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Non-steroidal Anti-inflammatory Drugs

A. Whelton, T. Stürmer, G. Porter
Published 2003 · Chemistry

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Introduction ___________________________________________________________ 419 Prostaglandins and renal function __________________________________________ 420 The prostaglandin pathway 420 Renal prostanoid receptors 421 Cyclooxygenase isoforms _________________________________________________ 422 Factors regulating isoform expression 422 Distribution within the kidney 422 Mechanism of action of NSAIDs ____________________________________________ 422 Renal syndromes associated with NSAIDs ____________________________________ 423 Acute deterioration of renal function 424 Salt and water retention 428 The concept of “renal sparing” NSAIDs 430 Nephrotic syndrome with interstitial nephritis 431 Chronic renal failure/papillary necrosis 432 Other NSAID-induced renal syndromes 434 Renal effects of COX-2 inhibitors ___________________________________________ 435 Effects on renal function: GFR/urinary sodium excretion 435 Incidence of adverse cardio-renal events 436 Concurrent use of an oral synthetic prostaglandin analog with a NSAID ___________ 444 Conclusions and future challenges _________________________________________ 445 References _____________________________________________________________ 449
This paper references
10.1016/S0002-9343(00)00496-4
Drug-induced hyperkalemia: old culprits and new offenders.
M. Perazella (2000)
10.1016/S0895-7061(01)01606-5
P-434: Effect of rofecoxib, celecoxib, and naproxen on blood pressure (BP) in elderly volunteers
J. Schwartz (2001)
10.1093/RHEUMATOLOGY/19.4.258
Ibuprofen induced hyponatraemia.
M. Blum (1980)
10.7326/0003-4819-121-4-199408150-00011
Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis
A. G. Johnson (1994)
10.2165/00002018-200225070-00007
Renal Failure Associated with the Use of Celecoxib and Rofecoxib
S. R. Ahmad (2002)
10.1001/JAMA.1981.03320020046023
Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy.
M. Galler (1981)
10.1093/QJMED/90.6.411
Increased salt retention and hypertension from non-steroidal agents in the elderly.
E. Mulkerrin (1997)
10.1016/S0140-6736(00)05083-2
Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib
J. L. Rocha (2001)
10.1001/JAMA.1996.03540060042033
Reversible Membranous Nephropathy Associated With the Use of Nonsteroidal Anti-inflammatory Drugs
M. Radford (1996)
10.1159/000166764
Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs.
P. A. Abraham (1984)
10.1053/SARH.2002.37216
Anti-inflammatory agents and renal function.
D. Brater (2002)
10.7326/0003-4819-90-5-783
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism.
S. Y. Tan (1979)
10.1159/000206989
Indomethacin-induced hyperkalemia and renal failure in multiple myeloma.
G. Paladini (1982)
10.1016/S0009-9236(99)70056-1
Renal effects of selective cyclooxygenase‐2 inhibition in normotensive salt‐depleted subjects
J. Rossat (1999)
10.1001/ARCHINTE.158.10.1108
NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics.
E. Heerdink (1998)
10.1056/NEJM200108093450607
The coxibs, selective inhibitors of cyclooxygenase-2.
G. FitzGerald (2001)
10.1152/AJPLEGACY.1967.213.4.939
Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion.
H. H. Johnston (1967)
10.1016/S0002-9343(99)00113-8
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications.
A. Whelton (1999)
Consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis.
G. Singh. (2003)
10.1038/KI.1993.293
Renal complications of nonsteroidal anti-inflammatory drugs.
D. Schlondorff (1993)
10.1038/205397A0
Effect of Prostaglandin (PGEI) on the Permeability Response of Toad Bladder to Vasopressin, Theophylline and Adenosine 3′,5′-monophosphate
J. Orloff (1965)
10.1053/AJKD.2002.33412
Celecoxib-induced acute interstitial nephritis.
Justine Henao (2002)
10.1159/000168299
Clinical characterization of drug-induced allergic nephritis.
