← Back to Search
Reactive Oxygen Species And Antioxidants In Luteal Cell Demise
H. Behrman, R. Aten, P. Kodaman, T. Zreik, P. Rinaudo
Published 1997 · Biology
Download PDFAnalyze on Scholarcy
The corpus luteum is the end-differentiated state of the primordial follicle and one of the major endocrine substructures of the ovary. The formation and involution of the corpus luteum occurs by processes that are regulated by endocrine, paracrine, and intracrine agents of the pituitary, the uterus (in nonprimates), the ovary, and the immune system. The physiological role of the corpus luteum is the secretion of products necessary for the establishment and maintenance of pregnancy. The more prominent luteal products are progesterone, estrogens, androgens, and peptides such as relaxin and oxytocin. Other products include inhibin and its family members, eicosanoids, cytokines, growth factors, and oxygen radicals. It is now evident that the historical perspective of the corpus luteum as an organ of progesterone and estradiol secretion governed solely by feedback regulation of luteinizing hormone (LH) is inadequate. In this chapter, we offer one view of corpus luteum regression and its regulation based on recent findings of this lab and others using the pseudopregnant rat model.
This paper references
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
J. F. Wößner (1991)
A cell adhesion receptor antiserum abolishes, whereas laminin and fibronectin glycoprotein components of extracellular matrix promote, luteinization of cultured rat granulosa cells.
R. Aten (1995)
Hormonal regulation and tissue-specific localization of alpha 2-macroglobulin in rat ovarian follicles and corpora lutea.
D. Gaddy-Kurten (1989)
Guanidinoacetate methyltransferase in the mouse: extensive expression in Sertoli cells of testis and in microvilli of caput epididymis.
H. Lee (1994)
Structure and mechanism of 70-kDa heat-shock-related proteins.
D. McKay (1993)
The Collagens: Biochemistry and Pathophysiology
E. J. Kucharz (1992)
Heat-Shock Proteins and Gamma-Delta T Cells
C. Brosnan (1992)
Plasma membrane changes in the rat corpus luteum induced by oxygen radical generation.
X. Wu (1993)
Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.
M. Santoro (1989)
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
R. Aitken (1989)
Hydroperoxide metabolism in mammalian organs.
B. Chance (1979)
DERMAL CONNECTIVE TISSUE MODULATED BY PHARMACOLOGIC AGENTS
A. Oikarinen (1992)
The control of oxidant stress at fertilization.
B. Shapiro (1991)
Indomethacin treatment prevents prolactin-induced luteolysis in the rat.
J. E. Sánchez-Criado (1987)
Tissue distribution of constitutive and induced soluble peroxidase in rat. Purification and characterization from lacrimal gland.
P. K. De (1992)
The B lymphocyte: a newly recognized source of reactive oxygen species with immunoregulatory potential.
F. Maly (1990)
Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells.
Y. Margolin (1990)
Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development.
R. A. Bucco (1995)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
R. M. Palmer (1987)
The superoxide-generating oxidase of phagocytic cells
F. Morel (1991)
Modulation of bovine luteal cell synthetic capacity by interferon-gamma.
D. L. Fairchild (1991)
Stimulation of phospholipase A2 by xanthine oxidase in the rat corpus luteum.
X. Wu (1992)
Calcium is an inhibitor of luteinizing hormone-sensitive adenylate cyclase in the luteal cell.
L. Dorflinger (1984)
Methimazole and propylthiouracil inhibit the oxygen free radical-induced expression of a 72 kilodalton heat shock protein in Graves' retroocular fibroblasts.
A. Heufelder (1992)
Activation of the heat shock transcription factor by hypoxia in mammalian cells.
I. Benjamin (1990)
Differential screening of ovarian cDNA libraries detected the expression of the porcine collagenase inhibitor gene in functional corpora lutea
T. Tanaka (1992)
Formation of thyroid hormones.
J. Nunez (1982)
Enzymic synthesis of L-ascorbic acid in different animal species.
A. Grollman (1957)
The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).
B. Clark (1994)
Prostaglandins in reproductive processes.
B. Caldwell (1981)
The role of ascorbic acid in mesenchymal differentiation.
R. Franceschi (1992)
Chaperones: helpers along the pathways to protein folding.
E. Craig (1993)
Preovulatory changes in ovarian expression of collagenases and tissue metalloproteinase inhibitor messenger ribonucleic acid: role of eicosanoids.
R. Reich (1991)
Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione.
Toshiaki Koizumi (1993)
Treatment of sheep with prostaglandin F2 alpha enhances production of a luteal chemoattractant for eosinophils.
W J Murdoch (1987)
Association of lipid peroxidation during luteal regression in the rat and natural aging in the rotifer
M. Sawada (1985)
Possible involvement of myeloperoxidase in lipid peroxidation.
T. Stelmaszyńska (1992)
Heat-Shock Proteins and Immunopathology
D. Aquino (1992)
Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.
H. Krieger-Brauer (1992)
Antioxidant functions of carotenoids.
