Online citations, reference lists, and bibliographies.
← Back to Search

Anti‐Tumor Activity Of Doxorubicin‐loaded Boehmite Nanocontainers

Carmen Seidl, S. Simonato, E. Zittel, U. Schepers, C. Feldmann
Published 2019 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Doxorubicin-filled boehmite nanocontainers, DOX@γ-AlO(OH), with a mean diameter of 40 nm and a wall thickness of 10 nm are prepared via a microemulsion strategy and studied as drug carriers for cancer treatment. Nanocontainer structure and drug load are examined in detail based on different analytical tools. The DOX load is optimized on highest load at lowest side effects according to blood counts. Cell uptake, DOX-based fluorescence detection and systemic toxicity are evaluated based on in vitro and in vivo models. Toxicity and activity of the DOX@AlO(OH) nanocontainers are compared with non-filled AlO(OH) hollow spheres and free DOX as references and show promising results. An orthotopic breast cancer BALB/c mouse model validates the activity of DOX@AlO(OH) in vivo at lower side effects than for free DOX.
This paper references
10.1021/nn400769e
Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI.
Ying Chao (2013)
10.1039/C8RA06176A
Gold nanorod-based multifunctional nanocarrier for synergistic chemo-photothermal therapy in tumors
Y. Wang (2018)
10.1021/nn901181c
Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.
Jian You (2010)
10.1016/j.nano.2007.12.002
Fluorescence intensity and lifetime imaging of free and micellar-encapsulated doxorubicin in living cells.
Xiaowen Dai (2008)
10.1021/acsami.7b11423
Sequential Delivery of Doxorubicin and Zoledronic Acid to Breast Cancer Cells by CB[7]-Modified Iron Oxide Nanoparticles.
F. Benyettou (2017)
10.1111/j.2042-7158.2012.01567.x
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
Oktay Tacar (2013)
10.1038/491S58A
Nanotechnology: Carrying drugs
K. Bourzac (2012)
10.1021/acs.nanolett.9b00657
Facile Hydrophobization of siRNA with Anticancer Drug for Non-Cationic Nanocarrier-Mediated Systemic Delivery.
Congfei Xu (2019)
10.1021/nn900440e
Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy.
L. Ma (2009)
10.1021/ar200084x
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.
C. Tassa (2011)
10.1021/acsomega.8b00427
Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells
R. Jin (2018)
10.1021/acs.langmuir.8b02390
Delivery of Doxorubicin Using Double-Layered Core-Shell Nanocarrier Based on Magnetic Fe3O4 Core and Salep Shells.
S. H. Hosseini (2018)
10.1021/nn100816s
Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles.
Atul Asati (2010)
10.1021/ACSABM.9B00230
Efficient Co-delivery of Doxorubicin and Methotrexate by pH-Sensitive Dual-Functional Nanomicelles for Enhanced Synergistic Antitumor Efficacy
You-Mei Li (2019)
10.1021/acsnano.8b00932
Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials.
R. Freund (2018)
10.1021/ACSOMEGA.9B00870
A Composite of Hyaluronic Acid-Modified Graphene Oxide and Iron Oxide Nanoparticles for Targeted Drug Delivery and Magnetothermal Therapy
Nilkamal Pramanik (2019)
10.1021/acsami.7b03317
Bioreducible Polymer Nanocarrier Based on Multivalent Choline Phosphate for Enhanced Cellular Uptake and Intracellular Delivery of Doxorubicin.
W. Wang (2017)
10.1016/j.jconrel.2012.03.020
Doxil®--the first FDA-approved nano-drug: lessons learned.
Y. Barenholz (2012)
10.1021/acsnano.8b09786
Gold Cube-in-Cube Based Oxygen Nanogenerator: A Theranostic Nanoplatform for Modulating Tumor Microenvironment for Precise Chemo-Phototherapy and Multimodal Imaging.
X. Zhang (2019)
10.1002/anie.201903256
Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles.
Chuanqi Peng (2019)
10.1021/acsnano.7b03245
Engineering Compartmentalized Biomimetic Micro- and Nanocontainers.
