← Back to Search
Biosensing Systems Based On Genetically Engineered Whole Cells
A. Struss, P. Pasini, S. Daunert
Published 2010 · Biology
Save to my Library
Download PDFAnalyze on Scholarcy
Genetically engineered whole cells as biosensing systems in biosensors have been employed, in the past two decades, for the detection of a variety of analytes. In addition to being rapid, specific/selective, and sensitive, these whole-cell-based sensing systems provide information pertaining to the analyte bioavailability. This information is particularly important to study the effect of harmful/toxic chemicals on living systems. The whole cells used for designing and developing cell-based sensing systems can be either prokaryotic or eukaryotic in nature. These intact prokaryotic or eukaryotic cells can be genetically engineered to recognize the analytes of interest and respond with the production of a measurable signal in a dose-dependent manner. Generally, prokaryotic bacterial whole-cell sensing systems are developed by introducing a plasmid construct with a reporter gene fused to a promoter, which is induced by a target analyte through a regulatory protein. Similarly, a receptor, which is activated by a target analyte, is coupled with a reporter gene for the development of genetically modified eukaryotic cell-based biosensing systems. The most commonly used reporter proteins in whole-cell biosensing include luminescent proteins, such as bacterial and firefly luciferases; green fluorescent protein along with its variants; and β-galactosidase. The analytes that can be detected using genetically manipulated whole-cell sensing systems range from general toxicants and cell stress factors to specific analytes, such as metals, metalloids, organic pollutants, sugars, drugs, and bacterial signaling molecules. In order to develop self-contained sensing devices based on recombinant whole-cell sensing systems, preservation, miniaturization, and portability are important issues that need to be addressed.
This paper references
Scale‐up and Optimization of the Low‐Temperature Inducible cspA Promoter System
J. Vasina (1998)
Design and Application of a Biosensor for Monitoring Toxicity of Compounds to Eukaryotes
R. P. Hollis (2000)
Enhancing the sensitivity of a two-stage continuous toxicity monitoring system through the manipulation of the dilution rate.
M. Gu (2002)
Green fluorescent protein in the design of a living biosensing system for L-arabinose.
R. Shetty (1999)
Microbial O2- and H2O2-electrode sensors for alcohol assays based on the use of permeabilized mutant yeast cells as the sensitive bioelements.
M. V. Gonchar (1998)
Analysis of bioavailable phenols from natural samples by recombinant luminescent bacterial sensors.
Anu Leedjärv (2006)
Bioluminescent-bioreporter integrated circuits form novel whole-cell biosensors
M. Simpson (1998)
Determination of Geno- and Cytotoxicity of Groundwater and Sediments Using the Recombinant SWITCH Test
C. Baumstark-Khan (2005)
Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity
M. Takeyoshi (2003)
Bioluminescent sensors for detection of bioavailable Hg(II) in the environment.
O. Selifonova (1993)
Living bacterial cell array for genotoxin monitoring.
Y. Kuang (2004)
A recombinant Escherichia coli sensor strain for the detection of tetracyclines.
M. Korpela (1998)
Bacterial bioluminescent emission from recombinant Escherichia coli harboring a recA::luxCDABE fusion.
M. Gu (2000)
Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substances.
V. Afanassiev (2000)
Development of a set of simple bacterial biosensors for quantitative and rapid measurements of arsenite and arsenate in potable water.
Judith Stocker (2003)
Sol–gel luminescence biosensors: Encapsulation of recombinant E. coli reporters in thick silicate films
J. Premkumar (2002)
Toxicity monitoring and classification of endocrine disrupting chemicals (EDCs) using recombinant bioluminescent bacteria.
M. Gu (2002)
Bioavailable nitrate detection in water by an immobilized luminescent cyanobacterial reporter strain
F. Mbeunkui (2002)
Shining the light: the mechanism of the bioluminescence reaction of calcium-binding photoproteins.
Y. Ohmiya (1996)
Evaluation of a GFP reporter gene construct for environmental arsenic detection.
F. F. Roberto (2002)
Making bio-sense of toxicity: new developments in whole-cell biosensors.
S. Sørensen (2006)
High-specificity and high-sensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay.
P. Hastwell (2006)
Internal response correction for fluorescent whole-cell biosensors.
M. Mirasoli (2002)
Quantitative comparisons of in vitro assays for estrogenic activities.
H. Fang (2000)
The discovery of aequorin and green fluorescent protein
O. Shimomura (2005)
Rapid, Sensitive Bioluminescent Reporter Technology for Naphthalene Exposure and Biodegradation
J. King (1990)
Evaluation of estrogenic activity of organic biocides using ER-binding and YES assay.
A. Nakama (2007)
Development and Testing of a Bacterial Biosensor for Toluene-Based Environmental Contaminants
B. M. Willardson (1998)
Constricted flux through the branched-chain amino acid biosynthetic enzyme acetolactate synthase triggers elevated expression of genes regulated by rpoS and internal acidification.
T. V. Van Dyk (1998)
A biosensor for the detection of gas toxicity using a recombinant bioluminescent bacterium.
G. C. Gil (2000)
Fiber-optic-based biomonitoring of benzene derivatives by recombinant E. coli bearing luciferase gene-fused TOL-plasmid immobilized on the fiber-optic end.
Y. Ikariyama (1997)
Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography.
P. Shaw (1997)
Responses to toxicants of an Escherichia coli strain carrying a uspA'::lux genetic fusion and an E. coli strain carrying a grpE'::lux fusion are similar.
T. V. Van Dyk (1995)
A group-specific microbiological test for the detection of tetracycline residues in raw milk.
J. Kurittu (2000)
Direct quantification of N-(3-oxo-hexanoyl)-L-homoserine lactone in culture supernatant using a whole-cell bioreporter.
L. Yan (2007)
Optical biosensor for environmental on-line monitoring of naphthalene and salicylate bioavailability with an immobilized bioluminescent catabolic reporter bacterium.
A. Heitzer (1994)
A novel continuous toxicity test system using a luminously modified freshwater bacterium.
J. Cho (2004)
Environmental Biosensors Using Bioluminescent Bacteria
M. Gu (2005)
Chemical sensing of DNT by engineered olfactory yeast strain.
V. Radhika (2007)
On-chip genotoxic bioassay based on bioluminescence reporter system using three-dimensional microfluidic network
Koji Maehana (2006)
Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen
E. Routledge (1996)
On-line microbial biosensing and fingerprinting of water pollutants.
A. Horsburgh (2002)
Green fluorescent protein-based biosensor for detecting SOS-inducing activity of genotoxic compounds.
M. Kostrzynska (2002)
Detection of tetracyclines with luminescent bacterial strains.
J. Kurittu (2000)
Novel Cyanobacterial Biosensor for Detection of Herbicides
C. Shao (2002)
Controlled Field Release of a Bioluminescent Genetically Engineered Microorganism for Bioremediation Process Monitoring and Control
S. Ripp (2000)
Sensing antimonite and arsenite at the subattomole level with genetically engineered bioluminescent bacteria.
S. Ramanathan (1997)
A novel and sensitive test for rapid determination of water toxicity
S. Ulitzur (2002)
Amperometric measurement of copper ions with a deputy substrate using a novel Saccharomyces cerevisiae sensor.
M. Lehmann (2000)
Fluorescence-based sensing system for copper using genetically engineered living yeast cells.
R. Shetty (2004)
Bacterial bioluminescence: organization, regulation, and application of the lux genes
E. Meighen (1993)
Alcaligenes eutrophus as a Bacterial Chromate Sensor
Nicola Peitzsch (1998)
A Chromosomally Based tod-luxCDABEWhole-Cell Reporter for Benzene, Toluene, Ethybenzene, and Xylene (BTEX) Sensing
B. Applegate (1998)
Isolation and expression of a cDNA encoding Renilla reniformis luciferase.
W. Lorenz (1991)
Evaluation of interactive toxicity of chlorophenols in water and soil using lux-marked biosensors.
T. Tiensing (2002)
Stress-Based Identification and Classification of Antibacterial Agents: Second-Generation Escherichia coli Reporter Strains and Optimization of Detection
Elyse Shapiro (2002)
Development and Characterization of a Green Fluorescent Protein-Based Bacterial Biosensor for Bioavailable Toluene and Related Compounds
Lawrence Stiner (2002)
Bioluminescent assays for high-throughput screening.
Frank Fan (2007)
Characterization of a new solvent-responsive gene locus in Pseudomonas putida F1 and its functionalization as a versatile biosensor.
P. Phoenix (2003)
Versatile biosensor vectors for detection and quantification of mercury.
L. Hansen (2000)
Antibody-based immobilization of bioluminescent bacterial sensor cells.
J. Premkumar (2001)
Use of an ultrasensitive recombinant cell bioassay to determine estrogen levels in girls with precocious puberty treated with a luteinizing hormone-releasing hormone agonist.
K. Klein (1998)
Recombinant luminescent bacteria for measuring bioavailable arsenite and antimonite.
S. Tauriainen (1997)
Sensing of aromatic compounds by the DmpR transcriptional activator of phenol-catabolizing Pseudomonas sp. strain CF600.
V. Shingler (1994)
A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation.
A. W. Knight (2004)
The Use of Whole-Cell Biosensors to Detect and Quantify Compounds or Conditions Affecting Biological Systems
L. Hansen (2001)
Structure of bacterial luciferase.
T. Baldwin (1995)
Stress responsive bacteria: biosensors as environmental monitors.
A. Vollmer (2004)
Characterization and optimization of two methods in the immobilization of 12 bioluminescent strains.
R. Mitchell (2006)
Detection of DNA damage by use of Escherichia coli carrying recA'::lux, uvrA'::lux, or alkA'::lux reporter plasmids.
A. Vollmer (1997)
Construction of a Bioluminescent Reporter Strain To Detect Polychlorinated Biphenyls
A. Layton (1998)
Bioluminescent bioreporter integrated circuits: potentially small, rugged and inexpensive whole‐cell biosensors for remote environmental monitoring
D. Nivens (2004)
Whole-cell living biosensors—are they ready for environmental application?
H. Harms (2006)
Distinct responses of a recA::luxCDABE Escherichia coli strain to direct and indirect DNA damaging agents.
J. Min (1999)
LuxArray, a high-density, genomewide transcription analysis of Escherichia coli using bioluminescent reporter strains.
T. V. Van Dyk (2001)
Chemiluminescence: sensitive detection technology for reporter gene assays.
I. Bronstein (1996)
ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls
J. Feliciano (2006)
Detecting AhR ligands in sediments using bioluminescent reporter yeast.
P. Leskinen (2008)
Construction and characterization of novel dual stress-responsive bacterial biosensors.
R. Mitchell (2004)
Luminescent bacterial sensor for cadmium and lead.
S. Tauriainen (1998)
Measurement of cytoplasmic copper, silver, and gold with a lux biosensor shows copper and silver, but not gold, efflux by the CopA ATPase of Escherichia coli
J. V. Stoyanov (2003)
The eukaryote alternative: Advantages of using yeasts in place of bacteria in microbial biosensor development
R. Walmsley (2000)
Microbial whole-cell sensing systems of environmental pollutants.
S. Belkin (2003)
Optical imaging fiber-based single live cell arrays: a high-density cell assay platform.
I. Biran (2002)
Chlorocatechol detection based on a clc operon/reporter gene system.
X. Guan (2000)
Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays.
E. Sonneveld (2005)
Measurement of firefly luciferase reporter gene activity from cells and lysates using Escherichia coli arsenite and mercury sensors.
S. Tauriainen (1999)
Life with 6000 Genes
A. Goffeau (1996)
Environmental Chemistry of Soils
M. Mcbride (1994)
Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays.
J. Legler (2002)
The construction and application of a lux‐based nitrate biosensor
A. Prest (1997)
Biosensing of benzene derivatives in the environment by luminescent Escherichia coli.
E. Kobatake (1995)
Fluorescent Bacteria Encapsulated in Sol−Gel Derived Silicate Films
J. Premkumar (2002)
Advances in preservation methods: keeping biosensor microorganisms alive and active.
Joakim Bjerketorp (2006)
Heterogeneity of iron bioavailability on plants assessed with a whole-cell GFP-based bacterial biosensor.
D. Joyner (2000)
Detection of polychlorinated biphenyls employing chemical dechlorination followed by biphenyl whole cell sensing system
Shifen Xu (2005)
Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes.
