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Zebrafish: Model For The Study Of Inflammation And The Innate Immune Response To Infectious Diseases.

B. Novoa, A. Figueras
Published 2012 · Biology, Medicine

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The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to study vertebrate development and hematopoiesis and recently, it has been adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune responses because adaptive immune system is morphologically and functionally mature only after 4-6 weeks postfertilization. This temporal separation provides a suitable system to study the vertebrate innate immune response in vivo, independently from the adaptive immune response. The transparency of early life stages allows a useful real-time visualization. Adult zebrafish which have complete (innate and adaptative) immune systems offer also advantages over other vertebrate infection models: small size, relatively rapid life cycle, ease of breeding, and a growing list of molecular tools for the study of infectious diseases. In this review, we have tried to give some examples of the potential of zebrafish as a valuable model in innate immunity and inflammation studies.
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10.3390/cells9041018
Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man
Abigail Elliot (2020)
10.3389/fphar.2020.00864
Phyllolobium chinense Fisch Flavonoids (PCFF) Suppresses the M1 Polarization of LPS-Stimulated RAW264.7 Macrophages by Inhibiting NF-κB/iNOS Signaling Pathway
Hua Fan (2020)
10.4081/ejh.2020.3161
Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish
L. Uyttebroek (2020)
10.1007/978-3-030-43855-5_6
Antimicrobial Nanotechnology in Preventing the Transmission of Infectious Disease
Juan Bueno (2020)
10.1016/j.phymed.2020.153237
Anthocyanins isolated from Hibiscus syriacus L. attenuate lipopolysaccharide-induced inflammation and endotoxic shock by inhibiting the TLR4/MD2-mediated NF-κB signaling pathway.
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne (2020)
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