T. Trantidou (2017)
10.1556/ABiol.62.2011.3.4
Effect of garlic on high fat induced obesity.
M. Kim (2011)
10.1021/NL072074F
Nanoscale γ-AlO(OH) Hollow Spheres: Synthesis and Container-Type Functionality
D. Buchold (2007)
10.1039/C8TB03198C
A novel pH-responsive hollow mesoporous silica nanoparticle (HMSN) system encapsulating doxorubicin (DOX) and glucose oxidase (GOX) for potential cancer treatment
Kaiwu Cheng (2019)
10.1002/ijc.25516
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
J. Ferlay (2010)
10.1021/acsnano.8b01921
On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent.
S. Lee (2018)
10.1557/MRS.2012.202
Fighting cancer with nanoparticle medicines - The nanoscale matters
M. Davis (2012)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1039/C2JM31609A
ZnO nanocontainers: structural study and controlled release
P. Leidinger (2012)
10.1021/acs.inorgchem.7b02697
Magnetic Metal-Organic Framework Composite by Fast and Facile Mechanochemical Process.
M. Bellusci (2018)
10.1038/s41565-018-0356-z
Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness
Fei Peng (2019)
10.1021/ACS.CHEMMATER.7B03735
Morphology Evolution and Spatially Selective Functionalization of Hierarchically Porous Silica Nanospheres for Improved Multidrug Delivery
N. Li (2017)
10.1002/anie.201505493
Isoniazid@Fe2 O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria.
P. Leidinger (2015)
10.1021/cr300009x
Bioinorganic chemistry of Alzheimer's disease.
Kasper P. Kepp (2012)
10.1039/c7tb02429k
Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery.
Mingyang Hei (2017)
10.1002/chem.201703498
Designed Synthesis of Au/Fe3 O4 @C Janus Nanoparticles for Dual-Modal Imaging and Actively Targeted Chemo-Photothermal Synergistic Therapy of Cancer Cells.
Q. Zhang (2017)
10.1038/nnano.2007.387
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
10.3891/ACTA.CHEM.SCAND.36A-0303
Deuteration of Crystalline Hydroxides. Hydrogen Bonds of gamma-AlOO(H,D) and gamma-FeOO(H,D).
A. N. Christensen (1982)
10.1080/1061186021000072447
Dose Dependency of Pharmacokinetics and Therapeutic Efficacy of Pegylated Liposomal Doxorubicin (DOXIL) in Murine Models
A. Gabizon (2002)
10.1021/ACS.CHEMMATER.7B02274
Chelation Competition Induced Polymerization (CCIP): A Binding Energy Based Strategy for Nonspherical Polymer Nanocontainers’ Fabrication
Siyuan Xiang (2017)
10.1039/C8TB00989A
A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy.
Lin Huang (2018)
10.1038/s41467-017-02088-w
Structural absorption by barbule microstructures of super black bird of paradise feathers
D. E. McCoy (2017)
10.1002/anie.201807158
Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled Drug Delivery, Release, and Imaging.
T. Senthilkumar (2018)
10.1111/j.1538-7836.2009.03477.x
Doxorubicin‐induced platelet cytotoxicity: a new contributory factor for doxorubicin‐mediated thrombocytopenia
E-J Kim (2009)
10.1002/ADFM.201703313
High‐Drug‐Loading Mesoporous Silica Nanorods with Reduced Toxicity for Precise Cancer Therapy against Nasopharyngeal Carcinoma
Yuanyuan You (2017)
10.1021/acsnano.8b06655
Spatial, Temporal, and Dose Control of Drug Delivery using Noninvasive Magnetic Stimulation.
Wei Chen (2019)
10.1002/anie.201604263
Microemulsions: Options To Expand the Synthesis of Inorganic Nanoparticles.
S. Wolf (2016)
10.1021/acsnano.8b05639
Regulation of Ca2+ Signaling for Drug-Resistant Breast Cancer Therapy with Mesoporous Silica Nanocapsule Encapsulated Doxorubicin/siRNA Cocktail.
S. Wang (2019)
10.1039/c8cc04363a
A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units.
P. Cui (2018)
10.1039/c3dt50659b
Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity.
B. Wang (2013)



Semantic Scholar Logo Some data provided by SemanticScholar