T. Shibasaki (1991)
10.1111/j.1572-0241.2000.02194.x
Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor
J. Goldstein (2000)
10.1038/KI.1985.11
Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men.
D. Brater (1985)
10.1002/j.1552-4604.1990.tb03487.x
Acute Interstitial Nephritis with Glomerulopathy Due to Nonsteroidal Anti‐Inflammatory Agents: A Review of Its Clinical Spectrum and Effects of Steroid Therapy
J. L. Porile (1990)
10.1002/j.1552-4604.1995.tb04088.x
Renal Effects of Over‐the‐Counter Analgesics
A. Whelton (1995)
10.1097/00000441-199004000-00002
Ibuprofen-associated renal impairment in a large general internal medicine practice.
M. Murray (1990)
10.7326/0003-4819-106-2-235
Suprofen-related nephrotoxicity. A distinct clinical syndrome.
D. Hart (1987)
The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis.
A. Schwarz (2000)
10.1016/S0149-2918(98)80049-0
The impact of nonsteroidal anti-inflammatory drugs on hypertension: alternative analgesics for patients at risk.
G. Ruoff (1998)
10.1001/JAMA.1978.03280400048019
The Renal Circulation
B. Margolis (1984)
10.1016/0140-6736(90)91908-S
Blood pressure and coronary heart disease
R. Collins (1990)
10.1097/00045391-200007020-00004
Renal and Related Cardiovascular Effects of Conventional and COX-2-Specific NSAIDs and Non-NSAID Analgesics
A. Whelton (2000)
10.1001/JAMA.1977.03270430058021
Edema associated with ibuprofen therapy.
R. Schooley (1977)
10.1038/KI.1987.164
The clinical significance of inhibition of renal prostaglandin synthesis.
C. Patrono (1987)
10.1053/AJKD.2002.36349
Nephrotic syndrome and interstitial nephritis associated with celecoxib.
A. Alper (2002)
10.1016/S0272-6386(12)80155-7
Chronic renal disease and papillary necrosis associated with the long-term use of nonsteroidal anti-inflammatory drugs as the sole or predominant analgesic.
M. Segasothy (1994)
10.1111/J.0954-6820.1976.TB06701.X
The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome.
L. Arisz (1976)
10.1159/000166578
Ibuprofen-induced acute renal failure with acute tubular necrosis.
H. Fong (1982)
10.1056/NEJM195506232522508
Anuria following phenylbutazone therapy.
J. Weisman (1955)
10.1172/JCI108733
Inhibition of sodium transport by prostaglandin E2 across the isolated, perfused rabbit collecting tubule.
J. Stokes (1977)
10.1001/jama.283.15.1967
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group.
B. Davis (2000)
10.1001/JAMA.1982.03330210046033
Sulindac. A potentially renal-sparing nonsteroidal anti-inflammatory drug.
R. D. Bunning (1982)
10.1161/01.CIR.0000132491.96623.04
Nonsteroidal Antiinflammatory Drugs and the Risk of Myocardial Infarction in the General Population
L. Garcia Rodriguez (2004)
10.7326/0003-4819-133-5-200009050-00024
Acute Renal Failure Associated with Rofecoxib
G. Wolf (2000)
10.1056/NEJMOA010323
Acetaminophen, aspirin, and chronic renal failure.
C. M. Fored (2001)
10.1161/01.RES.36.1.204
Enhanced Renal Prostaglandin Production in the Dog: II. EFFECTS ON INTRARENAL HEMODYNAMICS
Lucas C. T. Chang (1975)
Indomethacin-induced azotaemia and hyperkalaemia: a case study.
Nicholls Mg (1981)
10.1016/S0002-9343(01)00942-1
Determinants of impaired renal function with use of nonsteroidal anti-inflammatory drugs: the importance of half-life and other medications.
T. Stürmer (2001)
10.1038/NEWBIO231232A0
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
J. Vane (1971)
10.1046/J.1365-2125.1999.00869.X
Glomerular, tubular and interstitial nephritis associated with non-steroidal antiinflammatory drugs. Evidence of a common mechanism.
