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Pharmacokinetics And Pharmacodynamics Of Curcumin.

R. Sharma, W. Steward, A. Gescher
Published 2007 · Medicine

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Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2-8% of most turmeric preparations. Preclinical data from animal models and phase I clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing. Efficient first-pass metabolism and some degree of intestinal metabolism, particularly glucuronidation and sulfation of curcumin, might explain its poor systemic availability when administered via the oral route. A daily oral dose of 3.6 g of curcumin is compatible with detectable levels of the parent compound in colorectal tissue from patients with cancer. The levels demonstrated might be sufficient to exert pharmacological activity. There appears to be negligible distribution of the parent drug to hepatic tissue or other tissues beyond the gastrointestinal tract. Curcumin possesses wide-ranging anti-inflammatory and anticancer properties. Many of these biological activities can be attributed to its potent antioxidant capacity at neutral and acidic pH, its inhibition of cell signaling pathways at multiple levels, its diverse effects on cellular enzymes, and its effects on cell adhesion and angiogenesis. In particular, curcumin's ability to alter gene transcription and induce apoptosis in preclinical models advocates its potential utility in cancer chemoprevention and chemotherapy. With regard to considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat or prevent human diseases, curcumin is currently a leading agent.
This paper references
10.1016/J.BBRC.2005.07.174
Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells.
M. Woo (2005)
Induction of glutathione S-transferase activity by curcumin in mice.
M. Susan (1992)
10.3892/ijo.3.6.1131
Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens.
W. Nijhoff (1993)
10.1016/S0016-5085(98)82694-2
Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.
S. Singh (1998)
The glutathione S-transferases supergene family
J. D. Hayes (1995)
The effect of curcumin on glutathione linked detoxification enzymes in rat liver
J. T. Piper (1998)
10.1002/cber.191004302168
Zur Kenntnis des Curcumins
G. Ciamician (1897)
Relationship with drug levels
R. A. Sharma (2001)
Nitric oxide inhibits DNA ligase activity : Potential mechanisms for NOmediated DNA damage
D. A. Wink M. Graziewicz (1996)
Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with post-operative inflammation
R. R. Satoskar (1986)
10.2307/2418770
Plants Consumed by Man.
R. Ornduff (1975)
10.1093/carcin/17.11.2501
Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage.
M. Graziewicz (1996)
10.1055/S-2006-957450
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
G. Shoba (1998)
An essential regulator of NOmediated apoptosis
A. Von Knethen (1997)
10.3109/00498257809069589
The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat.
G. Holder (1978)
Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.
S. Plummer (2001)
10.1207/s15327914nc5502_2
Curcumin Content of Turmeric and Curry Powders
R. Tayyem (2006)
10.1074/JBC.M410647200
Sensitization of Taxol-induced Apoptosis by Curcumin Involves Down-regulation of Nuclear Factor-κB and the Serine/Threonine Kinase Akt and Is Independent of Tubulin Polymerization*
Smitha V. Bava (2005)
10.1016/0300-483X(81)90027-5
Metabolism of curcumin--studies with [3H]curcumin.
V. Ravindranath (1981)
The seventh DeWitt S
A. H. Conney (2003)
10.4049/JIMMUNOL.171.7.3863
Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells 1
A. Bharti (2003)
10.1096/fj.02-0916fje
Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells
J. Dye (2004)
10.1002/(SICI)1099-1573(199906)13:4<318::AID-PTR445>3.0.CO;2-7
Efficacy of curcumin in the management of chronic anterior uveitis.
B. Lal (1999)
10.1038/sj.onc.1202980
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex
S. Plummer (1999)
10.1093/CARCIN/20.5.911
Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes.
A. Dinkova-Kostova (1999)
10.1016/0009-2797(95)03684-9
Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1.
P. Firozi (1996)
10.1002/1099-1573(200009)14:6<443::AID-PTR619>3.0.CO;2-V
Role of curcumin in idiopathic inflammatory orbital pseudotumours.
B. Lal (2000)
10.1053/GAST.2002.37050
Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice.
Ken Sugimoto (2002)
10.1002/JCB.20059
Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells.
W. Chan (2004)
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.
C. Ireson (2001)
Nitric oxide induces oxidative damage in addition to deaminiation in macrophage DNA
T. deRojas-Walker (1995)
10.1124/JPET.105.084434
Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways
Y. Moon (2005)
Anticancer potential of curcumin: preclinical and clinical studies.
B. Aggarwal (2003)
P1: OTE/SPH P2: OTE SVNY332-Aggarwal February
(2007)
10.1093/CARCIN/BGH233
Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.
G. Collett (2004)
10.1007/s10620-005-3032-8
Curcumin Therapy in Inflammatory Bowel Disease: A Pilot Study
P. Holt (2005)
10.1002/jcb.240630706
Clinical development plan: curcumin.
(1996)
Modification by dietary curcumin and implications for clinical trials
R. G. Tunstall (2006)
10.1016/S0006-2952(98)00114-2
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties.
M. Chan (1998)
10.1016/S0925-4439(96)00032-4
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.
