Online citations, reference lists, and bibliographies.

Different Pathways Of Macromolecule Extravasation From Hyperpermeable Tumor Vessels.

D. Feng, J. Nagy, A. Dvorak, H. Dvorak
Published 2000 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Tumor microvessels are hyperpermeable to plasma proteins, a consequence of tumor cell-secreted vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). However, the pathways by which macromolecules extravasate from tumor vessels have been little investigated. To characterize tumor vessels more precisely and to elucidate the pathways by which macromolecules extravasated from them, we studied two well-defined, VPF/VEGF-secreting murine carcinomas, MOT and TA3/St. Whether grown in ascites or solid form, MOT tumors induced large, pericyte-poor "mother" vessels whose lining endothelium developed fenestrae that involved 1.8-5.6% of the surface. Fenestrae developed in parallel with markedly reduced endothelial cell vesiculo-vacuolar organelles (VVOs). TA3/St tumors, which secreted more VPF/VEGF than MOT tumors, elicited mother vessels with unchanged VVOs and without fenestrae. In both tumors, a plasma protein tracer, ferritin, extravasated through VVOs and in MOT tumors ferritin also extravasated through fenestrae. Endothelial gaps were not observed in either tumor. Thus, not all VPF/VEGF-secreting tumors induce fenestrated endothelium. Also, VVOs provide an internal store of membrane that can be transferred to the endothelial cell surface to provide the substantial increase in plasma membrane necessary for mother vessel formation in MOT tumors. Such transfer was apparently unnecessary in TA3/St tumors in which extensive early endothelial cell division provided the increased plasma membrane necessary for forming mother vessels.
This paper references
10.1126/science.3975602
Regulation of extravascular coagulation by microvascular permeability.
H. Dvorak (1985)
10.1113/jphysiol.1996.sp021287
Openings in frog microvascular endothelium induced by high intravascular pressures.
C. R. Neal (1996)
Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines.
D. Senger (1996)
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
H. Dvorak (1995)
10.1152/physrev.1983.63.4.1536
Cellular aspects of transcapillary exchange.
N. Simionescu (1983)
10.1002/aja.1001650206
Fetal and neonatal rat intestinal capillaries: permeability to carbon, ferritin, hemoglobin, and myoglobin.
A. Milici (1982)
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.
J. Grunstein (1999)
10.1016/S0002-9440(10)65668-4
Host microvasculature influence on tumor vascular morphology and endothelial gene expression.
W. Roberts (1998)
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor.
W. Roberts (1995)
First steps of tumor-related angiogenesis.
S. Paku (1991)
Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.
S. Kohn (1992)
10.1007/978-3-0348-9006-9
Regulation of Angiogenesis
I. Goldberg (1996)
10.1093/clinchem/38.1.71
Development of time-resolved immunofluorometric assay of vascular permeability factor.
K. T. Yeo (1992)
10.1016/0026-2862(87)90020-3
An analysis of the permeability of a fenestra.
J. Levick (1987)
Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.
K. T. Yeo (1993)
10.1091/mbc.3.2.211
Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.
B. Berse (1992)
10.1084/jem.176.5.1375
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing
L. F. Brown (1992)
10.1152/ajplung.1997.272.1.L155
Endothelial gaps: time course of formation and closure in inflamed venules of rats.
P. Baluk (1997)
Vascular endothelial growth factor. The trigger for neovascularization in the eye.
N. Ferrara (1995)
10.1002/jemt.1060060302
Procedural guide to specimen handling for the ultrastructural pathology service laboratory
A. Dvorak (1987)
10.1002/jlb.59.1.100
The vesiculo‐vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation
A. Dvorak (1996)
10.1111/J.1549-8719.1999.TB00085.X
Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators.
D. Feng (1999)
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.
J. Nagy (1995)
10.1111/J.1469-7793.1997.747BD.X
Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: many are transcellular pores.
D. Feng (1997)
10.1007/978-3-0348-9006-9_10
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
L. F. Brown (1997)
Neovasculature induced by vascular endothelial growth factor is fenestrated.
W. Roberts (1997)
Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice.
J. Nagy (1989)
10.1083/jcb.41.1.33
INTESTINAL CAPILLARIES: I. Permeability to Peroxidase and Ferritin
F. Clementi (1969)
Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity.
J. Nagy (1995)
10.1084/jem.183.5.1981
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin
D. Feng (1996)
10.1006/mvre.1996.0025
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Sybill Patan (1996)
10.1007/978-1-4613-0937-6
Endothelial Cell Biology in Health and Disease
N. Simionescu (1988)
10.1152/ajplung.1995.269.3.L403
Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy.
A. Hirata (1995)
Pathogenesis of malignant ascites formation: initiating events that lead to fluid accumulation.
J. Nagy (1993)
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation.
J. Nagy (1995)
10.1007/978-1-4613-0937-6_1
The Microvascular Endothelium Revisited
G. Palade (1988)
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation.
G. Breier (1992)
10.1113/jphysiol.1995.sp020977
Transcellular gaps in microvascular walls of frog and rat when permeability is increased by perfusion with the ionophore A23187.
C. R. Neal (1995)