C. Fuqua (1996)
Relative potencies of individual polycyclic aromatic hydrocarbons to induce dioxinlike and estrogenic responses in three cell lines
D. Villeneuve (2002)
Engineered Bacteria Based Biosensors for Monitoring Bioavailable Heavy Metals
S. Leth (2002)
Permeabilized cells of flavocytochrome b2 over-producing recombinant yeast Hansenula polymorpha as biological recognition element in amperometric lactate biosensors.
O. Smutok (2007)
Water toxicity detection by a panel of stress‐responsive luminescent bacteria
R. Pedahzur (2004)
Effector Specificity Mutants of the Transcriptional Activator NahR of Naphthalene Degrading Pseudomonas Define Protein Sites Involved in Binding of Aromatic Inducers*
A. Cebolla (1997)
A cell array biosensor for environmental toxicity analysis.
J. Lee (2005)
Endocrine disruptive effects of chemicals eluted from nitrile-butadiene rubber gloves using reporter gene assay systems.
Kanako Satoh (2008)
Enhancement in the sensitivity of a gas biosensor by using an advanced immobilization of a recombinant bioluminescent bacterium.
G. C. Gil (2002)
Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens.
B. Gutendorf (2001)
Photorhabdus luminescens luxCDABE promoter probe vectors.
T. V. Van Dyk (1998)
A microbial biosensor to predict bioavailable nickel in soil and its transfer to plants.
C. Tibazarwa (2001)
Genetically engineered whole-cell sensing systems: coupling biological recognition with reporter genes.
S. Daunert (2000)
Development of a novel, bioluminescence-based, fungal bioassay for toxicity testing.
H. J. Weitz (2002)
Construction of a whole-cell gene reporter for the fluorescent bioassay of nitrate.
C. J. Taylor (2004)
Reporter gene bioassays in environmental analysis
S. Köhler (2000)
Construction of a ColD cda Promoter-Based SOS-Green Fluorescent Protein Whole-Cell Biosensor with Higher Sensitivity toward Genotoxic Compounds than Constructs Based on recA, umuDC, or sulA Promoters
A. Norman (2005)
Development of a whole cell green fluorescent sensor for lysine quantification
V. Chalova (2008)
Application of high-density optical microwell arrays in a live-cell biosensing system.
L. A. Taylor (2000)
Construction of a sodA::luxCDABE fusion Escherichia coli: comparison with a katG fusion strain through their responses to oxidative stresses
H. Lee (2002)
Whole-cell bacterial sensors for the monitoring of phosphate bioavailability.
M. A. Dollard (2003)
A biosensor for environmental genotoxin screening based on an SOS lux assay in recombinant Escherichia coli cells.
L. Ptitsyn (1997)
An Escherichia coli biosensor capable of detecting both genotoxic and oxidative damage
R. Mitchell (2003)
Chip-based bioassay using bacterial sensor strains immobilized in three-dimensional microfluidic network.
H. Tani (2004)
Evaluation of a high throughput toxicity biosensor and comparison with a Daphnia magna bioassay.
B. Kim (2003)
Evaluation of a recombinant yeast cell estrogen screening assay.
N. Coldham (1997)
Green Fluorescent Protein as a Noninvasive Stress Probe in Resting Escherichia coli Cells
H. J. Cha (1999)
Toxicity biomonitoring of degradation byproducts using freeze-dried recombinant bioluminescent bacteria
S. H. Choi (2003)
Development and characterization of a whole-cell bioluminescent sensor for bioavailable middle-chain alkanes in contaminated groundwater samples.
P. Sticher (1997)
Developmental effects of dioxins and related endocrine disrupting chemicals.
L. Birnbaum (1995)
DRE-CALUX bioassay in comparison with HRGC/MS for measurement of toxic equivalence in environmental samples.
K. E. Joung (2007)
Applications of whole-cell bacterial sensors in biotechnology and environmental science
K. Yagi (2007)
Whole-cell biosensing of 3-chlorocatechol in liquids and soils
X. Guan (2002)
Bacterial biosensors for monitoring toxic metals.
S. Ramanathan (1997)
Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices.
