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Effect Of Surface Properties On Nanoparticle-cell Interactions.
Ayush Verma, F. Stellacci
Published 2010 · Materials Science, Medicine
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The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.
This paper references
Quantifying the Influence of Surface Coatings on Quantum Dot Uptake in Cells
E. Chang (2005)
Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles.
Y. Hu (2007)
S P Hong (2004)
Targeting of nanoparticles to the clathrin-mediated endocytic pathway.
Oshrat Harush-Frenkel (2007)
Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles.
I. El-Sayed (2006)
Nanoparticles of Compacted DNA Transfect Postmitotic Cells*
G. Liu (2003)
Enhancement of Intracellular Delivery of CdTe Quantum Dots (QDs) to Living Cells by Tat Conjugation
F. Xue (2006)
Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers.
A. Mecke (2005)
Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal.
H. Mok (2008)
Intracellular delivery of core-shell fluorescent silica nanoparticles.
Jason E. Fuller (2008)
Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview.
R. Shukla (2005)
Nanoparticle-induced surface reconstruction of phospholipid membranes
B. Wang (2008)
Multiplexed screening of cellular uptake of gold nanoparticles using laser desorption/ionization mass spectrometry.
Zheng-Jiang Zhu (2008)
Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics.
J. West (2003)
Aggregation-resistant water-soluble gold nanoparticles.
Layal L Rouhana (2007)
Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport.
Seungpyo Hong (2004)
Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating.
C. Wilhelm (2003)
Cell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives
Leena N. Patel (2007)
Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers.
Pascale R. Leroueil (2008)
Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group.
A. Mecke (2005)
Knocking down barriers: advances in siRNA delivery
K. Whitehead (2009)
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
N. Rosi (2006)
The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells.
Ángeles Villanueva (2009)
In vitro and intracellular production of peptide-encapsulated fluorescent silver nanoclusters.
J. Yu (2007)
Targeting and penetration of virus receptor bearing cells by nanoparticles coated with envelope proteins of Moloney murine leukemia virus.
Drew C Deniger (2006)
Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
Mini P. Thomas (2002)
In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.
L. Mortensen (2008)
Interaction of nanoparticles with lipid membrane.
Y. Roiter (2008)
Synthesis, characterization, and intracellular uptake of carboxyl-terminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles.
X. Shi (2007)
Multifunctional gold nanoparticle-peptide complexes for nuclear targeting.
A. Tkachenko (2003)
Study on the endocytosis and the internalization mechanism of aminosilane-coated Fe3O4 nanoparticles in vitro
Yong-jie Ma (2007)
Quantum dot-insect neuropeptide conjugates for fluorescence imaging, transfection, and nucleus targeting of living cells.
V. Biju (2007)
Transmembrane delivery of the cell-penetrating peptide conjugated semiconductor quantum dots.
B. Chen (2008)
Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators.
Jessica P. Ryman-Rasmussen (2007)
L. N. Patel (1977)
Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells
J. Xie (2007)
Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake.
K. Zhang (2008)
High-generation polycationic dendrimers are unusually effective at disrupting anionic vesicles: membrane bending model.
Z. Zhang (2000)
Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate.
T. Takeuchi (2006)
The intracellular uptake ability of chitosan-coated Poly (D,L-lactideco-glycolide) nanoparticles
B. Kim (2008)
Enhanced cell uptake of superparamagnetic iron oxide nanoparticles functionalized with dendritic guanidines.
A. L. Martin (2008)
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles.
Ayush Verma (2008)
Examination of nonendocytotic bulk transport of nanoparticles across phospholipid membranes.
S. K. Banerji (2007)
Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivatized surface coatings.
Brad A. Kairdolf (2008)
Defect Formation Induced by PAMAM Dendrimers on Pt-Supported Bilayer Lipid Membranes Investigated by Electrochemistry
W. Huang (2003)
Enhanced Introduction of Gold Nanoparticles into Vital Acidothiobacillus ferrooxidans by Carbon Nanotube-based Microwave Electroporation
J. Rojas-Chapana (2004)
Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential.
Swanand D. Patil (2007)
Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant.
E. Cho (2009)
Dendritic cell uptake of iron‐based magnetic nanoparticles
G. Goya (2008)
Photoregulated release of caged anticancer drugs from gold nanoparticles.
Sarit S Agasti (2009)
Uptake and intracellular fate of surface-modified gold nanoparticles.
P. Nativo (2008)
Direct gene transfer into mouse muscle in vivo.
J. Wolff (1990)
Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.
J. Green (2007)
Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.
D. Giljohann (2007)
Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides.
Igor L. Medintz (2008)
Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells.
Y. Hu (2007)
The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells.
Tsai-Hua Chung (2007)
Functional gold nanoparticle-peptide complexes as cell-targeting agents.
Linlin Sun (2008)
Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles.
Shilpa Sant (2008)
Biodegradable nanoparticles for drug and gene delivery to cells and tissue.
J. Panyam (2003)
Molecular Imaging in Cancer
R. Weissleder (2006)
Notice of Violation of IEEE Publication Principles Nuclear Localization of HIV-1 Tat Functionalized Gold Nanoparticles
C. Berry (2007)
Intracellular trafficking of magnetic nanoparticles to design multifunctional biovesicles.
