Criteria For Diagnosis And Classification Of Melanoma
Published 2004 · Medicine
The overwhelming majority of melanomas begin as intraepidermal or intraepithelial proliferations, which may or may not have some relationship to a melanocytic nevus (9–37) (Fig. 1A,B). Estimates of the frequency of melanomas developing in continuity with a nevus of any kind vary widely; approximately a third of melanomas have nevus remnants (38–40). The duration of this intraepidermal phase ranges from months to many years, during which these proliferative lesions show progressive degrees of architectural and cytologic atypicality (41).