P. Leskinen (2005)
Reporter genes lucFF, luxCDABE, gfp, and dsred have different characteristics in whole-cell bacterial sensors.
Kaisa Hakkila (2002)
A multi-channel continuous toxicity monitoring system using recombinant bioluminescent bacteria for classification of toxicity.
M. Gu (2001)
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
K. Gaido (1997)
A Dual‐Color Bacterial Reporter Strain for the Detection of Toxic and Genotoxic Effects
N. Hever (2006)
Study of the Response of a Biofilm Bacterial Community to UV Radiation
M. Elasri (1999)
Whole cell- and protein-based biosensors for the detection of bioavailable heavy metals in environmental samples
P. Corbisier (1999)
Simultaneous detection of analytes based on genetically engineered whole cell sensing systems
S. Shrestha (2001)
A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection.
E. Michelini (2005)
Optical imaging fiber-based live bacterial cell array biosensor.
I. Biran (2003)
Copper speciation and impacts on bacterial biosensors in the pore water of copper-contaminated soils.
R. Vulkan (2000)
Biosensing systems for the detection of bacterial quorum signaling molecules.
A. Kumari (2006)
Bioluminescence-based assays for detection and characterization of bacteria and chemicals in clinical laboratories.
P. Billard (1998)
[Advances in Biochemical Engineering/Biotechnology] Biomanufacturing Volume 87 || Whole-Cell-Based Biosensors for Environmental Biomonitoring and Application
Photoproteins as Reporters in Whole‐cell Sensing
J. Feliciano (2008)
Luminescence-based whole-cell-sensing systems for cadmium and lead using genetically engineered bacteria
R. Shetty (2003)
Remote sensing of microbial volatile organic compounds with a bioluminescent bioreporter integrated circuit
S. Ripp (2004)
Analytical approach for monitoring endocrine-disrupting compounds in urban waste water treatment plants
A. Roda (2006)
Development of biosensors for the detection of mercury and copper ions
D. Holmes (1994)
A luxCDABE-based bioluminescent bioreporter for the detection of phenol
D. Abd-El-Haleem (2002)
A bioluminescent sensor for high throughput toxicity classification.
B. Kim (2003)
Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening
J. Minic (2005)
Construction of spores for portable bacterial whole-cell biosensing systems.
Amol Date (2007)
Application of a mer-lux biosensor for estimating bioavailable mercury in soil
L. D. Rasmussen (2000)
Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.
M. Winson (1998)
Development and Application of Cell-Based Biosensors
J. Pancrazio (2004)
Recent advances using green and red fluorescent protein variants
A. Müller-Taubenberger (2007)
Whole cell strategies based on lux genes for high throughput applications toward new antimicrobials.
L. Galluzzi (2006)
On-line monitoring of gene expression.
I. Biran (1999)
Use of Luciferase Genes as Biosensors To Study Bacterial Physiology in the Digestive Tract
G. Corthier (1998)
Whole-cell-based biosensors for environmental biomonitoring and application.
M. Gu (2004)
A flow cytometry-optimized assay using an SOS-green fluorescent protein (SOS-GFP) whole-cell biosensor for the detection of genotoxins in complex environments.
A. Norman (2006)
Assessment of heavy metal bioavailability using Escherichia colizntAp::lux and copAp::lux-based biosensors
K. Riether (2001)
A single-use luciferase-based mercury biosensor using Escherichia coli HB101 immobilized in a latex copolymer film
O. Lyngberg (1999)
A portable toxicity biosensor using freeze-dried recombinant bioluminescent bacteria.
S. H. Choi (2002)
Construction of a nrdA::luxCDABE Fusion and Its Use in Escherichia coli as a DNA Damage Biosensor
E. T. Hwang (2008)
Androgenic and Antiandrogenic Effects of Alkylphenols and Parabens Assessed Using the Reporter Gene Assay with Stably Transfected CHO-K1 Cells (AR-EcoScreen System)
Kanako Satoh (2005)
Reporter gene technology: the future looks bright.
L. Naylor (1999)
Green fluorescent protein-like proteins in reef Anthozoa animals.
