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Areas 3a, 3b, And 1 Of Human Primary Somatosensory Cortex: 1. Microstructural Organization And Interindividual Variability

S. Geyer, A. Schleicher, K. Zilles
Published 1999 · Medicine, Psychology

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This study defines cytoarchitectonic areas 3a, 3b, and 1 of the human primary somatosensory cortex by objective delineation of cytoarchitectonic borders and ensuing cytoarchitectonic classification. This avoids subjective evaluation of microstructural differences which has so far been the only way to structurally define cortical areas. Ten brains were fixed in formalin or Bodian's fixative, embedded in paraffin, sectioned as a whole in the coronal plane at 20 microm, and cell stained. Cell bodies were segmented from the background by adaptive thresholding. Equidistant density profiles (125 microm wide, spacing 300 or 150 microm) were extracted perpendicularly to the pial surface across cortical layers II-VI and processed with multivariate statistical procedures. Positions of significant differences in shape between adjacent groups of profiles were correlated with the cytoarchitectonic pattern. Statistically significant borders can be reproduced at corresponding positions across a series of nearby sections. They match visible changes in cytoarchitecture in the cell-stained sections. Area 3a lies in the fundus of the central sulcus, and area 3b in the rostral bank of the postcentral gyrus. Area 1 lies on its crown and reaches down into the postcentral sulcus. Interareal borders, however, do not match macrostructural landmarks of the postcentral gyrus, and they considerably vary in their positions relative to these landmarks across different brains. Hence, only genuine microstructural analysis can define the borders between these cortical areas. Additional significant borders which do not correlate with visible changes in cytoarchitecture can be found within areas 3b and 1. They may represent somatotopy and/or cortical representations of different somatosensory receptors.
This paper references
The Developing European Computerized Human Brain Database for All Imaging Modalities
P. Roland (1996)
Automated image registration: II. Intersubject validation of linear and nonlinear models.
R. Woods (1998)
Gyri of the human neocortex: an MRI-based analysis of volume and variance.
D. Kennedy (1998)
Localization and variability of cytoarchitectonic areas in the human superior temporal cortex
J. Rademacher (1996)
Overlapping representation of fingers in the somatosensory cortex (area 2) of the conscious monkey
Y. Iwamura (1980)
Silver staining of cell bodies by means of physical development
B. Merker (1983)
Representations of the body surface in areas 3b and 1 of postcentral parietal cortex of cebus monkeys
D. Felleman (1983)
Human brain atlas: For high‐resolution functional and anatomical mapping
P. E. Roland (1994)
Brain atlases - a new research tool
P. Roland (1994)
Multiple representations of body movements in mesial area 6 and the adjacent cingulate cortex: An intracortical microstimulation study in the macaque monkey
G. Luppino (1991)
Broca's region revisited: Cytoarchitecture and intersubject variability
K. Amunts (1999)
Illusory Arm Movements Activate Cortical Motor Areas: A Positron Emission Tomography Study
E. Naito (1999)
In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior‐rostral sulci: Hemispheric asymmetries, gender differences and probability maps
T. Paus (1996)
ECHBD, a database for functional-structural and functional-functional relations in neuroimaging
P. Roland (1999)
Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping, and neurobiology.
J. Rademacher (1993)
Functions and structures of the motor cortices in humans
P. Roland (1996)
Functional magnetic resonance imaging of complex human movements
S. Rao (1993)
Possible involvement of primary motor cortex in mentally simulated movement: a functional magnetic resonance imaging study.
M. Roth (1996)
Microstructure and function of the primary somatosensory cortex of man. An integrative study using cytoarchitectonic mapping and PET
S. Geyer (1997)
Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach Coordinate System.
G. Rajkowska (1995)
Human cingulate and paracingulate sulci: pattern, variability, asymmetry, and probabilistic map.
T. Paus (1996)
Functional anatomy of the mental representation of upper extremity movements in healthy subjects.