U. Ravnskov (1999)
10.1038/sj.jhh.1001235
Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial
H. Celis (2001)
10.1161/01.HYP.0000014323.99765.16
Effects of Celecoxib on Ambulatory Blood Pressure in Hypertensive Patients on ACE Inhibitors
W. White (2002)
10.1046/J.1523-1755.2001.060002804.X
Drug-induced acute interstitial nephritis.
J. Rossert (2001)
10.1038/KI.1995.262
Glomerular actions of nitric oxide.
L. Raij (1995)
10.1001/JAMA.282.20.1929
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
M. Langman (1999)
10.1001/JAMA.1979.03300170042027
Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy.
F. Husserl (1979)
10.1177/009127000204200905
Effects of Celecoxib and Diclofenac on Blood Pressure, Renal Function, and Vasoactive Prostanoids in Young and Elderly Subjects
K. Dilger (2002)
10.1172/JCI109487
Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion.
J. Stokes (1979)
10.1038/sj.jhh.1001411
The different patterns of blood pressure elevation by rofecoxib and nabumetone
T. Reitblat (2002)
10.1016/0016-5085(83)90133-6
Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: Evidence for increased vasoconstrictor and decreased vasodilator factors
R. Zipser (1983)
Patterns of tubulo-interstitial damage associated with nonsteroidal antiinflammatory drugs.
Levin Ml (1988)
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
F. Catella-Lawson (1999)
10.1046/J.1523-1755.1998.06718.X
Regulation of renal function by prostaglandin E receptors.
M. Breyer (1998)
10.1002/ART.1780200403
Association of renal papillary necrosis and ankylosing spondylitis.
S. H. Lourie (1977)
10.1097/00045391-200007030-00004
Renal safety and tolerability of celecoxib, a novel cyclooxygenase-2 inhibitor.
A. Whelton (2000)
10.1056/NEJM198809153191106
Clinical implications of prostaglandin and thromboxane A2 formation (2).
J. Oates (1988)
10.1097/00075198-200112000-00005
Cyclooxygenase-2 selective inhibitors and the kidney.
M. Breyer (2001)
10.1097/00045391-199701000-00011
ACUTE RENAL PAPILLARY NECROSIS INDUCED BY IBUPROFEN
M. Atta (1997)
Analgesic nephropathy and the use of nonsteroidal anti-inflammatory drugs in renal patients: new insight.
B. Wm (1998)
10.1152/AJPRENAL.1997.272.4.F460
Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: implication for renal function.
M. Kömhoff (1997)
10.1001/JAMA.1994.03520100043031
Initiation of antihypertensive treatment during nonsteroidal anti-inflammatory drug therapy.
J. Gurwitz (1994)
10.1038/sj.jhh.1000485
Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension
VM Campese (1997)
10.1056/NEJM198403013100905
Renal syndromes associated with nonsteroidal antiinflammatory drugs.
D. M. Clive (1984)
10.1016/S0272-6386(96)90570-3
The renal effects of nonsteroidal anti-inflammatory drugs: summary and recommendations.
W. Bennett (1996)
10.1161/01.CIR.91.7.1981
Aging and endothelial function in normotensive subjects and patients with essential hypertension.
S. Taddei (1995)
10.7326/0003-4819-89-3-336
Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus.
R. Kimberly (1978)
10.1016/S0002-9343(99)00369-1
Effects of nonsteroidal anti-inflammatory drugs on renal function: focus on cyclooxygenase-2-selective inhibition.
D. Brater (1999)
10.1177/00912700022008766
Effects of Celecoxib, a Novel Cyclooxygenase‐2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial
P. Leese (2000)
10.1111/j.1532-5415.1999.tb02561.x
The Renal Effects of Nonsteroidal Anti‐inflammatory Drugs in Older People: Findings from the Established Populations for Epidemiologic Studies of the Elderly
T. Field (1999)
10.1001/JAMA.284.10.1247
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
F. Silverstein (2000)
Cyclooxygenase-2 in the kidney.