M. Kuo (1996)
Loss of Apc+ in intestinal adenomas from Min mice.
C. Luongo (1994)
10.1093/CARCIN/BGI089
Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).
Suresh R Volate (2005)
10.1006/PHRS.1998.0404
Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages.
Y. Abe (1999)
10.3109/10409239509083491
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
J. Hayes (1995)
10.1080/01635589609514468
Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
M. Jiang (1996)
10.1111/J.1600-0773.1978.TB02240.X
A study on the fate of curcumin in the rat.
B. Wahlström (1978)
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
R. Sharma (2001)
10.1093/JNCI/91.1.86
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.
S. Ambs (1999)
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
R. Sharma (2001)
An ultrasound study
A. Raysid (1999)
Evaluation of anti-inflammatory-property of curcumin (diferuloyl methane) in patients with postoperative inflammation
Satoskar Rr (1986)
10.1080/21548331.1990.11704095
Pharmacokinetics and pharmacodynamics.
D. Greenblatt (1990)
Biotransformation of curcumin through reduction and glucuronidation in mice.
M. Pan (1999)
10.1016/J.BCP.2004.05.032
Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.
A. Duvoix (2004)
10.1016/S0192-0561(99)00050-8
Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells.
B. Gupta (1999)
10.1016/0304-3835(92)90223-I
Reversal of aflatoxin induced liver damage by turmeric and curcumin.
K. Soni (1992)
10.1124/MOL.105.018374
Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols
C. Andreadi (2006)
10.1016/S0378-8741(98)00234-7
Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal.
D. Eigner (1999)
10.32388/568784
Clinical development plan
G. Kelloff (1994)
10.1016/S1383-5718(02)00016-5
Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats.
Y. Shukla (2002)
10.1016/S0272-6386(96)90297-8
Immunosuppressants: cellular and molecular mechanisms of action.
M. Suthanthiran (1996)
Curcurmin activates the haem oxygenase1 gene via regulation of Nrf 2 and the antioxidantresponsive element
M. Hoque (2003)
10.1016/S0006-2952(98)00143-9
Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
H. Ciolino (1998)
10.1091/MBC.10.2.361
NF-κB and AP-1 Activation by Nitric Oxide Attenuated Apoptotic Cell Death in RAW 264.7 Macrophages
A. V. Knethen (1999)
Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.
S. Perkins (2002)
10.1093/CARCIN/23.8.1307
Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin.
N. Li (2002)
10.1158/1078-0432.CCR-05-1192
Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice
B. Aggarwal (2005)
NF- B and AP-1 activation by nitric oxide attenuated apoptotic death in RAW 264.7 macrophages
A. Von Knethen (1999)
Studies with [3H] curcumin
V. Ravindranath (1981)
Structure. Chem Ber
J Milobedzka (1910)
NF-␬B and AP-1 activation by nitric oxide attenuated apoptotic death in RAW 264.7 macrophages
A Von Knethen (1999)
10.1016/0300-483X(80)90122-5
Absorption and tissue distribution of curcumin in rats.
V. Ravindranath (1980)
Cancer patients who experienced diagnostic genetic testing for cancer susceptibility: reactions and behavior after the disclosure of a positive test result.
V. Bonadona (2002)
10.1080/10408690490424702
Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
B. Joe (2004)
10.1016/S1470-2045(00)00256-4
Role of nitric oxide in carcinogenesis and tumour progression.
P. Lala (2001)
10.1177/030089168707300105
Turmeric and Curcumin as Topical Agents in Cancer Therapy
R. Kuttan (1987)
Preliminary study on antirheumatic activity of curcumin (diferuloyl methane).
S. D. Deodhar (1980)
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
C. Ireson (2002)
10.1042/BJ20021619
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.
Elisabeth Balogun (2003)
10.1016/0006-2952(95)00171-U
Inhibition of tumor necrosis factor by curcumin, a phytochemical.
M. Chan (1995)
Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture.
A. Conney (2003)
10.1055/s-2006-960004
Pharmacology of Curcuma longa.
H. P. Ammon (1991)
10.5040/9781474247115.0051
The pilot study.
C. Baird (2000)
10.1126/SCIENCE.1093941
Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects
M. Egan (2004)
Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.
H. Samaha (1997)
Biomarkers of systemic activity and compliance
R. A. Sharma (2004)
10.1096/fasebj.11.11.9285487
Cyclooxygenase‐2: an essential regulator of NO‐mediated apoptosis
A. von Knethen (1997)
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
G. Garcea (2005)
10.1016/S1357-2725(98)00015-6
Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.
J. T. Piper (1998)
10.1016/0300-483X(81)90056-1
In vitro studies on the intestinal absorption of curcumin in rats.
V. Ravindranath (1981)
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
C. Rao (1995)
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
T. Kawamori (1999)
10.1006/bbrc.1995.1076
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages.
I. Brouet (1995)
10.1016/J.EJCA.2005.10.024
Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials.
R. Tunstall (2006)
Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.
