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DOI: 10.1006/cbir.1993.1067

Inhibition Of An Endogenous Growth‐related Proteinase Enhances The Recovery Of A Negative Growth Regulator From Cultured Human Cells.

S. Manilal, G. K. Scott, C. Tse
Published 1993 · Biology, Medicine

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The possibility that a growth‐related proteinase may act by degrading a negative growth regulatory protein has been investigated. Proteinase inhibitors which inhibit the enzyme also enhance the accumulation of the growth regulator by human fibroblasts. The negative growth regulator shows a similar specificity of inhibition of cellular growth to inhibitors of the growth‐related proteinase.
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