R. Harris (2000)
10.1016/S0272-6386(00)70266-6
Are selective COX-2 inhibitors nephrotoxic?
M. Perazella (2000)
10.5694/J.1326-5377.1979.TB127061.X
Indomethacin-induced hyperkalaemia.
MacCarthy Ep (1979)
10.1152/AJPLEGACY.1974.226.5.1015
Effects of prostaglandins E1 and E2 on renal sodium reabsorption and Starling forces.
J. Strandhoy (1974)
10.1097/00045391-200101000-00009
Cox-2-specific inhibitors: definition of a new therapeutic concept.
K. Verburg (2001)
10.1056/NEJM200011233432103
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.
C. Bombardier (2000)
10.1097/00004872-199917080-00020
Evaluation of the potential interaction between NaCl and prostaglandin inhibition in elderly individuals with isolated systolic hypertension.
S. Alam (1999)
10.1001/ARCHINTE.160.10.1465
Effects of celecoxib and naproxen on renal function in the elderly.
A. Whelton (2000)
10.1007/BF00562902
Acute effects of acetylsalicylic acid on renal function in normal man
K. J. Berg (2004)
10.1016/S0140-6736(80)90122-1
MEFENAMIC ACID NEPHROPATHY
C. Robertson (1980)
10.1002/j.1552-4604.1989.tb03275.x
Sulindac Kinetics and Effects on Renal Function and Prostaglandin Excretion in Renal Insufficiency
D. Klassen (1989)
10.1001/ARCHINTE.1993.00410040045007
A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure.
J. E. Pope (1993)
10.1016/S0272-6386(03)00647-4
Analgesic use and change in kidney function in apparently healthy men.
T. Kurth (2003)
10.1097/00004872-200205000-00037
Effect of indomethacin on the antihypertensive efficacy of valsartan and lisinopril: a multicentre study
Roberto Fogari (2002)
10.1016/0002-9343(83)91161-0
T and B lymphocyte subsets in fenoprofen nephropathy.
I. Stachura (1983)
10.7326/0003-4819-96-3-317
Reversible acute renal failure from combined triamterene and indomethacin: a study in healthy subjects.
L. Favre (1982)
10.7326/0003-4819-91-1-47
Acute oliguric renal failure induced by indomethacin: possible mechanism.
J. Walshe (1979)
10.1042/CS0700501
Effects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency.
C. Mistry (1986)
10.1007/BF00587912
Comparison of the effects of the prostaglandins A1, E2, and F2α on kidney function in dogs
G. Fülgraff (2004)
10.1002/j.1552-4604.1991.tb03743.x
Nonsteroidal Anti‐Inflammatory Drugs: Effects on Kidney Function
A. Whelton (1991)
10.1056/NEJM198003203021215
Irreversible renal failure after indomethacin in steroid-resistant nephrosis.
C. Kleinknecht (1980)
10.1046/J.1365-2125.2002.01637.X
Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction.
R. Schlienger (2002)
10.1056/NEJM199412223312502
Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs.
T. Perneger (1994)
10.1001/JAMA.286.3.315
Analgesic use and renal function in men.
K. Rexrode (2001)
The classification of cyclooxygenase inhibitors.
L. Lipsky (1998)
10.1093/RHEUMATOLOGY/30.1.56
No effect of misoprostol on renal function of rheumatoid patients treated with diclofenac.
M. Boers (1991)
10.1210/JCEM-48-6-895
Prostaglandins: modulators of renal function and pressor resistance in chronic liver disease.
R. Zipser (1979)
10.1016/S0140-6736(96)07631-3
Basal nitric oxide synthesis in essential hypertension
P. Forte (1997)
10.1016/S0002-9149(02)02661-9
Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis.
A. Whelton (2002)
10.1001/ARCHINTE.164.14.1519
Lifetime nonnarcotic analgesic use and decline in renal function in women.