K. Stephan (1995)
Use of implicit motor imagery for visual shape discrimination as revealed by PET
L. Parsons (1995)
Architectonics of the Human Telencephalic Cortex
P. D. H. Braak (1980)
Three-Dimensional Statistical Analysis of Sulcal Variability in the Human Brain
P. Thompson (1996)
A quantitative approach to cytoarchitectonics: Analysis of structural inhomogeneities in nervous tissue using an image analyser
A. Schleicher (1990)
Representations of the body surface in postcentral parietal cortex of Macaca fascicularis
R. Nelson (1980)
Mapping motor representations with positron emission tomography
J. Decety (1994)
Architecture of superior and mesial area 6 and the adjacent cingulate cortex in the macaque monkey
M. Matelli (1991)
Supplementary motor area and other cortical areas in organization of voluntary movements in man.
P. Roland (1980)
Variability in hand surface representations in areas 3b and 1 in adult owl and squirrel monkeys
M. Merzenich (1987)
A functional magnetic resonance imaging study of cortical regions associated with motor task execution and motor ideation in humans
M. Leonardo (1995)
Cytoarchitectural maps of the human brain in standard anatomical space
P. Roland (1997)
Two different areas within the primary motor cortex of man
S. Geyer (1996)
The isocortex of man
Percival Bailey (1951)
Observer-Independent Method for Microstructural Parcellation of Cerebral Cortex: A Quantitative Approach to Cytoarchitectonics
A. Schleicher (1999)
Architectonic and receptor autoradiographic mapping of the human primary somatosensory cortex
S. Geyer (1995)
Estimation of volume fractions in nervous tissue with an image analyzer
A. Wree (1982)
Functional magnetic resonance imaging at 1.5 T during sensorimotor and cognitive task.
P. Sabbah (1995)
Modular segregation of functional cell classes within the postcentral somatosensory cortex of monkeys.
M. Sur (1981)
Morphology, morphometry and probability mapping of the pars opercularis of the inferior frontal gyrus: an in vivo MRI analysis
F. Tomaiuolo (1999)
Histological Studies on the Localization of Cerebral Function
I. H. Coriat (1906)
Statistics of deformations in histology and application to improved alignment with MRI
T. Schormann (1995)
The columnar organization of the neocortex.
V. Mountcastle (1997)
Cortical surface modeling reveals gross morphometric correlates of individual differences
W. Loftus (1995)
Bilateral hand representation in the postcentral somatosensory cortex
Y. Iwamura (1994)
A New Approach to Fast Elastic Alignment with Applications to Human Brain
T. Schormann (1996)
A histologically visible representation of the fingers and palm in primate area 3b and its immutability following long-term deafferentations.
N. Jain (1998)
Representations of the body surface in cortical areas 3b and 1 of squirrel monkeys: Comparisons with other primates
M. Sur (1982)
A method of observer-independent cytoarchitectonic mapping of the human cortex
A. Schleicher (1995)
Limitations of the principal-axes theory
T. Schormann (1997)
The cytoarchitecture of the cerebral cortex of ateles: A critical examination of architectonic studies
K. Lashley (1946)
Representations of the face, teeth and oral cavity in areas 3b and 1 of somatosensory cortex in squirrel monkeys
C. Cusick (1986)
Structure of the human sensorimotor system. I: Morphology and cytoarchitecture of the central sulcus.
L. White (1997)
Normal variation in the frequency and location of human auditory cortex landmarks. Heschl's gyrus: where is it?
C. Leonard (1998)
Genetic variability of human brain size and cortical gyral patterns.
A. J. Bartley (1997)
Quantifying variability in the planum temporale: a probability map.