N. Krinsky (1989)
THE HISTOCHEMISTRY OF OVARIAN MACROPHAGES IN THE RAT.
D. Bulmer (1964)
The generation of utilization of chlorinated oxidants by human neutrophils
S. Test (1986)
Metal chelators reverse the action of hydrogen peroxide in rat luteal cells
B. Musicki (1993)
Hypophysectomy and a replacement therapy in the rat
P. E. Smith (1930)
Luteal Membrane Binding of Prostaglandin F2α and Sensitivity of Corpora Lutea to Prostaglandin F2α-Induced Luteolysis in Pseudopregnant Rats*
K. Wright (1980)
Localization of stress protein-70 in ovine corpora lutea during prostaglandin-induced luteolysis.
L. A. McPherson (1993)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
Biological actions of carotenoids 1
A. Bendich (1989)
The entry of ascorbic acid into the corpus luteum in vivo and in vitro and the effect of luteinizing hormone.
D. Stansfield (1967)
Identification of a superoxide-generating NADPH oxidase system in human fibroblasts.
B. Meier (1991)
Oxidative injury and the heat shock response.
Y. Donati (1990)
Inactivation of peroxidase by hydrogen peroxide and its protection by a reductant agent.
M. Arnao (1990)
Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells.
B. Musicki (1994)
Ovarian vitamin E accumulation: evidence for a role of lipoproteins.
R. Aten (1994)
Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins.
J. L. Bruce (1993)
Accumulation of hypothiocyanite ion during peroxidase-catalyzed oxidation of thiocyanate ion.
T. Aune (1977)
A Corpus Luteum-Stimulating Substance in the Rat Placenta.∗
E. B. Astwood (1938)
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.
S. Nomura (1989)
Specific binding of prostaglandin F2α to membranes of rat corpora lutea
K. Wright (1979)
Cell death: the significance of apoptosis.
A. Wyllie (1980)
Transport and stability of ascorbic acid in pituitary cultures
E. I. Cullen (1986)
Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease.
W. Welch (1992)
Free radicals in biology and medicine
B. Halliwell (1985)
Ascorbic acid transport by isolated bovine adrenal cortical cells.
F. Finn (1980)
Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein.
S. King (1995)
Stress proteins, autoimmunity, and autoimmune disease
Winfield Jb (1991)
Production of leukotriene B4 by luteal tissues of sheeo treated with prostaglandin F2α
L. E. Steadman (1988)
Highly sensitive chemiluminescence method for determining myeloperoxidase in human polymorphonuclear leukocytes.
K. Uehara (1991)
Regulation of ovarian antioxidant vitamins, reduced glutathione, and lipid peroxidation by luteinizing hormone and prostaglandin F2 alpha.
R. Aten (1992)
Prolactin-Induced Morphological Luteal Regression Unaffected by LH∗ †
G. Macdonald (1969)
The histological dating of the human corpus luteum of menstruation.
G. Corner (1956)
The rat 78,000 dalton glucose-regulated protein (GRP78) as a precursor for the rat steroidogenesis-activator polypeptide (SAP): the SAP coding sequence is homologous with the terminal end of GRP78.
X. Li (1989)
Vitamins and Hormones
R. Harris (1948)
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
R. J. Gryglewski (1986)
Oxidative inactivation of myeloperoxidase released from human neutrophils.
S. Edwards (1987)
Evidence that hydrogen peroxide blocks hormone-sensitive cholesterol transport into mitochondria of rat luteal cells.
H. Behrman (1991)
Control of the LH receptor by prolactin and prostaglandin F2alpha in rat corpora lutea.
D. Grinwich (1976)
Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.
J. Geesin (1988)
A phorbol ester, phorbol 12-myristate 13-acetate, and a calcium ionophore, A23187, can mimic the luteolytic effect of prostaglandin F2 alpha in isolated rat luteal cells.
M. S. Baum (1987)
Transcriptional control of rat heme oxygenase by heat shock.
S. Shibahara (1987)
Protective role of vitamin E in biological systems.
L. Packer (1991)
Ascorbic acid in endocrine systems.
M. Levine (1985)
Hormone induction of ascorbic acid transport in immature granulosa cells.
H. Behrman (1996)
In vivo generation of hydrogen peroxide in the rat corpus luteum during luteolysis.
J. C. Riley (1991)
Studies on the mechanism controlling generation of superoxide radical in luteinized rat ovaries during regression.
M. Sawada (1994)
Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.
S. Marklund (1974)
Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis
M. Wiedau-Pazos (1996)
Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1.
A. Horwich (1993)
Immunosuppressive levels of glucocorticoid block extrauterine luteolysins in the rat.
F. Wang (1993)
Apoptosis during luteal regression in cattle.
J. Juengel (1993)
Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells.
T. Endo (1993)
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.
H. Schmidt (1992)
How do polypeptides cross the mitochondrial membranes?
W. Neupert (1990)
Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60.
F. Hartl (1992)
Heat Shock Proteins in Cellular Defense Mechanisms and Immunitya a
A. Healy (1992)
Luteolysis is linked to luteinizing hormone-induced depletion of adenosine triphosphate in vivo.