G. Curhan (2004)
10.1097/00000441-200204000-00003
Cox‐2 Inhibitors: Today and Tomorrow
R. Mcmurray (2002)
10.1016/S0149-2918(01)80121-1
A comparison of renal-related adverse drug reactions between rofecoxib and celecoxib, based on the World Health Organization/Uppsala Monitoring Centre safety database.
S. Zhao (2001)
10.1093/OXFORDJOURNALS.QJMED.A069100
Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure.
J. Evans (1995)
10.1073/PNAS.90.24.11693
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
J. Mitchell (1993)
10.1073/PNAS.89.16.7384
Human cyclooxygenase-2 cDNA.
T. Hla (1992)
10.1002/ART.1780240917
Renal papillary necrosis due to ibuprofen.
G. M. Shah (1981)
10.1001/ARCHINTE.1996.00440200041005
Nonsteroidal anti-inflammatory drugs and the risk of hospitalization for acute renal failure.
S. Pérez Gutthann (1996)
10.1097/00041552-200101000-00014
Cyclooxygenase 2 and the kidney
M. Breyer (2001)
10.7326/0003-4819-112-8-568
Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison.
A. Whelton (1990)
10.7326/0003-4819-142-3-200502010-00005
Patients Exposed to Rofecoxib and Celecoxib Have Different Odds of Nonfatal Myocardial Infarction
S. Kimmel (2005)
Indomethacin- and Moduretic--induced hyperkalemia.
R. Mor (1983)
10.7326/0003-4819-126-3-199702010-00003
Parenteral Ketorolac: The Risk for Acute Renal Failure
H. Feldman (1997)
10.1159/000183692
Sulindac reduces the urinary excretion of prostaglandins and impairs renal function in cirrhosis with ascites.
E. Quintero (1986)
10.1001/JAMA.1980.03310100045031
Indomethacin-induced hyperkalemia in three patients with gouty arthritis.
J. Findling (1980)
10.1001/ARCHSURG.1971.01350090102024
Papillary necrosis following phenylbutazone ingestion.
A. Morales (1971)
10.1016/0002-9343(91)90485-G
Nonsteroidal anti-inflammatory drugs and antihypertensives.
M. Houston (1991)
10.1002/j.1552-4604.1991.tb03768.x
Minimization of Indomethacin‐Induced Reduction in Renal Function by Misoprostol
M. Weir (1991)
10.1097/00045391-199511000-00006
Effects of Misoprostol on Nonsteroidal Anti-Inflammatory Drug-Induced Renal Insufficiency in Patients with Stable Chronic Renal Failure: A Double-Blind, Crossover Study.
A. Whelton (1995)
10.1161/01.RES.36.1.197
Enhanced renal prostaglandin production in the dog. I. Effects on renal function.
J. Tannenbaum (1975)
10.1016/0049-0172(85)90035-6
Renal complications of nonsteroidal antiinflammatory drugs: identification and monitoring of those at risk.
J. Blackshear (1985)
10.1016/S0140-6736(04)16299-5
Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
M. Mamdani (2004)
10.1001/ARCHINTE.164.22.2472
Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction.
Lorenz M Fischer (2004)
10.1152/AJPLEGACY.1974.227.4.801
Redistribution of renal cortical blood flow during inhibition of prostaglandin synthesis.
M. Kirschenbaum (1974)
10.1016/S0140-6736(88)92892-9
PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
DavidY Graham (1988)
10.1097/00041552-200103000-00001
Nonsteroidal anti-inflammatory drugs and the kidney
T. Stürmer (2001)
10.1097/00045391-199511000-00003
Effects of Misoprostol on Contrast-Induced Renal Dysfunction.
Lawrence Gurkowski (1995)
10.1016/0014-5793(93)80263-T
Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues
G. O'neill (1993)
10.1001/ARCHINTE.162.3.265
Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study.
J. Feenstra (2002)
10.1161/01.HYP.0000035856.77718.DA
Nonnarcotic Analgesic Use and the Risk of Hypertension in US Women
J. Dedier (2002)
10.1016/0002-9343(84)90849-0
Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate.