C. Wilhelm (2008)
Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes.
B. Chithrani (2007)
The cell penetrating peptides pVEC and W2-pVEC induce transformation of gel phase domains in phospholipid bilayers without affecting their integrity.
M. E. Herbig (2006)
Quantification of the force of nanoparticle-cell membrane interactions and its influence on intracellular trafficking of nanoparticles.
Jaspreet K. Vasir (2008)
PEG-ylated cationic CdSe/ZnS QDs as an efficient intracellular labeling agent.
Junghan Lee (2008)
Regulated portals of entry into the cell
S. Conner (2003)
Molecular Effects of Uptake of Gold Nanoparticles in HeLa Cells
J. Khan (2007)
Understanding biophysicochemical interactions at the nano-bio interface.
A. Nel (2009)
PAMAM dendrimer interactions with supported lipid bilayers: a kinetic and mechanistic investigation.
Srinivas Parimi (2008)
Peptide antisense nanoparticles
Pinal C. Patel (2008)
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
B. Chithrani (2006)
Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding.
G. Ruan (2007)
Cellular interactions of lauric acid and dextran-coated magnetite nanoparticles
P. Pradhan (2007)
Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability.
Seungpyo Hong (2006)
Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells.
P. Thoren (2003)
Cell-penetrating peptides: mechanism and kinetics of cargo delivery.
M. Zorko (2005)
Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?
Pascale R. Leroueil (2007)
Nanoparticle-mediated cellular response is size-dependent.
W. Jiang (2008)
Gold nanoparticle-mediated transfection of mammalian cells.
Kulmeet K Sandhu (2002)
This paper is referenced by
Cellular uptake of nanoparticles by membrane penetration: a study combining confocal microscopy with FTIR spectroelectrochemistry.
T. Wang (2012)
Chitosan-based gene delivery vectors targeted to the peripheral nervous system.
Hugo Oliveira (2010)
Silver nanoparticles produced by laser ablation for a study on the effect of SERS with low laser power on N719 dye and Rhodamine-B
Nelson Fabian Villegas Borrero (2019)
Nanobubble-Affibody: Novel ultrasound contrast agents for targeted molecular ultrasound imaging of tumor.
Hengli Yang (2015)
Drug Targeting Strategies Based on Charge Dependent Uptake of Nanoparticles into Cancer Cells.
Maryam Saadat (2019)
Exploring the Plasma Membrane via Computer Simulations
Fabio Lolicato (2020)
Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA
Q. Zheng (2020)
Mapping the surface adsorption forces of nanomaterials in biological systems.
Xin R. Xia (2011)
Beauty is skin deep: a surface monolayer perspective on nanoparticle interactions with cells and bio-macromolecules.
K. Saha (2011)
Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling.
Z. Qu (2013)
Facile synthesis and direct characterization of surface-charge-controlled magnetic iron oxide nanoparticles and their role in gene transfection in human leukemic T cell
Hee-Kyung Na (2019)
Quantitative Analysis of the Correlation between Cell Size and Cellular Uptake of Particles.
Jawahar Khetan (2019)
In Vivo Pharmacokinetics of Magnetic Nanoparticles.
C. Caro (2018)
Reshma J. Nevagi (2018)
Organically Modified Silica Nanoparticles Interaction with Macrophage Cells: Assessment of Cell Viability on the Basis of Physicochemical Properties.
D. Kumar (2015)
Cells on hierarchically-structured platforms hosting functionalized nanoparticles.
C. Simitzi (2018)
SERS and integrative imaging upon internalization of quantum dots into human oral epithelial cells.
E. Cepeda-Pérez (2016)
Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice.
F. Silva (2016)
Differential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant.
Karin Binnemars-Postma (2016)
Phosphorylated Peptide Functionalization of Lanthanide Upconversion Nanoparticles for Tuning Nanomaterial-Cell Interactions.
Chi Yao (2016)
Dextran Coated Cerium Oxide Nanoparticles for Inhibiting Bone Cancer Cell Functions
Ece Alpaslan (2015)
A simple method of growing silver chloride nanocubes on silver nanowires.
H. H. Khaligh (2015)
Lignin Nanoparticle as a Novel Green Carrier for the Efficient Delivery of Resveratrol
Lin Dai (2017)
Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.
Sai Archana Krovi (2012)
Hollow chitosan–silica nanospheres for doxorubicin delivery to cancer cells with enhanced antitumor effect in vivo
E. Yan (2011)
Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel
H. Y. Yoon (2019)
Three-layered polyplex as a microRNA targeted delivery system for breast cancer gene therapy.
Y. Li (2017)
Controlling colloidal stability of silica nanoparticles during bioconjugation reactions with proteins and improving their longer-term stability, handling and storage.
C. Moore (2015)
Enhanced Antimicrobial Activity of Biofunctionalized Zirconia Nanoparticles
M. Khan (2020)
Assembly of selective biomimetic surface on an electrode surface: a design of nano-bio interface for biosensing.
T. Gao (2015)
Investigation the cytotoxicity and photo-induced toxicity of carbon dot on yeast cell.
Z. Bagheri (2018)
Charging and discharging of single colloidal particles at oil/water interfaces
P. Gao (2014)See more