L. Soodak (1988)
Effects of prostaglandin F2 alpha treatment on LH and dibutyryl cyclic AMP-stimulated progesterone secretion by isolated rat luteal cells.
A. W. Jordan (1981)
Superoxide radical production in plasma membrane samples from regressing rat corpora lutea.
M. Sawada (1989)
Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein.
M. Traber (1984)
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
N. Boudreau (1995)
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.
C. Dupuy (1991)
Response of mammalian cells to metabolic stress; changes in cell physiology and structure/function of stress proteins.
Welch Wj (1991)
Tumor necrosis factor production and accumulation of inflammatory cells in the corpus luteum of pseudopregnancy and pregnancy in rabbits.
P. Bagavandoss (1990)
Macrophages in corpora lutea of mice: characterization and effects on steroid secretion.
T. Kirsch (1981)
The antigonadotropic actions of prostaglandin F2 alpha and phorbol ester are mediated by separate processes in rat luteal cells.
B. Musicki (1990)
Adhesion receptors of the immune system
T. Springer (1990)
Absorption, transport and metabolism of vitamin E.
C. Drevon (1991)
Physiological and pharmacological inhibitors of luteinizing hormone-dependent steroidogenesis induce heat shock protein-70 in rat luteal cells.
A. Khanna (1995)
The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells.
D. Stocco (1993)
Structural luteolysis in hypophysectomized rats.
P. Malven (1969)
Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells
A. Khanna (1994)
Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity.
J. Álvarez (1987)
Metabolism of 25-hydroxycholesterol by rat luteal mitochondria and dispersed cells.
M. E. Toaff (1982)
Mechanism of the rapid antigonadotropic action of prostaglandins in cultured luteal cells.
J. Thomas (1978)
Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo.
L. Garren (1965)
Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries.
J. S. Mann (1991)
Coordinate induction and activation of metalloproteinase and ascorbate depletion in structural luteolysis.
T. Endo (1993)
Effects of neutrophils in rat luteal cells.
J. Pepperell (1992)
Inhibition of gonadotropin action and progesterone synthesis by xanthine oxidase in rat luteal cells.
E. Gatzuli (1991)
Trophic stimulation of steroidogenesis: in search of the elusive trigger.
P. Hall (1985)
Synthesis of Heat Shock/Stress Proteins during Cellular Injury
T. Nowak (1993)
Luteolytic actions of peroxide in rat ovarian cells.
H. Behrman (1989)
Mechanism of deletion of endothelial cells during regression of the corpus luteum.
Azmi Ti (1984)
Hydrogen peroxide activates immediate binding of a Drosophila factor to DNA heat-shock regulatory element in vivo and in vitro.
J. Becker (1990)
Effect of hypophysectomy, prolactin, and prostaglandin F2 alpha on gonadotropin binding in vivo and in vitro in the corpus luteum.
H. Behrman (1978)
Studies on the human corpus luteum. I. Observations on the ultrastructure of development and regression of the luteal cells during the menstrual cycle.
E. Adams (1969)
A luteolytic action of prolactin in hypophysectomized rats.
P. Malven (1966)
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.
K. Sarge (1993)
Lymphocyte interactions with extracellular matrix
Y. Shimizu (1991)
Heat shock protein-70 induction mediates luteal regression in the rat.
A. Khanna (1995)
Changes in activities of superoxide dismutase and lipid peroxide in corpus luteum during pregnancy in rats.
N. Sugino (1993)
Heat shock induces the transcriptional activation of c-fos protooncogene.
F. Colotta (1990)
Role of selected nutrients in synthesis, accumulation, and chemical modification of connective tissue proteins.
D. Tinker (1985)
Cellular functions of ascorbic acid.
H. Padh (1990)
Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.
J. Zweier (1988)
Transport of ascorbic acid and other water-soluble vitamins.
R. C. Rose (1988)
Lipid hydroperoxides evoke antigonadotropic and antisteroidogenic activity in rat luteal cells.
P. Kodaman (1994)
Interaction of myeloperoxidase with peroxynitrite. A comparison with lactoperoxidase, horseradish peroxidase and catalase.
R. Floris (1993)
Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.
G. Visner (1990)
Endocrine regulation of ascorbic acid transport and secretion in luteal cells.
B. Musicki (1996)
Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.
R. Morimoto (1992)
Regulation of heat shock protein synthesis by gonadotropins in cultured granulosa cells.
A. Ben-Ze’ev (1989)
A requirement for the intercellular messenger nitric oxide in long-term potentiation.
E. Schuman (1991)
Flavonoids as superoxide scavengers and antioxidants.
C. Yuting (1990)
Formation and maintenance of corpora lutea in laboratory animals.
G. Greenwald (1968)
This paper is referenced by
Catalase and glutathione peroxidase expression in bovine corpus luteum during the estrous cycle and their modulation by prostaglandin F2α and H2O2
H. V. Vu (2014)