W. L. Bender (1984)
10.1016/S0002-9343(00)00699-9
Renal aspects of treatment with conventional nonsteroidal anti-inflammatory drugs versus cyclooxygenase-2-specific inhibitors.
A. Whelton (2001)
10.1093/OXFORDJOURNALS.AJE.A010234
Nonsteroidal antiinflammatory drugs and acute renal failure in elderly persons.
M. Griffin (2000)
10.1073/PNAS.89.11.4888
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
M. O'Banion (1992)
10.1002/1529-0131(200107)44:7<1587::AID-ART282>3.0.CO;2-X
A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee.
T. Pincus (2001)
10.1038/clpt.1984.144
Effects of sulindac and indomethacin on renal prostaglandin synthesis
J. Sedor (1984)
10.1016/S0140-6736(97)05381-6
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension
J. Staessen (1997)
10.1001/ARCHINTE.160.6.777
Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem.
J. Page (2000)
10.1016/S0140-6736(99)07330-4
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
J. Staessen (2000)
10.1093/RHEUMATOLOGY/34.2.162
Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis.
M. Segasothy (1995)
10.1046/J.1523-1755.1999.00742.X
Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat.
C. Blume (1999)
10.1056/NEJM198402023100502
Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin.
G. Ciabattoni (1984)
10.1172/JCI117620
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
R. Harris (1994)
10.7326/0003-4819-41-5-1075
Phenylbutazone toxicity: report of a case of acute renal failure.
M. B. Lipsett (1954)
10.1001/ARCHINTE.163.4.481
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly.
M. Mamdani (2003)
Angiotensin II and prostaglandin interactions on systemic and renal effects of L-NAME in humans.
P. Perinotto (2001)
10.1159/000180733
The effect of indomethacin on kidney function and plasma renin activity in man.
A. J. Donker (1976)
10.1097/00007611-198506000-00039
Severe hyperkalemia caused by indomethacin and potassium supplementation.
F. Akbarpour (1985)
10.1016/S0895-7061(01)01811-8
P-166: Effects of ibuprofen (IB), nabumetone (N) and celecoxib (C) on blood pressure (BP) control in hypertensive patients on ACE inhibitors
R. H. Palmer (2001)
10.7326/0003-4819-133-1-200007040-00002
Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet
S. Swan (2000)
10.1001/ARCHINTE.1981.00340060110027
Hyperkalemia associated with indomethacin.
R. Goldszer (1981)
10.1016/S0140-6736(75)90705-9
Letter: Urinals soaked in disinfectants.
Emmerson Am (1975)
10.1007/s00228-004-0761-0
Association between concomitant use of several systemic NSAIDs and an excess risk of adverse drug reaction. A case/non-case study from the French Pharmacovigilance system database
F. Clinard (2004)
The use of nonheparinized hemodialysis after orthotopic liver transplantation - The University of Nebraska Medical Center experience
M. Wilson (1988)
10.1016/S0895-7061(01)01704-6
P-490: Projected risks and costs of cardiovascular disease due to increased systolic blood pressure associated with use of rofecoxib
M. Russell (2001)
10.1172/JCI108108
Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney.
R. Anderson (1975)
10.1097/00045391-200103000-00003
Cyclooxygenase-2–Specific Inhibitors and Cardiorenal Function: A Randomized, Controlled Trial of Celecoxib and Rofecoxib in Older Hypertensive Osteoarthritis Patients
A. Whelton (2001)
10.1016/0140-6736(90)90944-Z
Blood pressure, stroke, and coronary heart disease: Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context
R. Collins (1990)
10.1177/009127000004001005
Comparative Inhibitory Activity of Rofecoxib, Meloxicam, Diclofenac, Ibuprofen, and Naproxen on COX‐2 versus COX‐1 in Healthy Volunteers
A. Hecken (2000)
Subclinical renal toxicity in rheumatic patients receiving longterm treatment with nonsteroidal antiinflammatory drugs.
J. Calvo-alen (1994)



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