754
Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity
J. Menéndez (2005)
10.1021/BI00655A006
Interaction specificity of the anthracyclines with deoxyribonucleic acid.
E. Gabbay (1976)
10.1158/1078-0432.CCR-04-1049
Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer
J. Yano (2004)
10.1124/jpet.106.101154
A Mechanistic Study of Enhanced Doxorubicin Uptake and Retention in Multidrug Resistant Breast Cancer Cells Using a Polymer-Lipid Hybrid Nanoparticle System
H. L. Wong (2006)
10.1038/bjc.1993.244
Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.
H. Coley (1993)
10.1038/nnano.2007.108
Mesoporous silica nanoparticles deliver DNA and chemicals into plants.
F. Torney (2007)
10.1016/0959-8049(96)00051-2
Glutathione and related enzymes in multidrug resistance.
M. O'Brien (1996)
10.1002/SMLL.200700005
Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs.
J. Lu (2007)
10.1073/PNAS.0504926102
Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain.
D. Bharali (2005)
10.1016/S0959-8049(05)80025-5
Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture.
S. Bennis (1994)
Petfrs WHM, d Vries EGE
C Meijer (1991)
Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.
D. Goren (2000)
10.1038/sj.cgt.7700706
Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
R. Lima (2004)
10.1016/J.BIOPHA.2005.01.003
Mechanism of multidrug resistance in relation to passive membrane permeation.
G. Eytan (2005)
10.1016/S0168-3659(02)00016-0
Differences in the intracellular fate of free and polymer-bound doxorubicin.
O. Hovorka (2002)
10.1158/0008-5472.CAN-08-1468
Drug delivery with carbon nanotubes for in vivo cancer treatment.
Zhuang Liu (2008)
10.1021/BC049851C
pH-Responsive copolymer assemblies for controlled release of doxorubicin.
E. Gillies (2005)
10.1038/NMAT1737
Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer
Y. Wang (2006)
10.1002/ANIE.200604295
siRNA delivery into human T cells and primary cells with carbon-nanotube transporters.
Zhuang Liu (2007)
10.1016/S0163-7258(99)00073-X
Resistance mechanisms associated with altered intracellular distribution of anticancer agents.
A. Larsen (2000)
10.1073/pnas.0805374105
Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
Elena A. Dubikovskaya (2008)
10.1002/IJC.2910490419
Combined in vitro modulation of adriamycin resistance
C. Meijer (1991)



This paper is referenced by
10.1021/ACSBIOMATERIALS.5B00305
Targeting Wnt canonical signaling by recombinant sFRP1 bound luminescent Au-nanocluster embedded nanoparticles in cancer theranostics
Archita Ghoshal (2015)
10.1016/j.addr.2020.02.005
Nanotechnology approaches in the current therapy of skin cancer.
L. N. Borgheti-Cardoso (2020)
10.1021/ACS.JPCC.6B06759
Dual-Responsive Mesoporous Silica Nanoparticles Mediated Codelivery of Doxorubicin and Bcl-2 SiRNA for Targeted Treatment of Breast Cancer
X. Zhou (2016)
10.1002/smll.201602697
Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer.
Y. Li (2017)
10.1517/17425247.2012.683173
Nanocarrier systems for delivery of siRNA to ovarian cancer tissues
Eshrat Gharaei Fathabadi (2012)
10.1016/j.addr.2013.09.017
Nanotechnology approaches for personalized treatment of multidrug resistant cancers.
T. Minko (2013)
10.1016/j.biotechadv.2014.05.006
Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers.
Vasilios Tsouris (2014)
10.1016/j.ab.2016.12.004
Synthesis of silica-PAMAM dendrimer nanoparticles as promising carriers in Neuro blastoma cells.
O. Yesil-Celiktas (2017)
10.1177/0885328217737187
Fabrication of self-assembled folate–biotin-quaternized starch nanoparticles as co-carrier of doxorubicin and siRNA
Liangping Li (2017)
10.5772/intechopen.90430
P-Glycoprotein Efflux Transporters and Its Resistance Its Inhibitors and Therapeutic Aspects
Chenmala Karthika (2020)
10.1016/j.biomaterials.2013.01.051
Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation.
S. Shen (2013)
10.7150/thno.13130
Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375
Tan Yang (2016)
Nanoparticle delivery of siRNA for cancer therapy
Yunching Chen (2010)
10.1016/j.biomaterials.2011.07.032
Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles.
H. Wang (2011)
10.1016/j.bioactmat.2020.09.015
Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids
Dan Li (2021)
10.1007/s12274-017-1961-0
Nanomaterial-assisted sensitization of oncotherapy
Yufei Wang (2018)
10.1016/j.bbagen.2010.04.007
Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation.
A. Kunzmann (2011)
10.1016/J.JSSC.2011.10.037
Transition metal-chelating surfactant micelle templates for facile synthesis of mesoporous silica nanoparticles
Hye Sun Lee (2012)
10.2174/138920112800624418
Nanocarriers for the simultaneous co-delivery of therapeutic genes and anticancer drugs.
N. Choudhury (2012)
10.1039/c2nr31853a
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy.
Yuling Xiao (2012)
10.1201/B12959-5
Mesoporous Ceramics as Drug Delivery Systems
María Vallet-Regí (2012)
10.1007/978-1-4614-7876-8_15
Nanotherapeutics in Multidrug Resistance
Min Han (2013)
10.1080/10717544.2016.1228716
A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy
S. Wu (2017)
10.1016/j.biomaterials.2017.04.028
Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer.
L. Sun (2017)
10.2147/IJN.S174068
Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer
Tuğba Yildiz (2018)
10.1517/17425247.2011.547470
Drug delivery systems for differential release in combination therapy
Hongbin Zhang (2011)
10.1007/978-3-030-26672-1_2
Therapeutic Use of Inorganic Nanomaterials in Malignant Diseases
A. Lupu (2020)
10.1007/978-981-13-6004-6_3
Nanomaterials-Based siRNA Delivery: Routes of Administration, Hurdles and Role of Nanocarriers
N. Gupta (2019)
PROOF COVER SHEET
S. K. Pindiprolu ()
10.1002/adhm.201300607
Tumor-targeting multifunctional nanoparticles for siRNA delivery: recent advances in cancer therapy.
S. H. Ku (2014)
10.1201/B19205-22
PSi Substrates for Raman, Terahertz, and Atomic Absorption Spectroscopy
G. Korotcenkov (2016)
10.3389/fmolb.2020.00193
Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance
Yihan Yao (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar