A Hippocampal Protein Associated With Paraneoplastic Neurologic Syndrome And Small Cell Lung Carcinoma.
K. Sakai, M. Gofuku, Y. Kitagawa, T. Ogasawara, G. Hirose, M. Yamazaki, C. S. Koh, N. Yanagisawa, L. Steinman
Published 1994 · Biology, Medicine
Download PDFAnalyze on Scholarcy
A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.
This paper is referenced by
A census of human RNA-binding proteins
Stefanie Gerstberger (2014)
Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy
Meleeneh Kazarian (2010)
Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis
H. Park (2000)
Antibody recognition and RNA binding of a neuronal nuclear autoantigen associated with paraneoplastic neurological syndromes and small cell lung carcinoma
T. Kumagai (1999)
Regulation and inflammatory effects of tristetraprolin in macrophages
U. Jalonen (2008)
Detection of HuD transcripts by means of reverse transcriptase and polymerase chain reaction: implications for the detection of minimal residual disease in patients with small cell lung cancer.
M. Torà (2000)
Interaction of a Paraneoplastic Cerebellar Degeneration-Associated Neuronal Protein with the Nuclear Helix-Loop-Helix Leucine Zipper Protein MRG X
K. Sakai (2002)
Alternative role of HuD splicing variants in neuronal differentiation.
S. Hayashi (2015)
Paraneoplastic encephalomyelitis: an update of the effects of the anti-Hu immune response on the nervous system and tumour
R. Voltz (1997)
Identification of specific protein-RNA target sites using libraries of natural sequences.
L. Andrews (1999)
EGF , epithelium and Misexpression of ELRB in Xenopus 295 Misexpression of the RNA-binding protein ELRB in Xenopus presumptive neurectoderm induces proliferation arrest and programmed cell death
M. Perron (1999)
Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development.
G. Clayton (1998)
Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer
V. D’alessandro (2008)
Two GC-rich boxes in huC promoter play distinct roles in controlling its neuronal specific expression in zebrafish embryos.
C. Zhao (2006)
HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts
D. Lazarova (1999)
Binding of neuronal ELAV‐like proteins to the uridine‐rich sequence in the 3′‐untranslated region of tumor necrosis factor‐α messenger RNA
K. Sakai (1999)
Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.
S. Gultekin (2000)
Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer.
Christian Kroun Damgaard (2013)
Identification of protein-RNA and protein-protein interactions by the neuronal HuC protein of Mus musculus.
Bradley Guy Simpson (2013)
Induction of cytotoxic T lymphocytes specific for paraneoplastic cerebellar degeneration-associated antigen in vivo by DNA immunization.
K. Sakai (2001)
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report
S. Ingber (2008)
酒井 宏一郎 (2008)
Reversible limbic encephalitis caused by ovarian teratoma
K. Nokura (1997)
Herpes encephalitis and paraneoplastic limbic encephalitis
K. Nagashima (1998)
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
C. Fletcher (1997)
Regulation of Neuronal Excitability by the RNA-Binding Protein Rbfox1
Celine K. Vuong (2017)
Neurologic paraneoplastic antibodies (anti‐Yo; anti‐Hu; anti‐Ri)
J. Dalmau (1994)
mRNA Stability and the Control of Gene Expression: Implications for Human Disease
E. Hollams (2004)
Paraneoplastic neurologic syndromes.
G. Hirose (1996)
Localization of the human HuR gene to chromosome 19p13.2
Wei-jun Ma (1996)
The molecular regulation of Hox gene RNA processing during Drosophila embryonic development
Casandra Edelweiss Villava Robles (2015)
Examination of the expanding pathways for the regulation of p21 expression and activity.
Yong-Sam Jung (2010)See more