C. Westbury (1999)
Double representation of the body surface within cytoarchitectonic area 3b and 1 in “SI” in the owl monkey (aotus trivirgatus)
M. Merzenich (1978)
Cytoarchitectonic mapping of cortical areas on the first transverse temporal gyrus and intersubject variability
P. Morosan (1996)
Cortical blood vessels of the human brain
H. Duvernoy (1981)
Structural divisions and functional fields in the human cerebral cortex
P. Roland (1998)
Talairach: Co-planar stereotaxic atlas of the human brain
J. Talairach (1988)
Vergleichende Lokalisationslehre der Grosshirnrinde
Jelliffe. (1910)
Three‐Dimensional linear and nonlinear transformations: An integration of light microscopical and MRI data
T. Schormann (1998)
The insular cortex: morphological and vascular anatomic characteristics.
G. Varnavas (1999)
Involvement of primary motor cortex in motor imagery and mental practice
M. Hallett (1994)
Diversity in receptive field properties of vertical neuronal arrays in the crown of the postcentral gyrus of the conscious monkey
Y. Iwamura (2004)
A tension-based theory of morphogenesis and compact wiring in the central nervous system
D. Essen (1997)
Multimodal Image Coregistration and Partitioning—A Unified Framework
J. Ashburner (1997)
Anthropometric survey of the United Provinces, 1941: a statistical study.
P. C. Mahalanobis (1949)
Quantitative analysis of sulci in the human cerebral cortex: Development, regional heterogeneity, gender difference, asymmetry, intersubject variability and cortical architecture
K. Zilles (1997)
Neurophysiology of preparation, movement and imagery
J. Sanes (1994)
Primary Motor and Sensory Cortex Activation during Motor Performance and Motor Imagery: A Functional Magnetic Resonance Imaging Study
C. Porro (1996)
Modular distribution of neurons with slowly adapting and rapidly adapting responses in area 3b of somatosensory cortex in monkeys.
M. Sur (1984)
Brodmann's Areas 17 and 18 Brought into Stereotaxic Space—Where and How Variable?
K. Amunts (2000)
Atlas of the Cerebral Sulci
小野 道夫 (1990)
Multiple representations of the body within the primary somatosensory cortex of primates.
J. Kaas (1979)
Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen
C. Economo (1925)
Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans.
V. Penhune (1996)

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Tadahik oShibata (2002)
Quantitative genetic modeling of variation in human brain morphology.
W. Baaré (2001)
Cortical plasticity, dynamic neural fields and self-organization. (Plasticité corticale, champs neuronaux dynamiques et auto-organisation)
Georgios Detorakis (2013)
Distinct fine‐scale fMRI activation patterns of contra‐ and ipsilateral somatosensory areas 3b and 1 in humans
Elizabeth Ann Stringer (2014)
Comparing Like with Like: The Power of Knowing Where You Are
R. Turner (2014)
Development of a touch stimulator for functional magnetic-resonance imaging
Amer Qassim Mallah Alhussain (2013)
Direct stimulation of somatosensory cortex results in slower reaction times compared to peripheral touch in humans
David J. Caldwell (2019)
Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex
L. Cerliani (2012)
Myeloarchitecture and Maps of the Cerebral Cortex
K. Zilles (2015)
The neural correlates of reading impairment in adults with developmental dyslexia:evidence from fMRI between group analyses and an fMRI multiple-case study
A. Reid (2014)
Brain signal changes of sensory cortex according to surface roughness of boneless corsets
Jie Yuan (2020)
Deformation Field Morphometry Reveals Age-Related Structural Differences between the Brains of Adults up to 51 Years
P. Pieperhoff (2008)
Does Anticipation of Pain Affect Cortical Nociceptive Systems?
C. Porro (2002)
Prefrontal Control of the Tactile Sense
Juha Gogulski (2018)
Cyto-, Myelo-, and Receptor Architectonics of the Human Parietal Cortex
K. Zilles (2001)
Variability and asymmetry in the human precentral motor system. A cytoarchitectonic and myeloarchitectonic brain mapping study.
J. Rademacher (2001)
Probing the reaching–grasping network in humans through multivoxel pattern decoding
M. G. Di Bono (2015)
Dipole source analyses of early median nerve SEP components obtained from subdural grid recordings.
U. Baumgärtner (2010)
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