C. Yan (2005)
Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance
R A Sharma (2004)
10.1093/CARCIN/20.3.445
Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells.
F. Zhang (1999)
10.1093/CARCIN/19.8.1357
Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.
S. Singh (1998)
10.1021/tx00045a020
Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA.
T. deRojas-Walker (1995)
Dose escalation of curcumin in healthy adults
M. T. Ruffin (2003)
10.1038/sj.bjc.6601623
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
G. Garcea (2004)
10.1093/CARCIN/22.3.467
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
K. Imaida (2001)
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
A. Cheng (2001)
10.1046/j.1365-2036.1999.00464.x
The effect of curcumin and placebo on human gall‐bladder function: an ultrasound study
Rasyid (1999)



This paper is referenced by
10.1007/s11064-016-2034-6
Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson’s Disease
M. D. Pandareesh (2016)
10.1016/j.bmcl.2012.02.056
Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin.
J. Lal (2012)
10.1002/ptr.4863
Curcumin serves as a human kv1.3 blocker to inhibit effector memory T lymphocyte activities.
Yi-tian Lian (2013)
10.1002/EJIC.201402884
Remarkable Selectivity and Photo‐Cytotoxicity of an Oxidovanadium(IV) Complex of Curcumin in Visible Light
Samya Banerjee (2015)
10.5772/INTECHOPEN.78687
Skeletal Muscle as a Therapeutic Target for Natural Products to Reverse Metabolic Syndrome
Sithandiwe E Mazibuko-Mbeje (2018)
10.1007/978-3-030-16807-0
Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications
Shahid Akbar (2020)
10.3109/10717544.2011.595842
Lung-targeted delivery system of curcumin loaded gelatin microspheres
Fengliang Cao (2011)
10.1016/j.bmc.2008.10.044
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
G. Liang (2009)
10.1016/j.ctim.2014.07.006
Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial.
Y. Panahi (2014)
10.1002/9783527683031.CH12
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
Andrew M. Lewis (2015)
10.1111/IJFS.13241
Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice
Bo Liu (2016)
10.1080/1028415X.2017.1345425
Mechanistic comparison of current pharmacological treatments and novel phytochemicals to target amyloid peptides in Alzheimer’s and neurodegenerative diseases
Neelima Ayyalasomayajula (2018)
10.1007/s00280-018-3654-0
A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer
R. Greil (2018)
10.1152/ajprenal.90732.2008
Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation.
S. Ghosh (2009)
10.3177/JNSV.61.37
Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study.
Y. Sunagawa (2015)
10.1158/0008-5472.CAN-07-6246
Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.
V. Milacic (2008)
10.1016/j.biotechadv.2008.07.001
Plant in vitro culture for the production of antioxidants--a review.
A. Matkowski (2008)
Particle size modification of curcumin and its effect on plasma and tissue distribution
M. Louisa (2019)
SYNTHESIS, SCREENING AND NANOTECHNOLOGY BASED IN VIVO DRUG DELIVERYOF CURCUMIN AND ITS ANALOGUES
Thota Srilatha (2012)
10.1016/j.ijpharm.2015.04.046
Poly(D,L-lactic acid)-glycerol-based nanoparticles for curcumin delivery.
In-Soo Yoon (2015)
10.1524/ncrs.2009.224.14.347
Crystal structure of ortho-(2e,5e) - 2,5-bis(2-methoxy-benzylidene)cyclopentanone,C21H20O3
C. Zhao (2009)
10.1002/chem.201901527
A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity.
Alessia Colombo (2019)
10.1007/978-3-030-16807-0_83
Curcuma longa L. (Zingiberaceae)
Shahid Akbar (2020)
10.3748/wjg.v20.i23.7242
Nanotechnology applications for the therapy of liver fibrosis.
L. Giannitrapani (2014)
10.1007/s13346-011-0033-3
Comparative oral bioavailability advantage from curcumin formulations
Bhushan Munjal (2011)
10.1007/s11051-014-2317-2
Construction and characterization of curcumin nanoparticles system
Weitong Sun (2014)
10.1039/C5RA00018A
Curcumin entrapped folic acid conjugated PLGA–PEG nanoparticles exhibit enhanced anticancer activity by site specific delivery
J. J. Pillai (2015)
10.1002/jbt.22481
Role of α-tocopherol and Lactobacillus plantarum in the alleviation of mercuric chloride-induced testicular atrophy in rat's model: Implication of molecular mechanisms.
Laila M Fadda (2020)
10.1080/10408391003698677
Polyphenols and Human Health: A Prospectus
F. Visioli (2011)
10.22038/AJP.2013.74
Turmeric active substance, curcumin, enhanced apomorphine-induced yawning in rats
Esmaeal Tamaddonfard (2013)
10.1016/j.carbpol.2018.10.073
In vitro permeability enhancement of curcumin across Caco-2 cells monolayers using electrospun xanthan-chitosan nanofibers.
A. Faralli (2019)
10.1136/acupmed-2011-010116
Acupuncture Combined with Curcumin Attenuates Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats
Feng Zhang (2012)
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