The Nervous System As A Target For Toxic Agents
Published 1988 · Chemistry
Damage to cells from toxic agents is of most serious consequence in those tissues where restoration of function through cell division or regeneration of cell processes is difficult or impossible. This situation is most characteristic of the nervous system. Mature neurons undergo cell division either rarely or not at all and restoration of complex cell processes interacting with other cell processes may be impossible even if the neuron does not die. In addition the large size and specialized biochemistry of some of the neurons makes them uniquely susceptible to specific toxic agents, especially those interfering with availability of oxygen.