A. Miyawaki (2002)
Development of a Specific and Sensitive Bacteria Sensor for Detection of Mercury at Picomolar Levels in Environment
T. Omura (2004)
Hydroxylated polychlorinated biphenyl detection based on a genetically engineered bioluminescent whole-cell sensing system.
K. Turner (2007)
Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols
A. Wise (2000)
Detection of organomercurials with sensor bacteria.
A. Ivask (2001)
Stress-activated bioluminescent Escherichia coli sensors for antimicrobial agents detection.
Elyse Shapiro (2007)
Green fluorescent protein as a reporter for the DNA damage‐induced gene RAD54 in Saccharomyces cerevisiae
R. Walmsley (1997)
A transformed fish cell line expressing a green fluorescent protein-luciferase fusion gene responding to cellular stress.
A. Molina (2002)
Use of tests in yeasts and fungi in the detection and evaluation of carcinogens.
Parry Jm (1999)
Whole-cell-reporter-gene-based biosensing systems on a compact disk microfluidics platform.
A. Rothert (2005)
Cyanobacteria carrying ansmt-lux transcriptional fusion as biosensors for the detection of heavy metal cations
J. Erbe (2005)
A Luminescence-Based Mercury Biosensor
M. Virta (1995)
The cda GenoTox assay: a new and sensitive method for detection of environmental genotoxins, including nitroarenes and aromatic amines.
Trine Østergaard (2007)
gfp-Based N-Acyl Homoserine-Lactone Sensor Systems for Detection of Bacterial Communication
J. D. Andersen (2001)
Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water.
A. Murk (1996)
Bioluminescent whole cell optical fiber sensor to genotoxicants: system optimization
B. Polyak (2001)
Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities.
E. Sonneveld (2006)
Detection of bioavailable heavy metals in EILATox‐Oregon samples using whole‐cell luminescent bacterial sensors in suspension or immobilized onto fibre‐optic tips
Kaisa Hakkila (2004)
Use of the luminescent bacterial system for the rapid assessment of aquatic toxicity.
A. Bulich (1981)
In vivo bioluminescence imaging to evaluate estrogenic activities of endocrine disrupters.
A. Pillon (2005)
Specific detection of p-chlorobenzoic acid by Escherichia coli bearing a plasmid-borne fcbA'::lux fusion.
Y. Rozen (1999)
'Rec-lac test' for detecting SOS-inducing activity of environmental genotoxic substance.
T. Nunoshiba (1991)
Improved bacterial SOS promoter∷lux fusions for genotoxicity detection.
Y. Davidov (2000)
Factors affecting the toxicity of dioxin-like toxicants: a molecular approach to risk assessment of dioxins.
M. Brown (1992)
Genotoxicity monitoring using a 2D-spectroscopic GFP whole cell biosensing system
Amelita J. Bartolome (2003)
This paper is referenced by
Paper-based analytical devices for electrochemical study of the breathing process of red blood cells.
Xiang-yun Lin (2015)
Genetically Designed Bacterial Biosystems for Environmental and Biomedical Applications
Leslie D. Knecht (2014)
Bacteria nanoparticle toxicity testing : toward the use of original methods and complex matrices
Florian Mallevre (2016)
Advances in biosensors: Principle, architecture and applications ☆
V. Perumal (2014)
5 Microbial Indicators for Monitoring Pollution and Bioremediation
Tingting Xua (2016)
Microbial Indicators for Monitoring Pollution and Bioremediation
T. Xu (2014)
Détection des Ochratoxines A dans la production alimentaire par l’utilisation d’aptacapteur capacitif
Moez M. Elsaadani (2019)
Genetically modified whole-cell bioreporters for environmental assessment.
Tingting Xu (2013)
Feasibility of using biosensors for heavy metal detection in complex matrices such as bio-slurries
M. Vasilenko (2012)
Análisis y estudio de la interacción de escherichia coli ETEC E9034A con carburo de silicio amorfo hidrogenado como soporte inmovilizador
Pérez Coyotl (2018)
Biotechnological Advances in the Design of Algae-Based Biosensors.
A. Antonacci (2019)
Bacterial spores as platforms for bioanalytical and biomedical applications
Leslie D. Knecht (2011)
Fluorescence based fiber optic and planar waveguide biosensors. A review
E. Benito-Peña (2016)