This paper is referenced by
10.1200/JCO.2002.10.088
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.
H. Dvorak (2002)
10.1016/J.AANAT.2005.04.003
Endothelial vesiculo-vacuolar organelles, pockets and multi-layered fenestrated lamellae in the capillaries of the mouse carotid body.
Amina B El-Fadaly (2005)
Multivalent nanoparticles for the treatment of ocular diseases
R. Hennig (2016)
10.1046/J.1523-1755.2001.00721.X
Red cell traverse through thin glomerular basement membranes.
J. Collar (2001)
10.1186/1479-5876-7-51
Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors
H. Sarin (2009)
10.3390/ijms18030569
Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy
Yu-Guo Yuan (2017)
10.2353/ajpath.2009.090171
Vascular permeability and pathological angiogenesis in caveolin-1-null mice.
S. Chang (2009)
10.1016/j.biomaterials.2010.04.066
Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review.
F. Hallouard (2010)
Untersuchung neuartiger Substanzen auf antineoplastische und antiangiogene Eigenschaften beim testikulären Keimzelltumor
Benjamín Franklin (2013)
10.1016/J.CCR.2005.02.007
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
Ronit Satchi-Fainaro (2005)
10.1161/01.CIR.104.1.115
Angiogenesis Therapy: Amidst the Hype, the Neglected Potential for Serious Side Effects
S. Epstein (2001)
10.1016/j.bbrc.2008.12.129
VEGF-A and VEGF-F evoke distinct changes in vascular ultrastructure.
Y. Matsunaga (2009)
10.1016/J.CCR.2006.07.003
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Thuy L. Phung (2006)
10.2353/ajpath.2008.080014
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.
Axel M Küchler (2008)
10.1371/journal.pone.0002916
Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth
E. Gounaris (2008)
10.1038/sj.bjc.6602512
Elucidation of the tumoritropic principle of hypericin
M. Van de Putte (2005)
10.1016/S0360-3016(02)03920-2
DMXAA: an antivascular agent with multiple host responses.
B. Baguley (2002)
10.1096/fj.08-110494
Doxycycline induces membrane expression of VE‐cadherin on endothelial cells and prevents vascular hyperpermeability
O. Fainaru (2008)
10.1007/s00401-009-0541-0
Pathology and new players in the pathogenesis of brain edema
S. Nag (2009)
10.1038/SJ.NEO.7900238
Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.
A. Bogdanov (2002)
10.1101/SQB.2002.67.227
VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations.
J. Nagy (2002)
Roles in Angiogenesis and Arteriogenesis
J. Nagy (2003)
10.2174/0929867326666190517114450
Immunoliposomes in acute myeloid leukaemia therapy. An overview of possible targets and obstacles.
Aditi Singh (2019)
10.1016/S1050-1738(03)00056-2
VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.
J. Nagy (2003)
10.1146/ANNUREV.PATHOL.2.010506.134925
VEGF-A and the induction of pathological angiogenesis.
J. Nagy (2007)
10.1111/j.1600-0463.2004.apm1120904.x
Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites
I. Nascimento (2004)
10.1002/jcb.10399
Functional and molecular MR imaging of angiogenesis: Seeing the target, seeing it work
M. Neeman (2002)
10.1016/j.jconrel.2015.10.033
Multivalent nanoparticles bind the retinal and choroidal vasculature.
R. Hennig (2015)
Tumor interstitial fluid as modulator of cancer inflammation, thrombosis, immunity and angiogenesis.
Gianfranco Baronzio (2012)
10.1002/1096-9926(200101)63:1<42::AID-TERA1007>3.0.CO;2-K
Morphologic and histochemical study of blood capillaries in boar testes: effects of abdominal cryptorchidism.
E. Pinart (2001)
Angiogenesis and Antiangiogenic Treatment in Endometriosis
CC Vaduva (2019)
10.1201/B14002-6
Tumor Architecture and Targeted Delivery
Harold E. Dvorak (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar